Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner

著者: Bojan Shutinoski, Mansoureh Hakimi, Irene E. Harmsen, Michaela Lunn, Juliana Dutra Barbosa da Rocha, Nathalie A. Lengacher, Yi Zhou, Jasmine M. Khan, Angela Nguyen, Quinton Hake-Volling, Daniel N. El-Kodsi, Juan Li, Azadeh Alikashani, Claudine Beauchamp, Jay Majithia, Kevin M. Coombs, Derya R. Shimshek, Paul C. Marcogliese, David S. Park, John D. Rioux, Dana J. Philpott, John Woulfe, Shawn Hayley, Subash Sad, Julianna J. Tomlinson, Earl G. Brown, Michael G. Schlossmacher - Science Translational Medicine 2019 被引用: 102

alleles may alter the course of microbial infections by modulating inflammation, and this may be dependent on the sex and genotype of the host as well as the type of pathogen.