Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

著者: Matthias Pauthner, Joseph P. Nkolola, Colin Havenar‐Daughton, Ben Murrell, Samantha Reiss, Raiza Bastidas, Jérémie Prévost, Rebecca Nedellec, Benjamin von Bredow, Peter Abbink, Christopher A. Cottrell, Daniel W. Kulp, Talar Tokatlian, Bartek Nogal, Matteo Bianchi, Hui Li, Jeong Hyun Lee, Salvatore T. Butera, David T. Evans, Lars Hangartner, Andrés Finzi, Ian A. Wilson, Richard T. Wyatt, Darrell J. Irvine, William R. Schief, Andrew B. Ward, Rogier W. Sanders, Shane Crotty, George M. Shaw, Dan H. Barouch, Dennis R. Burton - Immunity 2018 被引用: 175

nAb titer of ∼1:500 afforded more than 90% protection from medium-dose SHIV infection. In contrast, antibody-dependent cellular cytotoxicity and T cell activity did not correlate with protection. Therefore, Env protein-based vaccination strategies can protect against hard-to-neutralize SHIV challenge in rhesus macaques by inducing tier 2 nAbs, provided appropriate neutralizing titers can be reached and maintained.