The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

著者: Jérémy Manry, Paul Bastard, Adrian Gervais, Tom Le Voyer, Jérémie Rosain, Quentin Philippot, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Shohei Eto, Marina García-Prat, Lucy Bizien, Alba Parra-Martínez, Rui Yang, Liis Haljasmägi, Mélanie Migaud, Karita Särekannu, Julia Maslovskaja, Nicolas de Prost, Yacine Tandjaoui-Lambiotte, Charles‐Édouard Luyt, Blanca Amador-Borrero, Alexandre Gaudet, Julien Poissy, Pascal Morel, Pascale Richard, Fabrice Cognasse, Jesús Troya, Sophie Trouillet‐Assant, Alexandre Belot, Kahina Saker, Pierre Garçon, Jacques G. Rivière, Jean‐Christophe Lagier, Stéphanie Gentile, Lindsey B. Rosen, Elana Shaw, Tomohiro Morio, Junko Tanaka, David Dalmau, Pierre‐Louis Tharaux, D. Sène, Alain Stépanian, Bruno Mégarbane, Vasiliki Triantafyllia, Arnaud Fekkar, James R. Heath, José Luis Franco, Juan‐Manuel Anaya, Jordi Solé‐Violán, Luisa Imberti, Andrea Biondi, Paolo Bonfanti, Riccardo Castagnoli, Ottavia M. Delmonte, Yu Zhang, Andrew L. Snow, Steven M. Holland, Catherine M. Biggs, Marcela Moncada‐Vélez, Andrés A. Arias, Lazaro Lorenzo, Soraya Boucherit, Dany Anglicheau, Anna M. Planas, Filomeen Haerynck, Sotiriјa Duvlis, Tayfun Özçelık, Sevgi Keleş, Ahmed Aziz Bousfiha, Jalila El Bakkouri, Carolina Ramı́rez-Santana, Stéphane Paul, Qiang Pan‐Hammarström, Lennart Hammarström, Annabelle Dupont, Alina Kurolap, Christine N. Metz, Alessandro Aiuti, Giorgio Casari, Vito Lampasona, Fabio Ciceri, Lucila Akune Barreiros, Elena Domínguez‐Garrido, Mateus Vidigal, Mayana Zatz, Diederik van de Beek, Sabina Sahanic, Ivan Tancevski, Yuriy Stepanovskyy, Oksana Boyarchuk, Yoko Nukui, Miyuki Tsumura, Loreto Vidaur, Stuart G. Tangye, Sonia Burrel, Darragh Duffy, Lluis Quintana-Murci, Adam Klocperk, Nelli Y. Kann, Anna Shcherbina, YL Lau, Daniel Leung, Matthieu Coulongeat, Julien Marlet, Rutger Koning, Luis Felipe Reyes, Angélique Chauvineau‐Grenier, Fabienne Venet, Guillaume Monneret, Michel C. Nussenzweig, Romain Arrestier, Idris Boudhabhay, Hagit Baris Feldman, David Hagin, Joost Wauters, Isabelle Meyts, Adam H. Dyer, Seán Kennelly, Nollaig M. Bourke, Rabih Halwani, Fatemeh Saheb Sharif‐Askari, Karim Dorgham, Jérôme Sallette, Souad Mehlal Sedkaoui, Suzan A. AlKhater, Raül Rigo‐Bonnin, Francisco Morandeira, Lucie Roussel, Donald C. Vinh, Christian Erikstrup, Antônio Condino‐Neto, Carolina Prando, Анастасія Бондаренко, András N. Spaan, Laurent Gilardin, Jacques Fellay, Stanislas Lyonnet, Kaya Bilgüvar, Richard P. Lifton, Shrikant Mane, HGID Lab, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, French COVID Cohort Study Group, Imagine