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Hiroshi Handa

1977–2024 年に発表

158
論文数
22,648
被引用数
86
h 指数
156
i10 指数

被引用数

Hiroshi Handa の年別被引用数1977 年: 被引用 1 件1978 年: 被引用 2 件1979 年: 被引用 3 件1980 年: 被引用 5 件1981 年: 被引用 8 件1982 年: 被引用 4 件1983 年: 被引用 7 件1984 年: 被引用 7 件1985 年: 被引用 5 件1986 年: 被引用 6 件1987 年: 被引用 5 件1988 年: 被引用 3 件1989 年: 被引用 2 件1990 年: 被引用 5 件1991 年: 被引用 8 件1992 年: 被引用 12 件1993 年: 被引用 7 件1994 年: 被引用 25 件1995 年: 被引用 25 件1996 年: 被引用 21 件1997 年: 被引用 37 件1998 年: 被引用 60 件1999 年: 被引用 86 件2000 年: 被引用 120 件2001 年: 被引用 118 件2002 年: 被引用 161 件2003 年: 被引用 176 件2004 年: 被引用 142 件2005 年: 被引用 148 件2006 年: 被引用 198 件2007 年: 被引用 177 件2008 年: 被引用 187 件2009 年: 被引用 165 件2010 年: 被引用 197 件2011 年: 被引用 202 件2012 年: 被引用 202 件2013 年: 被引用 228 件2014 年: 被引用 187 件2015 年: 被引用 182 件2016 年: 被引用 179 件2017 年: 被引用 213 件2018 年: 被引用 225 件2019 年: 被引用 613 件2020 年: 被引用 782 件2021 年: 被引用 825 件2022 年: 被引用 672 件2023 年: 被引用 477 件2024 年: 被引用 768 件2025 年: 被引用 406 件2026 年: 被引用 8 件

引用元

国・地域

この著者を引用した国・地域の世界地図アメリカ合衆国: 引用元論文 2,579 件、この内訳の 31.7%中国: 引用元論文 863 件、この内訳の 10.6%日本: 引用元論文 545 件、この内訳の 6.7%イギリス: 引用元論文 536 件、この内訳の 6.6%ドイツ: 引用元論文 494 件、この内訳の 6.1%フランス: 引用元論文 302 件、この内訳の 3.7%イタリア: 引用元論文 265 件、この内訳の 3.3%カナダ: 引用元論文 251 件、この内訳の 3.1%スペイン: 引用元論文 183 件、この内訳の 2.2%スイス: 引用元論文 170 件、この内訳の 2.1%オランダ: 引用元論文 148 件、この内訳の 1.8%オーストラリア: 引用元論文 143 件、この内訳の 1.8%
0%31.7%その他 20.3%

機関

分野

  • Biochemistry, Genetics and Molecular Biology60%
  • Medicine27.7%
  • Immunology and Microbiology4.4%
  • Neuroscience1.8%
  • Agricultural and Biological Sciences1.3%
  • Chemistry1%
  • その他3.8%

トピック

  • Protein Degradation and Inhibitors6.9%
  • Ubiquitin and proteasome pathways5.3%
  • RNA Research and Splicing5.1%
  • Genomics and Chromatin Dynamics4.1%
  • Multiple Myeloma Research and Treatments3.4%
  • RNA modifications and cancer3.1%
  • その他72.1%

共著者

全論文

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  1. Identification of a Primary Target of Thalidomide Teratogenicity

    著者: Takumi Ito, Hideki Ando, Takayuki Suzuki, Toshihiko Ogura, Kentaro Hotta, Yoshimasa Imamura, Yuki Yamaguchi, Hiroshi Handa - Science 2010 被引用: 2,119

  2. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

    著者: Mary E. Matyskiela, Gang Lu, Takumi Ito, Barbra Pagarigan, Chin-Chun Lu, Karen Miller, Wei Fang, Naiyu Wang, Derek Nguyen, Jack Houston, Gilles Carmel, Tam Tran, Mariko Riley, Lyn’Al Nosaka, Gabriel C. Lander, Svetlana Gaidarova, Shuichan Xu, Alexander L. Ruchelman, Hiroshi Handa, James Carmichael, Thomas O. Daniel, Brian E. Cathers, Antonia Lopez‐Girona, Philip P. Chamberlain - Nature 2016 被引用: 692

  3. Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs

    著者: Philip P. Chamberlain, Antonia Lopez‐Girona, Karen Miller, Gilles Carmel, Barbra Pagarigan, B. Chie-Leon, Emily Rychak, Laura G. Corral, Yan Ren, Maria Wang, Mariko Riley, S.L. Delker, Takumi Ito, Hideki Ando, Tomoyuki Mori, Yoshinori Hirano, Hiroshi Handa, Toshio Hakoshima, Thomas O. Daniel, Brian E. Cathers - Nature Structural & Molecular Biology 2014 被引用: 515

