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Robert Vassar

Active 1989–2025

108
Papers
28,783
Citations
73
h-index
102
i10-index

Citations

Citations per year for Robert Vassar1962: 1 citations1989: 5 citations1990: 9 citations1991: 19 citations1992: 36 citations1993: 53 citations1994: 70 citations1995: 50 citations1996: 78 citations1997: 60 citations1998: 71 citations1999: 85 citations2000: 155 citations2001: 223 citations2002: 234 citations2003: 189 citations2004: 264 citations2005: 226 citations2006: 265 citations2007: 257 citations2008: 282 citations2009: 284 citations2010: 335 citations2011: 356 citations2012: 377 citations2013: 333 citations2014: 402 citations2015: 386 citations2016: 453 citations2017: 409 citations2018: 377 citations2019: 1,004 citations2020: 1,055 citations2021: 1,030 citations2022: 848 citations2023: 715 citations2024: 1,038 citations2025: 661 citations2026: 22 citations2027: 1 citations1963–1988: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 4,085 citing papers, 31.1% of this breakdownChina: 1,295 citing papers, 9.9% of this breakdownGermany: 815 citing papers, 6.2% of this breakdownUnited Kingdom: 701 citing papers, 5.3% of this breakdownJapan: 513 citing papers, 3.9% of this breakdownIndia: 435 citing papers, 3.3% of this breakdownItaly: 423 citing papers, 3.2% of this breakdownSouth Korea: 390 citing papers, 3% of this breakdownCanada: 386 citing papers, 2.9% of this breakdownFrance: 338 citing papers, 2.6% of this breakdownSpain: 308 citing papers, 2.4% of this breakdownAustralia: 298 citing papers, 2.3% of this breakdown
0%31.1%Other 23.9%

Institutions

Fields

  • Medicine55.3%
  • Biochemistry, Genetics and Molecular Biology18.7%
  • Neuroscience18.3%
  • Computer Science3%
  • Immunology and Microbiology1.2%
  • Agricultural and Biological Sciences0.7%
  • Other2.8%

Topics

  • Alzheimer's disease research and treatments18.8%
  • Cholinesterase and Neurodegenerative Diseases5.9%
  • Neuroinflammation and Neurodegeneration Mechanisms5.1%
  • Computational Drug Discovery Methods5%
  • Neuroscience and Neuropharmacology Research2.6%
  • Tryptophan and brain disorders2.2%
  • Other60.4%

Coauthors

All papers

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  1. Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

    Authors: Holly D. Oakley, Sarah L. Cole, Sreemathi Logan, Erika Maus, Pei Shao, Jeffery Craft, Angela Guillozet-Bongaarts, Masuo Ohno, John F. Disterhoft, Linda Van Eldik, R. Stephen Berry, Robert Vassar - Journal of Neuroscience 2006 cited by 3,581

  2. The β-Secretase BACE1 in Alzheimer’s Disease

    Authors: Harald Hampel, Robert Vassar, Bart De Strooper, John Hardy, Michael Willem, Neeraj Singh, John Zhou, Riqiang Yan, Eugeen Vanmechelen, Ann De Vos, Robert Nisticò, Massimo Corbo, Bruno P. Imbimbo, Johannes Streffer, Iryna Voytyuk, Maarten Timmers, Amir Abbas Tahami Monfared, Michael C. Irizarry, Bruce Albala, Akihiko Koyama, Naoto Watanabe, Teiji Kimura, Lisa Yarenis, Simone Lista, Lynn D. Kramer, Andrea Vergallo - Biological Psychiatry 2020 cited by 666

  3. The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored

    Authors: Sidhanth Chandra, Sangram S. Sisodia, Robert Vassar - Molecular Neurodegeneration 2023 cited by 265

  4. APP mouse models for Alzheimer's disease preclinical studies

    Authors: Hiroki Sasaguri, Per Nilsson, Shoko Hashimoto, Kenichi Nagata, Takashi Saito, Bart De Strooper, John Hardy, Robert Vassar, Bengt Winblad, Takaomi C. Saido - The EMBO Journal 2017 cited by 785

  5. β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

    Authors: Robert Vassar, Brian D. Bennett, Safura Babu‐Khan, Steve Kahn, Elizabeth A. Mendiaz, Paul Denis, David B. Teplow, Sandra L. Ross, Patricia Amarante, Richard Loeloff, Yi Luo, Seth Fisher, Janis Fuller, Steven Edenson, Jackson Lile, Mark A. Jarosinski, Anja Leona Biere, Eileen Curran, Teresa L. Burgess, Jean-Claude Louis, Frank M. Collins, James Treanor, Gary N. Rogers, Martin Citron - Science 1999 cited by 3,836

  6. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease

    Authors: Ji‐Yeun Hur, Georgia Frost, Xianzhong Wu, Christina J. Crump, Si Pan, Eitan Wong, Marilia Barros, Thomas Li, Pengju Nie, Yujia Zhai, Jen Chyong Wang, Julia TCW, Lei Guo, Andrew McKenzie, Ming Chen, Xianxiao Zhou, Minghui Wang, Yotam Sagi, Alan E. Renton, Bianca Esposito, Yong Kim, Katherine R. Sadleir, Ivy Trinh, Robert A. Rissman, Robert Vassar, Bin Zhang, Douglas S. Johnson, Eliezer Masliah, Paul Greengard, Alison Goate, Yue‐Ming Li - Nature 2020 cited by 394

