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Karen O’Rourke

Active 1985–2021

Also published as
Karen O'Rourke
41
Papers
29,161
Citations
39
h-index
40
i10-index

Citations

Citations per year for Karen O’Rourke1979: 1 citations1985: 4 citations1986: 13 citations1987: 21 citations1988: 15 citations1989: 14 citations1990: 18 citations1991: 26 citations1992: 44 citations1993: 34 citations1994: 21 citations1995: 59 citations1996: 312 citations1997: 736 citations1998: 828 citations1999: 732 citations2000: 549 citations2001: 372 citations2002: 271 citations2003: 275 citations2004: 248 citations2005: 228 citations2006: 266 citations2007: 244 citations2008: 260 citations2009: 291 citations2010: 273 citations2011: 324 citations2012: 287 citations2013: 276 citations2014: 218 citations2015: 241 citations2016: 237 citations2017: 288 citations2018: 256 citations2019: 669 citations2020: 788 citations2021: 785 citations2022: 710 citations2023: 581 citations2024: 669 citations2025: 353 citations2026: 13 citations1980–1984: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 4,820 citing papers, 34.7% of this breakdownChina: 1,981 citing papers, 14.3% of this breakdownGermany: 880 citing papers, 6.3% of this breakdownUnited Kingdom: 704 citing papers, 5.1% of this breakdownJapan: 657 citing papers, 4.7% of this breakdownCanada: 496 citing papers, 3.6% of this breakdownFrance: 470 citing papers, 3.4% of this breakdownAustralia: 445 citing papers, 3.2% of this breakdownSwitzerland: 302 citing papers, 2.2% of this breakdownSouth Korea: 276 citing papers, 2% of this breakdownItaly: 265 citing papers, 1.9% of this breakdownBelgium: 233 citing papers, 1.7% of this breakdown
0%34.7%Other 16.9%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology68.7%
  • Medicine16.8%
  • Immunology and Microbiology10.1%
  • Neuroscience1.4%
  • Agricultural and Biological Sciences1.1%
  • Nursing0.4%
  • Other1.5%

Topics

  • Inflammasome and immune disorders10.8%
  • Cell death mechanisms and regulation9.2%
  • interferon and immune responses4.6%
  • Immune Response and Inflammation4.5%
  • NF-κB Signaling Pathways4.2%
  • Ubiquitin and proteasome pathways2.8%
  • Other63.9%

Coauthors

All papers

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  1. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

    Authors: Nobuhiko Kayagaki, Irma B. Stowe, Bettina L. Lee, Karen O’Rourke, Keith R. Anderson, Søren Warming, Trinna Cuellar, Benjamin Haley, Merone Roose‐Girma, Qui Phung, Peter S. Liu, Jennie R. Lill, Hong Li, Jiansheng Wu, Sarah Kummerfeld, Juan Zhang, Wyne P. Lee, Scott J. Snipas, Guy S. Salvesen, Lucy X. Morris, Linda Fitzgerald, Yafei Zhang, Edward M. Bertram, Christopher C. Goodnow, Vishva M. Dixit - Nature 2015 cited by 3,743

  2. NINJ1 mediates plasma membrane rupture during lytic cell death

    Authors: Nobuhiko Kayagaki, Opher S. Kornfeld, Bettina L. Lee, Irma B. Stowe, Karen O’Rourke, Qingling Li, Wendy Sandoval, Donghong Yan, Jing‐Qiong Kang, Min Xu, Juan Zhang, Wyne P. Lee, Brent S. McKenzie, Gözde Ulas, Jian Payandeh, Merone Roose‐Girma, Zora Modrušan, Rohit Reja, Meredith Sagolla, Joshua D. Webster, Vicky Cho, T. Daniel Andrews, Lucy X. Morris, Lisa A. Miosge, Christopher C. Goodnow, Edward M. Bertram, Vishva M. Dixit - Nature 2021 cited by 849

