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John G. Doench

Active 2003–2026

162
Papers
44,042
Citations
80
h-index
149
i10-index

Citations

Citations per year for John G. Doench1983: 2 citations1992: 1 citations1994: 1 citations1998: 2 citations2003: 25 citations2004: 90 citations2005: 117 citations2006: 113 citations2007: 140 citations2008: 123 citations2009: 111 citations2010: 84 citations2011: 83 citations2012: 58 citations2013: 43 citations2014: 156 citations2015: 269 citations2016: 350 citations2017: 479 citations2018: 652 citations2019: 1,695 citations2020: 2,384 citations2021: 2,659 citations2022: 2,532 citations2023: 2,298 citations2024: 3,376 citations2025: 1,838 citations2026: 83 citations1984–1991: no citations, so these years are not shown1993: no citations, so this year is not shown1995–1997: no citations, so these years are not shown1999–2002: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 7,683 citing papers, 30.5% of this breakdownChina: 4,588 citing papers, 18.2% of this breakdownGermany: 1,396 citing papers, 5.5% of this breakdownUnited Kingdom: 1,309 citing papers, 5.2% of this breakdownCanada: 768 citing papers, 3.1% of this breakdownFrance: 731 citing papers, 2.9% of this breakdownJapan: 684 citing papers, 2.7% of this breakdownItaly: 626 citing papers, 2.5% of this breakdownAustralia: 573 citing papers, 2.3% of this breakdownNetherlands: 520 citing papers, 2.1% of this breakdownSwitzerland: 515 citing papers, 2% of this breakdownSpain: 483 citing papers, 1.9% of this breakdown
0%30.5%Other 21.1%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology56%
  • Medicine30.9%
  • Immunology and Microbiology5.5%
  • Computer Science3%
  • Agricultural and Biological Sciences1.2%
  • Neuroscience1.1%
  • Other2.3%

Topics

  • CRISPR and Genetic Engineering6.7%
  • Ferroptosis and cancer prognosis3.8%
  • RNA modifications and cancer3.5%
  • MicroRNA in disease regulation2.2%
  • Epigenetics and DNA Methylation2.2%
  • RNA and protein synthesis mechanisms2.1%
  • Other79.5%

Coauthors

All papers

Open in search
  1. Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

    Authors: John G. Doench, Nicolò Fusi, Meagan E. Sullender, Mudra Hegde, Emma W Vaimberg, Katherine Donovan, Ian C. P. Smith, Zuzana Tóthová, Craig B. Wilen, Robert C. Orchard, Herbert W. Virgin, Jennifer Listgarten, David E. Root - Nature Biotechnology 2016 cited by 4,983

  2. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

    Authors: Vasanthi S. Viswanathan, Matthew J. Ryan, Harshil Dhruv, Shubhroz Gill, Ossia M. Eichhoff, Brinton Seashore‐Ludlow, Samuel D. Kaffenberger, John K. Eaton, Kenichi Shimada, Andrew J. Aguirre, Srinivas R. Viswanathan, Shrikanta Chattopadhyay, Pablo Tamayo, Wan Seok Yang, Matthew G. Rees, Sixun Chen, Žarko Bošković, Sarah Javaid, Cherrie Huang, Xiaoyun Wu, Yuen‐Yi Tseng, Elisabeth Roider, Dong Gao, James M. Cleary, Brian M. Wolpin, Jill P. Mesirov, Daniel A. Haber, Jeffrey A. Engelman, Jesse S. Boehm, Joanne Kotz, Cindy Hon, Yu Chen, William C. Hahn, Mitchell P. Levesque, John G. Doench, Michael E. Berens, Alykhan F. Shamji, Paul A. Clemons, Brent R. Stockwell, Stuart L. Schreiber - Nature 2017 cited by 2,059

  3. A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

    Authors: Aravind Subramanian, Rajiv Narayan, Steven M. Corsello, D. D. Peck, Ted Natoli, Xiaodong Lü, Joshua Gould, John F. Davis, Andrew A. Tubelli, Jacob K. Asiedu, David L. Lahr, Jodi Hirschman, Zihan Liu, Melanie Donahue, Bina Julian, Mariya Khan, David Wadden, Ian C. P. Smith, Daniel D. Lam, Arthur Liberzon, Courtney Toder, Mukta Bagul, Marek Orzechowski, Oana M. Enache, Federica Piccioni, Sarah Johnson, Nicholas Lyons, Alice H. Berger, Alykhan F. Shamji, Angela N. Brooks, Anita Vrcic, Corey Flynn, Jacqueline Rosains, David Y. Takeda, Roger Hu, Desiree Davison, Justin Lamb, Kristin Ardlie, Larson Hogstrom, Peyton Greenside, Nathanael S. Gray, Paul A. Clemons, Serena J. Silver, Xiaoyun Wu, Wen‐Ning Zhao, Willis Read-Button, Xiaohua Wu, Stephen J. Haggarty, Lucienne Ronco, Jesse S. Boehm, Stuart L. Schreiber, John G. Doench, Joshua A. Bittker, David E. Root, Bang Wong, Todd R. Golub - Cell 2017 cited by 3,788

