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William L. Klein

Active 1972–2025

101
Papers
29,969
Citations
79
h-index
100
i10-index

Citations

Citations per year for William L. Klein1973: 5 citations1974: 7 citations1975: 4 citations1976: 4 citations1977: 5 citations1978: 3 citations1979: 8 citations1980: 18 citations1981: 12 citations1982: 14 citations1983: 4 citations1984: 4 citations1985: 3 citations1986: 10 citations1987: 12 citations1988: 11 citations1989: 8 citations1990: 8 citations1991: 7 citations1992: 4 citations1993: 2 citations1994: 4 citations1995: 10 citations1996: 13 citations1997: 18 citations1998: 20 citations1999: 43 citations2000: 58 citations2001: 64 citations2002: 118 citations2003: 153 citations2004: 247 citations2005: 269 citations2006: 350 citations2007: 427 citations2008: 462 citations2009: 587 citations2010: 594 citations2011: 596 citations2012: 678 citations2013: 512 citations2014: 561 citations2015: 541 citations2016: 441 citations2017: 504 citations2018: 462 citations2019: 1,043 citations2020: 1,178 citations2021: 1,007 citations2022: 844 citations2023: 558 citations2024: 711 citations2025: 358 citations2026: 9 citations

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 3,635 citing papers, 29% of this breakdownChina: 1,265 citing papers, 10.1% of this breakdownUnited Kingdom: 694 citing papers, 5.6% of this breakdownGermany: 598 citing papers, 4.8% of this breakdownItaly: 514 citing papers, 4.1% of this breakdownCanada: 493 citing papers, 3.9% of this breakdownJapan: 405 citing papers, 3.2% of this breakdownIndia: 376 citing papers, 3% of this breakdownSpain: 331 citing papers, 2.7% of this breakdownFrance: 326 citing papers, 2.6% of this breakdownAustralia: 323 citing papers, 2.6% of this breakdownSouth Korea: 290 citing papers, 2.3% of this breakdown
0%29%Other 26.1%

Institutions

Fields

  • Medicine61.6%
  • Biochemistry, Genetics and Molecular Biology18.5%
  • Neuroscience12.2%
  • Materials Science2.6%
  • Engineering1.1%
  • Computer Science0.8%
  • Other3.2%

Topics

  • Alzheimer's disease research and treatments21.6%
  • Cholinesterase and Neurodegenerative Diseases5.3%
  • Neuroinflammation and Neurodegeneration Mechanisms4.6%
  • Computational Drug Discovery Methods4.2%
  • Neuroscience and Neuropharmacology Research4.1%
  • Prion Diseases and Protein Misfolding2.1%
  • Other58.1%

Coauthors

All papers

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  1. The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

    Authors: Erika N. Cline, Maíra A. Bicca, Kirsten L. Viola, William L. Klein - Journal of Alzheimer s Disease 2018 cited by 868

  2. Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins

    Authors: Mary P. Lambert, Avlin Barlow, Brett A. Chromy, Cathryn Edwards, Rachel D. Freed, M. Liosatos, Todd E. Morgan, Irina Rozovsky, Barbara L. Trommer, Kirsten L. Viola, P.A. Wals, C. Zhang, Caleb E. Finch, Grant A. Krafft, William L. Klein - National Academy of Sciences, Proceedings of the National Academy of Sciences 1998 cited by 3,506

  3. Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

    Authors: Kirsten L. Viola, William L. Klein - Acta Neuropathologica 2015 cited by 621

  4. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

    Authors: Theresa R. Bomfim, Letícia Forny‐Germano, Luciana B. Sathler, Jordano Brito‐Moreira, Jean‐Christophe Houzel, Helena Decker, Michael Silverman, Hala Kazi, Helen M. Melo, Paula L. McClean, Christian Hölscher, Steven E. Arnold, Konrad Talbot, William L. Klein, Douglas P. Munoz, Sérgio T. Ferreira, Fernanda G. De Felice - Journal of Clinical Investigation 2012 cited by 824

