NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis

Authors: Bingyuan Huang, Zhuwan Lyu, Qiwei Qian, Yong Chen, Jun Zhang, Bo Li, Yikang Li, Jubo Liang, Qiaoyan Liu, You Li, Ruiling Chen, Min Lian, Xiao Xiao, Qi Miao, Qixia Wang, Jing‐Yuan Fang, Zhe‐Xiong Lian, Yanmei Li, Ruqi Tang, Thomas Helleday, M. Eric Gershwin, Zhengrui You, Xiong Ma - Journal of Hepatology 2022 cited by 56

BACKGROUND & AIMS: T-cell subpopulations and investigate their immunobiology in PBC. METHODS: cells in vivo was studied by 2-octynoic acid-BSA (2OA-BSA) immunization, Nudt1 conditional knock-out and adoptive co-transfer in a murine model. RESULTS: cell durable survival and TGFβ-Smad signaling. CONCLUSIONS: cell accumulation and longevity represents a novel therapeutic target in PBC. LAY SUMMARY: T cell subset, and worked out the mechanisms of its hyperactivation and longevity, which could be exploited therapeutically.