  4. Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors I karos and A iolos via modulation of the E 3 ubiquitin ligase complex CRL 4 CRBN

    著者: Anita K. Gandhi, Jian Kang, Courtney G. Havens, Thomas A. Conklin, Yuhong Ning, Lei Wu, Takumi Ito, Hideki Ando, Michelle F. Waldman, Anjan Thakurta, Anke Klippel, Hiroshi Handa, Thomas O. Daniel, Peter Schäfer, Rajesh Chopra - British Journal of Haematology 2013 被引用: 621

  5. Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders

    著者: Junichi Yamamoto, Takumi Ito, Yuki Yamaguchi, Hiroshi Handa - Chemical Society Reviews 2022 被引用: 150

  6. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

    著者: Antonia Lopez‐Girona, Derek Mendy, Takumi Ito, Karl N. Miller, Anita K. Gandhi, Jian Kang, Satoki Karasawa, Gilles Carmel, Pilgrim J. Jackson, Mahan Abbasian, Ali Mahmoudi, Brian E. Cathers, Emily Rychak, Svetlana Gaidarova, R Chen, Peter Schäfer, Hiroshi Handa, Tom Daniel, Jilly F. Evans, Rajesh Chopra - Leukemia 2012 被引用: 798

  7. Efficacy and safety of the neonatal Fc receptor inhibitor efgartigimod in adults with primary immune thrombocytopenia (ADVANCE IV): a multicentre, randomised, placebo-controlled, phase 3 trial

    著者: Catherine M. Broome, Vickie McDonald, Yoshitaka Miyakawa, Monica Carpenedo, David J. Kuter, Hanny Al‐Samkari, James B. Bussel, Marie Godar, Jaume Ayguasanosa, Kristof De Beuf, Francesco Rodeghiero, Marc Michel, Adrian C. Newland, Michael Fillitz, Paul Knoebl, Stef Meers, Ismail Amine, Jaromír Gumulec, Antonín Hluší, Jiřı́ Mayer, Philippe Quittet, Jean‐François Viallard, M Betaneli, I Datikashvili-David, Genadi Iosava, Levan Makhaldiani, László Rejtő, Nino Sharashenidze, Stefanie Groepper, Alexander Röth, Aryan Hamed, Árpád Illés, Monica Carpenedo, Andrea Artoni, Monica Bocchia, Barbara Gamberi, Alessandra Borchiellini, Esther Natalie Olíva, Andrea Patriarca, Simona Tomassetti, Yoshitaka Miyakawa, Kiyoshi Ando, Hiroshi Handa, Shinya Katsutani, Kaichi Nishiwaki, Shoko Ito, Tomoki� Ito, Fransien de Boer, A.J. Gerard Jansen, Hanna Ciepłuch, Szymon Fornagiel, Sebastian Grosicki, Maria Soroka‐Wojtaszko, Jacek Treliński, Б. А. Бакиров, Elena Borisenkova, Elena Volodicheva, Yuri Shatokhin, Andrey Proydakov, Maria Aranzazu Alonso, María Eva Mingot‐Castellano, Blanca Sánchez‐González, Blanca Sanchez-Gonzalez, Meltem Aylı, Tuba Hacıbekiroğlu, Ahmet Muzaffer Demir, Meliha Nalçacı, Mehmet Sönmez, Anıl Tombak, Selami Koçak Toprak, Burhan Turgut, Filiz Vural, Münci Yağcı, Fevzi Altuntaş, Mehmet Turgut, Emın Kaya, Nataliya Romanyuk, Vickie McDonald, Syed Rashid Saeed Kazmi, Catherine M. Broome, Spero R. Cataland, Ketan Doshi, Steven R. Lentz, Michael Boxer, Richard Rosenberg, Michael Boxer, Richard Rosenberg - The Lancet 2023 被引用: 91

  8. NELF, a Multisubunit Complex Containing RD, Cooperates with DSIF to Repress RNA Polymerase II Elongation

    著者: Yuki Yamaguchi, Toshiyuki Takagi, Tadashi Wada, Keiichi Yano, Akiko Furuya, Seiji Sugimoto, Jun Hasegawa, Hiroshi Handa - Cell 1999 被引用: 842

  9. DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

    著者: Takuro Wada, Toshiyuki Takagi, Yuki Yamaguchi, Anwarul Ferdous, Takeshi Imai, Susumu Hirose, Satoru Sugimoto, Keiichi Yano, Grant A. Hartzog, Fred Winston, Stephen Buratowski, Hiroshi Handa - Genes & Development 1998 被引用: 747

  10. Redox Regulation of NF-κB Activation: Distinct Redox Regulation Between the Cytoplasm and the Nucleus

    著者: Yasuaki Kabe, Kozue Ando, Satoshi Hirao, Makoto Yoshida, Hiroshi Handa - Antioxidants and Redox Signaling 2005 被引用: 573