COVID-Group, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank Investigators, COVID Human Genetic Effort, CP-COVID-19 Group, CONSTANCES cohort, 3C-Dijon Study, Cerba Health-Care, Etablissement Français du Sang Study group, Mark S. Anderson, Bertrand Boisson, Vivien Béziat, Shen‐Ying Zhang, Evangelos Andreakos, Olivier Hermine, Aurora Pujol, Pärt Peterson, Trine H. Mogensen, Lee Rowen, James Mond, Stéphanie Debette, Xavier de Lamballerie, Charles Burdet, Lila Bouadma, Marie Zins, Pere Soler‐Palacín, Roger Colobran, Guy Gorochov, Xavier Solanich, Sophie Susen, Javier Martínez‐Picado, Didier Raoult, Marc Vasse, Peter K. Gregersen, Lorenzo Piemonti, Carlos Rodríguez‐Gallego, Luigi D. Notarangelo, Helen C. Su, Kai Kisand, Satoshi Okada, Anne Puel, Emmanuelle Jouanguy, Charles M. Rice, Pierre Tiberghien, Qian Zhang, Jean‐Laurent Casanova, Laurent Abel, Aurélie Cobat, Peng Zhang, Yoann Seeleuthner, Estelle Talouarn, Astrid Marchal, Daniela Matuozzo, Aliénor de la Chapelle, Jie Chen, Maya Chrabieh, Dana Liu, Yelena Nemirowskaya, Inés Marín Cruz, Marie Materna, Sophie Pelet, C Thibault, Zhiyong Liu, Jorge Abad, Giulia Accordino, Cristian Achille, Sergio Aguilera, Aina Aguiló‐Cucurull, Alessandro Aiuti, Esra Akyüz Özkan, Ilad Alavi Darazam, Jonathan Antonio Roblero Albisures, Juan C. Aldave, Miquel Alfonso Ramos, Sajid Ali, Anna Aliberti, Seyed Alireza Nadji, Gülsüm Alkan, Suzan A. AlKhater, Jérôme Allardet-Servent, Luís M. Allende, Rebeca Alonso‐Arias, Mohammed Alshahrani, Laia Alsina, Marie‐Alexandra Alyanakian, Blanca Amador Borrero, Zahir Amoura, Arnau Antolí, Romain Arrestier, Mélodie Aubart, Teresa Auguet, Iryna Avramenko, Gökhan Aytekіn, Axelle Azot, Seiamak Bahram, Fanny Bajolle, Fausto Baldanti, Aurélie Baldolli, Mayte Ballester, Hagit Baris Feldman, Benoı̂t Barrou, Federica Barzaghi, Sabrina Basso, Gülsüm İclal Bayhan, Alexandre Bélot, Liliana Bezrodnik, Agurtzane Bilbao, Géraldine Blanchard‐Rohner, Ignacio Blanco, Adeline Blandinières, Daniel Blázquez‐Gamero, Alexandre Bleibtreu, Markéta Bloomfield, Mireia Bolívar-Prados, Анастасія Бондаренко, A. Borghesi, Raphaël Borie, Elisabeth Botdhlo-Nevers, Ahmed Aziz Bousfiha, Aurore Bousquet, David Boutolleau, Claire Bouvattier, Oksana Boyarchuk, Juliette Bravais, M. Luisa Briones, Marie‐Eve Brunner, Raffaele Bruno, Maria Rita Passos‐Bueno, Huda Bukhari, Jacinta Bustamante, Juan José Cáceres Agra, Ruggero Capra, Raphaël Carapito, Maria Carrabba, Giorgio Casari, Carlos Casasnovas, Marion Caséris, Irene Cassaniti, Martin Castelle, Francesco Castelli, Martín Castillo de Vera, Mateus Vidigal de Castro, Émilie Catherinot, Jale Bengi Çelik, Alessandro Ceschi, Martin Chalumeau, Bruno Charbit, Matthew Pellan