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Hitoshi Endou

Active 1980–2024

140
Papers
27,058
Citations
100
h-index
139
i10-index

Citations

Citations per year for Hitoshi Endou1981: 4 citations1982: 1 citations1984: 2 citations1986: 1 citations1987: 2 citations1989: 1 citations1991: 3 citations1992: 2 citations1993: 3 citations1996: 2 citations1997: 7 citations1998: 26 citations1999: 77 citations2000: 176 citations2001: 228 citations2002: 384 citations2003: 420 citations2004: 564 citations2005: 388 citations2006: 357 citations2007: 357 citations2008: 483 citations2009: 337 citations2010: 327 citations2011: 285 citations2012: 347 citations2013: 242 citations2014: 267 citations2015: 190 citations2016: 198 citations2017: 221 citations2018: 204 citations2019: 615 citations2020: 723 citations2021: 596 citations2022: 412 citations2023: 315 citations2024: 534 citations2025: 215 citations2026: 1 citations1983: no citations, so this year is not shown1985: no citations, so this year is not shown1988: no citations, so this year is not shown1990: no citations, so this year is not shown1994–1995: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 1,592 citing papers, 26% of this breakdownJapan: 740 citing papers, 12.1% of this breakdownChina: 618 citing papers, 10.1% of this breakdownGermany: 407 citing papers, 6.6% of this breakdownUnited Kingdom: 316 citing papers, 5.2% of this breakdownSwitzerland: 187 citing papers, 3.1% of this breakdownCanada: 184 citing papers, 3% of this breakdownItaly: 177 citing papers, 2.9% of this breakdownNetherlands: 174 citing papers, 2.8% of this breakdownFrance: 173 citing papers, 2.8% of this breakdownAustralia: 138 citing papers, 2.3% of this breakdownSpain: 122 citing papers, 2% of this breakdown
0%26%Other 21.1%

Institutions

Fields

  • Medicine52.4%
  • Biochemistry, Genetics and Molecular Biology33.6%
  • Neuroscience5.9%
  • Immunology and Microbiology2.2%
  • Environmental Science1.8%
  • Agricultural and Biological Sciences1.2%
  • Other2.9%

Topics

  • Amino Acid Enzymes and Metabolism7.6%
  • Drug Transport and Resistance Mechanisms6.8%
  • Gout, Hyperuricemia, Uric Acid4.9%
  • Metabolism and Genetic Disorders3%
  • Epigenetics and DNA Methylation2.9%
  • Pharmacological Effects and Toxicity Studies2.9%
  • Other71.9%

Coauthors

All papers

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  1. Molecular identification of a renal urate–anion exchanger that regulates blood urate levels

    Authors: Atsushi Enomoto, Hiroaki Kimura, Arthit Chairoungdua, Yasuhiro Shigeta, Promsuk Jutabha, Seok Ho, Makoto Hosoyamada, Michio Takeda, Takashi Sekine, Takashi Igarashi, Hirotaka Matsuo, Yuichi Kikuchi, Oda T, Kimiyoshi Ichida, Tatsuo Hosoya, Kaoru Shimokata, Toshimitsu Niwa, Yoshikatsu Kanai, Hitoshi Endou - Nature 2002 cited by 1,551

  2. Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)

    Authors: Yoshikatsu Kanai, Hiroko Segawa, Ken‐ichi Miyamoto, Hiroshi Uchino, Eiji Takeda, Hitoshi Endou - Journal of Biological Chemistry 1998 cited by 1,105

  3. Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines

    Authors: Osamu Yanagida, Yoshikatsu Kanai, Arthit Chairoungdua, Do Kyung Kim, Hiroko Segawa, Tomoko Nii, Seok Ho, Hirotaka Matsuo, Junichi Fukushima, Yoshiki Fukasawa, Yoshiko Tani, Yutaka Taketani, Hiroshi Uchino, Ju Young Kim, Jun Inatomi, Isao Okayasu, Ken‐ichi Miyamoto, Eiji Takeda, Tomoyuki Goya, Hitoshi Endou - Biochimica et Biophysica Acta (BBA) - Biomembranes 2001 cited by 739

