Lawrence A. Loeb
Active 1929–2021
- 129
- Papers
- 30,569
- Citations
- 98
- h-index
- 129
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Biochemistry, Genetics and Molecular Biology63.4%
- Medicine22.8%
- Immunology and Microbiology3.9%
- Agricultural and Biological Sciences2%
- Environmental Science2%
- Nursing1.1%
- Other4.8%
Topics
- DNA Repair Mechanisms8.5%
- Cancer Genomics and Diagnostics4.9%
- DNA and Nucleic Acid Chemistry3.3%
- Carcinogens and Genotoxicity Assessment3.1%
- Mitochondrial Function and Pathology3%
- CRISPR and Genetic Engineering2.9%
- Other74.3%
Coauthors
- Thomas A. Kunkel10
- Jesse J. Salk9
- Edward Fox8
- Ashwini S. Kamath‐Loeb7
- Robert A. Beckman7
- Albert S. Mildvan6
- Bradley D. Preston6
- Jiang-Cheng Shen6
- Michael Fry6
- Jason H. Bielas5
- Keith R. Loeb5
- Marc J. Prindle5
- Premal H. Patel5
- Scott R. Kennedy5
- B D Preston4
- George M. Martin4
- Mary J. Emond4
- Michael Schmitt4
- Michael W. Schmitt4
- Roel M. Schaaper4
- Aimee L. Jackson3
- Brendan F. Kohrn3
- Clark F. Springgate3
- Curtis C. Harris3
All papers
- Detection of ultra-rare mutations by next-generation sequencing
Authors: Michael W. Schmitt, Scott R. Kennedy, Jesse J. Salk, Edward Fox, Joseph B. Hiatt, Lawrence A. Loeb - National Academy of Sciences, Proceedings of the National Academy of Sciences 2012 cited by 1,096
- Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations
Authors: Jesse J. Salk, Michael W. Schmitt, Lawrence A. Loeb - Nature Reviews Genetics 2018 cited by 574
- Detecting ultralow-frequency mutations by Duplex Sequencing
Authors: Scott R. Kennedy, Michael W. Schmitt, Edward Fox, Brendan F. Kohrn, Jesse J. Salk, Eun Hyun Ahn, Marc J. Prindle, Kawai J Kuong, Jiang-Cheng Shen, Rosa‐Ana Risques, Lawrence A. Loeb - Nature Protocols 2014 cited by 539
- Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage
Authors: Scott R. Kennedy, Jesse J. Salk, Michael Schmitt, Lawrence A. Loeb - PLoS Genetics 2013 cited by 377
- Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging
Authors: Dao‐Fu Dai, Luis F. Santana, Marc Vermulst, Daniela M. Tomazela, Mary J. Emond, Michael J. MacCoss, Katherine A. Gollahon, George M. Martin, Lawrence A. Loeb, Warren Ladiges, Peter S. Rabinovitch - Circulation 2009 cited by 493
- 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.
