Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways

Authors: Ramin S. Herati, Luisa Victoria Silva, Laura A. Vella, Alexander Muselman, Cécile Alanio, Bertram Bengsch, Raj K. Kurupati, Senthil Kannan, Sasikanth Manne, Andrew V. Kossenkov, David H. Canaday, Susan A. Doyle, Hildegund C.J. Ertl, Kenneth E. Schmader, E. John Wherry - Cell Reports Medicine 2021 cited by 54

cTfh display strong enrichment for signatures of underlying age-associated biological changes. These data highlight the ability to use vaccine-induced cTfh as cellular "biosensors" of underlying inflammatory and/or overall immune health.