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John R. Cirrito

Active 2000–2026

70
Papers
20,265
Citations
55
h-index
67
i10-index

Citations

Citations per year for John R. Cirrito2000: 1 citations2001: 6 citations2002: 18 citations2003: 11 citations2004: 35 citations2005: 52 citations2006: 63 citations2007: 74 citations2008: 108 citations2009: 152 citations2010: 173 citations2011: 213 citations2012: 275 citations2013: 331 citations2014: 426 citations2015: 435 citations2016: 428 citations2017: 517 citations2018: 448 citations2019: 1,015 citations2020: 1,143 citations2021: 1,050 citations2022: 865 citations2023: 800 citations2024: 953 citations2025: 500 citations2026: 18 citations

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 3,643 citing papers, 32.3% of this breakdownChina: 1,120 citing papers, 9.9% of this breakdownUnited Kingdom: 760 citing papers, 6.7% of this breakdownGermany: 616 citing papers, 5.5% of this breakdownCanada: 413 citing papers, 3.7% of this breakdownItaly: 376 citing papers, 3.3% of this breakdownFrance: 339 citing papers, 3% of this breakdownJapan: 323 citing papers, 2.9% of this breakdownSpain: 322 citing papers, 2.9% of this breakdownAustralia: 319 citing papers, 2.8% of this breakdownSweden: 289 citing papers, 2.6% of this breakdownNetherlands: 236 citing papers, 2.1% of this breakdown
0%32.3%Other 22.3%

Institutions

Fields

  • Medicine48.5%
  • Neuroscience33.2%
  • Biochemistry, Genetics and Molecular Biology11.1%
  • Psychology2.7%
  • Immunology and Microbiology2.1%
  • Computer Science0.5%
  • Other1.9%

Topics

  • Alzheimer's disease research and treatments17.2%
  • Neuroinflammation and Neurodegeneration Mechanisms9.1%
  • Neuroscience and Neuropharmacology Research3.9%
  • Dementia and Cognitive Impairment Research3.1%
  • Cholinesterase and Neurodegenerative Diseases3%
  • Sleep and Wakefulness Research2.5%
  • Other61.2%

Coauthors

All papers

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  1. TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

    Authors: Yaming Wang, Marina Cella, Kaitlin Mallinson, Jason D. Ulrich, Katherine L. Young, Michelle L. Robinette, Susan Gilfillan, Gokul M. Krishnan, Shwetha Sudhakar, Bernd H. Zinselmeyer, David M. Holtzman, John R. Cirrito, Marco Colonna - Cell 2015 cited by 1,826

  2. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

    Authors: Jerrah K. Holth, Sarah K. Fritschi, Chanung Wang, Nigel P. Pedersen, John R. Cirrito, Thomas E. Mahan, Mary Beth Finn, Melissa Manis, Joel C. Geerling, Patrick M. Fuller, Brendan P. Lucey, David M. Holtzman - Science 2019 cited by 816

  3. TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

    Authors: Yaming Wang, Tyler K. Ulland, Jason D. Ulrich, Wilbur M. Song, John A. Tzaferis, Justin T. Hole, Peng Yuan, Thomas E. Mahan, Yang Shi, Susan Gilfillan, Marina Cella, Jaime Grutzendler, Ronald B. DeMattos, John R. Cirrito, David M. Holtzman, Marco Colonna - The Journal of Experimental Medicine 2016 cited by 882

  4. Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

    Authors: Jae-Eun Kang, Miranda M. Lim, Randall J. Bateman, James J. Lee, Liam P. Smyth, John R. Cirrito, Nobuhiro Fujiki, Seiji Nishino, David M. Holtzman - Science 2009 cited by 1,574

  5. Neuronal activity regulates extracellular tau in vivo

    Authors: Kaoru Yamada, Jerrah K. Holth, Fan Liao, Floy R. Stewart, Thomas E. Mahan, Hong Jiang, John R. Cirrito, Tirth K. Patel, Katja Hochgräfe, Eva‐Maria Mandelkow, David M. Holtzman - The Journal of Experimental Medicine 2014 cited by 602

