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Paul Polakis

1985–2020 年に発表

72
論文数
26,719
被引用数
68
h 指数
71
i10 指数

被引用数

Paul Polakis の年別被引用数1986 年: 被引用 1 件1987 年: 被引用 1 件1988 年: 被引用 3 件1989 年: 被引用 4 件1990 年: 被引用 12 件1991 年: 被引用 52 件1992 年: 被引用 67 件1993 年: 被引用 73 件1994 年: 被引用 115 件1995 年: 被引用 118 件1996 年: 被引用 190 件1997 年: 被引用 333 件1998 年: 被引用 347 件1999 年: 被引用 545 件2000 年: 被引用 590 件2001 年: 被引用 587 件2002 年: 被引用 572 件2003 年: 被引用 456 件2004 年: 被引用 467 件2005 年: 被引用 391 件2006 年: 被引用 309 件2007 年: 被引用 239 件2008 年: 被引用 333 件2009 年: 被引用 250 件2010 年: 被引用 207 件2011 年: 被引用 219 件2012 年: 被引用 277 件2013 年: 被引用 236 件2014 年: 被引用 273 件2015 年: 被引用 266 件2016 年: 被引用 217 件2017 年: 被引用 234 件2018 年: 被引用 203 件2019 年: 被引用 624 件2020 年: 被引用 543 件2021 年: 被引用 439 件2022 年: 被引用 303 件2023 年: 被引用 222 件2024 年: 被引用 301 件2025 年: 被引用 157 件2026 年: 被引用 2 件

引用元

国・地域

この著者を引用した国・地域の世界地図アメリカ合衆国: 引用元論文 3,498 件、この内訳の 38%中国: 引用元論文 806 件、この内訳の 8.8%イギリス: 引用元論文 623 件、この内訳の 6.8%ドイツ: 引用元論文 557 件、この内訳の 6%日本: 引用元論文 515 件、この内訳の 5.6%フランス: 引用元論文 333 件、この内訳の 3.6%カナダ: 引用元論文 298 件、この内訳の 3.2%オランダ: 引用元論文 255 件、この内訳の 2.8%イタリア: 引用元論文 189 件、この内訳の 2%スイス: 引用元論文 181 件、この内訳の 2%オーストラリア: 引用元論文 173 件、この内訳の 1.9%韓国: 引用元論文 163 件、この内訳の 1.8%
0%38%その他 17.5%

機関

分野

  • Biochemistry, Genetics and Molecular Biology63.3%
  • Medicine29.3%
  • Neuroscience2.3%
  • Immunology and Microbiology1.8%
  • Chemistry1.2%
  • Materials Science0.7%
  • その他1.4%

トピック

  • Wnt/β-catenin signaling in development and cancer13.1%
  • Cancer-related gene regulation8.7%
  • Monoclonal and Polyclonal Antibodies Research4%
  • HER2/EGFR in Cancer Research3.1%
  • Kruppel-like factors research2.1%
  • Cancer Cells and Metastasis2%
  • その他67%

共著者

全論文

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  1. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

    著者: Jagath R. Junutula, Helga Raab, Suzanna Clark, Sunil Bhakta, Douglas D. Leipold, Sylvia Weir, Yvonne Chen, Michelle Simpson, Siao Ping Tsai, Mark S. Dennis, Yanmei Lu, Y. Gloria Meng, Carl Ng, Jihong Yang, Chien C Lee, Eileen Duenas, Jeffrey Gorrell, Viswanatham Katta, Amy Kim, Kevin S. McDorman, Kelly M. Flagella, Rayna Venook, Sarajane Ross, Susan D. Spencer, Wai Lee Wong, Henry B. Lowman, Richard Vandlen, Mark X. Sliwkowski, Richard H. Scheller, Paul Polakis, William Mallet - Nature Biotechnology 2008 被引用: 1,354

