Jan M. van Deursen
Active 1996–2024
- 78
- Papers
- 34,034
- Citations
- 69
- h-index
- 78
- i10-index
Citations
Citation sources
Countries
Institutions
- Harvard University1%
- Mayo Clinic0.9%
- Mayo Clinic in Florida0.8%
- Inserm0.7%
- National Institutes of Health0.7%
- Howard Hughes Medical Institute0.6%
- Other95.3%
Fields
- Medicine49.7%
- Biochemistry, Genetics and Molecular Biology33.4%
- Immunology and Microbiology8.8%
- Neuroscience4.8%
- Agricultural and Biological Sciences0.6%
- Engineering0.5%
- Other2.2%
Topics
- Telomeres, Telomerase, and Senescence7.3%
- Genetics, Aging, and Longevity in Model Organisms2.3%
- Epigenetics and DNA Methylation2.2%
- Cytokine Signaling Pathways and Interactions2.1%
- Microtubule and mitosis dynamics2%
- Immune Cell Function and Interaction1.8%
- Other82.3%
Coauthors
- Darren J. Baker36
- Karthik B. Jeganathan23
- Liviu Malureanu11
- Bennett G. Childs10
- Ines Sturmlechner9
- Janine H. van Ree9
- Hu Li8
- Cheng Zhang7
- Bart van de Sluis6
- Masakazu Hamada6
- Cynthia J. Sieben5
- Fang Jin5
- Hyun-Ja Nam5
- Gerard C. Grosveld4
- James L. Kirkland4
- Robin M. Ricke4
- Alexander Meves3
- James N. Ihle3
- Judith Campisi3
- Matej Durik3
- Meelad M. Dawlaty3
- Naomi Hamada3
- Nathan K. LeBrasseur3
- Raul O. Fierro Velasco3
All papers
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Authors: Darren J. Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K. LeBrasseur, Bennett G. Childs, Bart van de Sluis, James L. Kirkland, Jan M. van Deursen - Nature 2011 cited by 3,688
- Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Authors: Darren J. Baker, Bennett G. Childs, Matej Durik, Melinde E. Wijers, Cynthia J. Sieben, Jian Zhong, Rachel A. Saltness, Karthik B. Jeganathan, Grace Verzosa, Abdulmohammad Pezeshki, Khashayarsha Khazaie, Jordan D. Miller, Jan M. van Deursen - Nature 2016 cited by 2,819
- Cellular senescence in aging and age-related disease: from mechanisms to therapy
Authors: Bennett G. Childs, Matej Durik, Darren J. Baker, Jan M. van Deursen - Nature Medicine 2015 cited by 2,312
- The role of senescent cells in ageing
Authors: Jan M. van Deursen - Nature 2014 cited by 2,648
- Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
Authors: Tyler J. Bussian, Asef Aziz, Charlton F. Meyer, Barbara L. Swenson, Jan M. van Deursen, Darren J. Baker - Nature 2018 cited by 1,293
- Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
Authors: Ok Hee Jeon, Chaekyu Kim, Remi-Martin Laberge, Marco Demaria, Sona Rathod, Alain P. Vasserot, Jae Wook Chung, Do Hun Kim, Yan Poon, Nathaniel E. David, Darren J. Baker, Jan M. van Deursen, Judith Campisi, Jennifer H. Elisseeff - Nature Medicine 2017 cited by 1,486
- Senescent cells: an emerging target for diseases of ageing
Authors: Bennett G. Childs, Martina Gluscevic, Darren J. Baker, Remi-Martin Laberge, Dan Marquess, J. Dananberg, Jan M. van Deursen - Nature Reviews Drug Discovery 2017 cited by 1,228
- Senescent intimal foam cells are deleterious at all stages of atherosclerosis
Authors: Bennett G. Childs, Darren J. Baker, Tobias Wijshake, Cheryl A. Conover, Judith Campisi, Jan M. van Deursen - Science 2016 cited by 1,178
- CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels
Authors: Claudia C.S. Chini, Thais Peclat, Gina M. Warner, Sonu Kashyap, Jair Machado Espíndola‐Netto, Guilherme C. de Oliveira, Lilian Sales Gomez, Kelly A. Hogan, Mariana G. Tarragó, Amrutesh S. Puranik, Guillermo Agorrody, Katie L. Thompson, Kevin Dang, Starlynn Clarke, Bennett G. Childs, Karina S. Kanamori, Micaela A. Witte, Paola Vidal, Anna L. Kirkland, Marco De Cecco, Karthikeyani Chellappa, Melanie R. McReynolds, Connor S.R. Jankowski, Tamar Tchkonia, James L. Kirkland, John M. Sedivy, Jan M. van Deursen, Darren J. Baker, Wim van Schooten, Joshua D. Rabinowitz, Joseph A. Baur, Eduardo N. Chini - Nature Metabolism 2020 cited by 328
- Senescence and apoptosis: dueling or complementary cell fates?
