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Akin Akinc

2002–2024 年に発表

41
論文数
23,887
被引用数
39
h 指数
40
i10 指数

被引用数

Akin Akinc の年別被引用数1989 年: 被引用 1 件1994 年: 被引用 4 件2002 年: 被引用 2 件2003 年: 被引用 3 件2004 年: 被引用 17 件2005 年: 被引用 68 件2006 年: 被引用 132 件2007 年: 被引用 173 件2008 年: 被引用 188 件2009 年: 被引用 220 件2010 年: 被引用 219 件2011 年: 被引用 268 件2012 年: 被引用 337 件2013 年: 被引用 267 件2014 年: 被引用 310 件2015 年: 被引用 342 件2016 年: 被引用 353 件2017 年: 被引用 293 件2018 年: 被引用 391 件2019 年: 被引用 879 件2020 年: 被引用 1,038 件2021 年: 被引用 1,190 件2022 年: 被引用 1,121 件2023 年: 被引用 1,095 件2024 年: 被引用 1,475 件2025 年: 被引用 908 件2026 年: 被引用 28 件1990〜1993 年は被引用が無いため表示していません1995〜2001 年は被引用が無いため表示していません

引用元

国・地域

この著者を引用した国・地域の世界地図アメリカ合衆国: 引用元論文 2,803 件、この内訳の 28.9%中国: 引用元論文 1,405 件、この内訳の 14.5%ドイツ: 引用元論文 506 件、この内訳の 5.2%イギリス: 引用元論文 441 件、この内訳の 4.6%カナダ: 引用元論文 425 件、この内訳の 4.4%日本: 引用元論文 326 件、この内訳の 3.4%フランス: 引用元論文 244 件、この内訳の 2.5%オーストラリア: 引用元論文 240 件、この内訳の 2.5%韓国: 引用元論文 237 件、この内訳の 2.4%イタリア: 引用元論文 235 件、この内訳の 2.4%オランダ: 引用元論文 232 件、この内訳の 2.4%インド: 引用元論文 227 件、この内訳の 2.3%
0%28.9%その他 24.5%

機関

分野

  • Biochemistry, Genetics and Molecular Biology69%
  • Medicine15.7%
  • Materials Science6.2%
  • Immunology and Microbiology3.8%
  • Engineering2.2%
  • Pharmacology, Toxicology and Pharmaceutics0.8%
  • その他2.3%

トピック

  • RNA Interference and Gene Delivery20.5%
  • Advanced biosensing and bioanalysis techniques12.2%
  • MicroRNA in disease regulation4.8%
  • Nanoparticle-Based Drug Delivery4.1%
  • Virus-based gene therapy research3.7%
  • Immunotherapy and Immune Responses2.7%
  • その他52%

共著者

全論文

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  1. The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

    著者: Akin Akinc, Martin A. Maier, Muthiah Manoharan, Kevin Fitzgerald, Muthusamy Jayaraman, Scott Barros, Steven M. Ansell, Xinyao Du, Michael J. Hope, Thomas D. Madden, Barbara L. Mui, Sean C. Semple, Ying K. Tam, Marco A. Ciufolini, Dominik Witzigmann, Jayesh A. Kulkarni, Roy van der Meel, Pieter R. Cullis - Nature Nanotechnology 2019 被引用: 1,569

  2. Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

    著者: Jérôme Gilleron, William Querbes, Anja Zeigerer, Anna Borodovsky, Giovanni Marsico, Undine Schubert, K. Manygoats, Sarah Seifert, Cordula Andree, Martin Stöter, Hila Epstein-Barash, Ligang Zhang, Victor Koteliansky, Kevin Fitzgerald, Eugenio Fava, Marc Bickle, Yannis Kalaidzidis, Akin Akinc, Martin A. Maier, Marino Zerial - Nature Biotechnology 2013 被引用: 1,576

  3. Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

    著者: Muthusamy Jayaraman, Steven M. Ansell, Barbara L. Mui, Ying K. Tam, Jianxin Chen, Xinyao Du, David Butler, Laxman Eltepu, Shigeo Matsuda, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Ismail M. Hafez, Akin Akinc, Martin A. Maier, Mark A. Tracy, Pieter R. Cullis, Thomas D. Madden, Muthiah Manoharan, Michael J. Hope - Angewandte Chemie 2012 被引用: 1,221

  4. Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

    著者: Akin Akinc, William Querbes, Soma De, June Qin, Maria Frank-Kamenetsky, K. N. Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, William Cantley, J. Robert Dorkin, James S. Butler, LiuLiang Qin, Timothy Racie, Andrew Sprague, Eugenio Fava, Anja Zeigerer, Michael J. Hope, Marino Zerial, Dinah W.Y. Sah, Kevin Fitzgerald, Mark A. Tracy, Muthiah Manoharan, Victor Koteliansky, Antonin de Fougerolles, Martin A. Maier - Molecular Therapy 2010 被引用: 1,215

