APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid

Authors: Na Zhao, Olivia N. Attrebi, Yingxue Ren, Wenhui Qiao, Berkiye Sonustun, Yuka A. Martens, Axel Meneses, Fuyao Li, Francis Shue, Jiaying Zheng, Alexandra J. Van Ingelgom, Mary Dabney Davis, Aishe Kurti, Joshua A. Knight, Cynthia Linares, Yixing Chen, Marion Delenclos, Chia‐Chen Liu, John Denis Fryer, Yan W. Asmann, Pamela J. McLean, Dennis W. Dickson, Owen A. Ross, Guojun Bu - Science Translational Medicine 2020 cited by 163

APOE4 exacerbates α-synuclein pathology in a synucleinopathy mouse model, and APOE4 genotype associates with increased α-synuclein pathology in humans.