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Hozumi Motohashi

Active 1994–2025

108
Papers
28,360
Citations
73
h-index
106
i10-index

Citations

Citations per year for Hozumi Motohashi1990: 1 citations1994: 4 citations1995: 12 citations1996: 5 citations1997: 22 citations1998: 35 citations1999: 38 citations2000: 44 citations2001: 47 citations2002: 43 citations2003: 67 citations2004: 110 citations2005: 124 citations2006: 151 citations2007: 136 citations2008: 149 citations2009: 187 citations2010: 244 citations2011: 228 citations2012: 279 citations2013: 364 citations2014: 388 citations2015: 470 citations2016: 435 citations2017: 480 citations2018: 431 citations2019: 1,290 citations2020: 1,677 citations2021: 1,480 citations2022: 1,412 citations2023: 1,159 citations2024: 1,619 citations2025: 835 citations2026: 35 citations1991–1993: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 2,887 citing papers, 22.1% of this breakdownChina: 2,878 citing papers, 22% of this breakdownJapan: 1,181 citing papers, 9% of this breakdownUnited Kingdom: 654 citing papers, 5% of this breakdownGermany: 468 citing papers, 3.6% of this breakdownItaly: 448 citing papers, 3.4% of this breakdownSouth Korea: 355 citing papers, 2.7% of this breakdownCanada: 288 citing papers, 2.2% of this breakdownIndia: 288 citing papers, 2.2% of this breakdownFrance: 248 citing papers, 1.9% of this breakdownSpain: 241 citing papers, 1.8% of this breakdownAustralia: 196 citing papers, 1.5% of this breakdown
0%22.1%Other 22.6%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology54.3%
  • Medicine31%
  • Immunology and Microbiology3.5%
  • Neuroscience2.9%
  • Agricultural and Biological Sciences1.8%
  • Pharmacology, Toxicology and Pharmaceutics1.7%
  • Other4.8%

Topics

  • Genomics, phytochemicals, and oxidative stress12%
  • Autophagy in Disease and Therapy3.7%
  • Glutathione Transferases and Polymorphisms3.3%
  • Sulfur Compounds in Biology2.3%
  • Ferroptosis and cancer prognosis1.7%
  • Epigenetics and DNA Methylation1.6%
  • Other75.4%

Coauthors

All papers

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  1. The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

    Authors: Masayuki Yamamoto, Thomas W. Kensler, Hozumi Motohashi - Physiological Reviews 2018 cited by 1,876

  2. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

    Authors: Eri Kobayashi, Takafumi Suzuki, Ryo Funayama, Takeshi Nagashima, Makiko Hayashi, Hiroki Sekine, Nobuyuki Tanaka, Takashi Moriguchi, Hozumi Motohashi, Keiko Nakayama, Masayuki Yamamoto - Nature Communications 2016 cited by 1,824

  3. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

    Authors: Masaaki Komatsu, Hirofumi Kurokawa, Satoshi Waguri, Keiko Taguchi, Akira Kobayashi, Yoshinobu Ichimura, Yu‐shin Sou, Izumi Ueno, Ayako Sakamoto, Kit I. Tong, Mihee Kim, Yasumasa Nishito, Shun-ichiro Iemura, Tohru Natsume, Takashi Ueno, Eiki Kominami, Hozumi Motohashi, Keiji Tanaka, Masayuki Yamamoto - Nature Cell Biology 2010 cited by 2,399

  4. Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

    Authors: Yoshinobu Ichimura, Satoshi Waguri, Yu‐shin Sou, Shun Kageyama, Jun Hasegawa, Ryosuke Ishimura, Tetsuya Saito, Yinjie Yang, Tsuguka Kouno, Toshiaki Fukutomi, Takayuki Hoshii, Atsushi Hirao, Kenji Takagi, Tsunehiro Mizushima, Hozumi Motohashi, Myung‐Shik Lee, Tamotsu Yoshimori, Keiji Tanaka, Masayuki Yamamoto, Masaaki Komatsu - Molecular Cell 2013 cited by 1,221

