HBEGF + macrophages in rheumatoid arthritis induce fibroblast invasiveness

Authors: David Kuo, Jennifer Ding, Ian S. Cohn, Fan Zhang, Kevin Wei, Deepak A. Rao, Cristina Rozo, Upneet K. Sokhi, Sara Shanaj, David J. Oliver, Adriana P. Echeverria, Edward F. DiCarlo, Michael B. Brenner, Vivian P. Bykerk, Susan M. Goodman, Soumya Raychaudhuri, Gunnar Rätsch, Lionel B. Ivashkiv, Laura T. Donlin - Science Translational Medicine 2019 cited by 258

inflammatory macrophages; however, in some cases, medication redirected them into a state that is not expected to resolve inflammation. These data highlight how advances in our understanding of chronically inflamed human tissues and the effects of medications therein can be achieved by studies on local macrophage phenotypes and intercellular interactions.