Cheng, Père Clavé, Bonaventura Clotet, Anna Codina, Yves Cohen, Roger Colobran, Cloé Comarmond, Alain Combes, Patrizia Comoli, Angelo Guido Corsico, Taner Çoşkuner, Aleksandar Cvetkovski, Cyril Cyrus, David Dalmau, François Danion, D.R. Darley, Vincent Das, Nicolás Dauby, Stéphane Dauger, Paul De Munter, Loïc de Pontual, Amin Dehban, Geoffroy Delplancq, Alexandre Demoule, Isabelle Desguerre, Antonio Di Sabatino, Jean‐Luc Diehl, Stephanie Dobbelaere, Elena Domínguez‐Garrido, C Dubost, Olov Ekwall, Şefika Elmas Bozdemir, Marwa H. Elnagdy, Melike Emiroğlu, Akifumi Endo, Emine Hafize Erdeniz, Selma Erol Aytekin, Maria Pilar Etxart Lasa, Romain Euvrard, Giovanna Fabio, Laurence Faivre, Antonin Falck, Muriel Fartoukh, Morgane Faure, Miguel Fernández‐Arquero, Ricard Ferrer, José Ferreres, Carlos Flores, Bruno François, Victòria Fumadó, Kitty S. C. Fung, Francesca Fusco, Alenka Gagro, Blanca García‐Solis, Pascale Gaussem, Zeynep Gayretli, Juana Gil-Herrera, Laurent Gilardin, Audrey Giraud Gatineau, Mònica Girona‐Alarcón, Karen Alejandra Cifuentes Godínez, Jean‐Christophe Goffard, Nacho Gonzales, Luis Ignacio González‐Granado, Rafaela González‐Montelongo, Antoine Guerder, Belgi̇n Gülhan, Victor Daniel Gumucio, Leif G. Hanitsch, Jan Gunst, Marta Gut, Jérôme Hadjadj, Filomeen Haerynck, Rabih Halwani, Lennart Hammarström, Selda Hançerli, Tetyana Hariyan, Nevin Hatipoğlu, Deniz Heppekcan, Elisa Hernández-Brito, Po-ki Ho, María Soledad Holanda-Peña, Juan Pablo Horcajada, Sami Hraiech, L. Humbert, Ivan Fan-Ngai Hung, Alejandro Iglesias, Antonio Íñigo-Campos, Matthieu Jamme, María J. Arranz, Marie-Thérèse Jimeno, Iolanda Jordán, Saliha Kanık Yüksek, Yalcin Burak Kara, Aydın Karahan, Adem Karbuz, Kadriye Kart Yaşar, Özgür Kasapçopur, Kenichi Kashimada, Sevgi Keleş, Yasemin Kendir Demirkol, Yasutoshi Kido, Can Kizil, Ahmet Osman Kılıç, Adam Klocperk, Maria Daganou, Evangelia Koukaki, Antonia Koutsoukou, Vasiliki Rapti, Konstantinos Syrigos, Zbigniew Król, Hatem Ksouri, Paul Kuentz, Arthur M. C. Kwan, Yat Wah M. Kwan, Janette Kwok, Jean‐Christophe Lagier, David S. Y. Lam, Francesca Conti, Andrea Pession, Vicky Lampropoulou, Fanny Lanternier, YL Lau, Fleur Le Bourgeois, Yee‐Sin Leo, Rafael León‐López, Daniel Leung, Michael Levin, Michaël Levy, Romain Lévy, Zhi Li, Daniele Lilleri, Edson Jose Adrian Bolanos Lima, Agnès Linglart, Eduardo López‐Collazo, José M. Lorenzo-Salazar, Céline Louapre, Catherine Lubetzki, Kwok-Cheung Lung, Charles-Edouard Luyt, David Chien Lye, Cinthia Magnone, Davood Mansouri, Enrico Marchioni, Carola Marioli, Majid Marjani, Lino Marques, Jesus Marquez Pereira, Andrea Martín-Nalda, David Martínez Pueyo, Javier