  4. Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

    Authors: Ophir Shalem, Neville E. Sanjana, Ella Hartenian, Xi Shi, David Scott, Tarjei S. Mikkelsen, Dirk Heckl, Benjamin L. Ebert, David E. Root, John G. Doench, Feng Zhang - Science 2013 cited by 5,596

  5. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

    Authors: Yilong Zou, Michael J. Palte, Amy Deik, Haoxin Li, John K. Eaton, Wenyu Wang, Yuen‐Yi Tseng, Rebecca Deasy, Maria Kost‐Alimova, Vlado Dančík, Elizaveta S. Leshchiner, Vasanthi S. Viswanathan, Sabina Signoretti, Toni K. Choueiri, Jesse S. Boehm, Bridget K. Wagner, John G. Doench, Clary B. Clish, Paul A. Clemons, Stuart L. Schreiber - Nature Communications 2019 cited by 865

  6. Cytochrome P450 oxidoreductase contributes tophospholipid peroxidation in ferroptosis

    Authors: Yilong Zou, Haoxin Li, Emily Graham, Amy Deik, John K. Eaton, Wenyu Wang, Gerardo Sandoval-Gomez, Clary B. Clish, John G. Doench, Stuart L. Schreiber - Nature Chemical Biology 2020 cited by 705

  7. Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

    Authors: Kendall R Sanson, Ruth E. Hanna, Mudra Hegde, Katherine Donovan, Christine Strand, Meagan E. Sullender, Emma W Vaimberg, Amy Goodale, David E. Root, Federica Piccioni, John G. Doench - Nature Communications 2018 cited by 1,130

  8. Discovering the anticancer potential of non-oncology drugs by systematic viability profiling

    Authors: Steven M. Corsello, Rohith T. Nagari, Ryan D. Spangler, Jordan Rossen, Mustafa Kocak, Jordan Bryan, Ranad Humeidi, D. D. Peck, Xiaoyun Wu, Andrew Tang, Vickie M. Wang, Samantha Bender, Evan Lemire, Rajiv Narayan, Philip Montgomery, Uri Ben‐David, Colin W. Garvie, Yejia Chen, Matthew G. Rees, Nicholas Lyons, James M. McFarland, Bang Wong, Li Wang, Nancy Dumont, Patrick J. O’Hearn, Eric Stefan, John G. Doench, Caitlin Harrington, Heidi Greulich, Matthew Meyerson, Francisca Vázquez, Aravind Subramanian, Jennifer A. Roth, Joshua A. Bittker, Jesse S. Boehm, Christopher C. Mader, Aviad Tsherniak, Todd R. Golub - Nature Cancer 2020 cited by 883

  9. In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

    Authors: Robert T. Manguso, Hans W. Pope, Margaret D. Zimmer, Flavian D. Brown, Kathleen B. Yates, Brian C. Miller, Natalie B. Collins, Kevin Bi, Martin W. LaFleur, Vikram R. Juneja, Sarah A. Weiss, Jennifer A. Lo, David E. Fisher, Diana Miao, Eliezer M. Van Allen, David E. Root, Arlene H. Sharpe, John G. Doench, W. Nicholas Haining - Nature 2017 cited by 1,172

  10. Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

    Authors: Charles L. Evavold, Iva Hafner‐Bratkovič, Pascal Devant, Jasmin M. D’Andrea, Elsy M. Ngwa, Elvira Boršić, John G. Doench, Martin W. LaFleur, Arlene H. Sharpe, Jay R. Thiagarajah, Jonathan C. Kagan - Cell 2021 cited by 417

  11. A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing

    Authors: Deng Pan, Aya Kobayashi, Peng Jiang, Lucas Ferrari de Andrade, Rong En Tay, Adrienne Luoma, Daphne Tsoucas, Xintao Qiu, Klothilda Lim, Prakash K. Rao, Henry W. Long, Guo‐Cheng Yuan, John G. Doench, Myles Brown, X. Shirley Liu, Kai W. Wucherpfennig - Science 2018 cited by 875

