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Muthiah Manoharan

1989–2025 年に発表

102
論文数
36,138
被引用数
77
h 指数
98
i10 指数

被引用数

Muthiah Manoharan の年別被引用数1990 年: 被引用 1 件1992 年: 被引用 1 件1993 年: 被引用 2 件1994 年: 被引用 4 件1995 年: 被引用 1 件1996 年: 被引用 8 件1997 年: 被引用 14 件1998 年: 被引用 11 件1999 年: 被引用 28 件2000 年: 被引用 19 件2001 年: 被引用 24 件2002 年: 被引用 35 件2003 年: 被引用 34 件2004 年: 被引用 38 件2005 年: 被引用 105 件2006 年: 被引用 227 件2007 年: 被引用 348 件2008 年: 被引用 425 件2009 年: 被引用 541 件2010 年: 被引用 490 件2011 年: 被引用 565 件2012 年: 被引用 559 件2013 年: 被引用 446 件2014 年: 被引用 448 件2015 年: 被引用 435 件2016 年: 被引用 426 件2017 年: 被引用 382 件2018 年: 被引用 471 件2019 年: 被引用 1,101 件2020 年: 被引用 1,356 件2021 年: 被引用 1,394 件2022 年: 被引用 1,360 件2023 年: 被引用 1,345 件2024 年: 被引用 1,987 件2025 年: 被引用 1,163 件2026 年: 被引用 29 件1991 年は被引用が無いため表示していません

引用元

国・地域

この著者を引用した国・地域の世界地図アメリカ合衆国: 引用元論文 4,271 件、この内訳の 30.9%中国: 引用元論文 1,947 件、この内訳の 14.1%ドイツ: 引用元論文 749 件、この内訳の 5.4%イギリス: 引用元論文 664 件、この内訳の 4.8%カナダ: 引用元論文 550 件、この内訳の 4%日本: 引用元論文 468 件、この内訳の 3.4%イタリア: 引用元論文 412 件、この内訳の 3%フランス: 引用元論文 363 件、この内訳の 2.6%インド: 引用元論文 341 件、この内訳の 2.5%オランダ: 引用元論文 316 件、この内訳の 2.3%オーストラリア: 引用元論文 315 件、この内訳の 2.3%韓国: 引用元論文 292 件、この内訳の 2.1%
0%30.9%その他 22.6%

機関

分野

  • Biochemistry, Genetics and Molecular Biology71%
  • Medicine14.7%
  • Immunology and Microbiology5.2%
  • Materials Science3.2%
  • Neuroscience2.1%
  • Engineering1.3%
  • その他2.5%

トピック

  • RNA Interference and Gene Delivery16.3%
  • Advanced biosensing and bioanalysis techniques10.4%
  • MicroRNA in disease regulation8.7%
  • Circular RNAs in diseases3.3%
  • Cancer-related molecular mechanisms research3%
  • DNA and Nucleic Acid Chemistry2.6%
  • その他55.7%

共著者

全論文

検索で開く
  1. The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

    著者: Akin Akinc, Martin A. Maier, Muthiah Manoharan, Kevin Fitzgerald, Muthusamy Jayaraman, Scott Barros, Steven M. Ansell, Xinyao Du, Michael J. Hope, Thomas D. Madden, Barbara L. Mui, Sean C. Semple, Ying K. Tam, Marco A. Ciufolini, Dominik Witzigmann, Jayesh A. Kulkarni, Roy van der Meel, Pieter R. Cullis - Nature Nanotechnology 2019 被引用: 1,569

  2. Chemistry, structure and function of approved oligonucleotide therapeutics

    著者: Martin Egli, Muthiah Manoharan - Nucleic Acids Research 2023 被引用: 768

  3. Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

    著者: Muthusamy Jayaraman, Steven M. Ansell, Barbara L. Mui, Ying K. Tam, Jianxin Chen, Xinyao Du, David Butler, Laxman Eltepu, Shigeo Matsuda, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Ismail M. Hafez, Akin Akinc, Martin A. Maier, Mark A. Tracy, Pieter R. Cullis, Thomas D. Madden, Muthiah Manoharan, Michael J. Hope - Angewandte Chemie 2012 被引用: 1,221