  5. Ferroptosis in health and disease

    Authors: Carsten Berndt, Hamed Alborzinia, Vera Skafar Amen, Scott Ayton, Uladzimir Barayeu, Alexander Bartelt, Hülya Bayır, Christina M. Bebber, Kıvanç Birsoy, Jan P. Böttcher, Simone Brabletz, Thomas Brabletz, Ashley R. Brown, Bernhard Brüne, Giorgia Bulli, Alix Bruneau, Quan Chen, Gina M. DeNicola, Tobias P. Dick, Ayelén Mariana Distéfano, Scott J. Dixon, Jan B. Engler, Julia Esser‐von Bieren, Maria Fedorova, José Pedro Friedmann Angeli, Manuel A. Friese, D. Fuhrmann, Ana J. García‐Sáez, Karolina Garbowicz, Magdalena Götz, Wei Gu, Linda Hammerich, Behrouz Hassannia, Xuejun Jiang, Aicha Jeridi, Yun Pyo Kang, Valerian E. Kagan, David B. Konrad, Stefan Kotschi, Lei Peng, Marlène Le Tertre, Sima Lev, Deguang Liang, Andreas Linkermann, Carolin Lohr, Svenja Lorenz, Tom Luedde, Axel Methner, Bernhard Michalke, Anna Milton, Junxia Min, Eikan Mishima, Sebastian Müller, Hozumi Motohashi, Martina U. Muckenthaler, Shohei Murakami, James A. Olzmann, Gabriela Carolina Pagnussat, Zijan Pan, Thales Papagiannakopoulos, Lohans Pedrera Puentes, Derek A. Pratt, Bettina Proneth, Lukas Ramsauer, Raphaël Rodriguez, Yoshiro Saito, Felix Schmidt, Carina Schmitt, Almut Schulze, Annemarie Schwab, A. R. Schwantes, Mariluz Soula, Benedikt Spitzlberger, Brent R. Stockwell, Leonie Thewes, Oliver Thorn‐Seshold, Shinya Toyokuni, Wulf Tonnus, Andreas Trumpp, Peter Vandenabeele, Tom Vanden Berghe, Vivek Venkataramani, Felix C. E. Vogel, Silvia von Karstedt, Fudi Wang, Frank Westermann, Chantal Wientjens, Christoph Wilhelm, Michele Wölk, Katherine Wu, Xin Yang, Yu Fan, Yilong Zou, Marcus Conrad - Redox Biology 2024 cited by 297

  6. Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

    Authors: Yoichiro Mitsuishi, Keiko Taguchi, Yukie Kawatani, Tatsuhiro Shibata, Toshihiro Nukiwa, Hiroyuki Aburatani, Masayuki Yamamoto, Hozumi Motohashi - Cancer Cell 2012 cited by 1,368

  7. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

    Authors: Keiko Taguchi, Hozumi Motohashi, Masayuki Yamamoto - Genes to Cells 2011 cited by 1,458

  8. Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

    Authors: Tomoaki Ida, Tomohiro Sawa, Hideshi Ihara, Yukihiro Tsuchiya, Yasuo Watanabe, Yoshito Kumagai, Makoto Suematsu, Hozumi Motohashi, Shigemoto Fujii, Tetsuro Matsunaga, Masayuki Yamamoto, Katsuhiko Ono, Nelmi O. Devarie‐Baez, Ming Xian, Jon M. Fukuto, Takaaki Akaike - National Academy of Sciences, Proceedings of the National Academy of Sciences 2014 cited by 917

  9. Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

    Authors: Takaaki Akaike, Tomoaki Ida, Fan‐Yan Wei, Motohiro Nishida, Yoshito Kumagai, Md. Morshedul Alam, Hideshi Ihara, Tomohiro Sawa, Tetsuro Matsunaga, Shingo Kasamatsu, Akiyuki Nishimura, Masanobu Morita, Kazuhito Tomizawa, Akira Nishimura, Satoshi Watanabe, Kenji Inaba, Hiroshi Shima, Nobuhiro Tanuma, Minkyung Jung, Shigemoto Fujii, Yasuo Watanabe, Masaki Ohmuraya, Péter Nagy, Martin Feelisch, Jon M. Fukuto, Hozumi Motohashi - Nature Communications 2017 cited by 543

  10. Nrf2–Keap1 defines a physiologically important stress response mechanism

    Authors: Hozumi Motohashi, Masayuki Yamamoto - Trends in Molecular Medicine 2004 cited by 1,712