  11. P-TEFb-Mediated Phosphorylation of hSpt5 C-Terminal Repeats Is Critical for Processive Transcription Elongation

    著者: Tomoko Yamada, Yuki Yamaguchi, Naoto Inukai, Sachiko Okamoto, Takashi Mura, Hiroshi Handa - Molecular Cell 2006 被引用: 394

  12. Structural basis of thalidomide enantiomer binding to cereblon

    著者: Tomoyuki Mori, Takumi Ito, Shujie Liu, Hideki Ando, Satoshi Sakamoto, Yuki Yamaguchi, Etsuko Tokunaga, Norio Shibata, Hiroshi Handa, Toshio Hakoshima - Scientific Reports 2018 被引用: 128

  13. Molecular mechanisms of thalidomide and its derivatives

    著者: Takumi Ito, Hiroshi Handa - Japan Academy Series B, Proceedings of the Japan Academy Series B 2020 被引用: 116

  14. Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon

    著者: Thang Van Nguyen, J. Eugene Lee, Michael J. Sweredoski, Seung-Joo Yang, Seung-Je Jeon, Joseph S. Harrison, Jung-Hyuk Yim, Sang Ghil Lee, Hiroshi Handa, Brian Kuhlman, Ji-Seon Jeong, Justin M. Reitsma, Chul‐Seung Park, Sonja Hess, Raymond J. Deshaies - Molecular Cell 2016 被引用: 179

  15. ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells

    著者: Junichi Yamamoto, Tetsufumi Suwa, Yuki Murase, Shumpei Tateno, Hirotaka Mizutome, Tomoko Asatsuma‐Okumura, Nobuyuki Shimizu, Tsutomu Kishi, Shuji Momose, Masahiro Kizaki, Takumi Ito, Yuki Yamaguchi, Hiroshi Handa - Nature Chemical Biology 2020 被引用: 99

  16. Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology

    著者: Takumi Ito, Yuki Yamaguchi, Hiroshi Handa - Cell chemical biology 2021 被引用: 56

  17. NELF and DSIF cause promoter proximal pausing on thehsp70promoter inDrosophila

    著者: Chwen-Huey Wu, Yuki Yamaguchi, Lawrence R. Benjamin, Maria Horvat‐Gordon, Jodi Washinsky, Espen Enerly, Jan Larsson, Andrew Lambertsson, Hiroshi Handa, David S. Gilmour - Genes & Development 2003 被引用: 311

  18. Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons

    著者: Kazuhide Asakawa, Hiroshi Handa, Koichi Kawakami - Nature Communications 2020 被引用: 96

  19. Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera

    著者: Yasuaki Kabe, Makoto Suematsu, Satoshi Sakamoto, Miwa Hirai, Ikko Koike, Takako Hishiki, Atsushi Matsuda, Yuichi Hasegawa, Koji Tsujita, Masayuki Ono, Naoko Minegishi, Atsushi Hozawa, Yoshinori Murakami, Michiaki Kubo, Makoto Itonaga, Hiroshi Handa - Clinical Chemistry 2018 被引用: 80

  20. Evidence that Negative Elongation Factor Represses Transcription Elongation through Binding to a DRB Sensitivity-Inducing Factor/RNA Polymerase II Complex and RNA

    著者: Yuki Yamaguchi, Naoto Inukai, Takashi Narita, Tadashi Wada, Hiroshi Handa - Molecular and Cellular Biology 2002 被引用: 228

  21. p63 is a cereblon substrate involved in thalidomide teratogenicity

    著者: Tomoko Asatsuma‐Okumura, Hideki Ando, Marco De Simone, Junichi Yamamoto, Tomomi Sato, Nobuyuki Shimizu, Kazuhide Asakawa, Yuki Yamaguchi, Takumi Ito, Luisa Guerrini, Hiroshi Handa - Nature Chemical Biology 2019 被引用: 137

  22. DNA damage‐induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation

    著者: Tsukasa Oda, Nanami Gotoh, Tetsuhiro Kasamatsu, Hiroshi Handa, Takayuki Saitoh, Nobuo Sasaki - Cell Proliferation 2023 被引用: 31

  23. DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes

    著者: Junichi Yamamoto, Yuri Hagiwara, Kunitoshi Chiba, Tomoyasu Isobe, Takashi Narita, Hiroshi Handa, Yuki Yamaguchi - Nature Communications 2014 被引用: 106

  24. Evidence that P‐TEFb alleviates the negative effect of DSIF on RNA polymerase II‐dependent transcription in vitro

    著者: Takuro Wada, Toshiyuki Takagi, Yuki Yamaguchi, Daisuke Watanabe, Hiroshi Handa - The EMBO Journal 1998 被引用: 356