  4. Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

    著者: Akin Akinc, William Querbes, Soma De, June Qin, Maria Frank-Kamenetsky, K. N. Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, William Cantley, J. Robert Dorkin, James S. Butler, LiuLiang Qin, Timothy Racie, Andrew Sprague, Eugenio Fava, Anja Zeigerer, Michael J. Hope, Marino Zerial, Dinah W.Y. Sah, Kevin Fitzgerald, Mark A. Tracy, Muthiah Manoharan, Victor Koteliansky, Antonin de Fougerolles, Martin A. Maier - Molecular Therapy 2010 被引用: 1,215

  5. Rational design of cationic lipids for siRNA delivery

    著者: Sean C. Semple, Akin Akinc, Jianxin Chen, Ammen P. Sandhu, Barbara L. Mui, Connie K Cho, Dinah W.Y. Sah, Derrick Stebbing, Erin Crosley, Ed Yaworski, Ismail M. Hafez, J. Robert Dorkin, June Qin, Kieu Lam, Kallanthottathil G. Rajeev, Kim F. Wong, Lloyd B. Jeffs, Lubomir V. Nechev, Merete L. Eisenhardt, Muthusamy Jayaraman, Mikameh Kazem, Martin A. Maier, Masuna Srinivasulu, Michael J Weinstein, Qingmin Chen, Rene Alvarez, Scott Barros, Soma De, Sandra K. Klimuk, Todd Borland, Verbena Kosovrasti, William Cantley, Ying K. Tam, Muthiah Manoharan, Marco A. Ciufolini, Mark A. Tracy, Antonin de Fougerolles, Ian MacLachlan, Pieter R. Cullis, Thomas D. Madden, Michael J. Hope - Nature Biotechnology 2010 被引用: 1,779

  6. Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

    著者: Martin A. Maier, Muthusamy Jayaraman, Shigeo Matsuda, Ju Liu, Scott Barros, William Querbes, Ying K. Tam, Steven M. Ansell, Varun Kumar, June Qin, Xuemei Zhang, Qianfan Wang, Sue Panesar, Renta Hutabarat, Mary Carioto, Julia Hettinger, Kandasamy Pachamuthu, David Butler, Kallanthottathil G. Rajeev, Bo Pang, Klaus Charissé, Kevin Fitzgerald, Barbara L. Mui, Xinyao Du, Pieter R. Cullis, Thomas D. Madden, Michael J. Hope, Muthiah Manoharan, Akin Akinc - Molecular Therapy 2013 被引用: 619

  7. Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

    著者: Barbara L. Mui, Ying K. Tam, Muthusamy Jayaraman, Steven M. Ansell, Xinyao Du, Yuen Yi C. Tam, Paulo J.C. Lin, Sam Chen, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Muthiah Manoharan, Akin Akinc, Martin A. Maier, Pieter R. Cullis, Thomas D. Madden, Michael J. Hope - Molecular Therapy — Nucleic Acids 2013 被引用: 482

  8. Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

    著者: Anders Wittrup, Angela Ai, Xing Liu, Péter Hamar, Radiana Trifonova, Klaus Charissé, Muthiah Manoharan, Tomas Kirchhausen, Judy Lieberman - Nature Biotechnology 2015 被引用: 661

  9. Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

    著者: Jayaprakash K. Nair, Jennifer L. S. Willoughby, Amy Chan, Klaus Charissé, Md. Rowshon Alam, Qianfan Wang, Menno Hoekstra, Kandasamy Pachamuthu, Alexander V. Kel’in, Stuart Milstein, Nate Taneja, Jonathan O′Shea, Sarfraz Shaikh, Ligang Zhang, Ronald J. van der Sluis, Michael E. Jung, Akin Akinc, Renta Hutabarat, Satya Kuchimanchi, Kevin Fitzgerald, Tracy Zimmermann, Theo J.C. van Berkel, Martin A. Maier, Kallanthottathil G. Rajeev, Muthiah Manoharan - Journal of the American Chemical Society 2014 被引用: 1,078