Martínez‐Picado, Iciar Marzana, Carmen Mata-Martínez, Alexis Mathian, Larissa R. B. Matos, Gail Matthews, Julien Mayaux, Raquel McLaughlin-Garcia, Philippe Meersseman, Jean‐Louis Mège, Armand Mekontso Dessap, Isabelle Melki, Federica Meloni, Jean–François Méritet, Paolo Merlani, Özge Metin Akcan, Isabelle Meyts, Mehdi Mezidi, Isabelle Migeotte, Maude Millereux, Matthieu Million, Tristan Mirault, Clotilde Mircher, Mehdi Mirsaeidi, Yoko Mizoguchi, Bhavi P. Modi, Francesco Mojoli, Elsa Moncomble, Abián Montesdeoca Melián, Antonio Morales Martínez, Francisco Morandeira, Pierre‐Emmanuel Morange, C. Mordacq, Guillaume Morelle, Stéphane J. Mouly, Adrián Muñoz‐Barrera, Cyril Nafati, Shintaro Nagashima, Yu Nakagama, Bénédicte Neven, João Farela Neves, Lisa F. P. Ng, Yuk-Yung Ng, H. Nielly, Yeray Nóvoa Medina, Esmeralda Núñez Cuadros, J. Gonzalo Ocejo‐Vinyals, Keisuke Okamoto, Mehdi Oualha, Amani Ouedrani, Tayfun Özçelık, Aslınur Özkaya Parlakay, Michele Pagani, Qiang Pan‐Hammarström, Maria Papadaki, Christophe Parizot, Philippe Parola, Tiffany Pascreau, Stéphane Paul, Estela Paz‐Artal, Sigifredo Pedraza‐Sánchez, José Luis Gálvez-Romero, Nancy Carolina González Pellecer, Silvia Pellegrini, Rebeca Pérez de Diego, Xosé Luis Pérez-Fernández, Aurélien Philippe, Quentin Philippot, Adrien Picod, Marc Pineton de Chambrun, Antonio Piralla, Laura Planas‐Serra, Dominique Ploin, Julien Poissy, Géraldine Poncelet, Garyphallia Poulakou, Marie Pouletty, Persia Pourshahnazari, Jia Li Qiu-Chen, Paul Quentric, Thomas Rambaud, Didier Raoult, Violette Raoult, Anne‐Sophie Rebillat, Claire Redin, Léa Resmini, Pilar Ricart, Jean‐Christophe Richard, Raül Rigo‐Bonnin, Nadia Rivet, Jacques G. Rivière, Gemma Rocamora-Blanch, Mathieu P. Rodero, Carlos Rodrigo, Luis Antonio Rodriguez, Carlos Rodríguez‐Gallego, Agustí Rodríguez‐Palmero, Carolina S. Romero, Anya Rothenbühler, Damien Roux, Νikoletta Ρovina, Flore Rozenberg, Yvon Ruch, Montse Ruiz, María Yolanda Ruiz del Prado, Juan Carlos Ruiz‐Rodríguez, Joan Sabater‐Riera, Kai Saks, Maria Salagianni, Oliver Sanchez, Adrián Sánchez‐Montalvá, Silvia Sánchez‐Ramón, Laire Schidlowski, Agatha Schlüter, Julien Schmidt, Matthieu Schmidt, Catharina Schuetz, Cyril Schweitzer, Francesco Scolari, Anna Šedivá, Luis Seijó, Analía Gisela Seminario, D. Sène, Piseth Seng, Sevtap Şenoğlu, Mikko Seppänen, Alex Serra-Llovich, Mohammad Shahrooei, Anna Shcherbina, Virginie Siguret, Eleni Siouti, David M. Smadja, Nikaïa Smith, Ali Sobh, Xavier Solanich, Jordi Solé‐Violán, Catherine Soler, Pere Soler-Palacín, Betül Sözeri, Giulia Maria Stella, Yuriy Stepanovskiy, Annabelle Stoclin, Fabio Silvio Taccone, Yacine Tandjaoui-Lambiotte, Jean‐Luc