  5. Rational design of cationic lipids for siRNA delivery

    著者: Sean C. Semple, Akin Akinc, Jianxin Chen, Ammen P. Sandhu, Barbara L. Mui, Connie K Cho, Dinah W.Y. Sah, Derrick Stebbing, Erin Crosley, Ed Yaworski, Ismail M. Hafez, J. Robert Dorkin, June Qin, Kieu Lam, Kallanthottathil G. Rajeev, Kim F. Wong, Lloyd B. Jeffs, Lubomir V. Nechev, Merete L. Eisenhardt, Muthusamy Jayaraman, Mikameh Kazem, Martin A. Maier, Masuna Srinivasulu, Michael J Weinstein, Qingmin Chen, Rene Alvarez, Scott Barros, Soma De, Sandra K. Klimuk, Todd Borland, Verbena Kosovrasti, William Cantley, Ying K. Tam, Muthiah Manoharan, Marco A. Ciufolini, Mark A. Tracy, Antonin de Fougerolles, Ian MacLachlan, Pieter R. Cullis, Thomas D. Madden, Michael J. Hope - Nature Biotechnology 2010 被引用: 1,779

  6. Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

    著者: Martin A. Maier, Muthusamy Jayaraman, Shigeo Matsuda, Ju Liu, Scott Barros, William Querbes, Ying K. Tam, Steven M. Ansell, Varun Kumar, June Qin, Xuemei Zhang, Qianfan Wang, Sue Panesar, Renta Hutabarat, Mary Carioto, Julia Hettinger, Kandasamy Pachamuthu, David Butler, Kallanthottathil G. Rajeev, Bo Pang, Klaus Charissé, Kevin Fitzgerald, Barbara L. Mui, Xinyao Du, Pieter R. Cullis, Thomas D. Madden, Michael J. Hope, Muthiah Manoharan, Akin Akinc - Molecular Therapy 2013 被引用: 619

  7. Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

    著者: Barbara L. Mui, Ying K. Tam, Muthusamy Jayaraman, Steven M. Ansell, Xinyao Du, Yuen Yi C. Tam, Paulo J.C. Lin, Sam Chen, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Muthiah Manoharan, Akin Akinc, Martin A. Maier, Pieter R. Cullis, Thomas D. Madden, Michael J. Hope - Molecular Therapy — Nucleic Acids 2013 被引用: 482

  8. Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

    著者: Jayaprakash K. Nair, Jennifer L. S. Willoughby, Amy Chan, Klaus Charissé, Md. Rowshon Alam, Qianfan Wang, Menno Hoekstra, Kandasamy Pachamuthu, Alexander V. Kel’in, Stuart Milstein, Nate Taneja, Jonathan O′Shea, Sarfraz Shaikh, Ligang Zhang, Ronald J. van der Sluis, Michael E. Jung, Akin Akinc, Renta Hutabarat, Satya Kuchimanchi, Kevin Fitzgerald, Tracy Zimmermann, Theo J.C. van Berkel, Martin A. Maier, Kallanthottathil G. Rajeev, Muthiah Manoharan - Journal of the American Chemical Society 2014 被引用: 1,078

  9. Lipid-like materials for low-dose, in vivo gene silencing

    著者: Kevin T. Love, Kerry P. Mahon, Christopher G. Levins, Kathryn A. Whitehead, William Querbes, J. Robert Dorkin, June Qin, William Cantley, Liu Liang Qin, Timothy Racie, Maria Frank-Kamenetsky, Ka Ning Yip, Rene Alvarez, Dinah W.Y. Sah, Antonin de Fougerolles, Kevin Fitzgerald, Victor Koteliansky, Akin Akinc, Róbert Langer, Daniel G. Anderson - National Academy of Sciences, Proceedings of the National Academy of Sciences 2010 被引用: 965

  10. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

    著者: Akin Akinc, Andreas Zumbuehl, Michael S. Goldberg, Elizaveta S. Leshchiner, Valentina Busini, Naushad Hossain, Sergio Bacallado, David N. Nguyen, Jason Fuller, Rene Alvarez, Anna Borodovsky, Todd Borland, Rainer Constien, Antonin de Fougerolles, J. Robert Dorkin, K. N. Jayaprakash, Muthusamy Jayaraman, Matthias John, Victor Koteliansky, Muthiah Manoharan, Lubomir V. Nechev, June Qin, Timothy Racie, Denitza Raitcheva, Kallanthottathil G. Rajeev, Dinah W.Y. Sah, Jürgen Soutschek, Ivanka Toudjarska, Hans‐Peter Vornlocher, Tracy Zimmermann, Róbert Langer, Daniel G. Anderson - Nature Biotechnology 2008 被引用: 1,220

