Brian J. Abraham
Active 2011–2024
- 63
- Papers
- 27,753
- Citations
- 49
- h-index
- 61
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Biochemistry, Genetics and Molecular Biology67.8%
- Medicine21.7%
- Immunology and Microbiology5.2%
- Neuroscience1.5%
- Agricultural and Biological Sciences1.2%
- Chemistry0.6%
- Other2%
Topics
- Genomics and Chromatin Dynamics10.5%
- RNA Research and Splicing8.6%
- RNA modifications and cancer5.3%
- Epigenetics and DNA Methylation4.1%
- Protein Degradation and Inhibitors3.6%
- RNA and protein synthesis mechanisms2.8%
- Other65.1%
Coauthors
- Richard A. Young44
- Tong Ihn Lee15
- A. Thomas Look13
- Adam D. Durbin13
- Mark W. Zimmerman12
- Nathanael S. Gray10
- Nicholas Kwiatkowski10
- Denes Hnisz9
- Tinghu Zhang9
- Nancy M. Hannett8
- Nina Weichert‐Leahey7
- Abraham S. Weintraub6
- Alessandra Dall’Agnese6
- Yang Guo6
- Alicia V. Zamudio5
- Charles H. Li5
- Isaac A. Klein5
- James E. Bradner5
- Jurian Schuijers5
- Lena K. Afeyan5
- Rudolf Jaenisch5
- Ann Boija4
- Benjamin R. Sabari4
- Daniel S. Day4
All papers
- Coactivator condensation at super-enhancers links phase separation and gene control
Authors: Benjamin R. Sabari, Alessandra Dall’Agnese, Ann Boija, Isaac A. Klein, Eliot L. Coffey, Krishna Shrinivas, Brian J. Abraham, Nancy M. Hannett, Alicia V. Zamudio, John C. Manteiga, Charles H. Li, Yang Guo, Daniel S. Day, Jurian Schuijers, Eliza Vasile, Sohail Malik, Denes Hnisz, Tong Ihn Lee, Ibrahim I. Cissé, Robert G. Roeder, Phillip A. Sharp, Arup K. Chakraborty, Richard A. Young - Science 2018 cited by 2,769
- Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
Authors: Warren A. Whyte, David A. Orlando, Denes Hnisz, Brian J. Abraham, Charles Y. Lin, Michael H. Kagey, Peter B. Rahl, Tong Ihn Lee, Richard A. Young - Cell 2013 cited by 4,411
- Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains
Authors: Ann Boija, Isaac A. Klein, Benjamin R. Sabari, Alessandra Dall’Agnese, Eliot L. Coffey, Alicia V. Zamudio, Charles H. Li, Krishna Shrinivas, John C. Manteiga, Nancy M. Hannett, Brian J. Abraham, Lena K. Afeyan, Yang Guo, Jenna K. Rimel, Charli B. Fant, Jurian Schuijers, Tong Ihn Lee, Dylan J. Taatjes, Richard A. Young - Cell 2018 cited by 1,973
- Super-Enhancers in the Control of Cell Identity and Disease
Authors: Denes Hnisz, Brian J. Abraham, Tong Ihn Lee, Ashley Lau, Violaine Saint‐André, Alla A. Sigova, Heather A. Hoke, Richard A. Young - Cell 2013 cited by 3,930
- YY1 Is a Structural Regulator of Enhancer-Promoter Loops
Authors: Abraham S. Weintraub, Charles H. Li, Alicia V. Zamudio, Alla A. Sigova, Nancy M. Hannett, Daniel S. Day, Brian J. Abraham, Malkiel A. Cohen, Behnam Nabet, Dennis L. Buckley, Yang Guo, Denes Hnisz, Rudolf Jaenisch, James E. Bradner, Nathanael S. Gray, Richard A. Young - Cell 2017 cited by 1,099
- Pol II phosphorylation regulates a switch between transcriptional and splicing condensates
Authors: Yang Guo, John C. Manteiga, Jonathan E. Henninger, Benjamin R. Sabari, Alessandra Dall’Agnese, Nancy M. Hannett, Jan-Hendrik Spille, Lena K. Afeyan, Alicia V. Zamudio, Krishna Shrinivas, Brian J. Abraham, Ann Boija, Tim-Michael Decker, Jenna K. Rimel, Charli B. Fant, Tong Ihn Lee, Ibrahim I. Cissé, Phillip A. Sharp, Dylan J. Taatjes, Richard A. Young - Nature 2019 cited by 729
- Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