  12. Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity

    Authors: Jonathan R. Brestoff, Craig B. Wilen, John R. Moley, Yongjia Li, Wei Zou, Nicole P. Malvin, Marina N. Rowen, Brian T. Saunders, Hongming Ma, Madison R. Mack, Barry L. Hykes, Dale R. Balce, Anthony Orvedahl, Jesse W. Williams, Nidhi Rohatgi, Xiaoyan Wang, Michael R. McAllaster, Scott A. Handley, Brian Kim, John G. Doench, Bernd H. Zinselmeyer, Michael Diamond, Herbert W. Virgin, Andrew E. Gelman, Steven L. Teitelbaum - Cell Metabolism 2020 cited by 388

  13. Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

    Authors: John G. Doench, Ella Hartenian, Daniel B. Graham, Zuzana Tóthová, Mudra Hegde, Ian C. P. Smith, Meagan E. Sullender, Benjamin L. Ebert, Ramnik J. Xavier, David E. Root - Nature Biotechnology 2014 cited by 1,722

  14. Mutational processes shape the landscape of TP53 mutations in human cancer

    Authors: Andrew O. Giacomelli, Xiaoping Yang, Robert Lintner, James M. McFarland, Marc Duby, Jaegil Kim, Thomas P. Howard, David Y. Takeda, Seav Huong Ly, Eejung Kim, Hugh Gannon, Brian Hurhula, Ted Sharpe, Amy Goodale, Briana Fritchman, Scott Steelman, Francisca Vázquez, Aviad Tsherniak, Andrew J. Aguirre, John G. Doench, Federica Piccioni, Charles W.M. Roberts, Matthew Meyerson, Gad Getz, Cory M. Johannessen, David E. Root, William C. Hahn - Nature Genetics 2018 cited by 598

  15. Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

    Authors: Jun Wei, Lingyun Long, Wenting Zheng, Yogesh Dhungana, Seon Ah Lim, Cliff Guy, Yanyan Wang, Yong‐Dong Wang, Chenxi Qian, Beisi Xu, Anil KC, Jordy Saravia, Hongling Huang, Jiyang Yu, John G. Doench, Terrence L. Geiger, Hongbo Chi - Nature 2019 cited by 436

  16. Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity

    Authors: Gabriel K. Griffin, Jingyi Wu, Arvin Iracheta‐Vellve, James C. Patti, Jeffrey Hsu, Thomas Davis, Deborah Dele‐Oni, Peter P. Du, Aya Halawi, Jeffrey J. Ishizuka, Sarah Kim, Susan Klaeger, Nelson H. Knudsen, Brian C. Miller, Tung H. Nguyen, Kira E. Olander, Malvina Papanastasiou, Suzanna Rachimi, Emily Robitschek, Emily M. Schneider, Mitchell D. Yeary, Margaret D. Zimmer, Jacob D. Jaffe, Steven A. Carr, John G. Doench, W. Nicholas Haining, Kathleen B. Yates, Robert T. Manguso, B Bernstein - Nature 2021 cited by 362

  17. MEN1 mutations mediate clinical resistance to menin inhibition

    Authors: Florian Perner, Eytan M. Stein, Daniela V. Wenge, Sukrit Singh, Jeonghyeon Kim, Athina Apazidis, Homa Rahnamoun, Disha Anand, Christian Marinaccio, Charlie Hatton, Yanhe Wen, Richard M. Stone, David Schaller, Shoron Mowla, Wenbin Xiao, Holly A. Gamlen, Aaron J. Stonestrom, Sonali Persaud, Elizabeth T. Ener, Jevon Cutler, John G. Doench, Gerard M. McGeehan, Andrea Volkamer, John D. Chodera, Radosław P. Nowak, Eric S. Fischer, Ross L. Levine, Scott A. Armstrong, Sheng F. Cai - Nature 2023 cited by 243

  18. Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade

    Authors: Jeffrey J. Ishizuka, Robert T. Manguso, Collins Cheruiyot, Kevin Bi, Arpit Panda, Arvin Iracheta‐Vellve, Brian C. Miller, Peter P. Du, Kathleen B. Yates, Juan Dubrot, Ilana Buchumenski, Dawn E. Comstock, Flavian D. Brown, Austin Ayer, Ian C. Kohnle, Hans W. Pope, Margaret D. Zimmer, Debattama R. Sen, Sarah Kate Lane-Reticker, Emily Robitschek, Gabriel K. Griffin, Natalie B. Collins, Adrienne H. Long, John G. Doench, David Kozono, Erez Y. Levanon, W. Nicholas Haining - Nature 2018 cited by 728