  11. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

    著者: Yizhou Dong, Kevin T. Love, J. Robert Dorkin, Sasilada Sirirungruang, Yunlong Zhang, Delai Chen, Roman L. Bogorad, Hao Yin, Yi Chen, Arturo J. Vegas, Christopher A. Alabi, Gaurav Sahay, Karsten Olejnik, Weiheng Wang, Avi Schroeder, Abigail K. R. Lytton‐Jean, Daniel J. Siegwart, Akin Akinc, Carmen Barnes, Scott Barros, Mary Carioto, Kevin Fitzgerald, Julia Hettinger, Varun Kumar, Tatiana I. Novobrantseva, June Qin, William Querbes, Victor Koteliansky, Róbert Langer, Daniel G. Anderson - National Academy of Sciences, Proceedings of the National Academy of Sciences 2014 被引用: 481

  12. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

    著者: James E. Dahlman, Carmen Barnes, Omar F. Khan, Aude Thiriot, Siddharth Jhunjunwala, Taylor E. Shaw, Yiping Xing, Hendrik B. Sager, Gaurav Sahay, Lauren Speciner, Andrew Bader, Roman L. Bogorad, Hao Yin, Tim Racie, Yizhou Dong, Shan Jiang, Danielle Seedorf, Apeksha Dave, Kamaljeet Singh Sandhu, Matthew J. Webber, Tatiana I. Novobrantseva, Vera M. Ruda, Abigail K. R. Lytton‐Jean, Christopher G. Levins, Brian T. Kalish, Dayna K. Mudge, Mario Pérez, Ludmila Abezgauz, Partha Dutta, Lynelle P. Smith, Klaus Charissé, Mark W. Kieran, Kevin Fitzgerald, Matthias Nahrendorf, Dganit Danino, Rubin M. Tuder, Ulrich H. von Andrian, Akin Akinc, Dipak Panigrahy, Avi Schroeder, Victor Koteliansky, Róbert Langer, Daniel G. Anderson - Nature Nanotechnology 2014 被引用: 573

  13. Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

    著者: Jayaprakash K. Nair, Husain Attarwala, Alfica Sehgal, Qianfan Wang, Krishna Aluri, Xuemei Zhang, Minggeng Gao, Ju Liu, Ramesh Indrakanti, Sally Schofield, Philip Kretschmer, Christopher R. Brown, Swati Gupta, Jennifer L. S. Willoughby, Julie A. Boshar, Vasant Jadhav, Klaus Charissé, Tracy Zimmermann, Kevin Fitzgerald, Muthiah Manoharan, Kallanthottathil G. Rajeev, Akin Akinc, Renta Hutabarat, Martin A. Maier - Nucleic Acids Research 2017 被引用: 270

  14. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

    著者: Jürgen Soutschek, Akin Akinc, Birgit Bramlage, Klaus Charissé, Rainer Constien, Mary Donoghue, Sayda M. Elbashir, Anke Geick, Philipp Hadwiger, Jens Harborth, Matthias John, Venkitasamy Kesavan, Gary Lavine, Rajendra K. Pandey, Timothy Racie, Kallanthottathil G. Rajeev, Ingo Röhl, Ivanka Toudjarska, Gang Wang, Silvio Wuschko, David Bumcrot, Victor Koteliansky, Stefan Limmer, Muthiah Manoharan, Hans‐Peter Vornlocher - Nature 2004 被引用: 2,187

  15. MicroRNAs 103 and 107 regulate insulin sensitivity

    著者: Mirko Trajkovski, Jean Hausser, Jürgen Soutschek, Bal Bhat, Akin Akinc, Mihaela Zavolan, Markus H. Heim, Markus Stoffel - Nature 2011 被引用: 993

  16. Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy

    著者: Varun Kumar, June Qin, Yongfeng Jiang, Richard G. Duncan, Benjamin Brigham, Shannon Fishman, Jayaprakash K. Nair, Akin Akinc, Scott Barros, Pia V. Kasperkovitz - Molecular Therapy — Nucleic Acids 2014 被引用: 217

  17. Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis

    著者: Akin Akinc, Mini Thomas, Alexander M. Klibanov, Róbert Langer - The Journal of Gene Medicine 2004 被引用: 1,329