  6. Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo

    Authors: John R. Cirrito, Kelvin A. Yamada, Mary Beth Finn, Robert S. Sloviter, Kelly R. Bales, Patrick C. May, Darryle D. Schoepp, Steven M. Paul, Steven Mennerick, David M. Holtzman - Neuron 2005 cited by 1,273

  7. Neuronal activity regulates the regional vulnerability to amyloid-β deposition

    Authors: Adam W. Bero, Ping Yan, Jee Hoon Roh, John R. Cirrito, Floy R. Stewart, Marcus E. Raichle, Jin‐Moo Lee, David M. Holtzman - Nature Neuroscience 2011 cited by 890

  8. Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1

    Authors: Takahisa Kanekiyo, John R. Cirrito, Chia‐Chen Liu, Mitsuru Shinohara, Jie Li, Dorothy R. Schuler, Motoko Shinohara, David M. Holtzman, Guojun Bu - Journal of Neuroscience 2013 cited by 279

  9. Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans

    Authors: John R. Cirrito, Brianne M. Disabato, Jessica L. Restivo, Deborah K. Verges, Whitney D. Goebel, Anshul Sathyan, Davinder Hayreh, Gina D’Angelo, Tammie L.S. Benzinger, Hyejin Yoon, Jungsu Kim, John C. Morris, Mark A. Mintun, Yvette I. Sheline - National Academy of Sciences, Proceedings of the National Academy of Sciences 2011 cited by 359

  10. Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

    Authors: Chia‐Chen Liu, Jin Hu, Na Zhao, Jian Wang, Na Wang, John R. Cirrito, Takahisa Kanekiyo, David M. Holtzman, Guojun Bu - Journal of Neuroscience 2017 cited by 261

  11. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model

    Authors: Pascal E. Sanchez, Lei Zhu, Laure Verret, Keith Vossel, Anna G. Orr, John R. Cirrito, Nino Devidze, Kaitlyn Ho, Gui-Qiu Yu, Jorge J. Palop, Lennart Mucke - National Academy of Sciences, Proceedings of the National Academy of Sciences 2012 cited by 647

  12. Enhancing Astrocytic Lysosome Biogenesis Facilitates Aβ Clearance and Attenuates Amyloid Plaque Pathogenesis

    Authors: Qingli Xiao, Ping Yan, Xiucui Ma, Haiyan Liu, Ronaldo Perez, Alec Zhu, Ernesto R. Gonzales, Jack M. Burchett, Dorothy R. Schuler, John R. Cirrito, Abhinav Diwan, Jin‐Moo Lee - Journal of Neuroscience 2014 cited by 266

  13. ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

    Authors: Paige E. Cramer, John R. Cirrito, Daniel W. Wesson, C. Y. Daniel Lee, J. Colleen Karlo, Adriana E. Zinn, Brad T. Casali, Jessica L. Restivo, Whitney D. Goebel, Michael J. James, Kurt R. Brunden, Donald A. Wilson, Gary E. Landreth - Science 2012 cited by 1,042

  14. Antisense Reduction of Tau in Adult Mice Protects against Seizures

    Authors: Sarah L. DeVos, Dustin Kenneth Goncharoff, Guojun Chen, Carey S. Kebodeaux, Kaoru Yamada, Floy R. Stewart, Dorothy R. Schuler, Susan E. Maloney, David F. Wozniak, Frank Rigo, C. Frank Bennett, John R. Cirrito, David M. Holtzman, Timothy M. Miller - Journal of Neuroscience 2013 cited by 312

  15. P-glycoprotein deficiency at the blood-brain barrier increases amyloid- deposition in an Alzheimer disease mouse model