  7. Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

    Authors: William A. Eimer, Robert Vassar - Molecular Neurodegeneration 2013 cited by 414

  8. AD-BERT: Using pre-trained language model to predict the progression from mild cognitive impairment to Alzheimer's disease

    Authors: Chengsheng Mao, Jie Xu, Luke V. Rasmussen, Yikuan Li, Prakash Adekkanattu, Jennifer A. Pacheco, Borna Bonakdarpour, Robert Vassar, Li Shen, Guoqian Jiang, Fei Wang, Jyotishman Pathak, Yuan Luo - Journal of Biomedical Informatics, J. Biomed. Informatics 2023 cited by 63

  9. The Alzheimer's disease Beta-secretase enzyme, BACE1

    Authors: Sarah L. Cole, Robert Vassar - Molecular Neurodegeneration 2007 cited by 545

  10. Targeting the β secretase BACE1 for Alzheimer's disease therapy

    Authors: Riqiang Yan, Robert Vassar - The Lancet Neurology 2014 cited by 624

  11. The case for low-level BACE1 inhibition for the prevention of Alzheimer disease

    Authors: Eric McDade, Iryna Voytyuk, Paul Aisen, Randall J. Bateman, María C. Carrillo, Bart De Strooper, Christian Haass, Eric M. Reiman, Reisa A. Sperling, Pierre N. Tariot, Riqiang Yan, Colin L. Masters, Robert Vassar, Stefan F. Lichtenthaler - Nature Reviews Neurology 2021 cited by 135

  12. The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

    Authors: Jie Zhao, Tracy O’Connor, Robert Vassar - Journal of Neuroinflammation 2011 cited by 360

  13. Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

    Authors: Katherine R. Sadleir, Patty C. Kandalepas, Virginie Buggia-Prévot, Daniel A. Nicholson, Gopal Thinakaran, Robert Vassar - Acta Neuropathologica 2016 cited by 296

  14. Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice

    Authors: Andrew Octavian Sasmita, Constanze Depp, T. I. Nazarenko, Ting Sun, Sophie B. Siems, Erinne Cherisse Ong, Yakum Bertrand Nkeh, Carolin Böhler, Xuan Yu, Bastian Bues, Lisa Evangelista, Shuying Mao, Bárbara Morgado, Zoe Y. Wu, Torben Ruhwedel, Swati Subramanian, Friederike Börensen, Katharina Overhoff, Lena Spieth, Stefan A. Berghoff, Katherine R. Sadleir, Robert Vassar, Simone Eggert, Sandra Goebbels, Takashi Saito, Takaomi C. Saido, Gesine Saher, Wiebke Möbius, Gonçalo Castelo‐Branco, Hans‐Wolfgang Klafki, Oliver Wirths, Jens Wiltfang, Sarah Jäkel, Riqiang Yan, Klaus‐Armin Nave - Nature Neuroscience 2024 cited by 101

  15. The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms

    Authors: Sidhanth Chandra, Antonio Di Meco, Hemraj B. Dodiya, Jelena Popović, Leah K. Cuddy, Ian Q. Weigle, Xiaoqiong Zhang, Katherine R. Sadleir, Sangram S. Sisodia, Robert Vassar - Molecular Neurodegeneration 2023 cited by 56

  16. The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

    Authors: Robert Vassar, Dora M. Kovacs, Riqiang Yan, Philip C. Wong - Journal of Neuroscience 2009 cited by 576

  17. Endothelial BACE1 Impairs Cerebral Small Vessels via Tight Junctions and eNOS

    Authors: Haoyue Zhou, Feng Gao, Xiaoli Yang, Tingting Lin, Zhenxing Li, Qiong Wang, Yang Yao, Lei Li, Xinxin Ding, Kaibin Shi, Qiang Liu, Hong Bao, Zhenyu Long, Zujun Wu, Robert Vassar, Xin Cheng, Rena Li, Yong Shen - Circulation Research 2022 cited by 76

  18. The secretases: enzymes with therapeutic potential in Alzheimer disease

    Authors: Bart De Strooper, Robert Vassar, Todd E. Golde - Nature Reviews Neurology 2010 cited by 787

  19. BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

    Authors: Robert Vassar - Alzheimer s Research & Therapy 2014 cited by 416

  20. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1

    Authors: Masuo Ohno, Lei Chang, Wilbur Tseng, Holly D. Oakley, Martin Citron, William L. Klein, Robert Vassar, John F. Disterhoft - European Journal of Neuroscience 2006 cited by 303

  21. The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

    Authors: Patty C. Kandalepas, Katherine R. Sadleir, William A. Eimer, Jie Zhao, Daniel A. Nicholson, Robert Vassar - Acta Neuropathologica 2013 cited by 241

  22. Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model

    Authors: Limor Avrahami, Dorit Farfara, Maya Shaham-Kol, Robert Vassar, Dan Frenkel, Hagit Eldar-Finkelman - Journal of Biological Chemistry 2012 cited by 227

  23. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

    Authors: Altea Rocchi, Soh Yamamoto, Tabitha C. Ting, Yuying Fan, Katherine R. Sadleir, Yigang Wang, Weiran Zhang, Sui Huang, Beth Levine, Robert Vassar, Congcong He - PLoS Genetics 2017 cited by 162

  24. Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models

    Authors: Fan Liao, Tony Zhang, Hong Jiang, Katheryn B. Lefton, Grace O. Robinson, Robert Vassar, Patrick M. Sullivan, David M. Holtzman - Acta Neuropathologica Communications 2015 cited by 78