  2. Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

    著者: Ben‐Quan Shen, Keyang Xu, Luna Liu, Helga Raab, Sunil Bhakta, Margaret Kenrick, Kathryn Parsons-Reponte, Janet Tien, Shang‐Fan Yu, Elaine Mai, Dongwei Li, Jay Tibbitts, Jakub Baudys, Ola M. Saad, Suzie J. Scales, Paul J McDonald, Philip E. Hass, Charles Eigenbrot, Trung Van Nguyen, Willy A. Solis, Reina N. Fuji, Kelly M. Flagella, Darshana Patel, Susan D. Spencer, Leslie A. Khawli, Allen Ebens, Wai Lee Wong, Richard Vandlen, Surinder Kaur, Mark X. Sliwkowski, Richard H. Scheller, Paul Polakis, Jagath R. Junutula - Nature Biotechnology 2012 被引用: 999

  3. Site-specific antibody drug conjugates for cancer therapy

    著者: Siler H. Panowski, Sunil Bhakta, Helga Raab, Paul Polakis, Jagath R. Junutula - mAbs 2013 被引用: 658

  4. A Novel Anti-CD22 Anthracycline-Based Antibody–Drug Conjugate (ADC) That Overcomes Resistance to Auristatin-Based ADCs

    著者: Shang‐Fan Yu, Bing Zheng, MaryAnn Go, Jeffrey Lau, Susan D. Spencer, Helga Raab, Robert Soriano, Suchit Jhunjhunwala, Robert Cohen, Michele Caruso, Paul Polakis, John A. Flygare, Andrew G. Polson - Clinical Cancer Research 2015 被引用: 162

  5. Targeting LGR5 + cells with an antibody-drug conjugate for the treatment of colon cancer

    著者: Melissa R. Junttila, Weiguang Mao, Xi Wang, Bu-Er Wang, Thinh Pham, John A. Flygare, Shang‐Fan Yu, Sharon Yee, David M. Goldenberg, Carter T. Fields, Jeffrey Eastham‐Anderson, Mallika Singh, Rajesh Vij, Jo-Anne Hongo, Ron Firestein, Melissa M. Schutten, Kelly M. Flagella, Paul Polakis, Andrew G. Polson - Science Translational Medicine 2015 被引用: 186

  6. Wnt Signaling in Cancer

    著者: Paul Polakis - Cold Spring Harbor Perspectives in Biology 2012 被引用: 851

  7. A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth

    著者: Ted Lau, Emily Chan, Marinella Callow, Jo Waaler, Jason Boggs, Robert A. Blake, Steven Magnuson, Amy Sambrone, Melissa M. Schutten, Ron Firestein, Ondřej Machoň, Vladimír Kořínek, Edna F. Choo, Dolores Diaz, Mark Merchant, Paul Polakis, Daniel D. Holsworth, Stefan Krauß, Mike Costa - Cancer Research 2013 被引用: 320

  8. Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

    著者: Bonnee Rubinfeld, Iris Albert, Emilio Porfiri, Carol J. Fiol, S Munemitsu, Paul Polakis - Science 1996 被引用: 1,421

  9. Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling

    著者: Marinella Callow, Hoanh Tran, Lilian Phu, Ted Lau, James Lee, Wendy Sandoval, Peter S. Liu, Sheila Bheddah, Janet Tao, Jennie R. Lill, Jo-Anne Hongo, David Davis, Donald S. Kirkpatrick, Paul Polakis, Mike Costa - PLoS ONE 2011 被引用: 225

  10. Wnt signaling and cancer

    著者: Paul Polakis - Genes & Development 2000 被引用: 3,173

  11. Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

    著者: Jagath R. Junutula, Kelly M. Flagella, Richard Graham, Kathryn L. Parsons, Edward Ha, Helga Raab, Sunil Bhakta, Trung Van Nguyen, Debra L. Dugger, Guangmin Li, Elaine Mai, Gail D. Lewis Phillips, Hajime Hiraragi, Reina N. Fuji, Jay Tibbitts, Richard Vandlen, Susan D. Spencer, Richard H. Scheller, Paul Polakis, Mark X. Sliwkowski - Clinical Cancer Research 2010 被引用: 292

  12. Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

    著者: Matthew J. Hart, Rico de los Santos, Iris Albert, Bonnee Rubinfeld, Paul Polakis - Current Biology 1998 被引用: 845