  4. CATs and HATs: the SLC7 family of amino acid transporters

    Authors: François Verrey, Ellen I. Closs, Carsten A. Wagner, Manuel Palacı́n, Hitoshi Endou, Yoshikatsu Kanai - Pflügers Archiv - European Journal of Physiology 2004 cited by 710

  5. l‐Type amino acid transporter 1 inhibitors inhibit tumor cell growth

    Authors: Koji Oda, Noriko Hosoda, Hiroshi Endô, Kunio SAITO, Kenji Tsujihara, Michio Yamamura, Takeshi Sakata, Naohiko Anzai, Michael F. Wempe, Yoshikatsu Kanai, Hitoshi Endou - Cancer Science 2009 cited by 270

  6. First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors

    Authors: Naohiro Okano, Daisuke Naruge, Kirio Kawai, Takaaki Kobayashi, Fumio Nagashima, Hitoshi Endou, Junji Furuse - Investigational New Drugs 2020 cited by 206

  7. Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

    Authors: Yongchan Lee, Pattama Wiriyasermkul, Chunhuan Jin, Lili Quan, Ryuichi Ohgaki, Suguru Okuda, Tsukasa Kusakizako, Tomohiro Nishizawa, Kazumasa Oda, Ryuichiro Ishitani, Takeshi Yokoyama, Takanori Nakane, Mikako Shirouzu, Hitoshi Endou, Shushi Nagamori, Yoshikatsu Kanai, Osamu Nureki - Nature Structural & Molecular Biology 2019 cited by 179

  8. The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)

    Authors: Yann Cormerais, Pierre André Massard, Milica Vučetić, Sandy Giuliano, Éric Tambutté, Jérôme Durivault, Valérie Vial, Hitoshi Endou, Michael F. Wempe, Scott K. Parks, Jacques Pouysségur - Journal of Biological Chemistry 2018 cited by 169

  9. Identification and Functional Characterization of a Na+-independent Neutral Amino Acid Transporter with Broad Substrate Selectivity

    Authors: Hiroko Segawa, Yoshiki Fukasawa, Ken‐ichi Miyamoto, Eiji Takeda, Hitoshi Endou, Yoshikatsu Kanai - Journal of Biological Chemistry 1999 cited by 500

  10. Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment

    Authors: Silvia Panetti, Nicola McJannett, Livingstone Fultang, Sarah Booth, Luciana Gneo, Ugo Scarpa, Charles J. Smith, Ashley Vardon, Lisa A. Vettore, Celina Whalley, Yi Pan, Csilla Várnai, Hitoshi Endou, Jonathan Barlow, Daniel A. Tennant, Andrew D. Beggs, Francis Mussai, Carmela De Santo - Blood Advances 2022 cited by 46

  11. Plasma Urate Level Is Directly Regulated by a Voltage-driven Urate Efflux Transporter URATv1 (SLC2A9) in Humans

    Authors: Naohiko Anzai, Kimiyoshi Ichida, Promsuk Jutabha, Tōru Kimura, Ellappan Babu, Chun Ji Jin, Sunena Srivastava, Kenichiro Kitamura, Ichiro Hisatome, Hitoshi Endou, Hiroyuki Sakurai - Journal of Biological Chemistry 2008 cited by 361

  12. Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation

    Authors: Lili Quan, Ryuichi Ohgaki, Saori Hara, Suguru Okuda, Ling Wei, Hiroki Okanishi, Shushi Nagamori, Hitoshi Endou, Yoshikatsu Kanai - Journal of Experimental & Clinical Cancer Research 2020 cited by 73

  13. Transport of Amino Acid-Related Compounds Mediated by L-Type Amino Acid Transporter 1 (LAT1): Insights Into the Mechanisms of Substrate Recognition

    Authors: Hiroshi Uchino, Yoshikatsu Kanai, Do Kyung Kim, Michael F. Wempe, Arthit Chairoungdua, Emiko Morimoto, M. W. Anders, Hitoshi Endou - Molecular Pharmacology 2002 cited by 406

