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Hiroshi Maeda

Active 1955–2025

Also published as
Hiroshi Maéda
308
Papers
67,798
Citations
114
h-index
222
i10-index

Citations

Citations per year for Hiroshi Maeda1967: 2 citations1968: 1 citations1969: 3 citations1970: 2 citations1971: 1 citations1972: 3 citations1973: 2 citations1974: 3 citations1975: 3 citations1976: 3 citations1977: 2 citations1978: 5 citations1979: 6 citations1980: 9 citations1981: 6 citations1982: 2 citations1983: 3 citations1984: 5 citations1985: 14 citations1986: 9 citations1987: 9 citations1988: 41 citations1989: 39 citations1990: 30 citations1991: 44 citations1992: 53 citations1993: 40 citations1994: 59 citations1995: 61 citations1996: 83 citations1997: 77 citations1998: 170 citations1999: 172 citations2000: 227 citations2001: 283 citations2002: 218 citations2003: 343 citations2004: 311 citations2005: 404 citations2006: 473 citations2007: 494 citations2008: 445 citations2009: 518 citations2010: 646 citations2011: 667 citations2012: 766 citations2013: 743 citations2014: 819 citations2015: 765 citations2016: 698 citations2017: 667 citations2018: 537 citations2019: 1,718 citations2020: 1,854 citations2021: 1,627 citations2022: 1,269 citations2023: 903 citations2024: 1,187 citations2025: 604 citations2026: 11 citations

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 4,328 citing papers, 22.4% of this breakdownChina: 3,327 citing papers, 17.2% of this breakdownJapan: 1,283 citing papers, 6.6% of this breakdownGermany: 786 citing papers, 4.1% of this breakdownUnited Kingdom: 786 citing papers, 4.1% of this breakdownIndia: 781 citing papers, 4% of this breakdownSouth Korea: 605 citing papers, 3.1% of this breakdownItaly: 541 citing papers, 2.8% of this breakdownFrance: 511 citing papers, 2.7% of this breakdownCanada: 504 citing papers, 2.6% of this breakdownAustralia: 416 citing papers, 2.2% of this breakdownNetherlands: 407 citing papers, 2.1% of this breakdown
0%22.4%Other 26.1%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology26.1%
  • Medicine23.3%
  • Materials Science22.5%
  • Engineering11.1%
  • Agricultural and Biological Sciences4%
  • Immunology and Microbiology2.9%
  • Other10.1%

Topics

  • Nanoparticle-Based Drug Delivery10.2%
  • Nanoplatforms for cancer theranostics7.2%
  • RNA Interference and Gene Delivery5.5%
  • Advanced biosensing and bioanalysis techniques3%
  • Photodynamic Therapy Research Studies1.3%
  • Nitric Oxide and Endothelin Effects1.1%
  • Other71.7%

Coauthors

All papers

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  1. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

    Authors: Yasuhiro Matsumura, Hiroshi Maeda - 1986 cited by 6,798

  2. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

    Authors: Hiroshi Maeda, Jun Wu, Tomohiro Sawa, Yasuhiro Matsumura, K. Hori - Journal of Controlled Release 2000 cited by 6,505

  3. The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

    Authors: Jun Fang, Hideaki Nakamura, Hiroshi Maeda - Advanced Drug Delivery Reviews 2010 cited by 3,500

  4. Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

    Authors: Jun Fang, Waliul Islam, Hiroshi Maeda - Advanced Drug Delivery Reviews 2020 cited by 724

  5. The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

    Authors: Hiroshi Maeda, Hideaki Nakamura, Jun Fang - Advanced Drug Delivery Reviews 2012 cited by 2,347

  6. The Shikimate Pathway and Aromatic Amino Acid Biosynthesis in Plants

    Authors: Hiroshi Maéda, Natalia Dudareva - Annual Review of Plant Biology 2012 cited by 1,539

  7. Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity

    Authors: Hiroshi Maeda - Advanced Drug Delivery Reviews 2015 cited by 1,161

  8. Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

    Authors: Uma Prabhakar, Hiroshi Maeda, Rakesh K. Jain, Eva M. Sevick‐Muraca, William C. Zamboni, Omid C. Farokhzad, Simon T. Barry, Alberto Gabizón, Piotr Grodzinski, David C. Blakey - Cancer Research 2013 cited by 1,465

  9. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting

    Authors: Hiroshi Maeda - Advances in Enzyme Regulation 2001 cited by 2,463

  10. Analyses of repeated failures in cancer therapy for solid tumors: poor tumor‐selective drug delivery, low therapeutic efficacy and unsustainable costs

    Authors: Hiroshi Maeda, Mahin Khatami - Clinical and Translational Medicine 2018 cited by 486