  13. Antibody Drug Conjugates for Cancer Therapy

    著者: Paul Polakis - Pharmacological Reviews 2015 被引用: 300

  14. Preclinical Development of an Anti-NaPi2b (SLC34A2) Antibody–Drug Conjugate as a Therapeutic for Non–Small Cell Lung and Ovarian Cancers

    著者: Kedan Lin, Bonnee Rubinfeld, Crystal Zhang, Ron Firestein, Eric B. Harstad, Leslie Roth, Siao Ping Tsai, Melissa M. Schutten, Keyang Xu, Maria Hristopoulos, Paul Polakis - Clinical Cancer Research 2015 被引用: 93

  15. Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

    著者: Bonnee Rubinfeld, Paul F. Robbins, Mona El‐Gamil, Iris Albert, Emilio Porfiri, Paul Polakis - Science 1997 被引用: 1,223

  16. The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell

    著者: Matthew J. Hart, Jean‐Paul Concordet, Irina Lassot, Iris Albert, Robson Santos, Hervé Durand, Christine Perret, Bonnee Rubinfeld, Florence Margottin-Goguet, Richard Bénarous, Paul Polakis - Current Biology 1999 被引用: 670

  17. High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers

    著者: Rachana Ohri, Sunil Bhakta, Aimee Fourie-O’Donohue, Josefa dela Cruz-Chuh, Siao Ping Tsai, Ryan Cook, BinQing Wei, Carl Ng, Athena W. Wong, Aaron B. Bos, Farzam Farahi, Jiten Bhakta, Thomas H. Pillow, Helga Raab, Richard Vandlen, Paul Polakis, Yichin Liu, Hans K. Erickson, Jagath R. Junutula, Katherine R. Kozak - Bioconjugate Chemistry 2018 被引用: 113

  18. The many ways of Wnt in cancer

    著者: Paul Polakis - Current Opinion in Genetics & Development 2007 被引用: 863

  19. Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering

    著者: Thomas H. Pillow, Janet Tien, Kathryn Parsons-Reponte, Sunil Bhakta, Hao Li, Leanna R. Staben, Guangmin Li, Josefa Chuh, Aimee Fourie-O’Donohue, Martine Darwish, Victor Yip, Luna Liu, Douglas D. Leipold, Dian Su, Elmer Wu, Susan D. Spencer, Ben‐Quan Shen, Keyang Xu, Katherine R. Kozak, Helga Raab, Richard Vandlen, Gail D. Lewis Phillips, Richard H. Scheller, Paul Polakis, Mark X. Sliwkowski, John A. Flygare, Jagath R. Junutula - Journal of Medicinal Chemistry 2014 被引用: 106

  20. Structural basis of the Axin–adenomatous polyposis coli interaction

    著者: K.E. Spink, Paul Polakis, William I. Weis - The EMBO Journal 2000 被引用: 207

  21. Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies

    著者: Yan Gong, Eric Bourhis, Cecilia Chiu, Scott Stawicki, Venita DeAlmeida, Bob Y. Liu, Khanhky Phamluong, Tim C. Cao, Richard A.D. Carano, James A. Ernst, Mark J. Solloway, Bonnee Rubinfeld, Rami N. Hannoush, Yan Wu, Paul Polakis, Mike Costa - PLoS ONE 2010 被引用: 206

  22. Wnt Signaling in Oncogenesis and Embryogenesis-a Look Outside the Nucleus

    著者: Mark Peifer, Paul Polakis - Science 2000 被引用: 1,254

  23. Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling

    著者: XiaoDong Huang, James C. McGann, Bob Y. Liu, Rami N. Hannoush, Jennie R. Lill, Victoria C. Pham, Kim Newton, Michael Kakunda, Jinfeng Liu, Christine Yu, S.G. Hymowitz, Jo-Anne Hongo, Anthony Wynshaw‐Boris, Paul Polakis, Richard M. Harland, Vishva M. Dixit - Science 2013 被引用: 111

  24. A GSK3‐binding peptide from FRAT1 selectively inhibits the GSK3‐catalysed phosphorylation of Axin and β‐catenin

    著者: Gareth M. Thomas, Sheelagh Frame, Michel Goedert, Inke Näthke, Paul Polakis, Philip Cohen - FEBS Letters 1999 被引用: 230