Stanley H. Appel
1961–2025 年に発表
- 153
- 論文数
- 28,682
- 被引用数
- 99
- h 指数
- 150
- i10 指数
被引用数
引用元
国・地域
機関
- Harvard University1.1%
- Inserm0.9%
- University College London0.8%
- Johns Hopkins University0.7%
- Massachusetts General Hospital0.7%
- King's College London0.6%
- その他95.2%
分野
- Medicine54.6%
- Neuroscience26.2%
- Biochemistry, Genetics and Molecular Biology14.7%
- Immunology and Microbiology2%
- Agricultural and Biological Sciences0.4%
- Nursing0.4%
- その他1.7%
トピック
- Amyotrophic Lateral Sclerosis Research12.7%
- Neuroinflammation and Neurodegeneration Mechanisms7.7%
- Neurogenetic and Muscular Disorders Research5.9%
- Parkinson's Disease Mechanisms and Treatments5.3%
- Alzheimer's disease research and treatments5.2%
- Nerve injury and regeneration2.5%
- その他60.7%
共著者
- David R. Beers45
- Weihua Zhao34
- Jenny S. Henkel19
- Jason R. Thonhoff17
- Aaron D. Thome14
- Alireza Faridar14
- Jinghong Wang14
- Shixiang Wen13
- R G Smith11
- Weidong Le11
- Ericka P. Simpson10
- Allen D. Roses9
- László Siklós9
- Maria E. Alexianu9
- Wenjie Xie9
- Albert Yen8
- Joseph C. Masdeu7
- Yi He7
- Enrico Stefani6
- J. Engelhardt6
- Joseph Jankovic6
- József I. Engelhardt6
- Merit Cudkowicz6
- Paul E. Schulz6
全論文
- Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies
著者: David R. Beers, Stanley H. Appel - The Lancet Neurology 2019 被引用: 372
- Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
著者: Elizabeth T. Cirulli, Brittany N. Lasseigne, Slavé Petrovski, Peter C. Sapp, Patrick A. Dion, Claire S. Leblond, Julien Couthouis, Yifan Lu, Quanli Wang, Brian J. Krueger, Zhong Ren, Jonathan Keebler, Yujun Han, Shawn Levy, Braden Boone, Jack R. Wimbish, Lindsay L. Waite, Angela L. Jones, John P. Carulli, Kelly L. Williams, John F. Staropoli, Winnie Xin, Alessandra Chesi, Alya R. Raphael, Diane McKenna‐Yasek, Janet Cady, J.M.B.V. de Jong, Kevin P. Kenna, Bradley Smith, Simon Topp, Jack W. Miller, Soragia Athina Gkazi, Ammar Al‐Chalabi, Leonard H. van den Berg, Jan H. Veldink, Vincenzo Silani, Nicola Ticozzi, Christopher E. Shaw, Robert H. Baloh, Stanley H. Appel, Ericka Simpson, Clotilde Lagier‐Tourenne, Stefan M. Pulst, Summer Gibson, John Q. Trojanowski, Lauren Elman, Leo McCluskey, Murray Grossman, Neil A. Shneider, Wendy K. Chung, John Ravits, Jonathan D. Glass, Katherine B. Sims, Vivianna M. Van Deerlin, Tom Maniatis, Sebastian Hayes, Alban Ordureau, Sharan Swarup, John E. Landers, Frank Baas, Andrew S. Allen, Richard Bedlack, J. Wade Harper, Aaron D. Gitler, Guy A. Rouleau, Robert H. Brown, Matthew B. Harms, Gregory M. Cooper, Tim Harris, R Myers, David B. Goldstein - Science 2015 被引用: 992
- An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study
著者: Timothy M. Miller, Alan Pestronk, William David, Jeffrey Rothstein, Ericka Simpson, Stanley H. Appel, Patricia L. Andres, Katy Mahoney, Peggy Allred, K. Alexander, Lyle W. Ostrow, David Schoenfeld, Eric A. Macklin, Daniel A Norris, Georgios Manousakis, Matthew J. Crisp, Richard Smith, C. Frank Bennett, Kathie M. Bishop, Merit Cudkowicz - The Lancet Neurology 2013 被引用: 607
- TDP-43 activates microglia through NF-κB and NLRP3 inflammasome
著者: Weihua Zhao, David R. Beers, Shaughn Bell, Jinghong Wang, Shixiang Wen, Robert H. Baloh, Stanley H. Appel - Experimental Neurology 2015 被引用: 242
- Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis
著者: Ethan A. Winkler, Jesse D. Sengillo, John S. Sullivan, Jenny S. Henkel, Stanley H. Appel, Berislav V. Zloković - Acta Neuropathologica 2012 被引用: 349
- ALS patients’ regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity
著者: David R. Beers, Weihua Zhao, Jinghong Wang, Xiujun Zhang, Shixiang Wen, Dan Neal, Jason R. Thonhoff, Abdullah Alsuliman, Elizabeth J. Shpall, Katy Rezvani, Stanley H. Appel - JCI Insight 2017 被引用: 256
- Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis
著者: David R. Beers, Jenny S. Henkel, Weihua Zhao, Jinghong Wang, Ailing Huang, Shixiang Wen, Bing Liao, Stanley H. Appel - Brain 2011 被引用: 422
- Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS
著者: Bing Liao, Weihua Zhao, David R. Beers, Jenny S. Henkel, Stanley H. Appel - Experimental Neurology 2012 被引用: 421
- Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