  10. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

    著者: Akin Akinc, Andreas Zumbuehl, Michael S. Goldberg, Elizaveta S. Leshchiner, Valentina Busini, Naushad Hossain, Sergio Bacallado, David N. Nguyen, Jason Fuller, Rene Alvarez, Anna Borodovsky, Todd Borland, Rainer Constien, Antonin de Fougerolles, J. Robert Dorkin, K. N. Jayaprakash, Muthusamy Jayaraman, Matthias John, Victor Koteliansky, Muthiah Manoharan, Lubomir V. Nechev, June Qin, Timothy Racie, Denitza Raitcheva, Kallanthottathil G. Rajeev, Dinah W.Y. Sah, Jürgen Soutschek, Ivanka Toudjarska, Hans‐Peter Vornlocher, Tracy Zimmermann, Róbert Langer, Daniel G. Anderson - Nature Biotechnology 2008 被引用: 1,220

  11. Silencing of microRNAs in vivo with ‘antagomirs’

    著者: Jan Krützfeldt, Nikolaus Rajewsky, Ravi Braich, Kallanthottathil G. Rajeev, Thomas Tuschl, Muthiah Manoharan, Markus Stoffel - Nature 2005 被引用: 3,971

  12. Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

    著者: Kirk Brown, Jayaprakash K. Nair, Maja M. Janas, Yesseinia Angleró-Rodríguez, Lan Dang, Haiyan Peng, Christopher S. Theile, Elena Castellanos-Rizaldos, Christopher R. Brown, Donald J. Foster, Jeffrey C. Kurz, Jeffrey C. Allen, Rajanikanth J Maganti, Jing Li, Shigeo Matsuda, Matthew Stricos, Tyler Chickering, Michelle Jung, Kelly Wassarman, Jeff Rollins, Lauren Blair Woods, Alex Kelin, Dale C. Guenther, Melissa W. Mobley, John R. Petrulis, Robin McDougall, Timothy Racie, Jessica Bombardier, Diana Cha, Saket Agarwal, Lei Johnson, Yongfeng Jiang, Scott Lentini, Jason A. Gilbert, Tuyen Nguyen, Samantha Chigas, Sarah LeBlanc, Urjana Poreci, Anne Kasper, Arlin B. Rogers, Saeho Chong, Wendell Davis, Jessica E. Sutherland, Adam Castoreno, Stuart Milstein, Mark K. Schlegel, Ivan Zlatev, Klaus Charissé, Mark Keating, Muthiah Manoharan, Kevin Fitzgerald, Jing‐Tao Wu, Martin A. Maier, Vasant Jadhav - Nature Biotechnology 2022 被引用: 245

  13. Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

    著者: Hyukjin Lee, Abigail K. R. Lytton‐Jean, Yi Chen, Kevin T. Love, Angela I. Park, Emmanouil D. Karagiannis, Alfica Sehgal, William Querbes, Christopher Zurenko, Muthusamy Jayaraman, Chang G. Peng, Klaus Charissé, Anna Borodovsky, Muthiah Manoharan, Jessica Donahoe, Jessica Truelove, Matthias Nahrendorf, Róbert Langer, Daniel G. Anderson - Nature Nanotechnology 2012 被引用: 1,172

  14. Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates

    著者: Christopher R. Brown, Swati Gupta, June Qin, Timothy Racie, He Guo, Scott Lentini, Ryan J. Malone, Mikyung Yu, Shigeo Matsuda, Svetlana Shulga‐Morskaya, Anil V. Nair, Christopher S. Theile, Karyn Schmidt, Azar Shahraz, Varun Goel, Rubina Parmar, Ivan Zlatev, Mark K. Schlegel, Jayaprakash K. Nair, Muthusamy Jayaraman, Muthiah Manoharan, Dennis Brown, Martin A. Maier, Vasant Jadhav - Nucleic Acids Research 2020 被引用: 277

  15. Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

    著者: Maja M. Janas, Mark K. Schlegel, Carole E. Harbison, Vedat O. Yilmaz, Yongfeng Jiang, Rubina Parmar, Ivan Zlatev, Adam Castoreno, Huilei Xu, Svetlana Shulga‐Morskaya, Kallanthottathil G. Rajeev, Muthiah Manoharan, Natalie Keirstead, Martin A. Maier, Vasant Jadhav - Nature Communications 2018 被引用: 266