Authors: Nicholas Kwiatkowski, Tinghu Zhang, Peter B. Rahl, Brian J. Abraham, Jessica Reddy, Scott B. Ficarro, Anahita Dastur, Arnaud Amzallag, Sridhar Ramaswamy, Bethany Tesar, Catherine E. Jenkins, Nancy M. Hannett, Douglas W. McMillin, Takaomi Sanda, Taebo Sim, Nam Doo Kim, Thomas Look, Constantine S. Mitsiades, Andrew P. Weng, Jennifer R. Brown, Cyril H. Benes, Jarrod A. Marto, Richard A. Young, Nathanael S. Gray - Nature 2014 cited by 908
- An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element
Authors: Marc R. Mansour, Brian J. Abraham, Lars Anders, Alla Berezovskaya, Alejandro Gutiérrez, Adam D. Durbin, Julia Etchin, Lee N. Lawton, Stephen E. Sallan, Lewis B. Silverman, Mignon L. Loh, Stephen P. Hunger, Takaomi Sanda, Richard A. Young, A. Thomas Look - Science 2014 cited by 829
- EP300 Selectively Controls the Enhancer Landscape of MYCN -Amplified Neuroblastoma
Authors: Adam D. Durbin, Tingjian Wang, Virangika K. Wimalasena, Mark W. Zimmerman, Deyao Li, Neekesh V. Dharia, Luca Mariani, Noha A.M. Shendy, Stephanie Nance, Anand G. Patel, Ying Shao, Maya Mundada, Lily Maxham, Paul M.C. Park, Logan H. Sigua, Ken Morita, Amy Saur Conway, Amanda L. Robichaud, Antonio R. Pérez‐Atayde, Melissa J. Bikowitz, Taylor R. Quinn, Olaf Wiest, John Easton, E. Schönbrunn, Martha L. Bulyk, Brian J. Abraham, Kimberly Stegmaier, A. Thomas Look, Jun Qi - Cancer Discovery 2021 cited by 163
- Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes
Authors: Alicia V. Zamudio, Alessandra Dall’Agnese, Jonathan E. Henninger, John C. Manteiga, Lena K. Afeyan, Nancy M. Hannett, Eliot L. Coffey, Charles H. Li, Ozgur Oksuz, Benjamin R. Sabari, Ann Boija, Isaac A. Klein, Susana Wilson Hawken, Jan-Hendrik Spille, Tim-Michael Decker, Ibrahim I. Cissé, Brian J. Abraham, Tong I. Lee, Dylan J. Taatjes, Jurian Schuijers, Richard A. Young - Molecular Cell 2019 cited by 302
- Control of Cell Identity Genes Occurs in Insulated Neighborhoods in Mammalian Chromosomes
Authors: Jill M. Dowen, Zi Peng Fan, Denes Hnisz, Gang Ren, Brian J. Abraham, Lyndon N. Zhang, Abraham S. Weintraub, Jurian Schuijers, Tong Ihn Lee, Keji Zhao, Richard A. Young - Cell 2014 cited by 949
- CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer
Authors: Edmond Chipumuro, Eugenio Marco, Camilla L. Christensen, Nicholas Kwiatkowski, Tinghu Zhang, Clark M. Hatheway, Brian J. Abraham, Bandana Sharma, Caleb M. Yeung, Abigail Altabef, Antonio R. Pérez‐Atayde, Kwok‐Kin Wong, Guo‐Cheng Yuan, Nathanael S. Gray, Richard A. Young, Rani E. George - Cell 2014 cited by 663
- Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers
Authors: Denes Hnisz, Jurian Schuijers, Charles Y. Lin, Brian J. Abraham, Tong Ihn Lee, James E. Bradner, Abraham S. Weintraub, Richard A. Young - Molecular Cell 2015 cited by 506
- CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer
Authors: Yubao Wang, Tinghu Zhang, Nicholas Kwiatkowski, Brian J. Abraham, Tong Ihn Lee, Shaozhen Xie, Haluk Yuzugullu, Thanh Von, Heyuan Li, Ziao Lin, Daniel G. Stover, Elgene Lim, Zhigang C. Wang, J. Dirk Iglehart, Richard A. Young, Nathanael S. Gray, Jean J. Zhao - Cell 2015 cited by 493
- The long noncoding RNA Wisper controls cardiac fibrosis and remodeling
Authors: Rudi Micheletti, Isabelle Plaisance, Brian J. Abraham, Alexandre Sarre, Ching-Chia Ting, Michael Alexanian, Daniel Maric, Damien Maison, Mohamed Nemir, Richard A. Young, Blanche Schroen, Arantxa González, Samir Ounzain, Thierry Pedrazzini - Science Translational Medicine 2017 cited by 337
- Transcription factor trapping by RNA in gene regulatory elements
