Tadalafil has biologic activity in human melanoma. Results of a pilot trial with Tadalafil in patients with metastatic Melanoma (TaMe)

著者: Jessica C. Hassel, Huanhuan Jiang, Carolin Bender, Julia K. Winkler, Alexandra Sevko, Ivan Shevchenko, Niels Halama, Antonia Dimitrakopoulou‐Strauss, Walter E. Haefeli, Dirk Jäger, Alexander Enk, Jochen Utikal, Viktor Umansky - OncoImmunology 2017 被引用: 94

T cells in the peripheral blood as compared with baseline. Our study suggests that the PDE-5 inhibitor tadalafil can improve clinical outcome of advanced melanoma patients by enhancing antitumor immunity and highlights its potential application in combined melanoma immunotherapy.