  18. RNAi-mediated gene silencing in non-human primates

    著者: Tracy Zimmermann, Amy C. H. Lee, Akin Akinc, Birgit Bramlage, David Bumcrot, Matthew Fedoruk, Jens Harborth, James Heyes, Lloyd B. Jeffs, Matthias John, Adam D. Judge, Kieu Lam, Kevin McClintock, Lubomir V. Nechev, Lorne Palmer, Timothy Racie, Ingo Röhl, Stephan Seiffert, Sumi Shanmugam, Vandana Sood, Jürgen Soutschek, Ivanka Toudjarska, Amanda J. Wheat, Ed Yaworski, William Zedalis, Victor Koteliansky, Muthiah Manoharan, Hans‐Peter Vornlocher, Ian MacLachlan - Nature 2006 被引用: 1,350

  19. Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

    著者: Akin Akinc, Michael S. Goldberg, June Qin, J. Robert Dorkin, Christina Gamba‐Vitalo, Martin A. Maier, K. N. Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, Muthiah Manoharan, Victor Koteliansky, Ingo Röhl, Elizaveta S. Leshchiner, Róbert Langer, Daniel G. Anderson - Molecular Therapy 2009 被引用: 349

  20. An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia

    著者: Alfica Sehgal, Scott Barros, Lacramioara Ivanciu, Brian C. Cooley, June Qin, Tim Racie, Julia Hettinger, Mary Carioto, Yongfeng Jiang, Josh Brodsky, Harsha Prabhala, Xuemei Zhang, Husain Attarwala, Renta Hutabarat, Don Foster, Stuart Milstein, Klaus Charissé, Satya Kuchimanchi, Martin A. Maier, Lubo Nechev, Kandasamy Pachamuthu, Alexander V. Kel’in, Jayaprakash K. Nair, Kallanthottathil G. Rajeev, Muthiah Manoharan, Rachel Meyers, Benny Sørensen, Amy Simon, Yesim Dargaud, Claude Négrier, Rodney M. Camire, Akin Akinc - Nature Medicine 2015 被引用: 297

  21. Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy

    著者: John Pasi, Savita Rangarajan, Pencho Georgiev, Tim Mant, Michael Desmond Creagh, Toshko Lissitchkov, David Bevan, Steve Austin, C. R. M. Hay, Inga Hegemann, Rashid Kazmi, Pratima Chowdary, Liana Gercheva, Vasily Mamonov, Margarita Timofeeva, Chang-Heok Soh, Pushkal Garg, Akshay Vaishnaw, Akin Akinc, Benny Sørensen, Margaret V. Ragni - New England Journal of Medicine 2017 被引用: 357

  22. 5′‐(E)‐Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA–GalNAc Conjugates

    著者: Rubina Parmar, Jennifer L. S. Willoughby, Jingxuan Liu, Donald J. Foster, Benjamin Brigham, Christopher S. Theile, Klaus Charissé, Akin Akinc, Erin N. Guidry, Yi Pei, Walter Strapps, Mark T. Cancilla, Matthew G. Stanton, Kallanthottathil G. Rajeev, Laura Sepp‐Lorenzino, Muthiah Manoharan, Rachel Meyers, Martin A. Maier, Vasant Jadhav - ChemBioChem 2016 被引用: 137

  23. Reversal of siRNA-mediated gene silencing in vivo

    著者: Ivan Zlatev, Adam Castoreno, Christopher R. Brown, June Qin, Scott Waldron, Mark K. Schlegel, Rohan Degaonkar, Svetlana Shulga‐Morskaya, Huilei Xu, Swati Gupta, Shigeo Matsuda, Akin Akinc, Kallanthottathil G. Rajeev, Muthiah Manoharan, Martin A. Maier, Vasant Jadhav - Nature Biotechnology 2018 被引用: 92

  24. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

    著者: Maria Frank-Kamenetsky, Aldo Grefhorst, Norma N. Anderson, Timothy Racie, Birgit Bramlage, Akin Akinc, David Butler, Klaus Charissé, Robert Dorkin, Yupeng Fan, Christina Gamba‐Vitalo, Philipp Hadwiger, Muthusamy Jayaraman, Matthias John, K. N. Jayaprakash, Martin A. Maier, Lubomir V. Nechev, Kallanthottathil G. Rajeev, Timothy Read, Ingo Röhl, Jürgen Soutschek, Pamela Tan, Jamie Wong, Gang Wang, Tracy Zimmermann, Antonin de Fougerolles, Hans-Peter Vornlocher, Róbert Langer, Daniel G. Anderson, Muthiah Manoharan, Victor Koteliansky, Jay D. Horton, Kevin Fitzgerald - National Academy of Sciences, Proceedings of the National Academy of Sciences 2008 被引用: 639