  5. TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

    Authors: Mychael V. Lourenco, Julia R. Clarke, Rudimar Luiz Frozza, Theresa R. Bomfim, Letícia Forny‐Germano, André F. Batista, Luciana B. Sathler, Jordano Brito‐Moreira, Olavo B. Amaral, Cesar A. Silva, Léo Freitas-Corrêa, Sheila Espírito‐Santo, Paula Campello‐Costa, Jean‐Christophe Houzel, William L. Klein, Christian Hölscher, José Barreto Campello Carvalheira, Aristóbolo M. Silva, Lı́cio A. Velloso, Douglas P. Munoz, Sérgio T. Ferreira, Fernanda G. De Felice - Cell Metabolism 2013 cited by 415

  6. NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

    Authors: Jun Yin, Fanpeng Zhao, Jeremy E. Chojnacki, Jacob Fulp, William L. Klein, Shijun Zhang, Xiongwei Zhu - Molecular Neurobiology 2017 cited by 225

  7. Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

    Authors: Pascale N. Lacor, Maria C. Buniel, Paul W. Furlow, Antonio Sanz-Clemente, Pauline T. Velasco, Margaret Wood, Kirsten L. Viola, William L. Klein - Journal of Neuroscience 2007 cited by 1,172

  8. Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

    Authors: Fernanda G. De Felice, Pauline T. Velasco, Mary P. Lambert, Kirsten L. Viola, Sara J. Fernandez, Sérgio T. Ferreira, William L. Klein - Journal of Biological Chemistry 2007 cited by 871

  9. The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non‐human primate model of Alzheimer's disease

    Authors: André F. Batista, Letícia Forny‐Germano, Julia R. Clarke, Natalia M. Lyra e Silva, Jordano Brito‐Moreira, Susan E. Boehnke, Andrew Winterborn, Brian C. Coe, Ann Lablans, Juliana F.S. Vital, Suelen Adriani Marques, Ana MB Martinez, Matthias Gralle, Christian Hölscher, William L. Klein, Jean‐Christophe Houzel, Sérgio T. Ferreira, Douglas P. Munoz, Fernanda G. De Felice - The Journal of Pathology 2018 cited by 243

  10. Amyloid beta oligomers induce impairment of neuronal insulin receptors

    Authors: Weiqin Zhao, Fernanda G. De Felice, Sara J. Fernandez, Hui Chen, Mary P. Lambert, Michael J. Quon, Grant A. Krafft, William L. Klein - The FASEB Journal 2007 cited by 585

  11. Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease

    Authors: Yun Yang, Vı́ctor Tapias, Diana Acosta, Hui Xu, Huan‐Lian Chen, Ruchika Bhawal, Elizabeth T. Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev, Jianer Chen, William L. Klein, Kirsten L. Viola, Sam Gandy, Vahram Haroutunian, M. Flint Beal, David Eliezer, Sheng Zhang, Gary E. Gibson - Nature Communications 2022 cited by 110

  12. Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

    Authors: Takayuki Kondo, Masashi Asai, Kayoko Tsukita, Yumiko Kutoku, Yutaka Ohsawa, Yoshihide Sunada, Keiko Imamura, Naohiro Egawa, Naoki Yahata, Keisuke Okita, Kazutoshi Takahashi, Isao Asaka, Takashi Aoi, Akira Watanabe, Kaori Watanabe, Chie Kadoya, Rie Nakano, Dai Watanabe, Kei Maruyama, Osamu Hori, Satoshi Hibino, Tominari Choshi, Tatsutoshi Nakahata, Hiroyuki Hioki, Takeshi Kaneko, Motoko Naitoh, Katsuhiro Yoshikawa, Satoko Yamawaki, Shigehiko Suzuki, Ryuji Hata, Shu-ichi Ueno, Tsuneyoshi Seki, Kazuhiro Kobayashi, Tatsushi Toda, Kazuma Murakami, Kazuhiro Irie, William L. Klein, Hiroshi Mori, Takashi Asada, Ryōsuke Takahashi, Nobuhisa Iwata, Shinya Yamanaka, Haruhisa Inoue - Cell stem cell 2013 cited by 752

  13. Amyloid-β-Induced Pathological Behaviors Are Suppressed byGinkgo bilobaExtract EGb 761 and Ginkgolides in TransgenicCaenorhabditis elegans