Taupin, Simon J. Tavernier, Loreto Vidaur, Benjamin Terrier, Guillaume Thiéry, Christian Thorball, Karolina Thörn, C. Thumerelle, Imran Tipu, Martin Tolstrup, Gabriele Tomasoni, Julie Toubiana, Josep Trenado Alvarez, Sophie Trouillet‐Assant, Jesús Troya, Owen Tak-Yin Tsang, Liina Tserel, Eugene Y. K. Tso, Alessandra Tucci, Şadiye Kübra Tüter Öz, Matilde Valeria Ursini, Takanori Utsumi, Y. Uzunhan, P. Vabres, Juan Valencia-Ramos, Ana Maria Van Den Rym, Isabelle Vandernoot, Valentina Vélez-Santamaría, Silvia Patricia Zuniga Veliz, Mateus C. Vidigal, Sébastien Viel, Cédric Villain, Marie E. Vilaire-Meunier, Judit Villar-García, Audrey Vincent, Guillaume Vogt, Guillaume Voiriot, Алла Волоха, Fanny Vuotto, Els Wauters, Joost Wauters, Alan Wu, Tak-Chiu Wu, Aysun Yahşi, Osman Yeşilbaş, Mehmet Yıldız, Barnaby Edward Young, Ufuk Yükselmiş, Mayana Zatz, Stefano Ghirardello, Valentina Zuccaro, Ana de Andrés, Jens Van Praet, Bart N. Lambrecht, Eva Van Braeckel, Cédric Bosteels, Levi Hoste, Eric A. J. Hoste, Fré Bauters, Jozefien De Clercq, Cathérine Heijmans, Hans Slabbynck, Leslie Naesens, Benoît Florkin, Cécile Boulanger, Dimitri Vanderlinden, Giuseppe Foti, Giacomo Bellani, Giuseppe Citerio, Ernesto Contro, Alberto Pesci, Maria Grazia Valsecchi, Marina Elena Cazzaniga, Jeffrey J. Danielson, Kerry Dobbs, Anuj Kashyap, Li Ding, Clifton L. Dalgard, Alessandra Sottini, Virginia Quaresima, Eugenia Quirós-Roldán, Camillo Rossi, Laura Rachele Bettini, Mariella D’Angiò, Ilaria Beretta, Daniela Montagna, Amelia Licari, Gian Luigi Marseglia, Isabella Batten, Conor Reddy, Matt McElheron, Claire Noonan, Emma Connolly, Aoife Fallon, Merete Storgaard, Sofie E. Jørgensen, Martin Tolstrup, Christian Erikstrup, Ole Birger Pedersen, Erik Sørensen, Susan Mikkelsen, Khoa Manh Dinh, Margit Anita Hørup Larsen, Isabella Worlewenut Paulsen, Jakob Hjorth von Stemann, Morten Hansen, Sisse Rye Ostrowski, Liam Townsend, Clíona Ní Cheallaigh, Colm Bergin, Ignacio Martín‐Loeches, Jean Dunne, Niall Conlon, Nollaig Bourke, Cliona O’Farrelly, Laurent Abel, Clotilde Allavena, Claire Andréjak, François Angoulvant, Cécile Azoulay, Delphine Bachelet, Marie Bartoli, Romain Basmaci, Sylvie Behillill, Marine Beluze, Nicolas Benech, Dehbia Benkerrou, Krishna Bhavsar, Laurent Bitker, Lila Bouadma, Maude Bouscambert‐Duchamp, Pauline Caraux Paz, Minerva Cervantes-Gonzalez, Anissa Chair, Catherine Chirouze, Alexandra Coelho, Hugues Cordel, Camille Couffignal, Sandrine Couffin-Cadiergues, Éric D’Ortenzio, Étienne de Montmollin, Alexa Debard, Marie‐Pierre Debray, Dominique Deplanque, Diane Descamps, Mathilde Desvallée, Alpha Diallo, Jean‐Luc Diehl, Alphonsine Diouf, Céline