  3. Cryopyrin activates the inflammasome in response to toxins and ATP

    Authors: Sanjeev Mariathasan, David S. Weiss, Kim Newton, Jacqueline McBride, Karen O’Rourke, Meron Roose-Girma, Wyne P. Lee, Yvette Weinrauch, Denise M. Monack, Vishva M. Dixit - Nature 2006 cited by 3,076

  4. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

    Authors: Ingrid E. Wertz, Karen O’Rourke, Honglin Zhou, Michael Eby, L. Aravind, Somasekar Seshagiri, Ping Wu, Christian Wiesmann, Rohan T. Baker, David L. Boone, Averil Ma, Eugene V. Koonin, Vishva M. Dixit - Nature 2004 cited by 1,843

  5. FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

    Authors: Marta Muzio, Arul M. Chinnaiyan, Frank Kischkel, Karen O’Rourke, Andrej Shevchenko, Jian Ni, Carsten Scaffidi, James D. Bretz, Mei Zhang, Reiner Gentz, Matthias Mann, Peter H. Krammer, Marcus E. Peter, Vishva M. Dixit - Cell 1996 cited by 3,067

  6. IRF2 transcriptionally induces GSDMD expression for pyroptosis

    Authors: Nobuhiko Kayagaki, Bettina L. Lee, Irma B. Stowe, Opher S. Kornfeld, Karen O’Rourke, Kathleen M. Mirrashidi, Benjamin Haley, Colin Watanabe, Merone Roose‐Girma, Zora Modrušan, Sarah Kummerfeld, Rohit Reja, Yafei Zhang, Vicky Cho, T. Daniel Andrews, Lucy X. Morris, Christopher C. Goodnow, Edward M. Bertram, Vishva M. Dixit - Science Signaling 2019 cited by 185

  7. Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

    Authors: Ingrid E. Wertz, Saritha Kusam, Cynthia Lam, Toru Okamoto, Wendy Sandoval, Daniel J. Anderson, Elizabeth Helgason, James A. Ernst, Mike Eby, Jinfeng Liu, Lisa D. Belmont, Joshua S. Kaminker, Karen O’Rourke, Kanan Pujara, Pawan Bir Kohli, Adam R. Johnson, Mark L. Chiu, Jennie R. Lill, Peter K. Jackson, Wayne J. Fairbrother, Somasekar Seshagiri, Mary J. C. Ludlam, Kevin G. Leong, Erin C. Dueber, Heather Maecker, David C.S. Huang, Vishva M. Dixit - Nature 2011 cited by 820

  8. Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

    Authors: Muneesh Tewari, Long T. Quan, Karen O’Rourke, Serge Desnoyers, Zhi Jiang Zeng, David R Beidler, Guy G. Poirier, Guy S. Salvesen, Vishva M. Dixit - Cell 1995 cited by 2,393

  9. FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

    Authors: Arul M. Chinnaiyan, Karen O’Rourke, Muneesh Tewari, Vishva M. Dixit - Cell 1995 cited by 2,427

  10. The Receptor for the Cytotoxic Ligand TRAIL

    Authors: Guohua Pan, Karen O’Rourke, Arul M. Chinnaiyan, Reiner Gentz, Reinhard Ebner, Jian Ni, Vishva M. Dixit - Science 1997 cited by 1,778

  11. A Deubiquitinase That Regulates Type I Interferon Production

    Authors: Nobuhiko Kayagaki, Qui Phung, Salina Chan, Ruchir Chaudhari, Casey Quan, Karen O’Rourke, Michael Eby, Eric M. Pietras, Genhong Cheng, J. Fernando Bazán, Zemin Zhang, David Arnott, Vishva M. Dixit - Science 2007 cited by 454

  12. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

    Authors: Martin Schwickart, Xiaodong Huang, Jennie R. Lill, Jinfeng Liu, Ronald E. Ferrando, Dorothy French, Heather Maecker, Karen O’Rourke, Fernando Bazán, Jeffrey Eastham‐Anderson, Yue Peng, David Dornan, David C.S. Huang, Vishva M. Dixit - Nature 2009 cited by 622