  11. Exploiting the enhanced permeability and retention effect for tumor targeting

    Authors: Arun K. Iyer, Khaled Greish, Jun Fang, Hiroshi Maeda - Drug Discovery Today 2006 cited by 1,827

  12. Macromolecular therapeutics in cancer treatment: The EPR effect and beyond

    Authors: Hiroshi Maeda - Journal of Controlled Release 2012 cited by 795

  13. Tyrosine biosynthesis, metabolism, and catabolism in plants

    Authors: Craig A. Schenck, Hiroshi Maéda - Phytochemistry 2018 cited by 282

  14. Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects

    Authors: Hiroshi Maeda - Bioconjugate Chemistry 2010 cited by 979

  15. Evolutionary History of Plant Metabolism

    Authors: Hiroshi Maéda, Alisdair R. Fernie - Annual Review of Plant Biology 2021 cited by 126

  16. Genome sequencing and analysis of Aspergillus oryzae

    Authors: Masayuki Machida, Kiyoshi Asai, Motoaki Sano, Toshihiro Tanaka, Toshitaka Kumagai, Goro Terai, Ken-Ichi Kusumoto, Toshihide Arima, Osamu Akita, Yutaka Kashiwagi, Keietsu Abe, Katsuya Gomi, Hiroyuki Horiuchi, Katsuhiko Kitamoto, Tetsuo Kobayashi, Michio Takeuchi, David W. Denning, James E. Galagan, William C. Nierman, Jiujiang Yu, David B. Archer, Joan W. Bennett, Deepak Bhatnagar, Thomas E. Cleveland, Natalie D. Fedorova, Osamu Gotoh, Hiroshi Horikawa, Akira Hosoyama, Masayuki Ichinomiya, Rie Igarashi, Kazuhiro Iwashita, Praveen R. Juvvadi, Masashi Kato, Yumiko Kato, Taishin Kin, Akira Kokubun, Hiroshi Maéda, Noriko Maeyama, Jun-ichi Maruyama, Hideki Nagasaki, Tasuku Nakajima, Ken Oda, Kinya Okada, Ian T. Paulsen, Kazutoshi Sakamoto, Toshihiko Sawano, Mikio Takahashi, Kumiko Takase, Yasunobu Terabayashi, Jennifer R. Wortman, Osamu Yamada, Youhei Yamagata, Hideharu Anazawa, Yoji Hata, Yoshinao Koide, Takashi Komori, Yasuji Koyama, Toshitaka Minetoki, Sivasundaram Suharnan, Akimitsu Tanaka, Katsumi Isono, Satoru Kuhara, Naotake Ogasawara, Hisashi Kikuchi - Nature 2005 cited by 1,266

  17. Therapeutic strategies by modulating oxygen stress in cancer and inflammation

    Authors: Jun Fang, Takahiro Seki, Hiroshi Maeda - Advanced Drug Delivery Reviews 2009 cited by 542

  18. The entry reaction of the plant shikimate pathway is subjected to highly complex metabolite-mediated regulation

    Authors: Ryo Yokoyama, Marcos V. V. de Oliveira, Bailey Kleven, Hiroshi Maéda - The Plant Cell 2020 cited by 119

  19. Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS

    Authors: Hiroshi Maeda, Tomohiro Sawa, Toshimitsu Konno - Journal of Controlled Release 2001 cited by 916

  20. An alternative pathway contributes to phenylalanine biosynthesis in plants via a cytosolic tyrosine:phenylpyruvate aminotransferase

    Authors: Heejin Yoo, Joshua R. Widhalm, Yichun Qian, Hiroshi Maéda, Bruce R. Cooper, Amber S. Jannasch, Itay Gonda, Efraim Lewinsohn, David Rhodes, Natalia Dudareva - Nature Communications 2013 cited by 241

  21. Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect

    Authors: Hiroshi Maeda, Gahininath Y. Bharate, Jurstine Daruwalla - European Journal of Pharmaceutics and Biopharmaceutics 2008 cited by 1,153

  22. The 35th Anniversary of the Discovery of EPR Effect: A New Wave of Nanomedicines for Tumor-Targeted Drug Delivery—Personal Remarks and Future Prospects

    Authors: Hiroshi Maeda - Journal of Personalized Medicine 2021 cited by 151

  23. Evolutionary origin and functional diversification of aminotransferases

    Authors: Kaan Koper, Sang‐Woo Han, Delia Casas‐Pastor, Yasuo Yoshikuni, Hiroshi Maéda - Journal of Biological Chemistry 2022 cited by 88

  24. Factors affecting the dynamics and heterogeneity of the EPR effect: pathophysiological and pathoanatomic features, drug formulations and physicochemical factors

    Authors: Rayhanul Islam, Hiroshi Maeda, Jun Fang - Expert Opinion on Drug Delivery 2021 cited by 84