J A Ledbetter
Active 1977–1997
- 88
- Papers
- 25,024
- Citations
- 84
- h-index
- 88
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Immunology and Microbiology46.3%
- Medicine34.3%
- Biochemistry, Genetics and Molecular Biology16.2%
- Neuroscience1.9%
- Agricultural and Biological Sciences0.3%
- Engineering0.2%
- Other0.8%
Topics
- T-cell and B-cell Immunology13.9%
- Immune Cell Function and Interaction12.3%
- Immunotherapy and Immune Responses9.1%
- Monoclonal and Polyclonal Antibodies Research5%
- Cancer Immunotherapy and Biomarkers3.3%
- Immune Response and Inflammation3.3%
- Other53.1%
Coauthors
- Alejandro Aruffo19
- Edward A. Clark14
- Gary L. Schieven13
- P S Linsley10
- Carl H. June9
- Laura S. Grosmaire8
- Nitin K. Damle8
- Paul J. Martin8
- Randolph J. Noelle8
- Peter S. Rabinovitch7
- P Beatty6
- Steven B. Kanner6
- C H June5
- Fatih M. Uckun5
- L A Herzenberg5
- R J Noelle5
- Craig B. Thompson4
- Diane Hollenbaugh4
- G L Shu4
- J A Hansen4
- Joseph B. Bolen4
- L Tuel-Ahlgren4
- Mary C. Fletcher4
- Peter S. Linsley4
All papers
- CTLA-4 is a second receptor for the B cell activation antigen B7.
Authors: Peter S. Linsley, William Brady, M Urnes, Laura S. Grosmaire, Nitin K. Damle, J A Ledbetter - The Journal of Experimental Medicine 1991 cited by 1,691
- Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
Authors: P S Linsley, JoAnne L. Greene, William Brady, Jürgen Bajorath, J A Ledbetter, Robert Peach - Immunity 1994 cited by 972
- The Role of the CD28 Receptor During T Cell Responses to Antigen
Authors: P S Linsley, J A Ledbetter - Annual Review of Immunology 1993 cited by 1,313
- CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.
Authors: Craig B. Thompson, Tullia Lindsten, J A Ledbetter, S L Kunkel, Howard A. Young, Stephen G. Emerson, Jeffrey M. Leiden, Carl H. June - National Academy of Sciences, Proceedings of the National Academy of Sciences 1989 cited by 659
- T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.
Authors: Peter S. Linsley, Edward A. Clark, J A Ledbetter - National Academy of Sciences, Proceedings of the National Academy of Sciences 1990 cited by 748
- Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.
Authors: P S Linsley, JoAnne L. Greene, Peng Tan, J Bradshaw, J A Ledbetter, Claudio Anasetti, Nitin K. Damle - The Journal of Experimental Medicine 1992 cited by 583
- Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.
Authors: P S Linsley, William Brady, Laura S. Grosmaire, Alejandro Aruffo, Nitin K. Damle, J A Ledbetter - The Journal of Experimental Medicine 1991 cited by 1,133
- gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.
Authors: Teresa M. Foy, Jon D. Laman, J A Ledbetter, Alejandro Aruffo, E Claassen, R J Noelle - The Journal of Experimental Medicine 1994 cited by 436
- Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4
Authors: Lieping Chen, Stephanie Ashe, William Brady, Ingegerd Hellström, Karl Erik Hellström, J A Ledbetter, Patrick O. McGowan, Peter S. Linsley - Cell 1992 cited by 1,068
- A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.
Authors: R J Noelle, Michael Roy, David M. Shepherd, Ivan Stamenkovic, J A Ledbetter, Alejandro Aruffo - National Academy of Sciences, Proceedings of the National Academy of Sciences 1992 cited by 810
- A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes.
Authors: Paul J. Martin, J A Ledbetter, Y Morishita, Carl H. June, P Beatty, J A Hansen - The Journal of Immunology 1986 cited by 195
- CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.
Authors: Koen Gerritse, Jon D. Laman, Randolph J. Noelle, Alejandro Aruffo, J A Ledbetter, W J Boersma, E Claassen - National Academy of Sciences, Proceedings of the National Academy of Sciences 1996 cited by 493
- In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.
Authors: Teresa M. Foy, David M. Shepherd, Fiona H. Durie, Alejandro Aruffo, J A Ledbetter, Randolph J. Noelle - The Journal of Experimental Medicine 1993 cited by 354
- Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils.
Authors: W. Conrad Liles, Peter A. Kiener, J A Ledbetter, Alejandro Aruffo, S J Klebanoff - The Journal of Experimental Medicine 1996 cited by 566
- The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co‐stimulatory activity.
Authors: Diane Hollenbaugh, Laura S. Grosmaire, C.D. Kullas, N. Jan Chalupny, Sten Braesch‐Andersen, Randolph J. Noelle, Ivan Stamenkovic, J A Ledbetter, Alejandro Aruffo - The EMBO Journal 1992 cited by 513
- The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome
Authors: Alejandro Aruffo, Mary Farrington, Diane Hollenbaugh, Xu Li, Athena Milatovich, Shigeaki Nonoyama, Jürgen Bajorath, Laura S. Grosmaire, Ronald E. Stenkamp, Michael Neubauer, Robert L. Roberts, R J Noelle, J A Ledbetter, Uta Francke, Hans D. Ochs - Cell 1993 cited by 826
- Definition of a common leukocyte cell-surface antigen (Lp95-150) associated with diverse cell-mediated immune functions.
Authors: P Beatty, J A Ledbetter, Paul J. Martin, T. H. Price, J A Hansen - The Journal of Immunology 1983 cited by 298
- B cell activation via CD40 is required for specific antibody production by antigen-stimulated human B cells.
Authors: Shigeaki Nonoyama, Diane Hollenbaugh, Alejandro Aruffo, J A Ledbetter, HD Ochs - The Journal of Experimental Medicine 1993 cited by 154
- An essential role for gp39, the ligand for CD40, in thymic selection.
Authors: Teresa M. Foy, Dawne M. Page, Thomas J. Waldschmidt, Arjan H. Schoneveld, Jon D. Laman, Sally R. Masters, Lorraine T. Tygrett, J A Ledbetter, Alejandro Aruffo, E Claassen, Jun Xu, Richard A. Flavell, S Oehen, Stephen Μ. Hedrick, Randolph J. Noelle - The Journal of Experimental Medicine 1995 cited by 146
- CD22-mediated stimulation of T cells regulates T-cell receptor/CD3-induced signaling.
Authors: A Aruffo, Steven B. Kanner, Dennis C. Sgroi, J A Ledbetter, Ivan Stamenkovic - National Academy of Sciences, Proceedings of the National Academy of Sciences 1992 cited by 88
- Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.
Authors: Patrick Tan, Claudio Anasetti, John A. Hansen, Jennifer Melrose, Mark W. Brunvand, J Bradshaw, J A Ledbetter, P S Linsley - The Journal of Experimental Medicine 1993 cited by 476
- Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.
Authors: Edward A. Clark, J A Ledbetter - National Academy of Sciences, Proceedings of the National Academy of Sciences 1986 cited by 432
- Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.
Authors: C H June, Mary C. Fletcher, J A Ledbetter, Lawrence E. Samelson - The Journal of Immunology 1990 cited by 427
- The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells.
Authors: Madhuri Roy, Thomas J. Waldschmidt, Alejandro Aruffo, J A Ledbetter, Randolph J. Noelle - The Journal of Immunology 1993 cited by 371