Dorival, François Dubos, Xavier Duval, Philippine Eloy, Vincent Enouf, Olivier Épaulard, Hélène Espérou, Marina Esposito-Farase, Manuel Etienne, Denis Garot, Nathalie Gault, Alexandre Gaymard, Jade Ghosn, Tristan Gigante, Morgane Gilg, François Goehringer, Jérémie Guedj, Alexandre Hoctin, Isabelle Hoffmann, Ikram Houas, Jean‐Sébastien Hulot, Salma Jaafoura, Ouifiya Kafif, Florentia Kaguelidou, Sabrina Kali, Younes Kerroumi, Antoine Khalil, Coralie Khan, Antoine Kimmoun, Fabrice Laine, Cédric Laouenan, Samira Laribi, Minh Quan Lê, Cyril Le Bris, Sylvie Le Gac, Quentin Le Hingrat, Soizic Le Mestre, Hervé Le Nagard, Adrien Lemaignen, Véronique Lemee, François‐Xavier Lescure, Sophie Letrou, Yves Lévy, Bruno Lina, Guillaume Lingas, Jean Christophe Lucet, Moïse Machado, Denis Malvy, Marina Mambert, Aldric Manuel, France Mentré, Amina Meziane, Hugo Mouquet, Jimmy Mullaert, Nadège Néant, Duc Hai Nguyen, Marion Noret, Aurélie Papadopoulos, Christelle Paul, Nathan Peiffer-Smadja, Vincent Peigne, Ventzislava Petrov–Sanchez, Gilles Peytavin, Huong Pham, Olivier Picone, Valentine Piquard, Julien Poissy, Oriane Puéchal, Manuel Rosa‐Calatrava, Bénédicte Rossignol, Patrick Rossignol, Carine Roy, Marion Schneider, Helen C. Su, Coralie Tardivon, Marie-Capucine Tellier, François Téoulé, Olivier Terrier, Jean‐François Timsit, Christelle Tual, Sarah Tubiana, Sylvie van der Werf, Noémie Vanel, Aurélie Veislinger, Benoît Visseaux, Aurélie Wiedemann, Yazdan Yazdanpanah, Jean‐Philippe Annereau, Luis Briseño-Roa, Olivier Gribouval, Jean‐Philippe Jaïs, Anna Pelet, Laurent Abel, Andrés Alcover, Hugues Aschard, Philippe Bousso, Nollaig Bourke, Petter Brodin, Pierre Bruhns, Nadine Cerf–Bensussan, Ana Cumano, Christophe d’Enfert, Ludovic Deriano, Marie‐Agnès Dillies, James P. Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Milena Hasan, Gunilla Karlsson Hedestam, Serge Herçberg, Molly A. Ingersoll, Olivier Lantz, Rose Anne Kenny, Mickaël Ménager, Frédérique Michel, Hugo Mouquet, Cliona O’Farrelly, Étienne Patin, Sandra Pellegrini, Antonio Rausell, Frédéric Rieux‐Laucat, Lars Rogge, Magnus Fontes, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Touvier, Marie‐Noëlle Ungeheuer, Christophe Zimmer, Matthew L. Albert, Darragh Duffy, Lluis Quintana-Murci, Loubna Alavoine, Sylvie Behillil, Charles Burdet, Charlotte Charpentier, Aline Dechanet, Diane Descamps, Xavier Duval, Jean-Luc Ecobichon, Vincent Enouf, Wahiba Frezouls, Nadhira Houhou, Ouifiya Kafif, Jonathan Lehacaut, Sophie Letrou, Bruno Lina, Jean‐Christophe Lucet, Pauline Manchon, Mariama Nouroudine, Valentine Piquard, Caroline Quintin, Michaël Thy, Sarah Tubiana, Sylvie van der Werf, Valérie Vignali, Benoît