  11. p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response

    Authors: Shun Kageyama, Sigurður Guðmundsson, Yu‐shin Sou, Yoshinobu Ichimura, Naoki Tamura, Saiko Kazuno, Takashi Ueno, Yoshiki Miura, Daisuke Noshiro, Manabu Abe, Tsunehiro Mizushima, Nobuaki Miura, Shujiro Okuda, Hozumi Motohashi, Jin‐A Lee, Kenji Sakimura, Tomoyuki Ohe, Nobuo N. Noda, Satoshi Waguri, Eeva‐Liisa Eskelinen, Masaaki Komatsu - Nature Communications 2021 cited by 288

  12. Toward clinical application of the Keap1–Nrf2 pathway

    Authors: Takafumi Suzuki, Hozumi Motohashi, Masayuki Yamamoto - Trends in Pharmacological Sciences 2013 cited by 669

  13. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

    Authors: Nobunao Wakabayashi, Ken Itoh, Junko Wakabayashi, Hozumi Motohashi, Shuhei Noda, Satoru Takahashi, Sumihisa Imakado, Tomoe KOTSUJI, Fujio Otsuka, Dennis R. Roop, Takanori Harada, James Douglas Engel, Masayuki Yamamoto - Nature Genetics 2003 cited by 888

  14. Keap1 degradation by autophagy for the maintenance of redox homeostasis

    Authors: Keiko Taguchi, Nanako Fujikawa, Masaaki Komatsu, Tetsuro Ishii, Michiaki Unno, Takaaki Akaike, Hozumi Motohashi, Masayuki Yamamoto - National Academy of Sciences, Proceedings of the National Academy of Sciences 2012 cited by 476

  15. NRF2 signalling in cytoprotection and metabolism

    Authors: Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi - British Journal of Pharmacology 2023 cited by 84

  16. Sulfide catabolism ameliorates hypoxic brain injury

    Authors: Eizo Marutani, Masanobu Morita, Shuichi Hirai, Shinichi Kai, Robert M. H. Grange, Yusuke Miyazaki, Fumiaki Nagashima, Lisa Traeger, Aurora Magliocca, Tomoaki Ida, Tetsuro Matsunaga, Daniel Flicker, Benjamin Corman, Naohiro Mori, Yumiko Yamazaki, Annabelle Batten, Rebecca Li, Tomohiro Tanaka, Takamitsu Ikeda, Akito Nakagawa, Dmitriy N. Atochin, Hideshi Ihara, Benjamin A. Olenchock, Xinggui Shen, Motohiro Nishida, Kenjiro Hanaoka, Christopher G. Kevil, Ming Xian, Donald B. Bloch, Takaaki Akaike, Allyson G. Hindle, Hozumi Motohashi, Fumito Ichinose - Nature Communications 2021 cited by 141

  17. Contribution of NRF2 to sulfur metabolism and mitochondrial activity

    Authors: Md. Morshedul Alam, Akihiro Kishino, Eunkyu Sung, Hiroki Sekine, Takaaki Abe, Shohei Murakami, Takaaki Akaike, Hozumi Motohashi - Redox Biology 2023 cited by 62

  18. p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

    Authors: Tetsuya Saito, Yoshinobu Ichimura, Keiko Taguchi, Takafumi Suzuki, Tsunehiro Mizushima, Kenji Takagi, Yuki Hirose, Masayuki Nagahashi, Tetsuro Iso, Toshiaki Fukutomi, Maki Ohishi, Keiko Endo, Takefumi Uemura, Yasumasa Nishito, Shujiro Okuda, Miki Obata, Tsuguka Kouno, Riyo Imamura, Yukio Tada, Rika Obata, Daisuke Yasuda, Kyôko Takahashi, Tsutomu Fujimura, Jingbo Pi, Myung‐Shik Lee, Takashi Ueno, Tomoyuki Ohe, Tadahiko Mashino, Toshifumi Wakai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Hozumi Motohashi, Satoshi Waguri, Tomoyoshi Soga, Masayuki Yamamoto, Keiji Tanaka, Masaaki Komatsu - Nature Communications 2016 cited by 372