Authors: Keith C. Cheng, D S Cahill, Hiroshi Kasai, S. Nishimura, Lawrence A. Loeb - Journal of Biological Chemistry 1992 cited by 1,845
- The influence of subclonal resistance mutations on targeted cancer therapy
Authors: Michael Schmitt, Lawrence A. Loeb, Jesse J. Salk - Nature Reviews Clinical Oncology 2015 cited by 231
- Mitochondrial point mutations do not limit the natural lifespan of mice
Authors: Marc Vermulst, Jason H. Bielas, Gregory C. Kujoth, Warren Ladiges, Peter S. Rabinovitch, Tomas A. Prolla, Lawrence A. Loeb - Nature Genetics 2007 cited by 415
- Significance of multiple mutations in cancer
Authors: Keith R. Loeb, Lawrence A. Loeb - Carcinogenesis 2000 cited by 457
- Human cancers express mutator phenotypes: origin, consequences and targeting
Authors: Lawrence A. Loeb - Nature reviews. Cancer 2011 cited by 402
- DNA polymerase delta in dna replication and genome maintenance
Authors: Marc J. Prindle, Lawrence A. Loeb - Environmental and Molecular Mutagenesis 2012 cited by 143
- Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan
Authors: Jesse J. Salk, Kaitlyn Loubet-Senear, Elisabeth Maritschnegg, Charles C. Valentine, Lindsey N. Williams, Jacob E. Higgins, Reinhard Horvat, Adriaan Vanderstichele, Daniela Nachmanson, Kathryn T. Baker, Mary J. Emond, Emily Loter, Maria Tretiakova, Thierry Soussi, Lawrence A. Loeb, Robert Zeillinger, P Speiser, Rosa Ana Risques - Cell Reports 2019 cited by 104
- Environmental and chemical carcinogenesis
Authors: Gerald N. Wogan, Stephen S. Hecht, James S. Felton, Allan H. Conney, Lawrence A. Loeb - Seminars in Cancer Biology 2004 cited by 655
- Mutational spectra of aflatoxin B 1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma
Authors: Supawadee Chawanthayatham, Charles C. Valentine, Bogdan I. Fedeles, Edward Fox, Lawrence A. Loeb, Stuart S. Levine, Stephen L. Slocum, Gerald N. Wogan, Robert G. Croy, John M. Essigmann - National Academy of Sciences, Proceedings of the National Academy of Sciences 2017 cited by 129
- DNA polymerases and human disease
Authors: Lawrence A. Loeb, Raymond J. Monnat - Nature Reviews Genetics 2008 cited by 317
- Multiple mutations and cancer
Authors: Lawrence A. Loeb, Keith R. Loeb, Jon P. Anderson - National Academy of Sciences, Proceedings of the National Academy of Sciences 2003 cited by 759
- The contribution of endogenous sources of DNA damage to the multiple mutations in cancer
Authors: Aimee L. Jackson, Lawrence A. Loeb - Mutation research. Fundamental and molecular mechanisms of mutagenesis 2001 cited by 626
- DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice
Authors: Marc Vermulst, Jonathan Wanagat, Gregory C. Kujoth, Jason H. Bielas, Peter S. Rabinovitch, Tomas A. Prolla, Lawrence A. Loeb - Nature Genetics 2008 cited by 413
- Human Werner Syndrome DNA Helicase Unwinds Tetrahelical Structures of the Fragile X Syndrome Repeat Sequence d(CGG)
Authors: Michael Fry, Lawrence A. Loeb - Journal of Biological Chemistry 1999 cited by 370
- Sequencing small genomic targets with high efficiency and extreme accuracy
Authors: Michael W. Schmitt, Edward Fox, Marc J. Prindle, Kate S. Reid-Bayliss, Lawrence D. True, Jerald P. Radich, Lawrence A. Loeb - Nature Methods 2015 cited by 183
- Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues
Authors: Jeffrey D. Krimmel, Michael Schmitt, Maria I. Harrell, Kathy Agnew, Scott R. Kennedy, Mary J. Emond, Lawrence A. Loeb, Elizabeth M. Swisher, Rosa Ana Risques - National Academy of Sciences, Proceedings of the National Academy of Sciences 2016 cited by 166
- The Werner syndrome protein is a DNA helicase
Authors: Matthew D. Gray, Jiang-Cheng Shen, Ashwini S. Kamath‐Loeb, A. Blank, Bryce L. Sopher, George M. Martin, Junko Oshima, Lawrence A. Loeb - Nature Genetics 1997 cited by 612
- Protein tolerance to random amino acid change
Authors: H. Henry Guo, Juno Choe, Lawrence A. Loeb - National Academy of Sciences, Proceedings of the National Academy of Sciences 2004 cited by 327
- Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I
Authors: Manel Camps, Jussi Naukkarinen, Ben P. Johnson, Lawrence A. Loeb - National Academy of Sciences, Proceedings of the National Academy of Sciences 2003 cited by 170
