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James L. Kirkland

Active 1984–2025

243
Papers
58,968
Citations
110
h-index
230
i10-index

Citations

Citations per year for James L. Kirkland1985: 2 citations1986: 17 citations1990: 1 citations1992: 1 citations1993: 2 citations1994: 2 citations1995: 2 citations1997: 5 citations1998: 3 citations1999: 3 citations2000: 8 citations2001: 13 citations2002: 18 citations2003: 10 citations2004: 28 citations2005: 21 citations2006: 52 citations2007: 51 citations2008: 69 citations2009: 56 citations2010: 107 citations2011: 112 citations2012: 168 citations2013: 242 citations2014: 273 citations2015: 285 citations2016: 503 citations2017: 612 citations2018: 878 citations2019: 2,257 citations2020: 3,458 citations2021: 3,838 citations2022: 3,804 citations2023: 3,683 citations2024: 5,575 citations2025: 3,263 citations2026: 70 citations1987–1989: no citations, so these years are not shown1991: no citations, so this year is not shown1996: no citations, so this year is not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 4,847 citing papers, 25.4% of this breakdownChina: 3,140 citing papers, 16.5% of this breakdownUnited Kingdom: 1,167 citing papers, 6.1% of this breakdownItaly: 834 citing papers, 4.4% of this breakdownGermany: 815 citing papers, 4.3% of this breakdownSpain: 578 citing papers, 3% of this breakdownCanada: 574 citing papers, 3% of this breakdownJapan: 554 citing papers, 2.9% of this breakdownFrance: 525 citing papers, 2.7% of this breakdownAustralia: 413 citing papers, 2.2% of this breakdownNetherlands: 408 citing papers, 2.1% of this breakdownSouth Korea: 403 citing papers, 2.1% of this breakdown
0%25.4%Other 25.3%

Institutions

Fields

  • Medicine60.7%
  • Biochemistry, Genetics and Molecular Biology25.4%
  • Immunology and Microbiology4.9%
  • Neuroscience4.3%
  • Engineering0.6%
  • Nursing0.6%
  • Other3.5%

Topics

  • Telomeres, Telomerase, and Senescence7%
  • Adipose Tissue and Metabolism3.9%
  • Genetics, Aging, and Longevity in Model Organisms2.9%
  • Adipokines, Inflammation, and Metabolic Diseases2.7%
  • Nutrition and Health in Aging1.8%
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms1.5%
  • Other80.2%

Coauthors

All papers

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  1. The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

    Authors: Yi Zhu, Tamar Tchkonia, Tamar Pirtskhalava, Adam C. Gower, Husheng Ding, Nino Giorgadze, Allyson K. Palmer, Yuji Ikeno, Gene B. Hubbard, Marc E. Lenburg, Steven P. O’Hara, Nicholas F. LaRusso, Jordan D. Miller, Carolyn M Roos, Grace Verzosa, Nathan K. LeBrasseur, Jonathan D. Wren, Joshua N. Farr, Sundeep Khosla, Michael B. Stout, Sara J. McGowan, Heike Fuhrmann‐Stroissnigg, Aditi U. Gurkar, Jing Zhao, Debora Colangelo, Akaitz Dorronsoro, Yuan Yuan Ling, Amira S. Barghouthy, Diana C. Navarro, Tokio Sano, Paul D. Robbins, Laura J. Niedernhofer, James L. Kirkland - Aging Cell 2015 cited by 2,425

  2. Senolytics improve physical function and increase lifespan in old age

    Authors: Ming Xu, Tamar Pirtskhalava, Joshua N. Farr, Bettina M. Weigand, Allyson K. Palmer, Megan Weivoda, Christina L. Inman, Mikołaj Ogrodnik, Christine Hachfeld, Daniel G. Fraser, Jennifer L Onken, Kurt O. Johnson, Grace Verzosa, Larissa Prata, Moritz Weigl, Nino Giorgadze, Nathan K. LeBrasseur, Jordan D. Miller, Diana Jurk, Ravinder J. Singh, David B. Allison, Keisuke Ejima, Gene B. Hubbard, Yuji Ikeno, Hajrunisa Čubro, Vesna D. Garovic, Xiaonan Hou, S. John Weroha, Paul D. Robbins, Laura J. Niedernhofer, Sundeep Khosla, Tamar Tchkonia, James L. Kirkland - Nature Medicine 2018 cited by 2,241

  3. Cellular senescence and senolytics: the path to the clinic

    Authors: Selim Chaib, Tamar Tchkonia, James L. Kirkland - Nature Medicine 2022 cited by 1,038