著者: David R. Beers, Jenny S. Henkel, Qin Xiao, Weihua Zhao, Jinghong Wang, Albert Yen, László Siklós, Scott R. McKercher, Stanley H. Appel - National Academy of Sciences, Proceedings of the National Academy of Sciences 2006 被引用: 721
- Regulatory T‐lymphocytes mediate amyotrophic lateral sclerosis progression and survival
著者: Jenny S. Henkel, David R. Beers, Shixiang Wen, Andreana L. Rivera, Karen M. Toennis, Joan E. Appel, Weihua Zhao, Dan H. Moore, Suzanne Z. Powell, Stanley H. Appel - EMBO Molecular Medicine 2012 被引用: 349
- Expanded autologous regulatory T-lymphocyte infusions in ALS
著者: Jason R. Thonhoff, David R. Beers, Weihua Zhao, Milvia Pleitez, Ericka P. Simpson, James D. Berry, Merit Cudkowicz, Stanley H. Appel - Neurology Neuroimmunology & Neuroinflammation 2018 被引用: 191
- Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes
著者: Weihua Zhao, David R. Beers, Kristopher G. Hooten, Douglas H. Sieglaff, Aijun Zhang, Shanker Kalyana‐Sundaram, Christopher Traini, Wendy S. Halsey, Ashley M. Hughes, Ganesh M. Sathe, George P. Livi, Guo-Huang Fan, Stanley H. Appel - JAMA Neurology 2017 被引用: 172
- Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis
著者: Jason R. Thonhoff, James D. Berry, Eric A. Macklin, David R. Beers, Patricia A. Mendoza, Weihua Zhao, Aaron D. Thome, Fabio Triolo, James J. Moon, Sabrina Paganoni, Merit Cudkowicz, Stanley H. Appel - Neurology Neuroimmunology & Neuroinflammation 2022 被引用: 67
- Presence of dendritic cells, MCP‐1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue
著者: Jenny S. Henkel, J. Engelhardt, László Siklós, Ericka P. Simpson, Seung Hyun Kim, Tianhong Pan, J. Clay Goodman, Teepu Siddique, David R. Beers, Stanley H. Appel - Annals of Neurology 2003 被引用: 548
- TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss
著者: Rosa Chiara Paolicelli, Ali Jawaid, Christopher M. Henstridge, Andrea Valeri, Mario Merlini, John Robinson, Edward B. Lee, Jamie Rose, Stanley H. Appel, Virginia M.‐Y. Lee, John Q. Trojanowski, Tara L. Spires‐Jones, Paul E. Schulz, Lawrence Rajendran - Neuron 2017 被引用: 258
- Restoring regulatory T-cell dysfunction in Alzheimer’s disease through ex vivo expansion
著者: Alireza Faridar, Aaron D. Thome, Weihua Zhao, Jason R. Thonhoff, David R. Beers, Belén Pascual, Joseph C. Masdeu, Stanley H. Appel - Brain Communications 2020 被引用: 101
- Prevalence and patterns of cognitive impairment in sporadic ALS
著者: George M. Ringholz, Stanley H. Appel, Major R. Bradshaw, Norma Cooke, Diane Mosnik, Paul E. Schulz - Neurology 2005 被引用: 839
- Amyotrophic lateral sclerosis is a systemic disease: peripheral contributions to inflammation-mediated neurodegeneration
著者: Stanley H. Appel, David R. Beers, Weihua Zhao - Current Opinion in Neurology 2021 被引用: 74
- Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease
著者: Alireza Faridar, Matthew Vasquez, Aaron D. Thome, Zheng Yin, Hui Xuan, Jing Hong Wang, Shixiang Wen, Xuping Li, Jason R. Thonhoff, Weihua Zhao, Hong Zhao, David R. Beers, Stephen T.C. Wong, Joseph C. Masdeu, Stanley H. Appel - Acta Neuropathologica Communications 2022 被引用: 59
- A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease
著者: Alireza Faridar, Abdulmunaim M. Eid, Aaron D. Thome, Weihua Zhao, David R. Beers, Maria B. Pascual, Mohammad Obadah Nakawah, Gustavo C. Román, Charles S. Davis, Michael Grundman, Joseph C. Masdeu, Stanley H. Appel - Translational Neurodegeneration 2023 被引用: 38
- Extracellular Vesicles Derived From Ex Vivo Expanded Regulatory T Cells Modulate In Vitro and In Vivo Inflammation
著者: Aaron D. Thome, Jason R. Thonhoff, Weihua Zhao, Alireza Faridar, Jinghong Wang, David R. Beers, Stanley H. Appel - Frontiers in Immunology 2022 被引用: 37
- Extracellular mutant SOD1 induces microglial‐mediated motoneuron injury
著者: Weihua Zhao, David R. Beers, Jenny S. Henkel, Wei Zhang, Makoto Urushitani, Jean‐Pierre Julien, Stanley H. Appel - Glia 2009 被引用: 282
- Microglia in ALS: The Good, The Bad, and The Resting
著者: Jenny S. Henkel, David R. Beers, Weihua Zhao, Stanley H. Appel - Journal of Neuroimmune Pharmacology 2009 被引用: 352
- Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson’s disease
著者: Aaron D. Thome, Farah Atassi, Jinghong Wang, Alireza Faridar, Weihua Zhao, Jason R. Thonhoff, David R. Beers, Eugene C. Lai, Stanley H. Appel - npj Parkinson s Disease 2021 被引用: 76
