Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

Authors: John G. Doench, Ella Hartenian, Daniel B. Graham, Zuzana Tóthová, Mudra Hegde, Ian C. P. Smith, Meagan E. Sullender, Benjamin L. Ebert, Ramnik J. Xavier, David E. Root - Nature Biotechnology 2014 cited by 1,722