  14. Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth

    Authors: Yann Cormerais, Sandy Giuliano, Renaud LeFloch, Benoît Front, Jérôme Durivault, Éric Tambutté, Pierre-André Massard, Laura Rodríguez de la Ballina, Hitoshi Endou, Michael F. Wempe, Manuel Palacı́n, Scott K. Parks, Jacques Pouysségur - Cancer Research 2016 cited by 242

  15. LAT1 Is a Critical Transporter of Essential Amino Acids for Immune Reactions in Activated Human T Cells

    Authors: Keitaro Hayashi, Promsuk Jutabha, Hitoshi Endou, Hironori Sagara, Naohiko Anzai - The Journal of Immunology 2013 cited by 224

  16. Substrate specificity to maintain cellular ATP along the mouse nephron

    Authors: Shunya Uchida, Hitoshi Endou - American Journal of Physiology-Renal Physiology 1988 cited by 154

  17. Identification and Characterization of a Na+-independent Neutral Amino Acid Transporter That Associates with the 4F2 Heavy Chain and Exhibits Substrate Selectivity for Small Neutral d- and l-Amino Acids

    Authors: Yoshiki Fukasawa, Hiroko Segawa, Ju Young Kim, Arthit Chairoungdua, Do Kyung Kim, Hirotaka Matsuo, Seok Ho, Hitoshi Endou, Yoshikatsu Kanai - Journal of Biological Chemistry 2000 cited by 283

  18. Interactions of urate transporter URAT1 in human kidney with uricosuric drugs

    Authors: Ho Jung Shin, Michio Takeda, Atsushi Enomoto, Masaaki Fujimura, Hiroki Miyazaki, Naohiko Anzai, Hitoshi Endou - Nephrology 2010 cited by 115

  19. Cloning and Functional Characterization of a System ASC-like Na+-dependent Neutral Amino Acid Transporter

    Authors: Naoko Utsunomiya‐Tate, Hitoshi Endou, Yoshikatsu Kanai - Journal of Biological Chemistry 1996 cited by 527

  20. The SLC22 drug transporter family

    Authors: Hermann Koepsell, Hitoshi Endou - Pflügers Archiv - European Journal of Physiology 2004 cited by 527

  21. Clinical and Molecular Analysis of Patients with Renal Hypouricemia in Japan-Influence of URAT1 Gene on Urinary Urate Excretion

    Authors: Kimiyoshi Ichida, Makoto Hosoyamada, Ichiro Hisatome, Atsushi Enomoto, Miho Hikita, Hitoshi Endou, Tatsuo Hosoya - Journal of the American Society of Nephrology 2004 cited by 380

  22. Human Sodium Phosphate Transporter 4 (hNPT4/SLC17A3) as a Common Renal Secretory Pathway for Drugs and Urate

    Authors: Promsuk Jutabha, Naohiko Anzai, Kenichiro Kitamura, Atsuo Taniguchi, Shuji Kaneko, Kunimasa Yan, Hideomi Yamada, Hidetaka Shimada, Tōru Kimura, Tomohisa Katada, Toshiyuki Fukutomi, Kimio Tomita, Wako Urano, Hisashi Yamanaka, George Seki, Toshiro Fujita, Yoshinori Moriyama, Akira Yamada, Shunya Uchida, Michael F. Wempe, Hitoshi Endou, Hiroyuki Sakurai - Journal of Biological Chemistry 2010 cited by 158

  23. Localization of Ang-1, -2, Tie-2, and VEGF expression at endothelial-pericyte interdigitation in rat angiogenesis

    Authors: Shin Wakui, Kiyofumi Yokoo, Tomoko Muto, Yoshihiko Suzuki, Hiroyuki Takahashi, Masakuni Furusato, Hiroshi Hano, Hitoshi Endou, Yoshikatsu Kanai - Laboratory Investigation 2006 cited by 139

  24. Pharmacologic inhibition of LAT1 predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells

    Authors: Kou Nishikubo, Ryuichi Ohgaki, Hiroki Okanishi, Suguru Okuda, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai - Journal of Cellular and Molecular Medicine 2022 cited by 31