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Yuichi Sugiyama

Active 1982–2026

269
Papers
39,309
Citations
115
h-index
257
i10-index

Citations

Citations per year for Yuichi Sugiyama1978: 1 citations1982: 2 citations1983: 4 citations1984: 2 citations1985: 7 citations1986: 11 citations1987: 2 citations1988: 3 citations1989: 3 citations1990: 9 citations1991: 13 citations1992: 23 citations1993: 31 citations1994: 83 citations1995: 67 citations1996: 43 citations1997: 81 citations1998: 120 citations1999: 183 citations2000: 267 citations2001: 298 citations2002: 402 citations2003: 471 citations2004: 456 citations2005: 512 citations2006: 723 citations2007: 525 citations2008: 625 citations2009: 562 citations2010: 545 citations2011: 480 citations2012: 544 citations2013: 468 citations2014: 387 citations2015: 289 citations2016: 327 citations2017: 282 citations2018: 240 citations2019: 875 citations2020: 804 citations2021: 617 citations2022: 486 citations2023: 354 citations2024: 485 citations2025: 240 citations2026: 6 citations1979–1981: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 2,584 citing papers, 27.4% of this breakdownJapan: 1,060 citing papers, 11.3% of this breakdownGermany: 668 citing papers, 7.1% of this breakdownUnited Kingdom: 634 citing papers, 6.7% of this breakdownChina: 592 citing papers, 6.3% of this breakdownNetherlands: 371 citing papers, 3.9% of this breakdownSwitzerland: 290 citing papers, 3.1% of this breakdownFrance: 275 citing papers, 2.9% of this breakdownCanada: 250 citing papers, 2.7% of this breakdownSweden: 244 citing papers, 2.6% of this breakdownItaly: 196 citing papers, 2.1% of this breakdownSouth Korea: 173 citing papers, 1.8% of this breakdown
0%27.4%Other 22.1%

Institutions

Fields

  • Medicine59.4%
  • Biochemistry, Genetics and Molecular Biology12%
  • Pharmacology, Toxicology and Pharmaceutics11.6%
  • Materials Science4.2%
  • Computer Science3.3%
  • Engineering2.3%
  • Other7.2%

Topics

  • Drug Transport and Resistance Mechanisms15.1%
  • Pharmacogenetics and Drug Metabolism6.6%
  • Pharmacological Effects and Toxicity Studies5.9%
  • Computational Drug Discovery Methods2.8%
  • Nanoparticle-Based Drug Delivery1.9%
  • Drug-Induced Hepatotoxicity and Protection1.8%
  • Other65.9%

Coauthors

All papers

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  1. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

    Authors: Patrício Godoy, Nicola J. Hewitt, Ute Albrecht, Melvin E. Andersen, Nariman Ansari, Sudin Bhattacharya, Johannes G. Bode, Jennifer Bolleyn, Christoph Borner, J Böttger, Albert Braeuning, Robert A. Budinsky, Britta Burkhardt, Neil R. Cameron, Giovanni Camussi, Chong-Su Cho, Yun-Jaie Choi, J. Craig Rowlands, Uta Dahmen, Georg Damm, Olaf Dirsch, M. Teresa Donato, Jian Dong, Steven Dooley, Dirk Drasdo, Rowena Eakins, Karine Sá Ferreira, Valentina Fonsato, Joanna Fraczek, Rolf Gebhardt, Andrew Gibson, Matthias Glanemann, Christopher E. Goldring, Marı́a José Gómez-Lechón, Geny M. M. Groothuis, Lena Gustavsson, Christelle Guyot, David Hallifax, Seddik Hammad, Adam S. Hayward, Dieter Häussinger, Claus Hellerbrand, Philip Hewitt, Stefan Hoehme, Hermann−Georg Holzhütter, J. Brian Houston, Jens Hrach, Kiyomi Ito, Hartmut Jaeschke, Verena Keitel, Jens Kelm, B. Kevin Park, Claus Kordes, Gerd A. Kullak‐Ublick, Edward L. LeCluyse, Peng Lü, Jennifer L. Luebke-Wheeler, Anna Lutz, Daniel J. Maltman, Madlen Matz‐Soja, Patrick D. McMullen, Irmgard Merfort, Simon Messner, Christoph Meyer, Jessica Mwinyi, Dean J. Naisbitt, Andreas K. Nüssler, Peter Olinga, Francesco Pampaloni, Jingbo Pi, Linda Pluta, Stefan Przyborski, Anup Ramachandran, Vera Rogiers, Cliff Rowe, Celine Schelcher, Kathrin Schmich, Michael Schwarz, Bijay Singh, Ernst H. K. Stelzer, Bruno Stieger, Regina Stöber, Yuichi Sugiyama, Ciro Tetta, Wolfgang E. Thasler, Tamara Vanhaecke, Mathieu Vinken, Thomas S. Weiß, A Widera, Courtney G. Woods, Jinghai J. Xu, Kathy Yarborough, Jan G. Hengstler - Archives of Toxicology 2013 cited by 1,275