Authors: Bennett G. Childs, Darren J. Baker, James L. Kirkland, Judith Campisi, Jan M. van Deursen - EMBO Reports 2014 cited by 889
- p21 produces a bioactive secretome that places stressed cells under immunosurveillance
Authors: Ines Sturmlechner, Cheng Zhang, Chance Sine, Erik-Jan van Deursen, Karthik B. Jeganathan, Naomi Hamada, Jan Grašič, David J. Friedman, Jeremy Stutchman, İsmail Can, Masakazu Hamada, Do Young Lim, Jeong‐Heon Lee, Tamás Ördög, Rémi-Martin Laberge, Virginia Smith Shapiro, Darren J. Baker, Hu Li, Jan M. van Deursen - Science 2021 cited by 266
- Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown
Authors: Yu Yamazaki, Darren J. Baker, Masaya Tachibana, Chia‐Chen Liu, Jan M. van Deursen, Thomas Brott, Guojun Bu, Takahisa Kanekiyo - Stroke 2016 cited by 247
- Cellular senescence in renal ageing and disease
Authors: Ines Sturmlechner, Matej Durik, Cynthia J. Sieben, Darren J. Baker, Jan M. van Deursen - Nature Reviews Nephrology 2016 cited by 337
- Senolytic therapies for healthy longevity
Authors: Jan M. van Deursen - Science 2019 cited by 236
- Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
Authors: Darren J. Baker, Carmen Pérez-Terzic, Fang Jin, Kevin S. Pitel, Nicolas J. Niederländer, Karthik B. Jeganathan, Satsuki Yamada, Santiago Reyes, Lois A. Rowe, Henry J. Hiddinga, Norman L. Eberhardt, André Terzic, Jan M. van Deursen - Nature Cell Biology 2008 cited by 397
- p21 induces a senescence program and skeletal muscle dysfunction
Authors: Davis A. Englund, Alyssa M. Jolliffe, Zaira Aversa, Xu Zhang, Ines Sturmlechner, Ayumi Sakamoto, Julianna D. Zeidler, Gina M. Warner, Colton McNinch, Thomas A. White, Eduardo N. Chini, Darren J. Baker, Jan M. van Deursen, Nathan K. LeBrasseur - Molecular Metabolism 2022 cited by 84
- SIRT2 induces the checkpoint kinase BubR1 to increase lifespan
Authors: Brian J. North, Michael A. Rosenberg, Karthik B. Jeganathan, Angela Hafner, Shaday Michán, Jing Dai, Darren J. Baker, Yana Cen, Lindsay E. Wu, Anthony A. Sauve, Jan M. van Deursen, Anthony Rosenzweig, David Sinclair - The EMBO Journal 2014 cited by 246
- Two-Step Senescence-Focused Cancer Therapies
Authors: Cynthia J. Sieben, Ines Sturmlechner, Bart van de Sluis, Jan M. van Deursen - Trends in Cell Biology 2018 cited by 231
- Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
Authors: Marissa Schafer, Thomas A. White, Glenda L. Evans, Jason M. Tonne, Grace Verzosa, Michael B. Stout, Daniel L. Mazula, Allyson K. Palmer, Darren J. Baker, Michael D. Jensen, Michael Torbenson, Jordan D. Miller, Yasuhiro Ikeda, Tamar Tchkonia, Jan M. van Deursen, James L. Kirkland, Nathan K. LeBrasseur - Diabetes 2016 cited by 259
- Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis
Authors: Bennett G. Childs, Cheng Zhang, Fahad Shuja, Ines Sturmlechner, Shawn Trewartha, Raul O. Fierro Velasco, Darren J. Baker, Hu Li, Jan M. van Deursen - Nature Aging 2021 cited by 70
- Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases
Authors: Ryan M. Naylor, Darren J. Baker, Jan M. van Deursen - Clinical Pharmacology & Therapeutics 2012 cited by 282
- Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies
Authors: Christopher Cherry, James I. Andorko, Kavita Krishnan, Joscelyn C. Mejías, Helen Nguyễn, Katlin B. Stivers, Elise Gray-Gaillard, Anna Ruta, Jin Han, Naomi Hamada, Masakazu Hamada, Ines Sturmlechner, Shawn Trewartha, John Michel, Locke Davenport Huyer, Matthew T. Wolf, Ada Tam, Alexis N. Peña, Shilpa Keerthivasan, Claude Jourdan Le Saux, Elana J. Fertig, Darren J. Baker, Franck Housseau, Jan M. van Deursen, Drew M. Pardoll, Jennifer H. Elisseeff - GeroScience 2023 cited by 65
- Senescent cells: a therapeutic target for cardiovascular disease
Authors: Bennett G. Childs, Hu Li, Jan M. van Deursen - Journal of Clinical Investigation 2018 cited by 190
- Therapy-Induced Senescence Drives Bone Loss
Authors: Zhangting Yao, Bhavna Murali, Qihao Ren, Xianmin Luo, Douglas V. Faget, Tom Cole, Biancamaria Ricci, Dinesh Thotala, Joseph B. Monahan, Jan M. van Deursen, Darren J. Baker, Roberta Faccio, Julie K. Schwarz, Sheila A. Stewart - Cancer Research 2020 cited by 127