Visseaux, Yazdan Yazdanpanah, Abir Chahine, Nawal Waucquier, Maria-Claire Migaud, Dominique Deplanque, Félix Djossou, Mayka Mergeay-Fabre, Aude Lucarelli, Magalie Demar, Léa Bruneau, Patrick Gérardin, Adrien Maillot, Christine Payet, Bruno Laviolle, Fabrice Laine, Christophe Paris, Mireille Desille‐Dugast, Julie Fouchard, Denis Malvy, Duc Hai Nguyen, Thierry Pistone, Pauline Perreau, Valérie Gissot, Carole L. E. Goas, Samatha Montagne, Lucie Richard, Catherine Chirouze, Kévin Bouiller, Maxime Desmarets, Alexandre Meunier, Marilou Bourgeon, Benjamin Lefèvre, Hélène Jeulin, Karine Legrand, Sandra Lomazzi, Bernard Tardy, Amandine Gagneux-Brunon, Frédérique Bertholon, Élisabeth Botelho-Nevers, Kouakam Christelle, Leturque Nicolas, Layidé Roufai, Karine Amat, Sandrine Couffin-Cadiergues, Hélène Espérou, Samia Hendou, Michiel A. van Agtmael, Anna Geke Algera, Brent Appelman, Frank van Baarle, Diane Bax, Martijn Beudel, Harm Jan Bogaard, Marije K. Bomers, Peter I. Bonta, Lieuwe D. J. Bos, Michela Botta, Justin de Brabander, Godelieve de Bree, Sanne de Bruin, David T. P. Buis, Marianna Bugiani, Esther Bulle, Osoul Chouchane, Alex Cloherty, Mirjam Dijkstra, Dave A. Dongelmans, Romein W. G. Dujardin, Paul Elbers, Lucas M. Fleuren, Suzanne E. Geerlings, Theo Geijtenbeek, Armand R. J. Girbes, Bram Goorhuis, Martin P. Grobusch, Florianne Hafkamp, Laura A. Hagens, Jörg Hamann, Vanessa Harris, Robert Hemke, Sabine Hermans, Leo Heunks, Markus W. Hollmann, Janneke Horn, Joppe W. Hovius, Menno D. de Jong, Rutger Koning, Endry H. T. Lim, Niels van Mourik, Jeaninne Nellen, Esther J. Nossent, Frederique Paulus, Edgar Peters, Dan Piña‐Fuentes, Tom van der Poll, Bennedikt Preckel, Jan M. Prins, Jorinde Raasveld, Tom D. Y. Reijnders, Maurits C. F. J. de Rotte, Michiel Schinkel, Marcus J. Schultz, Femke A. P. Schrauwen, Alex R. Schuurman, Jaap Schuurmans, Kim Sigaloff, Marleen A. Slim, Patrick Smeele, Marry R. Smit, Cornelis Stijnis, Willemke Stilma, Charlotte E. Teunissen, Patrick Thoral, Anissa M. Tsonas, Pieter R. Tuinman, Marc van der Valk, Denise P. Veelo, Carolien Volleman, Heder de Vries, Lonneke A. van Vught, Michèle van Vugt, Dorien Wouters, Aeilko H. Zwinderman, Matthijs C. Brouwer, W. Joost Wiersinga, Alexander P. J. Vlaar, Diederik van de Beek, Laurent Abel, Alessandro Aiuti, Saleh Al‐Muhsen, Fahd Al‐Mulla, Mark S. Anderson, Evangelos Andreakos, Andrés A. Arias, Hagit Baris Feldman, Alexandre Belot, Catherine M. Biggs, Dusan Bogunovic, Alexandre Bolze, Анастасія Бондаренко, Ahmed Aziz Bousfiha, Petter Brodin, Yenan T. Bryceson, Carlos D. Bustamante, Manish J. Butte, Giorgio Casari, Samya Chakravorty, John Christodoulou, Antônio