    Authors: Yanjue Wu, Zhixin Wu, Peter Butko, Yves Christen, Mary P. Lambert, William L. Klein, Christopher D. Link, Yuan Luo - Journal of Neuroscience 2006 cited by 411

  14. Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

    Authors: Marianne Renner, Pascale N. Lacor, Pauline T. Velasco, Jian Xu, Anis Contractor, William L. Klein, Antoine Triller - Neuron 2010 cited by 462

  15. Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates

    Authors: Letícia Forny‐Germano, Natalia M. Lyra e Silva, André F. Batista, Jordano Brito‐Moreira, Matthias Gralle, Susan E. Boehnke, Brian C. Coe, Ann Lablans, Suelen Adriani Marques, Ana Maria Blanco Martinez, William L. Klein, Jean‐Christophe Houzel, Sérgio T. Ferreira, Douglas P. Munoz, Fernanda G. De Felice - Journal of Neuroscience 2014 cited by 228

  16. Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers

    Authors: Pascale N. Lacor, Maria C. Buniel, Lei Chang, Sara J. Fernandez, Yuesong Gong, Kirsten L. Viola, Mary P. Lambert, Pauline T. Velasco, Eileen H. Bigio, Caleb E. Finch, Grant A. Krafft, William L. Klein - Journal of Neuroscience 2004 cited by 955

  17. Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

    Authors: Fernanda G. De Felice, Marcelo N. N. Vieira, Theresa R. Bomfim, Helena Decker, Pauline T. Velasco, Mary P. Lambert, Kirsten L. Viola, Wei-Qin Zhao, Sérgio T. Ferreira, William L. Klein - National Academy of Sciences, Proceedings of the National Academy of Sciences 2009 cited by 664

  18. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1

    Authors: Masuo Ohno, Lei Chang, Wilbur Tseng, Holly D. Oakley, Martin Citron, William L. Klein, Robert Vassar, John F. Disterhoft - European Journal of Neuroscience 2006 cited by 303

  19. Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology

    Authors: Jean‐Vianney Haure‐Mirande, Mickaël Audrain, Tomas Fanutza, Soong Ho Kim, William L. Klein, Charles Glabe, Ben Readhead, Joel T. Dudley, Robert D. Blitzer, Minghui Wang, Bin Zhang, Eric E. Schadt, Sam Gandy, Michelle E. Ehrlich - Acta Neuropathologica 2017 cited by 128

  20. Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain

    Authors: Lindsay A. Welikovitch, Sonia Do Carmo, Zsófia Maglóczky, Janice C. Malcolm, János Lőke, William L. Klein, Tamás F. Freund, A. Claudio Cuello - National Academy of Sciences, Proceedings of the National Academy of Sciences 2020 cited by 115

  21. Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

    Authors: Inger Lauritzen, Raphaëlle Pardossi‐Piquard, Alexandre Bourgeois, Sophie Pagnotta, Maria Grazia Biferi, Martine Barkats, Pascale N. Lacor, William L. Klein, Charlotte Bauer, Frédéric Checler - Acta Neuropathologica 2016 cited by 213

  22. Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

    Authors: Julia R. Clarke, Natalia M. Lyra e Silva, Cláudia P. Figueiredo, Rudimar Luiz Frozza, José Henrique Ledo, Danielle Beckman, Carlos K. Katashima, Daniela S. Razolli, Bruno M. Carvalho, Renata Frazão, Marina A. Silveira, Felipe C. Ribeiro, Theresa R. Bomfim, Fernanda Neves, William L. Klein, Rodrigo Medeiros, Frank M. LaFerla, José Barreto Campello Carvalheira, Mário J.A. Saad, Douglas P. Munoz, Lı́cio A. Velloso, Sérgio T. Ferreira, Fernanda G. De Felice - EMBO Molecular Medicine 2015 cited by 216

  23. Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

    Authors: Yuesong Gong, Lei Chang, Kirsten L. Viola, Pascale N. Lacor, Mary P. Lambert, Caleb E. Finch, Grant A. Krafft, William L. Klein - National Academy of Sciences, Proceedings of the National Academy of Sciences 2003 cited by 1,057

  24. The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

    Authors: Sérgio T. Ferreira, William L. Klein - Neurobiology of Learning and Memory 2011 cited by 446