  2. Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug‐Drug Interaction Evaluation: Perspectives From the International Transporter Consortium

    Authors: Xiaoyan Chu, Mingxiang Liao, Hong Shen, Kenta Yoshida, Arik A. Zur, Vikram Arya, Aleksandra Galetin, Kathleen M. Giacomini, Imad Hanna, Hiroyuki Kusuhara, Yurong Lai, David Rodrigues, Yuichi Sugiyama, Maciej J. Zamek‐Gliszczynski, Lei Zhang - Clinical Pharmacology & Therapeutics 2018 cited by 198

  3. Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations

    Authors: Kunal S. Taskar, Venkatesh Pilla Reddy, Howard Burt, Maria M. Posada, Manthena V. S. Varma, Ming Zheng, Mohammed Ullah, Arian Emami Riedmaier, Kenichi Umehara, Jan Snoeys, Masanori Nakakariya, Xiaoyan Chu, Maud Bénéton, Yuan Chen, Felix Huth, Rangaraj Narayanan, Dwaipayan Mukherjee, Vaishali Dixit, Yuichi Sugiyama, Sibylle Neuhoff - Clinical Pharmacology & Therapeutics 2019 cited by 141

  4. Involvement of Organic Cation Transporter 1 in Hepatic and Intestinal Distribution of Metformin

    Authors: Desheng Wang, Johan W. Jonker, Yukio Kato, Hiroyuki Kusuhara, Alfred H. Schinkel, Yuichi Sugiyama - Journal of Pharmacology and Experimental Therapeutics 2002 cited by 442

  5. Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug–drug interactions and interindividual differences in transporter and metabolic enzyme functions

    Authors: Yoshihisa Shitara, Yuichi Sugiyama - Pharmacology & Therapeutics 2006 cited by 574

  6. Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

    Authors: Yingying Guo, Xiaoyan Chu, Neil Parrott, Kim L. R. Brouwer, Vicky Hsu, Swati Nagar, Pär Matsson, Pradeep Sharma, Jan Snoeys, Yuichi Sugiyama, Daniel Tatosian, Jashvant D. Unadkat, Shiew‐Mei Huang, Aleksandra Galetin - Clinical Pharmacology & Therapeutics 2018 cited by 116

  7. Identification of Appropriate Endogenous Biomarker for Risk Assessment of Multidrug and Toxin Extrusion Protein‐Mediated Drug‐Drug Interactions in Healthy Volunteers

    Authors: Takeshi Miyake, Emi Kimoto, Lina Luo, Sumathy Mathialagan, Lauren Horlbogen, Ragu Ramanathan, Linda S. Wood, Jillian G. Johnson, Vu Le, Manoli Vourvahis, A. David Rodrigues, Chieko Muto, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara - Clinical Pharmacology & Therapeutics 2020 cited by 46

  8. Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium

    Authors: Sook Wah Yee, Deanna J. Brackman, E Ennis, Yuichi Sugiyama, Landry K. Kamdem, Rebecca Blanchard, Aleksandra Galetin, Lei Zhang, Kathleen M. Giacomini - Clinical Pharmacology & Therapeutics 2018 cited by 137

  9. Efflux of a suppressive neurotransmitter, GABA, across the blood–brain barrier

    Authors: Atsuyuki Kakee, Hitomi Takanaga, Tetsuya Terasaki, Mikihiko Naito, Takashi Tsuruo, Yuichi Sugiyama - Journal of Neurochemistry 2001 cited by 114

  10. PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3

    Authors: Takashi Yoshikado, Kota Toshimoto, Kazuya Maeda, Hiroyuki Kusuhara, Emi Kimoto, A. David Rodrigues, Kōji Chiba, Yuichi Sugiyama - CPT Pharmacometrics & Systems Pharmacology 2018 cited by 75

  11. N-Methylnicotinamide Is an Endogenous Probe for Evaluation of Drug–Drug Interactions Involving Multidrug and Toxin Extrusions (MATE1 and MATE2-K)

    Authors: S Ito, Hiroyuki Kusuhara, Yoshito Kumagai, Yoshinori Moriyama, Katsuhisa Inoue, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Kiyoshi Tanabe, Hiroaki Yuasa, Yuichi Sugiyama - Clinical Pharmacology & Therapeutics 2012 cited by 105

