John D. Hayes
1979–2025 年に発表
- 118
- 論文数
- 41,071
- 被引用数
- 93
- h 指数
- 118
- i10 指数
被引用数
引用元
国・地域
機関
- Johns Hopkins University0.7%
- University of Dundee0.5%
- Harvard University0.5%
- Tohoku University0.5%
- Johns Hopkins Medicine0.5%
- Inserm0.4%
- その他96.9%
分野
- Biochemistry, Genetics and Molecular Biology55.8%
- Medicine26.4%
- Agricultural and Biological Sciences3.1%
- Pharmacology, Toxicology and Pharmaceutics2.9%
- Neuroscience2.7%
- Environmental Science2.6%
- その他6.5%
トピック
- Genomics, phytochemicals, and oxidative stress13.8%
- Glutathione Transferases and Polymorphisms6.9%
- Autophagy in Disease and Therapy2%
- Redox biology and oxidative stress1.6%
- Sulfur Compounds in Biology1.4%
- Epigenetics and DNA Methylation1.4%
- その他72.9%
共著者
- Michael McMahon20
- Masayuki Yamamoto19
- Albena T. Dinkova‐Kostova17
- C. Roland Wolf15
- Ken Itoh11
- Sudhir Chowdhry10
- Larry G. Higgins8
- Antonio Cuadrado7
- D J Judah7
- Lesley I. McLellan7
- David J. Harrison6
- G.E. Neal6
- Yiguo Zhang6
- Ana I. Rojo5
- B Ketterer5
- Colin J. Henderson5
- Geoffrey J. Beckett5
- Giles E. Hardingham5
- Gordon E. Neal5
- Michael L.J. Ashford5
- Paul Baxter5
- Richard C. Strange5
- Tadayuki Tsujita5
- Calum Sutherland4
全論文
- Oxidative Stress in Cancer
著者: John D. Hayes, Albena T. Dinkova‐Kostova, Kenneth D. Tew - Cancer Cell 2020 被引用: 2,526
- The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
著者: John D. Hayes, Albena T. Dinkova‐Kostova - Trends in Biochemical Sciences 2014 被引用: 2,090
- Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
著者: Antonio Cuadrado, Ana I. Rojo, Geoffrey Wells, John D. Hayes, Sharon P. Cousin, William L. Rumsey, Otis C. Attucks, Stephen Franklin, Anna–Liisa Levonen, Thomas W. Kensler, Albena T. Dinkova‐Kostova - Nature Reviews Drug Discovery 2019 被引用: 1,393
- p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
著者: Ashish Jain, Trond Lamark, Eva Sjøttem, Kenneth Bowitz Larsen, Jane Atesoh Awuh, Aud Øvervatn, Michael McMahon, John D. Hayes, Terje Johansen - Journal of Biological Chemistry 2010 被引用: 1,473
- GLUTATHIONE TRANSFERASES
著者: John D. Hayes, Jack U. Flanagan, Ian R. Jowsey - The Annual Review of Pharmacology and Toxicology 2004 被引用: 3,511
- Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
著者: Sudhir Chowdhry, Yiguo Zhang, Michael McMahon, Calum Sutherland, Antonio Cuadrado, John D. Hayes - Oncogene 2012 被引用: 635
- Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
著者: Lauren E. Tebay, Holly Robertson, Stephen T. Durant, Steven Vitale, T.M. Penning, Albena T. Dinkova‐Kostova, John D. Hayes - Free Radical Biology and Medicine 2015 被引用: 819
- Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression
著者: Michael McMahon, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Journal of Biological Chemistry 2003 被引用: 1,131
- RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2
著者: Hongyan Wang, Kaihua Liu, Miao Geng, Peng Gao, Xiao‐Yuan Wu, Hai Yan, Yangxia Li, Yulong Li, Lin Luo, John D. Hayes, Xiu Jun Wang, Xiuwen Tang - Cancer Research 2013 被引用: 367
- SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
著者: Patricia Rada, Ana I. Rojo, Sudhir Chowdhry, Michael McMahon, John D. Hayes, Antonio Cuadrado - Molecular and Cellular Biology 2011 被引用: 744
- Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis
著者: Patricia Rada, Ana I. Rojo, Nathalie Evrard‐Todeschi, Nadia G. Innamorato, Axelle Cotte, Tomasz Jaworski, Julio C. Tobón-Velasco, Herman Devijver, María Flor García‐Mayoral, Fred Van Leuven, John D. Hayes, Gildas Bertho, Antonio Cuadrado - Molecular and Cellular Biology 2012 被引用: 473
- NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
著者: John D. Hayes, Michael McMahon - Trends in Biochemical Sciences 2009 被引用: 871
- Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
著者: Michael McMahon, Douglas J. Lamont, Kenneth A. Beattie, John D. Hayes - National Academy of Sciences, Proceedings of the National Academy of Sciences 2010 被引用: 438
- Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3
著者: John D. Hayes, Sudhir Chowdhry, Albena T. Dinkova‐Kostova, Calum Sutherland - Biochemical Society Transactions 2015 被引用: 177
- Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha
著者: Xiu Jun Wang, John D. Hayes, Colin J. Henderson, C. Roland Wolf - National Academy of Sciences, Proceedings of the National Academy of Sciences 2007 被引用: 303
- Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway
著者: John D. Hayes, Michael McMahon, Sudhir Chowdhry, Albena T. Dinkova‐Kostova - Antioxidants and Redox Signaling 2010 被引用: 535
- Redox-regulated Turnover of Nrf2 Is Determined by at Least Two Separate Protein Domains, the Redox-sensitive Neh2 Degron and the Redox-insensitive Neh6 Degron
著者: Michael McMahon, Nerys Thomas, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Journal of Biological Chemistry 2004 被引用: 395
- Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
著者: Ritu Sharma, David J. Harrison, Dorothy Kisielewski, Diane Cassidy, Alison D. McNeilly, Jennifer Gallagher, Shaun Walsh, Tadashi Honda, Rory J. McCrimmon, Albena T. Dinkova‐Kostova, Michael L.J. Ashford, John Dillon, John D. Hayes - Cellular and Molecular Gastroenterology and Hepatology 2017 被引用: 212
- Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2
著者: Boushra Bathish, Holly Robertson, John Dillon, Albena T. Dinkova‐Kostova, John D. Hayes - Free Radical Biology and Medicine 2022 被引用: 65
- Dimerization of Substrate Adaptors Can Facilitate Cullin-mediated Ubiquitylation of Proteins by a “Tethering” Mechanism
著者: Michael McMahon, Nerys Thomas, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Journal of Biological Chemistry 2006 被引用: 483
- The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I
著者: John D. Hayes, David Pulford - Critical Reviews in Biochemistry and Molecular Biology 1995 被引用: 3,486
- Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
著者: Simon A. Chanas, Qingwu Jiang, Michael McMahon, Gail K. McWalter, Lesley I. McLellan, Clifford R. Elcombe, Colin J. Henderson, C. Roland Wolf, Graeme J. Moffat, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Biochemical Journal 2002 被引用: 448
- Glutathione S-Transferase Polymorphisms and Their Biological Consequences
著者: John D. Hayes, Richard C. Strange - Pharmacology 2000 被引用: 1,002
- The Gasotransmitter Hydrogen Sulfide Induces Nrf2-Target Genes by Inactivating the Keap1 Ubiquitin Ligase Substrate Adaptor Through Formation of a Disulfide Bond Between Cys-226 and Cys-613
著者: John M Hourihan, J. Gerry Kenna, John D. Hayes - Antioxidants and Redox Signaling 2012 被引用: 226
