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Ken Itoh

1980–2025 年に発表

121
論文数
37,445
被引用数
85
h 指数
116
i10 指数

被引用数

Ken Itoh の年別被引用数1982 年: 被引用 3 件1983 年: 被引用 5 件1984 年: 被引用 2 件1985 年: 被引用 2 件1986 年: 被引用 2 件1987 年: 被引用 2 件1988 年: 被引用 2 件1990 年: 被引用 1 件1991 年: 被引用 1 件1992 年: 被引用 2 件1993 年: 被引用 7 件1994 年: 被引用 3 件1995 年: 被引用 17 件1996 年: 被引用 24 件1997 年: 被引用 36 件1998 年: 被引用 44 件1999 年: 被引用 63 件2000 年: 被引用 98 件2001 年: 被引用 153 件2002 年: 被引用 214 件2003 年: 被引用 411 件2004 年: 被引用 612 件2005 年: 被引用 607 件2006 年: 被引用 592 件2007 年: 被引用 617 件2008 年: 被引用 625 件2009 年: 被引用 713 件2010 年: 被引用 821 件2011 年: 被引用 678 件2012 年: 被引用 684 件2013 年: 被引用 690 件2014 年: 被引用 554 件2015 年: 被引用 671 件2016 年: 被引用 553 件2017 年: 被引用 561 件2018 年: 被引用 418 件2019 年: 被引用 1,258 件2020 年: 被引用 1,651 件2021 年: 被引用 1,265 件2022 年: 被引用 1,180 件2023 年: 被引用 859 件2024 年: 被引用 1,075 件2025 年: 被引用 524 件2026 年: 被引用 23 件1989 年は被引用が無いため表示していません

引用元

国・地域

この著者を引用した国・地域の世界地図アメリカ合衆国: 引用元論文 3,030 件、この内訳の 25.4%中国: 引用元論文 2,133 件、この内訳の 17.9%日本: 引用元論文 906 件、この内訳の 7.6%イギリス: 引用元論文 649 件、この内訳の 5.4%イタリア: 引用元論文 467 件、この内訳の 3.9%ドイツ: 引用元論文 430 件、この内訳の 3.6%韓国: 引用元論文 409 件、この内訳の 3.4%インド: 引用元論文 313 件、この内訳の 2.6%カナダ: 引用元論文 298 件、この内訳の 2.5%スペイン: 引用元論文 260 件、この内訳の 2.2%フランス: 引用元論文 229 件、この内訳の 1.9%オーストラリア: 引用元論文 192 件、この内訳の 1.6%
0%25.4%その他 22%

機関

分野

  • Biochemistry, Genetics and Molecular Biology57.5%
  • Medicine27.2%
  • Neuroscience3.4%
  • Immunology and Microbiology2.8%
  • Agricultural and Biological Sciences2.2%
  • Pharmacology, Toxicology and Pharmaceutics2.1%
  • その他4.8%

トピック

  • Genomics, phytochemicals, and oxidative stress15.4%
  • Glutathione Transferases and Polymorphisms4.5%
  • Heme Oxygenase-1 and Carbon Monoxide1.8%
  • Redox biology and oxidative stress1.5%
  • Ferroptosis and cancer prognosis1.5%
  • Free Radicals and Antioxidants1.4%
  • その他73.9%

共著者

全論文

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  1. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

    著者: Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh, Tetsuro Ishii, Kazuhiko Igarashi, James Douglas Engel, Masayuki Yamamoto - Genes & Development 1999 被引用: 3,581

  2. An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

    著者: Ken Itoh, Tomoki Chiba, Satoru Takahashi, Tetsuro Ishii, Kazuhiko Igarashi, Yasutake Katoh, Tatsuya Oyake, Norio Hayashi, Kimihiko Satoh, Ichiro Hatayama, M. Yamamoto, Yo-ichi Nabeshima - Biochemical and Biophysical Research Communications 1997 被引用: 3,952

  3. Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

    著者: Shuya Kasai, Sunao Shimizu, Yota Tatara, Junsei Mimura, Ken Itoh - Biomolecules 2020 被引用: 543

  4. Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

    著者: Michael McMahon, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Journal of Biological Chemistry 2003 被引用: 1,131

  5. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

    著者: Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole, Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh, Masayuki Yamamoto, Paul Talalay - National Academy of Sciences, Proceedings of the National Academy of Sciences 2002 被引用: 1,925

  6. Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model

    著者: Kit I. Tong, Yasutake Katoh, Hideki Kusunoki, Ken Itoh, Toshiyuki Tanaka, Masayuki Yamamoto - Molecular and Cellular Biology 2006 被引用: 738

  7. Electrophile Response Element-mediated Induction of the Cystine/Glutamate Exchange Transporter Gene Expression

    著者: Hiromi Sasaki, Hideyo Sato, Kazumi Kuriyama-Matsumura, Kanako Sato, Kanako Maebara, Hongyu Wang, Michiko Tamba, Ken Itoh, Masayuki Yamamoto, Shiro Bannai - Journal of Biological Chemistry 2002 被引用: 538

