The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

著者: Orit Rozenblatt–Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer Rood, Orr Ashenberg, Ethan Cerami, Robert J. Coffey, Emek Demir, Li Ding, Edward D. Esplin, James M. Ford, Jeremy Goecks, Sharmistha Ghosh, Joe W. Gray, Justin Guinney, Sean E. Hanlon, Shannon K. Hughes, E. Shelley Hwang, Christine A. Iacobuzio–Donahue, Judit Jané‐Valbuena, Bruce E. Johnson, Ken S. Lau, Tracy Lively, Sarah A. Mazzilli, Dana Pe’er, Sandro Santagata, Alex K. Shalek, Denis Schapiro, M Snyder, Peter K. Sorger, Avrum Spira, Sudhir Srivastava, Kai Tan, Robert B. West, Elizabeth H. Williams, Denise R. Aberle, Samuel I. Achilefu, Foluso O. Ademuyiwa, Andrew Adey, Rebecca Aft, Rachana Agarwal, Ruben A. Aguilar, Fatemeh Alikarami‬, Viola Allaj, Christopher I. Amos, Robert A. Anders, Michael Angelo, Kristen Anton, Orr Ashenberg, Jon C. Aster, Özgün Babur, Amir Bahmani, Akshay Balsubramani, David Barrett, Jennifer Beane, Diane E. Bender, Kathrin M. Bernt, Lynne D. Berry, Courtney B. Betts, Julie Bletz, Katie E. Blise, Adrienne Boire, Genevieve M. Boland, Alexander Borowsky, Kristopher R. Bosse, Matthew J. Bott, Ed Boyden, James D. Brooks, Raphael Bueno, Erik A. Burlingame, Qiuyin Cai, Joshua D. Campbell, Wagma Caravan, Ethan Cerami, Hassan Chaı̈b, Joseph M. Chan, Young Hwan Chang, Deyali Chatterjee, Ojasvi Chaudhary, Alyce A. Chen, Bob Chen, Changya Chen, Chia‐Hui Chen, Feng Chen, Yuan Chen, Milan G. Chheda, Koei Chin, Roxanne Chiu, Shih‐Kai Chu, Rodrigo Chuaqui, Jaeyoung Chun, Luis Cisneros, Robert J. Coffey, Graham A. Colditz, Kristina A. Cole, Natalie B. Collins, Kévin Contrepois, Lisa M. Coussens, Allison Creason, Daniel Crichton, Christina Curtis, Tanja M. Davidsen, Sherri R. Davies, Ino de Bruijn, Laura DelloStritto, Angelo De Marzo, Emek Demir, David G. DeNardo, Dinh Diep, Li Ding, Sharon J. Diskin, Xengie Doan, Julia L. Drewes, S. Dubinett, Michael A. Dyer, Jacklynn V. Egger, Jennifer Eng, Barbara E. Engelhardt, Graham S. Erwin, Edward D. Esplin, Laura Esserman, Alex Felmeister, Heidi S. Feiler, Ryan C. Fields, Stephen Fisher, Keith T. Flaherty, Jennifer Flournoy, James M. Ford, Angelo Fortunato, Allison Frangieh, Jennifer L. Frye, Robert S. Fulton, Danielle Galipeau, Siting Gan, Jianjiong Gao, Long Gao, Peng Gao, Vianne R. Gao, Tim Geiger, Ajit George, Gad Getz, Sharmistha Ghosh, Marios Giannakis, David L. Gibbs, William E. Gillanders, Jeremy Goecks, S. Peter Goedegebuure, Alanna Gould, Kate H.C. Gowers, Joe W. Gray, William J. Greenleaf, Jeremy S. Gresham, Jennifer L. Guerriero, Tuhin K. Guha, Alexander R. Guimarães, Justin Guinney, David A. Gutman, Nir Hacohen, Sean E. Hanlon, Casey R. Hansen, Olivier Harismendy, Kathleen A. Harris, Aaron N. Hata, Akimasa Hayashi, Cody N. Heiser, Karla Helvie, John M. Herndon, Gilliam Hirst, F. Stephen Hodi, Travis J. Hollmann, Aaron M. Horning, James J. Hsieh, Shannon Hughes, Won Jae Huh, Stephen P. Hunger, Shelley Hwang, Christine A. Iacobuzio–Donahue, Heba Ijaz, Benjamin Izar, Connor A. Jacobson, Sam M. Janes, Judit Jané‐Valbuena, Reyka G. Jayasinghe, Lihua Jiang, Brett Johnson, Bruce E. Johnson, Tao Ju, Humam Kadara, Klaus H. Kaestner, Jacob Kagan, Lukas Kalinke, Robert L. Keith, Aziz Khan, Warren A. Kibbe, Albert H. Kim, Erika Kim, Junhyong Kim, Annette Kolodzie, Mateusz Kopytra, Eran Kotler, Robert Krueger, Kostyantyn Krysan, Anshul Kundaje, Uri Ladabaum, Blue B. Lake, Huy Lam, Rozelle Laquindanum, Ken S. Lau, Ashley M. Laughney, Hayan Lee, Marc E. Lenburg, Carina A. Leonard, Ignaty Leshchiner, Rochelle Levy, Jerry Li, Christine G. Lian, Kian‐Huat Lim, Jia‐Ren Lin, Yiyun Lin, Qi Liu, Ruiyang Liu, Tracy Lively, William J.R. Longabaugh, Teri A. Longacre, X. Cynthia, Mary C. Macedonia, Tyler