  19. In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer

    Authors: Juan Dubrot, Peter P. Du, Sarah Kate Lane-Reticker, Emily Kessler, Audrey J. Muscato, Arnav Mehta, Samuel S. Freeman, Peter M. Allen, Kira E. Olander, Kyle Ockerman, Clara Wolfe, Fabius Wiesmann, Nelson H. Knudsen, Hsiao‐Wei Tsao, Arvin Iracheta‐Vellve, Emily M. Schneider, Andrea N. Rivera-Rosario, Ian C. Kohnle, Hans W. Pope, Austin Ayer, Gargi Mishra, Margaret D. Zimmer, Sarah Kim, Animesh Mahapatra, Hakimeh Ebrahimi-Nik, Dennie T. Frederick, Genevieve M. Boland, W. Nicholas Haining, David E. Root, John G. Doench, Nir Hacohen, Kathleen B. Yates, Robert T. Manguso - Nature Immunology 2022 cited by 222

  20. Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

    Authors: Romain Guièze, Vivian M. Liu, Daniel Rosebrock, Alexis A. Jourdain, María Hernández‐Sánchez, Aina Zurita Martinez, Jing Sun, Elisa ten Hacken, Kaitlyn Baranowski, Philip A. Thompson, Jin-Mi Heo, Zachary Cartun, Ozan Aygün, J. Bryan Iorgulescu, Wandi Zhang, Giulia Notarangelo, Dimitri Livitz, Shuqiang Li, Matthew S. Davids, Anat Biran, Stacey M. Fernandes, Jennifer R. Brown, Ana Lako, Zoe Ciantra, Matthew A. Lawlor, Derin B. Keskin, Namrata D. Udeshi, William G. Wierda, Kenneth J. Livak, Anthony Letai, Donna Neuberg, J. Wade Harper, Steven A. Carr, Federica Piccioni, Christopher J. Ott, Ignaty Leshchiner, Cory M. Johannessen, John G. Doench, Vamsi K. Mootha, Gad Getz, Catherine J. Wu - Cancer Cell 2019 cited by 360

  21. Cas9 activates the p53 pathway and selects for p53-inactivating mutations

    Authors: Oana M. Enache, Verónica Rendo, Mai Abdusamad, Daniel D. Lam, Desiree Davison, Sangita Pal, Naomi Currimjee, Julian M. Hess, Sasha Pantel, Anwesha Nag, Aaron R. Thorner, John G. Doench, Francisca Vázquez, Rameen Beroukhim, Todd R. Golub, Uri Ben‐David - Nature Genetics 2020 cited by 286

  22. Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

    Authors: Jin Wei, Mia Madel Alfajaro, Peter C. DeWeirdt, Ruth E. Hanna, William J. Lu-Culligan, Wesley L. Cai, Madison S. Strine, Shang-Min Zhang, Vincent R. Graziano, Cameron O. Schmitz, Jennifer Chen, Madeleine C. Mankowski, Renata B. Filler, Neal G. Ravindra, Victor Gasque, Fernando J. de Miguel, Ajinkya Patil, Huacui Chen, Kasopefoluwa Y. Oguntuyo, Laura Abriola, Yulia V. Surovtseva, Robert C. Orchard, Benhur Lee, Brett D. Lindenbach, Katerina Politi, David van Dijk, Cigall Kadoch, Matthew D. Simon, Qin Yan, John G. Doench, Craig B. Wilen - Cell 2020 cited by 587

  23. ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling

    Authors: Matteo Gentili, Bingxu Liu, Malvina Papanastasiou, Deborah Dele‐Oni, Marc A. Schwartz, Rebecca J. Carlson, Aziz Al’Khafaji, Karsten Krug, Adam Brown, John G. Doench, Steven A. Carr, Nir Hacohen - Nature Communications 2023 cited by 125

  24. Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs

    Authors: Jennifer Listgarten, Michael M. Weinstein, Benjamin P. Kleinstiver, Alexander A. Sousa, J. Keith Joung, Jake Crawford, Kevin Gao, Luong Hoang, Melih Elibol, John G. Doench, Nicolò Fusi - Nature Biomedical Engineering 2018 cited by 340