  13. Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

    Authors: Jonathan Jones, Nobuhiko Kayagaki, Petr Brož, Thomas Henry, Kim Newton, Karen O’Rourke, Salina Chan, Jennifer J. Dong, Yan Qu, Meron Roose-Girma, Vishva M. Dixit, Denise M. Monack - National Academy of Sciences, Proceedings of the National Academy of Sciences 2010 cited by 477

  14. Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95

    Authors: Arul M. Chinnaiyan, Karen O’Rourke, Guo-Liang Yu, Robert H. Lyons, Manish Garg, Delin Duan, Lily Xing, Reiner Gentz, Jian Ni, Vishva M. Dixit - Science 1996 cited by 654

  15. Human De-Etiolated-1 Regulates c-Jun by Assembling a CUL4A Ubiquitin Ligase

    Authors: Ingrid E. Wertz, Karen O’Rourke, Zemin Zhang, David Dornan, David Arnott, Raymond J. Deshaies, Vishva M. Dixit - Science 2004 cited by 370

  16. Association of C-Terminal Ubiquitin Hydrolase BRCA1-Associated Protein 1 with Cell Cycle Regulator Host Cell Factor 1

    Authors: Shahram Misaghi, Søren Ottosen, Anita Izrael-Tomasevic, David Arnott, Mohamed Lamkanfi, James Lee, Jinfeng Liu, Karen O’Rourke, Vishva M. Dixit, Angus C. Wilson - Molecular and Cellular Biology 2009 cited by 216

  17. Bcl10 activates the NF-κB pathway through ubiquitination of NEMO

    Authors: Honglin Zhou, Ingrid E. Wertz, Karen O’Rourke, Mark Ultsch, Somasekar Seshagiri, Michael Eby, Wei Xiao, Vishva M. Dixit - Nature 2003 cited by 526

  18. COP1 is a tumour suppressor that causes degradation of ETS transcription factors

    Authors: Alberto C. Vitari, Kevin G. Leong, Kim Newton, Cindy J. Yee, Karen O’Rourke, Jinfeng Liu, Lilian Phu, Rajesh Vij, Ronald E. Ferrando, Suzana S. Couto, Sankar Mohan, Ajay Pandita, Jo-Anne Hongo, David Arnott, Ingrid E. Wertz, Wei‐Qiang Gao, Dorothy French, Vishva M. Dixit - Nature 2011 cited by 171

  19. Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

    Authors: Guohua Pan, Karen O’Rourke, Vishva M. Dixit - Journal of Biological Chemistry 1998 cited by 522

  20. FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

    Authors: Arul M. Chinnaiyan, Clifford G. Tepper, Michael F. Seldin, Karen O’Rourke, Frank Kischkel, Stefan Hellbardt, Peter H. Krammer, Marcus E. Peter, Vishva M. Dixit - Journal of Biological Chemistry 1996 cited by 774

  21. Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

    Authors: Arul M. Chinnaiyan, Karen O’Rourke, Brian R. Lane, Vishva M. Dixit - Science 1997 cited by 638

  22. Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin.

    Authors: Vishva M. Dixit, S Green, Vidya Sarma, Lawrence B. Holzman, F.W. Wolf, Karen O’Rourke, Peter A. Ward, Edward V. Prochownik, R M Marks - Journal of Biological Chemistry 1990 cited by 376

  23. Identification of Paracaspases and Metacaspases

    Authors: Anthony G. Uren, Karen O’Rourke, L. Aravind, M. Teresa Pisabarro, Somasekar Seshagiri, Eugene V. Koonin, Vishva M. Dixit - Molecular Cell 2000 cited by 238

  24. The PYRIN domain: A member of the death domain‐fold superfamily

    Authors: Wayne J. Fairbrother, Nathaniel C. Gordon, Eric W. Humke, Karen O’Rourke, Melissa A. Starovasnik, Jianping Yin, Vishva M. Dixit - Protein Science 2001 cited by 153