  4. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

    Authors: Darren J. Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K. LeBrasseur, Bennett G. Childs, Bart van de Sluis, James L. Kirkland, Jan M. van Deursen - Nature 2011 cited by 3,688

  5. Cellular senescence: the good, the bad and the unknown

    Authors: Weijun Huang, LaTonya J. Hickson, Alfonso Eirin, James L. Kirkland, Lilach O. Lerman - Nature Reviews Nephrology 2022 cited by 1,094

  6. Sarcopenia: Aging-Related Loss of Muscle Mass and Function

    Authors: Lars Larsson, Hans Degens, Meishan Li, Leonardo Salviati, Young Il Lee, Wesley J. Thompson, James L. Kirkland, Marco Sandri - Physiological Reviews 2018 cited by 1,709

  7. Senolytic drugs: from discovery to translation

    Authors: James L. Kirkland, Tamar Tchkonia - Journal of Internal Medicine 2020 cited by 1,119

  8. Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

    Authors: LaTonya J. Hickson, Larissa Prata, Shane A. Bobart, Tamara K. Evans, Nino Giorgadze, Shahrukh Hashmi, Sandra M. Herrmann, Michael D. Jensen, Qingyi Jia, Kyra L. Jordan, Todd A. Kellogg, Sundeep Khosla, Daniel M. Koerber, Anthony B. Lagnado, Donna K. Lawson, Nathan K. LeBrasseur, Lilach O. Lerman, Kathleen M. McDonald, Travis J. McKenzie, João F. Passos, Robert J. Pignolo, Tamar Pirtskhalava, Ishran M. Saadiq, Kalli K. Schaefer, Stephen C. Textor, Stella Victorelli, Tammie L. Volkman, Ailing Xue, Mark Wentworth, Erin O. Wissler Gerdes, Yi Zhu, Tamar Tchkonia, James L. Kirkland - EBioMedicine 2019 cited by 1,286

  9. Cellular senescence mediates fibrotic pulmonary disease

    Authors: Marissa Schafer, Thomas A. White, Koji Iijima, Andrew J. Haak, Giovanni Ligresti, Elizabeth J. Atkinson, Ann L. Oberg, Jodie Birch, Hanna Salmonowicz, Yi Zhu, Daniel L. Mazula, Robert W. Brooks, Heike Fuhrmann‐Stroissnigg, Tamar Pirtskhalava, Y. S. Prakash, Tamar Tchkonia, Paul D. Robbins, Marie Christine Aubry, João F. Passos, James L. Kirkland, Daniel J. Tschumperlin, Hirohito Kita, Nathan K. LeBrasseur - Nature Communications 2017 cited by 1,571

  10. Fisetin is a senotherapeutic that extends health and lifespan

    Authors: Matthew J. Yousefzadeh, Yi Zhu, Sara J. McGowan, Luise Angelini, Heike Fuhrmann‐Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I. Melos, Tamar Pirtskhalava, Christina L. Inman, Collin A. McGuckian, Erin A. Wade, Jonathon I. Kato, Diego Grassi, Mark Wentworth, Christin E. Burd, Edgar A. Arriaga, Warren Ladiges, Tamar Tchkonia, James L. Kirkland, Paul D. Robbins, Laura J. Niedernhofer - EBioMedicine 2018 cited by 978

  11. Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

    Authors: Jamie N. Justice, Anoop M. Nambiar, Tamar Tchkonia, Nathan K. LeBrasseur, Rodolfo M. Pascual, Shahrukh Hashmi, Larissa Prata, Michał M. Masternak, Stephen B. Kritchevsky, Nicolas Musi, James L. Kirkland - EBioMedicine 2019 cited by 1,188

  12. Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

    Authors: Yi Zhu, Tamar Tchkonia, Heike Fuhrmann‐Stroissnigg, Haiming Dai, Yuanyuan Ling, Michael B. Stout, Tamar Pirtskhalava, Nino Giorgadze, Kurt O. Johnson, Cory B. Giles, Jonathan D. Wren, Laura J. Niedernhofer, Paul D. Robbins, James L. Kirkland - Aging Cell 2015 cited by 1,106

  13. Strategies for targeting senescent cells in human disease

    Authors: Nathan Gasek, George A. Kuchel, James L. Kirkland, Ming Xu - Nature Aging 2021 cited by 483

  14. Targeting cellular senescence prevents age-related bone loss in mice

    Authors: Joshua N. Farr, Ming Xu, Megan Weivoda, David G. Monroe, Daniel G. Fraser, Jennifer L Onken, Brittany A Negley, Jad Sfeir, Mikołaj Ogrodnik, Christine Hachfeld, Nathan K. LeBrasseur, Matthew T. Drake, Robert J. Pignolo, Tamar Pirtskhalava, Tamar Tchkonia, Merry Jo Oursler, James L. Kirkland, Sundeep Khosla - Nature Medicine 2017 cited by 1,142