    Authors: John R. Cirrito - Journal of Clinical Investigation 2005 cited by 643

  16. Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

    Authors: Andrew W. Kraft, Xiaoyan Hu, Hyejin Yoon, Ping Yan, Qingli Xiao, Yan Wang, So Chon Gil, Jennifer L. Brown, Ulrika Wilhelmsson, Jessica L. Restivo, John R. Cirrito, David M. Holtzman, Jungsu Kim, Milos Pekny, Jin‐Moo Lee - The FASEB Journal 2012 cited by 330

  17. Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

    Authors: Eva Czirr, Nicholas A. Castello, Kira I. Mosher, Joseph M. Castellano, Izumi V. Hinkson, Kurt M. Lucin, Bernat Baeza-Raja, Jae Kyu Ryu, Lulin Li, Sasha N. Farina, Nadia P. Belichenko, Frank M. Longo, Katerina Akassoglou, Markus Britschgi, John R. Cirrito, Tony Wyss‐Coray - The Journal of Experimental Medicine 2017 cited by 138

  18. Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification

    Authors: Nicholas J. Izzo, Carla M. Yuede, Kelsie M. LaBarbera, Colleen S. Limegrover, Courtney Rehak, Raymond Yurko, Lora Waybright, Gary C. Look, Gilbert M. Rishton, Hank Safferstein, Mary E. Hamby, Claire Williams, Kelsey Sadlek, Hannah M. Edwards, Charles S. Davis, Michael Grundman, Lon S. Schneider, Steven T. DeKosky, Daniel Chelsky, Ian Pike, Christopher M. Henstridge, Kaj Blennow, Henrik Zetterberg, Harry LeVine, Tara L. Spires‐Jones, John R. Cirrito, Susan M. Catalano - Alzheimer s & Dementia 2021 cited by 103

  19. Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

    Authors: John R. Cirrito, Jae-Eun Kang, Jiyeon Lee, Floy R. Stewart, Deborah K. Verges, Luz Silverio, Guojun Bu, Steven Mennerick, David M. Holtzman - Neuron 2008 cited by 653

  20. Matrix Metalloproteinases Expressed by Astrocytes Mediate Extracellular Amyloid-β Peptide Catabolism

    Authors: Ke‐Jie Yin, John R. Cirrito, Ping Yan, Xiaoyan Hu, Qingli Xiao, Xiaoou Pan, Randall J. Bateman, Haowei Song, Fong‐Fu Hsu, John Turk, Jan Xu, Chung Y. Hsu, Jason C. Mills, David M. Holtzman, Jin‐Moo Lee - Journal of Neuroscience 2006 cited by 365

  21. Amyloid‐beta oligomerization in Alzheimer dementia versus high‐pathology controls

    Authors: Thomas J. Esparza, Hanzhi Zhao, John R. Cirrito, Nigel J. Cairns, Randall J. Bateman, David M. Holtzman, David L. Brody - Annals of Neurology 2012 cited by 314

  22. Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis

    Authors: Qingli Xiao, Ping Yan, Xiucui Ma, Haiyan Liu, Ronaldo Perez, Alec Zhu, Ernesto R. Gonzales, Danielle L. Tripoli, Leah Czerniewski, Andrea Ballabio, John R. Cirrito, Abhinav Diwan, Jin‐Moo Lee - Journal of Neuroscience 2015 cited by 243

  23. Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease

    Authors: Kaoru Yamamoto, Zen‐ichi Tanei, Tadafumi Hashimoto, Tomoko Wakabayashi, Hiroyuki Okuno, Yasushi Naka, Ofer Yizhar, Lief E. Fenno, Masashi Fukayama, Haruhiko Bito, John R. Cirrito, David M. Holtzman, Karl Deisseroth, Takeshi Iwatsubo - Cell Reports 2015 cited by 232

  24. Aqp4 stop codon readthrough facilitates amyloid-β clearance from the brain

    Authors: Darshan Sapkota, Colin P. Florian, Brookelyn M. Doherty, Kelli McFarland White, Kate M Reardon, Xia Ge, Joel R. Garbow, Carla M. Yuede, John R. Cirrito, Joseph D. Dougherty - Brain 2022 cited by 50