ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression

著者: Hui Shi, Ting Tao, Brian J. Abraham, Adam D. Durbin, Mark W. Zimmerman, Cigall Kadoch, A. Thomas Look - Science Advances 2020 被引用: 93

is a haploinsufficient tumor suppressor in MYCN-driven neuroblastoma, whose depletion enhances tumor development and promotes the emergence of the more drug-resistant mesenchymal cell state.