  15. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

    Authors: Tamar Tchkonia, Yi Zhu, Jan van Deursen, Judith Campisi, James L. Kirkland - Journal of Clinical Investigation 2013 cited by 1,757

  16. Cellular senescence drives age-dependent hepatic steatosis

    Authors: Mikołaj Ogrodnik, Satomi Miwa, Tamar Tchkonia, Dina Tiniakos, Caroline Wilson, Albert Lahat, Christoper P. Day, Alastair D. Burt, Allyson K. Palmer, Quentin M. Anstee, Sushma Nagaraja Grellscheid, Jan H.J. Hoeijmakers, Sander Barnhoorn, Derek A. Mann, Thomas G. Bird, Wilbert P. Vermeij, James L. Kirkland, João F. Passos, Thomas von Zglinicki, Diana Jurk - Nature Communications 2017 cited by 1,036

  17. JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

    Authors: Ming Xu, Tamar Tchkonia, Husheng Ding, Mikołaj Ogrodnik, Ellen R. Lubbers, Tamar Pirtskhalava, Thomas A. White, Kurt O. Johnson, Michael B. Stout, Vojtěch Mezera, Nino Giorgadze, Michael D. Jensen, Nathan K. LeBrasseur, James L. Kirkland - National Academy of Sciences, Proceedings of the National Academy of Sciences 2015 cited by 892

  18. Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial

    Authors: Mitzi M. Gonzales, Valentina R. Garbarino, Tiffany F. Kautz, Juan Pablo Palavicini, Marisa Lopez‐Cruzan, Shiva Kazempour Dehkordi, Julia Mathews, Habil Zare, Peng Xu, Bin Zhang, Crystal Franklin, Mohamad Habes, Suzanne Craft, Ronald C. Petersen, Tamar Tchkonia, James L. Kirkland, Arash Salardini, Sudha Seshadri, Nicolas Musi, Miranda E. Orr - Nature Medicine 2023 cited by 247

  19. Cellular Senescence: A Translational Perspective

    Authors: James L. Kirkland, Tamar Tchkonia - EBioMedicine 2017 cited by 1,002

  20. New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

    Authors: Yi Zhu, Ewald J. Doornebal, Tamar Pirtskhalava, Nino Giorgadze, Mark Wentworth, Heike Fuhrmann‐Stroissnigg, Laura J. Niedernhofer, Paul D. Robbins, Tamar Tchkonia, James L. Kirkland - Aging 2017 cited by 726

  21. The role of cellular senescence in ageing and endocrine disease

    Authors: Sundeep Khosla, Joshua N. Farr, Tamar Tchkonia, James L. Kirkland - Nature Reviews Endocrinology 2020 cited by 518

  22. Senescent cell clearance by the immune system: Emerging therapeutic opportunities

    Authors: Larissa Prata, Inna G. Ovsyannikova, Tamar Tchkonia, James L. Kirkland - Seminars in Immunology 2018 cited by 480

  23. Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

    Authors: Mikołaj Ogrodnik, Shane A. Evans, Edward Fielder, Stella Victorelli, Patrick Krüger, Hanna Salmonowicz, Bettina M. Weigand, Ayush Patel, Tamar Pirtskhalava, Christine Inman, Kurt O. Johnson, Stephanie Dickinson, Azucena Rocha, Marissa Schafer, Yi Zhu, David B. Allison, Thomas von Zglinicki, Nathan K. LeBrasseur, Tamar Tchkonia, Nicola Neretti, João F. Passos, James L. Kirkland, Diana Jurk - Aging Cell 2021 cited by 404

  24. Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

    Authors: Allyson K. Palmer, Ming Xu, Yi Zhu, Tamar Pirtskhalava, Megan Weivoda, Christine Hachfeld, Larissa Prata, Theo H. van Dijk, Esther Verkade, Grace Casaclang‐Verzosa, Kurt O. Johnson, Hajrunisa Čubro, Ewald J. Doornebal, Mikołaj Ogrodnik, Diana Jurk, Michael D. Jensen, Eduardo N. Chini, Jordan D. Miller, Aleksey V. Matveyenko, Michael B. Stout, Marissa Schafer, Thomas A. White, LaTonya J. Hickson, Marco Demaria, Vesna D. Garovic, Joseph P. Grande, Edgar A. Arriaga, Folkert Kuipers, Thomas von Zglinicki, Nathan K. LeBrasseur, Judith Campisi, Tamar Tchkonia, James L. Kirkland - Aging Cell 2019 cited by 669