  12. Dose‐Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs

    Authors: Daiki Mori, Emi Kimoto, Brian Rago, Yusuke Kondo, Amanda King‐Ahmad, Ragu Ramanathan, Linda S. Wood, Jillian G. Johnson, Vu Le, Manoli Vourvahis, A. David Rodrigues, Chieko Muto, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara - Clinical Pharmacology & Therapeutics 2019 cited by 102

  13. Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance

    Authors: Maciej J. Zamek‐Gliszczynski, Vishal Sangha, Hong Shen, Bo Feng, Matthias Wittwer, Manthena V. S. Varma, Xiaomin Liang, Yuichi Sugiyama, Lei Zhang, Reina Bendayan - Clinical Pharmacology & Therapeutics 2022 cited by 60

  14. Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice.

    Authors: Nobuhiro Nishiyama, Souichiro Okazaki, Horacio Cabral, Masaki Miyamoto, Yukio Kato, Yuichi Sugiyama, Kazuto Nishio, Yasuhiro Matsumura, Kazunori Kataoka - 2003 cited by 602

  15. Transporters as a determinant of drug clearance and tissue distribution

    Authors: Yoshihisa Shitara, Toshiharu Horie, Yuichi Sugiyama - European Journal of Pharmaceutical Sciences 2006 cited by 491

  16. Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the Hepatic Uptake of Pitavastatin in Humans

    Authors: Masaru Hirano, Kazuya Maeda, Yoshihisa Shitara, Yuichi Sugiyama - Journal of Pharmacology and Experimental Therapeutics 2004 cited by 442

  17. Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption

    Authors: Yoshihisa Shitara, Kazuya Maeda, Kazuaki Ikejiri, Kenta Yoshida, Toshiharu Horie, Yuichi Sugiyama - Biopharmaceutics & Drug Disposition 2012 cited by 414

  18. Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development

    Authors: Masato Chiba, Yasuyuki Ishii, Yuichi Sugiyama - The AAPS Journal 2009 cited by 227

  19. Competitive Inhibition of the Luminal Efflux by Multidrug and Toxin Extrusions, but Not Basolateral Uptake by Organic Cation Transporter 2, Is the Likely Mechanism Underlying the Pharmacokinetic Drug-Drug Interactions Caused by Cimetidine in the Kidney

    Authors: Sumito Ito, Hiroyuki Kusuhara, Miyu Yokochi, Junko Toyoshima, Katsuhisa Inoue, Hiroaki Yuasa, Yuichi Sugiyama - Journal of Pharmacology and Experimental Therapeutics 2011 cited by 210

  20. Phase 0/microdosing approaches: time for mainstream application in drug development?

    Authors: Tal Burt, Graeme Young, Wooin Lee, Hiroyuki Kusuhara, Oliver Langer, Malcolm Rowland, Yuichi Sugiyama - Nature Reviews Drug Discovery 2020 cited by 101

  21. Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions

    Authors: Tatsuki Mochizuki, Maciej J. Zamek‐Gliszczynski, Kenta Yoshida, Jialin Mao, Kunal S. Taskar, Hideki Hirabayashi, Xiaoyan Chu, Yurong Lai, Tadayuki Takashima, Kevin Rockich, Yoshiyuki Yamaura, Kaku Fujiwara, Tadahaya Mizuno, Kazuya Maeda, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara - Clinical Pharmacology & Therapeutics 2022 cited by 37

  22. Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

    Authors: Xiaoyan Chu, Ken Korzekwa, Robert Elsby, Katherine S. Fenner, Aleksandra Galetin, Yurong Lai, Pär Matsson, Aaron M. Moss, Swati Nagar, Gus R. Rosania, Jingwen Bai, Joseph W. Polli, Yuichi Sugiyama, Kim L. R. Brouwer - Clinical Pharmacology & Therapeutics 2013 cited by 232

  23. Endogenous Probes for Drug Transporters: Balancing Vision With Reality

    Authors: AD Rodrigues, KS Taskar, Hiroyuki Kusuhara, Yuichi Sugiyama - Clinical Pharmacology & Therapeutics 2017 cited by 99

  24. Investigation of Endogenous Compounds Applicable to Drug–Drug Interaction Studies Involving the Renal Organic Anion Transporters, OAT1 and OAT3, in Humans

    Authors: Yuri Tsuruya, Koji Kato, Yamato Sano, Yuichiro Imamura, Kazuya Maeda, Yuji Kumagai, Yuichi Sugiyama, Hiroyuki Kusuhara - Drug Metabolism and Disposition 2016 cited by 75