The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

著者: Writing Group, M Snyder, Shin Lin, Amanda L. Posgai, Mark A. Atkinson, Aviv Regev, Jennifer Rood, Orit Rozenblatt–Rosen, Leslie Gaffney, Anna Hupalowska, Rahul Satija, Nils Gehlenborg, Jay Shendure, Julia Laskin, Pehr Harbury, Nicholas A. Nystrom, Jonathan C. Silverstein, Ziv Bar‐Joseph, Kun Zhang, Katy Börner, Yiing Lin, Richard Conroy, Dena Procaccini, Ananda L. Roy, Ajay Pillai, Marishka Brown, Zorina S. Galis, Caltech-UW TMC, Long Cai, Jay Shendure, Cole Trapnell, Shin Lin, Dana L. Jackson, Stanford-WashU TMC, Michael P. Snyder, Garry P. Nolan, William J. Greenleaf, Yiing Lin, Sylvia K. Plevritis, Sara Ahadi, Stephanie Nevins, Hayan Lee, Christian Schuerch, Sarah Black, Vishal G. Venkataraaman, Edward D. Esplin, Aaron Horning, Amir Bahmani, UCSD TMC, Kun Zhang, Xin Sun, Sanjay Jain, James S. Hagood, Gloria Pryhuber, Peter V. Kharchenko, Mark A. Atkinson, Bernd Bodenmiller, Todd M. Brusko, Michael Clare‐Salzler, Harry S. Nick, Kevin J. Otto, Amanda L. Posgai, Clive Wasserfall, Marda Jorgensen, Maigan Brusko, Sergio Maffioletti, Richard M. Caprioli, Jeffrey M. Spraggins, Danielle Gutierrez, Nathan Heath Patterson, Elizabeth K. Neumann, Raymond C. Harris, Mark deCaestecker, Agnes B. Fogo, Raf Van de Plas, Ken S. Lau, Long Cai, Guo‐Cheng Yuan, Qian Zhu, Ruben Dries, Harvard TTD, Peng Yin, Sinem K. Saka, Jocelyn Y. Kishi, Yu Wang, Isabel Goldaracena, Purdue TTD, Julia Laskin, DongHye Ye, Kristin Burnum-Johnson, Paul Piehowski, Charles Ansong, Ying Zhu, Stanford TTD, Pehr Harbury, Tushar Desai, Jay Mulye, Peter Chou, Monica Nagendran, Ziv Bar‐Joseph, Sarah A. Teichmann, Benedict Paten, Robert F. Murphy, Jian Ma, Vladimir Yu Kiselev, Carl Kingsford, Allyson Ricarte, Maria Keays, Sushma A. Akoju, Matthew Ruffalo, Nils Gehlenborg, Peter V. Kharchenko, Margaret E. Vella, Chuck McCallum, Katy Börner, Leonard E. Cross, Samuel H. Friedman, Randy Heiland, Bruce Herr, Paul Macklin, Ellen M. Quardokus, Lisel Record, James P. Sluka, Griffin M. Weber, Nicholas A. Nystrom, Jonathan C. Silverstein, Philip D. Blood, Alexander J. Ropelewski, William Shirey, Robin Scibek, Paula Mabee, W. Christopher Lenhardt, Kimberly Robasky, Stavros Michailidis, Rahul Satija, John C. Marioni, Aviv Regev, Andrew Butler, Tim Stuart, Eyal Fisher, Shila Ghazanfar, Jennifer Rood, Leslie Gaffney, Gökçen Eraslan, Tommaso Biancalani, Eeshit Dhaval Vaishnav, NIH HuBMAP Working Group, Richard Conroy, Dena Procaccini, Ananda L. Roy, Ajay Pillai, Marishka Brown, Zorina S. Galis, Pothur R. Srinivas, Aaron C. Pawlyk, Salvatore Sechi, Elizabeth L. Wilder, James M. Anderson - Nature 2019 被引用: 687

Transformative technologies are enabling the construction of three-dimensional maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution by supporting technology development, data acquisition, and detailed spatial mapping. HuBMAP will integrate its efforts with other funding agencies, programs, consortia, and the biomedical research community at large towards the shared vision of a comprehensive, accessible three-dimensional molecular and cellular atlas of the human body, in health and under various disease conditions.