Robert J. Lefkowitz
1970–2025 年に発表
- 484
- 論文数
- 138,466
- 被引用数
- 213
- h 指数
- 482
- i10 指数
被引用数
引用元
国・地域
機関
分野
- Biochemistry, Genetics and Molecular Biology55.2%
- Medicine25.3%
- Neuroscience12.3%
- Immunology and Microbiology2.6%
- Agricultural and Biological Sciences0.9%
- Psychology0.8%
- その他2.9%
トピック
- Receptor Mechanisms and Signaling14.4%
- Neuropeptides and Animal Physiology6%
- Protein Kinase Regulation and GTPase Signaling3.8%
- Neuroscience and Neuropharmacology Research3.3%
- Ion channel regulation and function2%
- Cellular transport and secretion1.7%
- その他68.8%
共著者
- Marc G. Caron121
- Louis M. Luttrell47
- Seungkirl Ahn45
- Walter J. Koch39
- Sudha K. Shenoy29
- Howard A. Rockman27
- Brian K. Kobilka26
- Richard T. Premont25
- Jeffrey Benovic24
- Yehia Daaka21
- Julie A. Pitcher20
- William E. Miller19
- Dean P. Staus18
- Erin J. Whalen18
- James Inglese18
- Brian E. Hawes17
- Jonathan D. Violin17
- Kunhong Xiao17
- Alem W. Kahsai16
- Laura M. Wingler16
- Arun K. Shukla14
- Biswaranjan Pani14
- Susanna Cotecchia14
- Tim van Biesen13
全論文
- Biased signalling: from simple switches to allosteric microprocessors
著者: Jeffrey S. Smith, Robert J. Lefkowitz, Sudarshan Rajagopal - Nature Reviews Drug Discovery 2018 被引用: 745
- Seven-transmembrane receptors
著者: Kristen L. Pierce, Richard T. Premont, Robert J. Lefkowitz - Nature Reviews Molecular Cell Biology 2002 被引用: 2,690
- GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling
著者: A. Thomsen, Bianca Plouffe, Thomas J. Cahill, Arun K. Shukla, Jeffrey Tarrasch, Annie Dosey, Alem W. Kahsai, Ryan T. Strachan, Biswaranjan Pani, Jacob P. Mahoney, Li-Yin Huang, Billy Breton, Franziska M. Heydenreich, Roger K. Sunahara, Georgios Skiniotis, Michel Bouvier, Robert J. Lefkowitz - Cell 2016 被引用: 578
- Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc
著者: Dean P. Staus, Hongli Hu, Michael J. Robertson, A.L.W. Kleinhenz, Laura M. Wingler, W. Darrell Capel, Naomi R. Latorraca, Robert J. Lefkowitz, Georgios Skiniotis - Nature 2020 被引用: 367
- Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR
著者: Laura M. Wingler, Meredith A. Skiba, Conor McMahon, Dean P. Staus, A.L.W. Kleinhenz, Carl‐Mikael Suomivuori, Naomi R. Latorraca, Ron O. Dror, Robert J. Lefkowitz, Andrew C. Kruse - Science 2020 被引用: 247
- Conformational Basis of G Protein-Coupled Receptor Signaling Versatility
著者: Laura M. Wingler, Robert J. Lefkowitz - Trends in Cell Biology 2020 被引用: 229
- Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
著者: Laura Bohn, Robert J. Lefkowitz, Raul R. Gainetdinov, Karsten Peppel, Marc G. Caron, Fang‐Tsyr Lin - Science 1999 被引用: 1,079
- Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis
著者: Thomas J. Cahill, A. Thomsen, Jeffrey Tarrasch, Bianca Plouffe, Anthony H. Nguyen, Fan Yang, Li-Yin Huang, Alem W. Kahsai, Daniel L. Bassoni, Bryant J. Gavino, Jane E. Lamerdin, Sarah Triest, Arun K. Shukla, Benjamin Berger, John R. Little, Albert Antar, Adi Blanc, Chang-xiu Qu, Xin Chen, Kouki Kawakami, Asuka Inoue, Junken Aoki, Jan Steyaert, Jin‐Peng Sun, Michel Bouvier, Georgios Skiniotis, Robert J. Lefkowitz - National Academy of Sciences, Proceedings of the National Academy of Sciences 2017 被引用: 385
- Transduction of Receptor Signals by ß-Arrestins
著者: Robert J. Lefkowitz, Sudha K. Shenoy - Science 2005 被引用: 1,721
- Distinct Phosphorylation Sites on the β 2 -Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin
著者: Kelly N. Nobles, Kunhong Xiao, Seungkirl Ahn, Arun K. Shukla, Christopher M. Lam, Sudarshan Rajagopal, Ryan T. Strachan, Teng‐Yi Huang, Erin A. Bressler, Makoto R. Hara, Sudha K. Shenoy, Steven P. Gygi, Robert J. Lefkowitz - Science Signaling 2011 被引用: 625
- Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor
著者: Carl‐Mikael Suomivuori, Naomi R. Latorraca, Laura M. Wingler, Stephan Eismann, Matthew C. King, A.L.W. Kleinhenz, Meredith A. Skiba, Dean P. Staus, Andrew C. Kruse, Robert J. Lefkowitz, Ron O. Dror - Science 2020 被引用: 242
- Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations
著者: Laura M. Wingler, Matthias Elgeti, Daniel Hilger, Naomi R. Latorraca, Michael T. Lerch, Dean P. Staus, Ron O. Dror, Brian K. Kobilka, Wayne L. Hubbell, Robert J. Lefkowitz - Cell 2019 被引用: 296
- Mechanism of β 2 AR regulation by an intracellular positive allosteric modulator
著者: Xiangyu Liu, Ali Masoudi, Alem W. Kahsai, Li-Yin Huang, Biswaranjan Pani, Dean P. Staus, Paul J. Shim, Kunio Hirata, Rishabh K. Simhal, Allison M. Schwalb, Paula Rambarat, Seungkirl Ahn, Robert J. Lefkowitz, Brian K. Kobilka - Science 2019 被引用: 133
- A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
著者: Makoto R. Hara, Jeffrey J. Kovacs, Erin J. Whalen, Sudarshan Rajagopal, Ryan T. Strachan, Wayne Grant, Aaron J. Towers, Barbara Williams, Christopher M. Lam, Kunhong Xiao, Sudha K. Shenoy, Simon G. Gregory, Seungkirl Ahn, Derek R. Duckett, Robert J. Lefkowitz - Nature 2011 被引用: 418
- μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
著者: Laura Bohn, Raul R. Gainetdinov, Fang‐Tsyr Lin, Robert J. Lefkowitz, Marc G. Caron - Nature 2000 被引用: 923
- β-arrestin-mediated receptor trafficking and signal transduction
著者: Sudha K. Shenoy, Robert J. Lefkowitz - Trends in Pharmacological Sciences 2011 被引用: 699
- A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
著者: James W. Wisler, Scott M. DeWire, Erin J. Whalen, Jonathan D. Violin, Matthew T. Drake, Seungkirl Ahn, Sudha K. Shenoy, Robert J. Lefkowitz - National Academy of Sciences, Proceedings of the National Academy of Sciences 2007 被引用: 598
- Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
著者: Dean P. Staus, Ryan T. Strachan, Aashish Manglik, Biswaranjan Pani, Alem W. Kahsai, Tae Hun Kim, Laura M. Wingler, Seungkirl Ahn, Arnab K. Chatterjee, Ali Masoudi, Andrew C. Kruse, Els Pardon, Jan Steyaert, William I. Weis, R. Scott Prosser, Brian K. Kobilka, Tommaso Costa, Robert J. Lefkowitz - Nature 2016 被引用: 328
- Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure
著者: Xiangyu Liu, Seungkirl Ahn, Alem W. Kahsai, Kai-Cheng Meng, Naomi R. Latorraca, Biswaranjan Pani, AJ Venkatakrishnan, Ali Masoudi, William I. Weis, Ron O. Dror, Xin Chen, Robert J. Lefkowitz, Brian K. Kobilka - Nature 2017 被引用: 206
- A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.
著者: A. De Léan, Jeffrey M. Stadel, Robert J. Lefkowitz - Journal of Biological Chemistry 1980 被引用: 1,605
- β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function
著者: Martin J. Lohse, Jeffrey Benovic, Juan Codina, Marc G. Caron, Robert J. Lefkowitz - Science 1990 被引用: 1,217
- β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
著者: Sudarshan Rajagopal, Ji‐Hee Kim, Seungkirl Ahn, Stewart Craig, Christopher M. Lam, Norma P. Gerard, Craig Gerard, Robert J. Lefkowitz - National Academy of Sciences, Proceedings of the National Academy of Sciences 2009 被引用: 595
- Visualization of arrestin recruitment by a G-protein-coupled receptor
著者: Arun K. Shukla, Gerwin Westfield, Kunhong Xiao, Rosana I. Reis, Li-Yin Huang, Prachi Tripathi‐Shukla, Jiang Qian, Sheng Li, Adi Blanc, Austin N. Oleskie, Anne M. Dosey, Min Su, Cui-Rong Liang, Ling-Ling Gu, Jin-Ming Shan, Xin Chen, Rachel Hanna, Minjung Choi, Yao Xiao, B.U. Klink, Alem W. Kahsai, Sachdev S. Sidhu, Shohei Koide, Pawel A. Penczek, Anthony A. Kossiakoff, Virgil L. Woods, Brian K. Kobilka, Georgios Skiniotis, Robert J. Lefkowitz - Nature 2014 被引用: 508
- Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide
著者: Arun K. Shukla, Aashish Manglik, Andrew C. Kruse, Kunhong Xiao, Rosana I. Reis, Wei-Chou Tseng, Dean P. Staus, Daniel Hilger, Serdar Uysal, Li-Yin Huang, Marcin Paduch, Prachi Tripathi‐Shukla, Akiko Koide, Shohei Koide, William I. Weis, Anthony A. Kossiakoff, Brian K. Kobilka, Robert J. Lefkowitz - Nature 2013 被引用: 476
