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Ken Itoh

Active 1980–2025

121
Papers
37,445
Citations
85
h-index
116
i10-index

Citations

Citations per year for Ken Itoh1982: 3 citations1983: 5 citations1984: 2 citations1985: 2 citations1986: 2 citations1987: 2 citations1988: 2 citations1990: 1 citations1991: 1 citations1992: 2 citations1993: 7 citations1994: 3 citations1995: 17 citations1996: 24 citations1997: 36 citations1998: 44 citations1999: 63 citations2000: 98 citations2001: 153 citations2002: 214 citations2003: 411 citations2004: 612 citations2005: 607 citations2006: 592 citations2007: 617 citations2008: 625 citations2009: 713 citations2010: 821 citations2011: 678 citations2012: 684 citations2013: 690 citations2014: 554 citations2015: 671 citations2016: 553 citations2017: 561 citations2018: 418 citations2019: 1,258 citations2020: 1,651 citations2021: 1,265 citations2022: 1,180 citations2023: 859 citations2024: 1,075 citations2025: 524 citations2026: 23 citations1989: no citations, so this year is not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 3,030 citing papers, 25.4% of this breakdownChina: 2,133 citing papers, 17.9% of this breakdownJapan: 906 citing papers, 7.6% of this breakdownUnited Kingdom: 649 citing papers, 5.4% of this breakdownItaly: 467 citing papers, 3.9% of this breakdownGermany: 430 citing papers, 3.6% of this breakdownSouth Korea: 409 citing papers, 3.4% of this breakdownIndia: 313 citing papers, 2.6% of this breakdownCanada: 298 citing papers, 2.5% of this breakdownSpain: 260 citing papers, 2.2% of this breakdownFrance: 229 citing papers, 1.9% of this breakdownAustralia: 192 citing papers, 1.6% of this breakdown
0%25.4%Other 22%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology57.5%
  • Medicine27.2%
  • Neuroscience3.4%
  • Immunology and Microbiology2.8%
  • Agricultural and Biological Sciences2.2%
  • Pharmacology, Toxicology and Pharmaceutics2.1%
  • Other4.8%

Topics

  • Genomics, phytochemicals, and oxidative stress15.4%
  • Glutathione Transferases and Polymorphisms4.5%
  • Heme Oxygenase-1 and Carbon Monoxide1.8%
  • Redox biology and oxidative stress1.5%
  • Ferroptosis and cancer prognosis1.5%
  • Free Radicals and Antioxidants1.4%
  • Other73.9%

Coauthors

All papers

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  1. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

    Authors: Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh, Tetsuro Ishii, Kazuhiko Igarashi, James Douglas Engel, Masayuki Yamamoto - Genes & Development 1999 cited by 3,581

  2. An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

    Authors: Ken Itoh, Tomoki Chiba, Satoru Takahashi, Tetsuro Ishii, Kazuhiko Igarashi, Yasutake Katoh, Tatsuya Oyake, Norio Hayashi, Kimihiko Satoh, Ichiro Hatayama, M. Yamamoto, Yo-ichi Nabeshima - Biochemical and Biophysical Research Communications 1997 cited by 3,952

  3. Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

    Authors: Shuya Kasai, Sunao Shimizu, Yota Tatara, Junsei Mimura, Ken Itoh - Biomolecules 2020 cited by 543

  4. Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

    Authors: Michael McMahon, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Journal of Biological Chemistry 2003 cited by 1,131

  5. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

    Authors: Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole, Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh, Masayuki Yamamoto, Paul Talalay - National Academy of Sciences, Proceedings of the National Academy of Sciences 2002 cited by 1,925

  6. Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model

    Authors: Kit I. Tong, Yasutake Katoh, Hideki Kusunoki, Ken Itoh, Toshiyuki Tanaka, Masayuki Yamamoto - Molecular and Cellular Biology 2006 cited by 738

  7. Electrophile Response Element-mediated Induction of the Cystine/Glutamate Exchange Transporter Gene Expression

    Authors: Hiromi Sasaki, Hideyo Sato, Kazumi Kuriyama-Matsumura, Kanako Sato, Kanako Maebara, Hongyu Wang, Michiko Tamba, Ken Itoh, Masayuki Yamamoto, Shiro Bannai - Journal of Biological Chemistry 2002 cited by 538

  8. Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

    Authors: Tetsuro Ishii, Ken Itoh, Satoru Takahashi, Hideyo Sato, Toru Yanagawa, Yasutake Katoh, Shiro Bannai, Masayuki Yamamoto - Journal of Biological Chemistry 2000 cited by 1,456