  8. Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

    著者: Tetsuro Ishii, Ken Itoh, Satoru Takahashi, Hideyo Sato, Toru Yanagawa, Yasutake Katoh, Shiro Bannai, Masayuki Yamamoto - Journal of Biological Chemistry 2000 被引用: 1,456

  9. Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

    著者: Yasutake Katoh, Ken Itoh, Eisaku Yoshida, Makoto Miyagishi, Akiyoshi Fukamizu, Masayuki Yamamoto - Genes to Cells 2001 被引用: 515

  10. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

    著者: Nobunao Wakabayashi, Ken Itoh, Junko Wakabayashi, Hozumi Motohashi, Shuhei Noda, Satoru Takahashi, Sumihisa Imakado, Tomoe KOTSUJI, Fujio Otsuka, Dennis R. Roop, Takanori Harada, James Douglas Engel, Masayuki Yamamoto - Nature Genetics 2003 被引用: 888

  11. Molecular mechanism activating nrf2–keap1 pathway in regulation of adaptive response to electrophiles

    著者: Ken Itoh, Kit I. Tong, Masayuki Yamamoto - Free Radical Biology and Medicine 2004 被引用: 860

  12. Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter

    著者: Mi-Kyoung Kwak, Ken Itoh, Masayuki Yamamoto, Thomas W. Kensler - Molecular and Cellular Biology 2002 被引用: 586

  13. Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages

    著者: Nobuhiko Harada, Masaya Kanayama, Atsushi Maruyama, Aruto Yoshida, Kyoko Tazumi, Tomonori Hosoya, Junsei Mimura, Tsutomu Toki, Jonathan Maher, Masayuki Yamamoto, Ken Itoh - Archives of Biochemistry and Biophysics 2011 被引用: 221

  14. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

    著者: Minerva Ramos‐Gómez, Mi-Kyoung Kwak, Patrick M. Dolan, Ken Itoh, Masayuki Yamamoto, Paul Talalay, Thomas W. Kensler - National Academy of Sciences, Proceedings of the National Academy of Sciences 2001 被引用: 1,093

  15. Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles

    著者: Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh, Tetsuro Ishii, Tania O'Connor, Masayuki Yamamoto - Genes to Cells 2003 被引用: 822

  16. Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

    著者: Ken Itoh, Junsei Mimura, Masayuki Yamamoto - Antioxidants and Redox Signaling 2010 被引用: 510

  17. Redox-regulated Turnover of Nrf2 Is Determined by at Least Two Separate Protein Domains, the Redox-sensitive Neh2 Degron and the Redox-insensitive Neh6 Degron

    著者: Michael McMahon, Nerys Thomas, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Journal of Biological Chemistry 2004 被引用: 395

  18. Dimerization of Substrate Adaptors Can Facilitate Cullin-mediated Ubiquitylation of Proteins by a “Tethering” Mechanism

    著者: Michael McMahon, Nerys Thomas, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Journal of Biological Chemistry 2006 被引用: 483

  19. Bach Proteins Belong to a Novel Family of BTB-Basic Leucine Zipper Transcription Factors That Interact with MafK and Regulate Transcription through the NF-E2 Site

    著者: Tatsuya Oyake, Ken Itoh, Hozumi Motohashi, Norio Hayashi, Hideto Hoshino, Makoto Nishizawa, Masayuki Yamamoto, Kazuhiko Igarashi - Molecular and Cellular Biology 1996 被引用: 658

  20. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

    著者: Simon A. Chanas, Qingwu Jiang, Michael McMahon, Gail K. McWalter, Lesley I. McLellan, Clifford R. Elcombe, Colin J. Henderson, C. Roland Wolf, Graeme J. Moffat, Ken Itoh, Masayuki Yamamoto, John D. Hayes - Biochemical Journal 2002 被引用: 448

  21. Cloning and Characterization of a Novel Erythroid Cell-Derived CNC Family Transcription Factor Heterodimerizing with the Small Maf Family Proteins

    著者: Ken Itoh, Kazuhiko Igarashi, Norio Hayashi, Makoto Nishizawa, Masayuki Yamamoto - Molecular and Cellular Biology 1995 被引用: 437

  22. C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

    著者: Sharadha Dayalan Naidu, Aki Muramatsu, Ryota Saito, Soichiro Asami, Tadashi Honda, Tomonori Hosoya, Ken Itoh, Masayuki Yamamoto, Takafumi Suzuki, Albena T. Dinkova‐Kostova - Scientific Reports 2018 被引用: 96

  23. Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

    著者: Shinsuke Homma, Yukio Ishii, Yuko Morishima, Tadahiro Yamadori, Yosuke Matsuno, Norihiro Haraguchi, Norihiro Kikuchi, Hiroaki Satoh, Tohru Sakamoto, Nobuyuki Hizawa, Ken Itoh, Masayuki Yamamoto - Clinical Cancer Research 2009 被引用: 417

  24. Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: Protection against reactive oxygen and nitrogen species‐induced cell injury

    著者: Hong Zhu, Ken Itoh, Masayuki Yamamoto, Jay L. Zweíer, Yunbo Li - FEBS Letters 2005 被引用: 389