FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma

Authors: Ying Wang, Zhaojie Lyu, Yanru Qin, Xia Wang, Liang-Zhan Sun, Yu Zhang, Lanqi Gong, Shayi Wu, Shuo Han, Ying Tang, Yongxu Jia, Dora Lai‐Wan Kwong, Ngar‐Woon Kam, Xin‐Yuan Guan - Theranostics 2020 cited by 170

FOXO1 facilitated M0-to-M2 polarization and the recruitment of M2 macrophages in the TME via the transcriptional modulation of CCL20 and CSF-1. Our data deciphered the FOXO1-dependent mechanism in M2 macrophage infiltration in the TME of ESCC, which has implications for the development of novel prognostic and therapeutic targets to optimize the current treatment against ESCC.