Condino‐Neto, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Murkesh Desai, Beth A. Drolet, Jamila El Baghdadi, Sara Elva Espinosa‐Padilla, Jacques Fellay, Carlos Flores, José Luis Franco, Antoine Froidure, Peter K. Gregersen, Filomeen Haerynck, David Hagin, Rabih Halwani, Lennart Hammarström, James R. Heath, Sarah E. Henrickson, Elena W.Y. Hsieh, Eystein S. Husebye, Kohsuke Imai, Yuval Itan, Erich D. Jarvis, Timokratis Karamitros, Kai Kisand, Cheng‐Lung Ku, YL Lau, Yun Ling, C. Lucas, Tom Maniatis, Davood Mansouri, László Maródi, Isabelle Meyts, Joshua D. Milner, Kristina Mironska, Trine H. Mogensen, Tomohiro Morio, Lisa F. P. Ng, Luigi D. Notarangelo, Antonio Novelli, Giuseppe Novelli, Cliona O’Farrelly, Satoshi Okada, Tayfun Özçelık, Qiang Pan‐Hammarström, Rebeca Pérez de Diego, Anna M. Planas, Jordi Pérez‐Tur, Lisa M. Arkin, Takaki Asano, Roger Colobran Oriol, Carolina Prando, Aurora Pujol, Lluís Quintana‐Murci, Laurent Rénia, Igor Resnick, Carlos Rodríguez‐Gallego, Vanessa Sancho‐Shimizu, Anna Šedivá, Mikko Seppänen, Mohammed Shahrooei, Anna Shcherbina, Ondřej Slabý, Andrew L. Snow, Pere Soler-Palacín, András N. Spaan, Ivan Tancevski, Stuart G. Tangye, Ahmad Abou Tayoun, Sathishkumar Ramaswamy, Stuart E. Turvey, K. M. Furkan Uddin, Mohammed Uddin, Diederik van de Beek, Donald C. Vinh, Horst von Bernuth, Mayana Zatz, Paweł Zawadzki, Bodo Grimbacher, Keisuke Okamoto, Jean W. Pape, David S. Perlin, Graziano Pesole, Joost Wauters, Helen C. Su, Jean‐Laurent Casanova, Paula Andrea Gaviria García, Gustavo Andrés Salguero López, Adriana Rojas-Villaraga, Verónica Posada Vélez, Lina Marcela Acevedo Landinez, Luisa Paola Duarte Correales, Oscar Gómez, Jeser Santiago Grass Guaqueta, Cristian Alejandro Ricaurte Pérez, Jorge Carrillo, José Alejandro Daza Vergara, Sandra Landinez, Rubén D. Mantilla, Jairo David Torres Yepes, Oscar Andrés Briceño Ricaurte, Carlos E. Pérez‐Díaz, Yady Nataly Mateus, Laura Mancera Navarro, Yhojan Rodríguez, Yeny Acosta‐Ampudia, Diana M. Monsalve, Manuel Rojas, Rachel Nadif, Marcel Goldberg, Anna Ozguler, Joseph Henny, Sylvie Lemonnier, Mireille Coeuret-Pellicer, Stéphane Le Got, Marie Zins, Christophe Tzourio, Stéphanie Debette, Carole Dufouil, Aïcha Soumaré, Morgane Lachaize, Nathalie Fievet, Amandine Flaig, Fernando Martin, Brigitte Bonneaudeau, Fabrice Cognasse, Dorothée Cannet, Pierre Gallian, Michel Jeanne, Pascal Morel, Magali Perroquin, Pascale Richard, Pierre Tiberghien, Hind Hamzeh‐Cognasse - Proceedings of the National Academy of Sciences, PNAS 2022 被引用: 193

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged <70 y and in >4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death.