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John D. Hayes

Active 1979–2025

118
Papers
41,071
Citations
93
h-index
118
i10-index

Citations

Citations per year for John D. Hayes1980: 1 citations1982: 1 citations1984: 3 citations1985: 1 citations1986: 5 citations1987: 4 citations1988: 9 citations1989: 13 citations1990: 20 citations1991: 30 citations1992: 44 citations1993: 52 citations1994: 41 citations1995: 64 citations1996: 59 citations1997: 100 citations1998: 114 citations1999: 122 citations2000: 151 citations2001: 214 citations2002: 196 citations2003: 206 citations2004: 292 citations2005: 309 citations2006: 309 citations2007: 293 citations2008: 274 citations2009: 334 citations2010: 423 citations2011: 458 citations2012: 438 citations2013: 404 citations2014: 444 citations2015: 518 citations2016: 474 citations2017: 454 citations2018: 388 citations2019: 1,280 citations2020: 1,613 citations2021: 1,536 citations2022: 1,300 citations2023: 1,093 citations2024: 1,451 citations2025: 715 citations2026: 23 citations1981: no citations, so this year is not shown1983: no citations, so this year is not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 3,274 citing papers, 21.8% of this breakdownChina: 2,717 citing papers, 18.1% of this breakdownUnited Kingdom: 962 citing papers, 6.4% of this breakdownItaly: 676 citing papers, 4.5% of this breakdownJapan: 636 citing papers, 4.2% of this breakdownGermany: 582 citing papers, 3.9% of this breakdownIndia: 431 citing papers, 2.9% of this breakdownSouth Korea: 413 citing papers, 2.7% of this breakdownSpain: 396 citing papers, 2.6% of this breakdownCanada: 345 citing papers, 2.3% of this breakdownFrance: 331 citing papers, 2.2% of this breakdownAustralia: 286 citing papers, 1.9% of this breakdown
0%21.8%Other 26.5%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology55.8%
  • Medicine26.4%
  • Agricultural and Biological Sciences3.1%
  • Pharmacology, Toxicology and Pharmaceutics2.9%
  • Neuroscience2.7%
  • Environmental Science2.6%
  • Other6.5%

Topics

  • Genomics, phytochemicals, and oxidative stress13.8%
  • Glutathione Transferases and Polymorphisms6.9%
  • Autophagy in Disease and Therapy2%
  • Redox biology and oxidative stress1.6%
  • Sulfur Compounds in Biology1.4%
  • Epigenetics and DNA Methylation1.4%
  • Other72.9%

Coauthors

All papers

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  1. Oxidative Stress in Cancer

    Authors: John D. Hayes, Albena T. Dinkova‐Kostova, Kenneth D. Tew - Cancer Cell 2020 cited by 2,526

  2. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

    Authors: John D. Hayes, Albena T. Dinkova‐Kostova - Trends in Biochemical Sciences 2014 cited by 2,090

  3. Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

    Authors: Antonio Cuadrado, Ana I. Rojo, Geoffrey Wells, John D. Hayes, Sharon P. Cousin, William L. Rumsey, Otis C. Attucks, Stephen Franklin, Anna–Liisa Levonen, Thomas W. Kensler, Albena T. Dinkova‐Kostova - Nature Reviews Drug Discovery 2019 cited by 1,393

  4. p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

    Authors: Ashish Jain, Trond Lamark, Eva Sjøttem, Kenneth Bowitz Larsen, Jane Atesoh Awuh, Aud Øvervatn, Michael McMahon, John D. Hayes, Terje Johansen - Journal of Biological Chemistry 2010 cited by 1,473

  5. GLUTATHIONE TRANSFERASES

    Authors: John D. Hayes, Jack U. Flanagan, Ian R. Jowsey - The Annual Review of Pharmacology and Toxicology 2004 cited by 3,511

  6. Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

    Authors: Sudhir Chowdhry, Yiguo Zhang, Michael McMahon, Calum Sutherland, Antonio Cuadrado, John D. Hayes - Oncogene 2012 cited by 635

  7. Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

    Authors: Lauren E. Tebay, Holly Robertson, Stephen T. Durant, Steven Vitale, T.M. Penning, Albena T. Dinkova‐Kostova, John D. Hayes - Free Radical Biology and Medicine 2015 cited by 819

