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A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice

Authors: Haixia Yang, Weicang Wang, Kymberleigh A. Romano, Min Gu, Katherine Z. Sanidad, Daeyoung Kim, Jun Yang, Birgitta Schmidt, Dipak Panigrahy, Ruisong Pei, Derek Martin, Emrah Ilker Ozay, Yuxin Wang, Mingyue Song, Bradley W. Bolling, Hang Xiao, Lisa M. Minter, Guang‐Yu Yang, Zhenhua Liu, Federico E. Rey, Guodong Zhang - Science Translational Medicine 2018 cited by 157

mice. Together, our results demonstrate that this widely used antimicrobial ingredient could have adverse effects on colonic inflammation and associated colon tumorigenesis through modulation of the gut microbiota and TLR4 signaling. Together, these results highlight the need to reassess the effects of TCS on human health and potentially update policies regulating the use of this widely used antimicrobial.

A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice | Litlas