  16. Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

    著者: Jayaprakash K. Nair, Husain Attarwala, Alfica Sehgal, Qianfan Wang, Krishna Aluri, Xuemei Zhang, Minggeng Gao, Ju Liu, Ramesh Indrakanti, Sally Schofield, Philip Kretschmer, Christopher R. Brown, Swati Gupta, Jennifer L. S. Willoughby, Julie A. Boshar, Vasant Jadhav, Klaus Charissé, Tracy Zimmermann, Kevin Fitzgerald, Muthiah Manoharan, Kallanthottathil G. Rajeev, Akin Akinc, Renta Hutabarat, Martin A. Maier - Nucleic Acids Research 2017 被引用: 270

  17. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

    著者: Jürgen Soutschek, Akin Akinc, Birgit Bramlage, Klaus Charissé, Rainer Constien, Mary Donoghue, Sayda M. Elbashir, Anke Geick, Philipp Hadwiger, Jens Harborth, Matthias John, Venkitasamy Kesavan, Gary Lavine, Rajendra K. Pandey, Timothy Racie, Kallanthottathil G. Rajeev, Ingo Röhl, Ivanka Toudjarska, Gang Wang, Silvio Wuschko, David Bumcrot, Victor Koteliansky, Stefan Limmer, Muthiah Manoharan, Hans‐Peter Vornlocher - Nature 2004 被引用: 2,187

  18. Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

    著者: Donald J. Foster, Christopher R. Brown, Sarfraz Shaikh, Casey Trapp, Mark K. Schlegel, Kun Qian, Alfica Sehgal, Kallanthottathil G. Rajeev, Vasant Jadhav, Muthiah Manoharan, Satya Kuchimanchi, Martin A. Maier, Stuart Milstein - Molecular Therapy 2018 被引用: 308

  19. Targeted siRNA lipid nanoparticles for the treatment of KRAS-mutant tumors

    著者: Shubaash Anthiya, Süleyman Can Öztürk, Hamdullah Yanık, Ece Tavukçuoğlu, Adem Şahin, Dhrubajyoti Datta, Klaus Charissé, David Moreira, Marı́a Isabel Loza, Alfonso Calvo, Einar Sulheim, Simon Loevenich, Geir Klinkenberg, Ruth Schmid, Muthiah Manoharan, Güneş Esendağlı, Marı́a José Alonso - Journal of Controlled Release 2023 被引用: 91

  20. From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization

    著者: Mark K. Schlegel, Maja M. Janas, Yongfeng Jiang, Joseph D. Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R. Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga‐Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O. Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp‐Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A. Maier - Nucleic Acids Research 2022 被引用: 90

  21. Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

    著者: Christian Wolfrum, Shuanping Shi, K. N. Jayaprakash, Muthusamy Jayaraman, Gang Wang, Rajendra K. Pandey, Kallanthottathil G. Rajeev, Tomoko Nakayama, Klaus Charrise, Esther Ndungo, Tracy Zimmermann, Victor Koteliansky, Muthiah Manoharan, Markus Stoffel - Nature Biotechnology 2007 被引用: 965

  22. RNAi therapeutics: a potential new class of pharmaceutical drugs

    著者: David Bumcrot, Muthiah Manoharan, Victor Koteliansky, Dinah W.Y. Sah - Nature Chemical Biology 2006 被引用: 1,085

  23. RNAi-mediated gene silencing in non-human primates

    著者: Tracy Zimmermann, Amy C. H. Lee, Akin Akinc, Birgit Bramlage, David Bumcrot, Matthew Fedoruk, Jens Harborth, James Heyes, Lloyd B. Jeffs, Matthias John, Adam D. Judge, Kieu Lam, Kevin McClintock, Lubomir V. Nechev, Lorne Palmer, Timothy Racie, Ingo Röhl, Stephan Seiffert, Sumi Shanmugam, Vandana Sood, Jürgen Soutschek, Ivanka Toudjarska, Amanda J. Wheat, Ed Yaworski, William Zedalis, Victor Koteliansky, Muthiah Manoharan, Hans‐Peter Vornlocher, Ian MacLachlan - Nature 2006 被引用: 1,350

  24. Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

    著者: Akin Akinc, Michael S. Goldberg, June Qin, J. Robert Dorkin, Christina Gamba‐Vitalo, Martin A. Maier, K. N. Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, Muthiah Manoharan, Victor Koteliansky, Ingo Röhl, Elizaveta S. Leshchiner, Róbert Langer, Daniel G. Anderson - Molecular Therapy 2009 被引用: 349