  19. FANTOM5 CAGE profiles of human and mouse samples

    Authors: Shuhei Noguchi, Takahiro Arakawa, Shiro Fukuda, Masaaki Furuno, Akira Hasegawa, Fumi Hori, Sachi Ishikawa-Kato, Kaoru Kaida, Ai Kaiho, Mutsumi Kanamori-Katayama, Tsugumi Kawashima, Miki Kojima, Atsutaka Kubosaki, Ri-ichiroh Manabe, Mitsuyoshi Murata, Sayaka Nagao-Sato, Kenichi Nakazato, Noriko Ninomiya, Hiromi Nishiyori-Sueki, Shohei Noma, Eri Saijyo, Akiko Saka, Mizuho Sakai, Christophe Simon, Naoko Suzuki, Michihira Tagami, Shoko Watanabe, Shigehiro Yoshida, Peter Arner, Richard A Axton, Magda Babina, J. Kenneth Baillie, Timothy C. Barnett, Anthony G Beckhouse, Antje Blumenthal, Beatrice Bodega, Alessandro Bonetti, James Briggs, Frank Brombacher, Ailsa J Carlisle, Hans Clevers, Carrie Davis, Michael Detmar, Taeko Dohi, Albert S.B. Edge, Matthias Edinger, Anna Ehrlund, Karl Ekwall, Mitsuhiro Endoh, Hideki Enomoto, Afsaneh Eslami, Michela Fagiolini, Lynsey Fairbairn, Mary C. Farach‐Carson, Geoffrey J. Faulkner, Carmelo Ferrai, Malcolm E Fisher, Lesley M. Forrester, Rie Fujita, Jun-ichi Furusawa, Teunis B. H. Geijtenbeek, T Gingeras, Dan Goldowitz, Sven Guhl, Reto Guler, Stefano Gustincich, Thomas J Ha, Masahide Hamaguchi, Mitsuko Hara, Yuki Hasegawa, Meenhard Herlyn, Peter Heutink, Kelly J Hitchens, David Hume, Tomokatsu Ikawa, Yuri Ishizu, Chieko Kai, Hiroshi Kawamoto, Yuki I. Kawamura, Judith S. Kempfle, Tony Kenna, Juha Kere, Levon M. Khachigian, Toshio Kitamura, Sarah Klein, S. Peter Klinken, Alan J. Knox, Soichi Kojima, Haruhiko Koseki, Shigeo Koyasu, Weon-Ju Lee, Andreas Lennartsson, Alan Mackay‐Sim, Niklas Mejhert, Yosuke Mizuno, Hiromasa Morikawa, Mitsuru Morimoto, Kazuyo Moro, Kelly J Morris, Hozumi Motohashi and 78 more - Scientific Data 2017 cited by 362

  20. Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity

    Authors: Tae Yamamoto, Takafumi Suzuki, Akira Kobayashi, Junko Wakabayashi, Jonathan Maher, Hozumi Motohashi, Masayuki Yamamoto - Molecular and Cellular Biology 2008 cited by 501

  21. NRF2 addiction in cancer cells

    Authors: Hiroshi Kitamura, Hozumi Motohashi - Cancer Science 2018 cited by 273

  22. Supersulphides provide airway protection in viral and chronic lung diseases

    Authors: Tetsuro Matsunaga, Hirohito Sano, Katsuya Takita, Masanobu Morita, Shun Yamanaka, Tomohiro Ichikawa, Tadahisa Numakura, Tomoaki Ida, Minkyung Jung, Seiryo Ogata, Sunghyeon Yoon, Naoya Fujino, Yorihiko Kyogoku, Yusaku Sasaki, Akira Koarai, Tsutomu Tamada, Atsuhiko Toyama, Takakazu Nakabayashi, Lisa Kageyama, Shigeru Kyuwa, Kenji Inaba, Satoshi Watanabe, Péter Nagy, Tomohiro Sawa, Hiroyuki Oshiumi, Masakazu Ichinose, Mitsuhiro Yamada, Hisatoshi Sugiura, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike - Nature Communications 2023 cited by 61

  23. Autophagy regulates lipid metabolism through selective turnover of NCoR1

    Authors: Tetsuya Saito, Akiko Kuma, Yuki Sugiura, Yoshinobu Ichimura, Miki Obata, Hiroshi Kitamura, Shujiro Okuda, Hyeon‐Cheol Lee, Kazutaka Ikeda, Yumi Kanegae, Izumu Saito, Johan Auwerx, Hozumi Motohashi, Makoto Suematsu, Tomoyoshi Soga, Takehiko Yokomizo, Satoshi Waguri, Noboru Mizushima, Masaaki Komatsu - Nature Communications 2019 cited by 195

  24. Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

    Authors: Kai Takaya, Takafumi Suzuki, Hozumi Motohashi, Ko Onodera, Susumu Satomi, Thomas W. Kensler, Masayuki Yamamoto - Free Radical Biology and Medicine 2012 cited by 269