Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

著者: Franz Ricklefs, Quazim A. Alayo, Harald Krenzlin, Ahmad Bakur Mahmoud, Maria C. Speranza, Hiroshi Nakashima, Josie Hayes, Kyungheon Lee, Leonora Balaj, Carmela Passaro, Arun K. Rooj, Susanne Krasemann, Bob S. Carter, Clark C. Chen, Tyler Steed, Jeffrey M. Treiber, Scott J. Rodig, Katherine S. Yang, Ichiro Nakano, Hakho Lee, Ralph Weissleder, Xandra O. Breakefield, Jakub Godlewski, Manfred Westphal, Katrin Lamszus, Gordon J. Freeman, Agnieszka Bronisz, Sean Lawler, E. Antonio Chiocca - Science Advances 2018 被引用: 610

. These results suggest that PD-L1 on EVs may be another mechanism for glioblastoma to suppress antitumor immunity and support the potential of EVs as biomarkers in tumor patients.