Madison, Christopher A. Maher, Anirban Maitra, Netta Mäkinen, Danika Makowski, Carlo C. Maley, Zoltan Maliga, Diego Mallo, John M. Maris, Nick Markham, Jeffrey R. Marks, Daniel Martínez, R. Jay Mashl, Ignas Masilionais, Jennifer L. Mason, Joan Massagué, Pierre P. Massion, Marissa S. Mattar, Richard Mazurchuk, Linas Mažutis, Sarah A. Mazzilli, Eliot T. McKinley, Joshua F. McMichael, Daniel T. Merrick, Matthew Meyerson, Julia R. Miessner, Gordon B. Mills, Meredith Mills, Suman Mondal, Motomi Mori, Yuriko Mori, Elizabeth Moses, Yaël P. Mossé, Jeremy L. Muhlich, Gëorge F. Murphy, Nicholas E. Navin, Tal Nawy, Michel Nederlof, Reid M. Ness, Stephanie Nevins, Milen Nikolov, Ajit J. Nirmal, Garry P. Nolan, Edward Novikov, Philipp Oberdoerffer, Brendan L. O’Connell, Michael Offin, Stephen T. Oh, Anastasiya Olson, Alex Ooms, Miguel Ossandon, Kouros Owzar, Swapnil Parmar, Tasleema Patel, Gary J. Patti, Dana Pe’er, Itsik Pe'er, Tao Peng, Daniel Persson, Marvin Petty, Hanspeter Pfister, Kornélia Polyák, Kamyar Esmaeili Pourfarhangi, Sidharth V. Puram, Qi Qiu, Àlvaro Quintanal-Villalonga, Arjun Raj, Marisol Ramirez‐Solano, Rumana Rashid, Ashley N. Reeb, Aviv Regev, Mary E. Reid, Adam Resnick, Sheila M. Reynolds, Jessica L. Riesterer, Scott J. Rodig, Joseph T. Roland, Sonia Rosenfield, Asaf Rotem, Sudipta Roy, Orit Rozenblatt–Rosen, Charles M. Rudin, Marc D. Ryser, Sandro Santagata, Maria Santi-Vicini, Kazuhito Sato, Denis Schapiro, Deborah Schrag, Nikolaus Schultz, Cynthia L. Sears, Rosalie C. Sears, Subrata Sen, Triparna Sen, Alex K. Shalek, Jeff Sheng, Quanhu Sheng, Kooresh I. Shoghi, Martha J. Shrubsole, Yu Shyr, Alexander B. Sibley, Kiara Siex, Alan J. Simmons, Dinah S. Singer, Shamilene Sivagnanam, Michal Slyper, M Snyder, Artem Sokolov, Sheng-Kwei Song, Peter K. Sorger, Austin N. Southard-Smith, Avrum Spira, Sudhir Srivastava, Janet M. Stein, Phillip B. Storm, Elizabeth H. Stover, Siri H. Strand, Timothy Su, Damir Sudar, Ryan J. Sullivan, Lea F. Surrey, Mario L. Suvà, Kai Tan, Nadezhda V. Terekhanova, Luke Ternes, Lisa Thammavong, Guillaume Thibault, George Thomas, Vésteinn Thórsson, Ellen Todres, Linh M. Tran, Madison Tyler, Yasin Uzun, Anil Vachani, Eliezer M. Van Allen, Simon Vandekar, Deborah J. Veis, Sébastien Vigneau, Arastoo Vossough, Angela J. Waanders, Nikhil Wagle, Liang-Bo Wang, Michael C. Wendl, Robert B. West, Elizabeth H. Williams, Chi-Yun Wu, Hao Wu, Hung‐Yi Wu, Matthew A. Wyczalkowski, Yubin Xie, Xiaolu Yang, Clarence Yapp, Wenbao Yu, Yinyin Yuan, Dadong Zhang, Kun Zhang, Mianlei Zhang, Nancy R. Zhang, Yantian Zhang, Yanyan Zhao, Daniel Cui Zhou, Zilu Zhou, Houxiang Zhu, Qin Zhu, Xiangzhu Zhu, Yuankun Zhu, Xiaowei Zhuang - Cell 2020 被引用: 615

Crucial transitions in cancer-including tumor initiation, local expansion, metastasis, and therapeutic resistance-involve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. The Human Tumor Atlas Network (HTAN), part of the National Cancer Institute (NCI) Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types. This effort complements both ongoing efforts to map healthy organs and previous large-scale cancer genomics approaches focused on bulk sequencing at a single point in time. Generating single-cell, multiparametric, longitudinal atlases and integrating them with clinical outcomes should help identify novel predictive biomarkers and features as well as therapeutically relevant cell types, cell states, and cellular interactions across transitions. The resulting tumor atlases should have a profound impact on our understanding of cancer biology and have the potential to improve cancer detection, prevention, and therapeutic discovery for better precision-medicine treatments of cancer patients and those at risk for cancer.