Authors: Alla A. Sigova, Brian J. Abraham, Ji Xiong, Benoit Molinié, Nancy M. Hannett, Yang Guo, Mohini Jangi, Cosmas Giallourakis, Phillip A. Sharp, Richard A. Young - Science 2015 cited by 527
- Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression
Authors: Frank Soldner, Yonatan Stelzer, Chikdu Shivalila, Brian J. Abraham, Jeanne C. Latourelle, M. Inmaculada Barrasa, Johanna Goldmann, Richard H. Myers, Richard A. Young, Rudolf Jaenisch - Nature 2016 cited by 527
- Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry
Authors: Adam D. Durbin, Mark W. Zimmerman, Neekesh V. Dharia, Brian J. Abraham, Amanda Balboni Iniguez, Nina Weichert‐Leahey, Shuning He, John M. Krill-Burger, David E. Root, Francisca Vázquez, Aviad Tsherniak, William C. Hahn, Todd R. Golub, Richard A. Young, A. Thomas Look, Kimberly Stegmaier - Nature Genetics 2018 cited by 302
- Models of human core transcriptional regulatory circuitries
Authors: Violaine Saint‐André, Alexander Federation, Charles Y. Lin, Brian J. Abraham, Jessica Reddy, Tong Ihn Lee, James E. Bradner, Richard A. Young - Genome Research 2016 cited by 313
- A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer
Authors: Paola Betancur, Brian J. Abraham, Ying Ying Yiu, Stephen B. Willingham, Farnaz Khameneh, Mark A. Zarnegar, Angera H. Kuo, Kelly M. McKenna, Yoko Kojima, Nicholas J. Leeper, Po Y. Ho, Phung Gip, Tomek Swigut, Richard I. Sherwood, Michael F. Clarke, George Somlo, Richard A. Young, Irving L. Weissman - Nature Communications 2017 cited by 231
- Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
Authors: Tinghu Zhang, Nicholas Kwiatkowski, Calla M Olson, Sarah E. Dixon-Clarke, Brian J. Abraham, Ann Katrin Greifenberg, Scott B. Ficarro, Jonathan M. Elkins, Yanke Liang, Nancy M. Hannett, Theresa Manz, Mingfeng Hao, Bartlomiej Bartkowiak, Arno L. Greenleaf, Jarrod A. Marto, Matthias Geyer, Alex N. Bullock, Richard A. Young, Nathanael S. Gray - Nature Chemical Biology 2016 cited by 372
- MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification
Authors: Mark W. Zimmerman, Yu Liu, Shuning He, Adam D. Durbin, Brian J. Abraham, John Easton, Ying Shao, Beisi Xu, Shizhen Zhu, Xiaoling Zhang, Zhaodong Li, Nina Weichert‐Leahey, Richard A. Young, Jinghui Zhang, A. Thomas Look - Cancer Discovery 2017 cited by 237
- Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas
Authors: Victoria Clark, Akdes Serin Harmancı, Hanwen Bai, Mark W. Youngblood, Tong Ihn Lee, Jacob F. Baranoski, A. Gulhan Ercan‐Sencicek, Brian J. Abraham, Abraham S. Weintraub, Denes Hnisz, Matthias Simon, Boris Krischek, E. Zeynep Erson‐Omay, Octavian Henegariu, Geneive Carrión-Grant, Ketu Mishra-Gorur, Daniel Durán, Johanna Goldmann, Johannes Schramm, Roland Goldbrunner, Joseph M. Piepmeier, Alexander O. Vortmeyer, Jennifer Moliterno Günel, Kaya Bilgüvar, Katsuhito Yasuno, Richard A. Young, Murat Günel - Nature Genetics 2016 cited by 357
- Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor
Authors: Camilla L. Christensen, Nicholas Kwiatkowski, Brian J. Abraham, Julián Carretero, Fátima Al‐Shahrour, Tinghu Zhang, Edmond Chipumuro, Grit S. Herter-Sprie, Esra A. Akbay, Abigail Altabef, Jianming Zhang, Takeshi Shimamura, Marzia Capelletti, Jakob B. Reibel, Jillian D. Cavanaugh, Peng Gao, Yan Liu, Signe Regner Michaelsen, Hans Skovgaard Poulsen, Amir Reza Aref, David A. Barbie, James E. Bradner, Rani E. George, Nathanael S. Gray, Richard A. Young, Kwok‐Kin Wong - Cancer Cell 2014 cited by 458