  8. Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

    Authors: Michael McMahon, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Journal of Biological Chemistry 2003 cited by 1,131

  9. RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

    Authors: Hongyan Wang, Kaihua Liu, Miao Geng, Peng Gao, Xiao‐Yuan Wu, Hai Yan, Yangxia Li, Yulong Li, Lin Luo, John D. Hayes, Xiu Jun Wang, Xiuwen Tang - Cancer Research 2013 cited by 367

  10. SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

    Authors: Patricia Rada, Ana I. Rojo, Sudhir Chowdhry, Michael McMahon, John D. Hayes, Antonio Cuadrado - Molecular and Cellular Biology 2011 cited by 744

  11. Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis

    Authors: Patricia Rada, Ana I. Rojo, Nathalie Evrard‐Todeschi, Nadia G. Innamorato, Axelle Cotte, Tomasz Jaworski, Julio C. Tobón-Velasco, Herman Devijver, María Flor García‐Mayoral, Fred Van Leuven, John D. Hayes, Gildas Bertho, Antonio Cuadrado - Molecular and Cellular Biology 2012 cited by 473

  12. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

    Authors: John D. Hayes, Michael McMahon - Trends in Biochemical Sciences 2009 cited by 871

  13. Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

    Authors: Michael McMahon, Douglas J. Lamont, Kenneth A. Beattie, John D. Hayes - National Academy of Sciences, Proceedings of the National Academy of Sciences 2010 cited by 438

  14. Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

    Authors: John D. Hayes, Sudhir Chowdhry, Albena T. Dinkova‐Kostova, Calum Sutherland - Biochemical Society Transactions 2015 cited by 177

  15. Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

    Authors: Xiu Jun Wang, John D. Hayes, Colin J. Henderson, C. Roland Wolf - National Academy of Sciences, Proceedings of the National Academy of Sciences 2007 cited by 303

  16. Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

    Authors: John D. Hayes, Michael McMahon, Sudhir Chowdhry, Albena T. Dinkova‐Kostova - Antioxidants and Redox Signaling 2010 cited by 535

  17. Redox-regulated Turnover of Nrf2 Is Determined by at Least Two Separate Protein Domains, the Redox-sensitive Neh2 Degron and the Redox-insensitive Neh6 Degron

    Authors: Michael McMahon, Nerys Thomas, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Journal of Biological Chemistry 2004 cited by 395

  18. Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

    Authors: Ritu Sharma, David J. Harrison, Dorothy Kisielewski, Diane Cassidy, Alison D. McNeilly, Jennifer Gallagher, Shaun Walsh, Tadashi Honda, Rory J. McCrimmon, Albena T. Dinkova‐Kostova, Michael L.J. Ashford, John Dillon, John D. Hayes - Cellular and Molecular Gastroenterology and Hepatology 2017 cited by 212

  19. Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2

    Authors: Boushra Bathish, Holly Robertson, John Dillon, Albena T. Dinkova‐Kostova, John D. Hayes - Free Radical Biology and Medicine 2022 cited by 65

  20. Dimerization of Substrate Adaptors Can Facilitate Cullin-mediated Ubiquitylation of Proteins by a “Tethering” Mechanism

    Authors: Michael McMahon, Nerys Thomas, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Journal of Biological Chemistry 2006 cited by 483

  21. The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

    Authors: John D. Hayes, David Pulford - Critical Reviews in Biochemistry and Molecular Biology 1995 cited by 3,486

  22. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

    Authors: Simon A. Chanas, Qingwu Jiang, Michael McMahon, Gail K. McWalter, Lesley I. McLellan, Clifford R. Elcombe, Colin J. Henderson, C. Roland Wolf, Graeme J. Moffat, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Biochemical Journal 2002 cited by 448

  23. Glutathione S-Transferase Polymorphisms and Their Biological Consequences

    Authors: John D. Hayes, Richard C. Strange - Pharmacology 2000 cited by 1,002

  24. The Gasotransmitter Hydrogen Sulfide Induces Nrf2-Target Genes by Inactivating the Keap1 Ubiquitin Ligase Substrate Adaptor Through Formation of a Disulfide Bond Between Cys-226 and Cys-613

    Authors: John M Hourihan, J. Gerry Kenna, John D. Hayes - Antioxidants and Redox Signaling 2012 cited by 226