  9. Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

    Authors: Yasutake Katoh, Ken Itoh, Eisaku Yoshida, Makoto Miyagishi, Akiyoshi Fukamizu, Masayuki Yamamoto - Genes to Cells 2001 cited by 515

  10. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

    Authors: Nobunao Wakabayashi, Ken Itoh, Junko Wakabayashi, Hozumi Motohashi, Shuhei Noda, Satoru Takahashi, Sumihisa Imakado, Tomoe KOTSUJI, Fujio Otsuka, Dennis R. Roop, Takanori Harada, James Douglas Engel, Masayuki Yamamoto - Nature Genetics 2003 cited by 888

  11. Molecular mechanism activating nrf2–keap1 pathway in regulation of adaptive response to electrophiles

    Authors: Ken Itoh, Kit I. Tong, Masayuki Yamamoto - Free Radical Biology and Medicine 2004 cited by 860

  12. Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter

    Authors: Mi-Kyoung Kwak, Ken Itoh, Masayuki Yamamoto, Thomas W. Kensler - Molecular and Cellular Biology 2002 cited by 586

  13. Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages

    Authors: Nobuhiko Harada, Masaya Kanayama, Atsushi Maruyama, Aruto Yoshida, Kyoko Tazumi, Tomonori Hosoya, Junsei Mimura, Tsutomu Toki, Jonathan Maher, Masayuki Yamamoto, Ken Itoh - Archives of Biochemistry and Biophysics 2011 cited by 221

  14. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

    Authors: Minerva Ramos‐Gómez, Mi-Kyoung Kwak, Patrick M. Dolan, Ken Itoh, Masayuki Yamamoto, Paul Talalay, Thomas W. Kensler - National Academy of Sciences, Proceedings of the National Academy of Sciences 2001 cited by 1,093

  15. Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles

    Authors: Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh, Tetsuro Ishii, Tania O'Connor, Masayuki Yamamoto - Genes to Cells 2003 cited by 822

  16. Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

    Authors: Ken Itoh, Junsei Mimura, Masayuki Yamamoto - Antioxidants and Redox Signaling 2010 cited by 510

  17. Redox-regulated Turnover of Nrf2 Is Determined by at Least Two Separate Protein Domains, the Redox-sensitive Neh2 Degron and the Redox-insensitive Neh6 Degron

    Authors: Michael McMahon, Nerys Thomas, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Journal of Biological Chemistry 2004 cited by 395

  18. Dimerization of Substrate Adaptors Can Facilitate Cullin-mediated Ubiquitylation of Proteins by a “Tethering” Mechanism

    Authors: Michael McMahon, Nerys Thomas, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Journal of Biological Chemistry 2006 cited by 483

  19. Bach Proteins Belong to a Novel Family of BTB-Basic Leucine Zipper Transcription Factors That Interact with MafK and Regulate Transcription through the NF-E2 Site

    Authors: Tatsuya Oyake, Ken Itoh, Hozumi Motohashi, Norio Hayashi, Hideto Hoshino, Makoto Nishizawa, Masayuki Yamamoto, Kazuhiko Igarashi - Molecular and Cellular Biology 1996 cited by 658

  20. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

    Authors: Simon A. Chanas, Qingwu Jiang, Michael McMahon, Gail K. McWalter, Lesley I. McLellan, Clifford R. Elcombe, Colin J. Henderson, C. Roland Wolf, Graeme J. Moffat, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Biochemical Journal 2002 cited by 448

  21. Cloning and Characterization of a Novel Erythroid Cell-Derived CNC Family Transcription Factor Heterodimerizing with the Small Maf Family Proteins

    Authors: Ken Itoh, Kazuhiko Igarashi, Norio Hayashi, Makoto Nishizawa, Masayuki Yamamoto - Molecular and Cellular Biology 1995 cited by 437

  22. C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

    Authors: Sharadha Dayalan Naidu, Aki Muramatsu, Ryota Saito, Soichiro Asami, Tadashi Honda, Tomonori Hosoya, Ken Itoh, Masayuki Yamamoto, Takafumi Suzuki, Albena T. Dinkova‐Kostova - Scientific Reports 2018 cited by 96

  23. Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

    Authors: Shinsuke Homma, Yukio Ishii, Yuko Morishima, Tadahiro Yamadori, Yosuke Matsuno, Norihiro Haraguchi, Norihiro Kikuchi, Hiroaki Satoh, Tohru Sakamoto, Nobuyuki Hizawa, Ken Itoh, Masayuki Yamamoto - Clinical Cancer Research 2009 cited by 417

  24. Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: Protection against reactive oxygen and nitrogen species‐induced cell injury

    Authors: Hong Zhu, Ken Itoh, Masayuki Yamamoto, Jay L. Zweíer, Yunbo Li - FEBS Letters 2005 cited by 389