litlas
Log inCreate account

Christopher W. Pugh

Active 1981–2025

94
Papers
41,198
Citations
80
h-index
93
i10-index

Citations

Citations per year for Christopher W. Pugh1926: 1 citations1967: 1 citations1970: 1 citations1982: 7 citations1983: 13 citations1984: 6 citations1985: 12 citations1986: 19 citations1987: 8 citations1988: 5 citations1989: 20 citations1990: 11 citations1991: 8 citations1992: 9 citations1993: 27 citations1994: 21 citations1995: 41 citations1996: 51 citations1997: 68 citations1998: 121 citations1999: 129 citations2000: 245 citations2001: 393 citations2002: 608 citations2003: 845 citations2004: 841 citations2005: 757 citations2006: 702 citations2007: 627 citations2008: 602 citations2009: 720 citations2010: 541 citations2011: 544 citations2012: 479 citations2013: 538 citations2014: 392 citations2015: 407 citations2016: 479 citations2017: 403 citations2018: 353 citations2019: 1,049 citations2020: 1,204 citations2021: 1,038 citations2022: 826 citations2023: 584 citations2024: 873 citations2025: 389 citations2026: 20 citations1927–1966: no citations, so these years are not shown1968–1969: no citations, so these years are not shown1971–1981: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 4,001 citing papers, 28.8% of this breakdownUnited Kingdom: 1,437 citing papers, 10.3% of this breakdownChina: 1,428 citing papers, 10.3% of this breakdownGermany: 790 citing papers, 5.7% of this breakdownJapan: 575 citing papers, 4.1% of this breakdownItaly: 489 citing papers, 3.5% of this breakdownCanada: 467 citing papers, 3.3% of this breakdownFrance: 414 citing papers, 3% of this breakdownNetherlands: 293 citing papers, 2.1% of this breakdownSwitzerland: 289 citing papers, 2.1% of this breakdownAustralia: 267 citing papers, 1.9% of this breakdownSpain: 264 citing papers, 1.9% of this breakdown
0%28.8%Other 23%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology62.2%
  • Medicine22.6%
  • Immunology and Microbiology5.1%
  • Engineering4.5%
  • Neuroscience1.7%
  • Environmental Science0.8%
  • Other3.1%

Topics

  • Cancer, Hypoxia, and Metabolism16.1%
  • Mitochondrial Function and Pathology2.9%
  • High Altitude and Hypoxia2.6%
  • Angiogenesis and VEGF in Cancer2.4%
  • Epigenetics and DNA Methylation2.4%
  • RNA modifications and cancer2.4%
  • Other71.2%

Coauthors

All papers

Open in search
  1. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

    Authors: Panu Jaakkola, David R. Mole, Ya‐Min Tian, Michael Wilson, Adriana Gielbert, Simon J. Gaskell, Alex von Kriegsheim, Holger Hebestreit, Mridul Mukherji, Christopher J. Schofield, Patrick H. Maxwell, Christopher W. Pugh, Peter J. Ratcliffe - Science 2001 cited by 5,538

  2. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

    Authors: Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang, Steven C. Clifford, Emma C. Vaux, Matthew E. Cockman, Charles C. Wykoff, Christopher W. Pugh, Eamonn R. Maher, Peter J. Ratcliffe - Nature 1999 cited by 5,225

  3. C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

    Authors: Andrew Epstein, Jonathan Gleadle, Luke A. McNeill, Kirsty S. Hewitson, John P. O’Rourke, David R. Mole, Mridul Mukherji, Eric Metzen, Michael Wilson, Anu Dhanda, Ya‐Min Tian, Norma Masson, Donald L. Hamilton, Panu Jaakkola, Robert Barstead, Jonathan Hodgkin, Patrick H. Maxwell, Christopher W. Pugh, Christopher J. Schofield, Peter J. Ratcliffe - Cell 2001 cited by 3,353

  4. Regulation of angiogenesis by hypoxia: role of the HIF system

    Authors: Christopher W. Pugh, Peter J. Ratcliffe - Nature Medicine 2003 cited by 2,511

  5. Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL

    Authors: Wai‐Ching Hon, Michael Wilson, Karl Harlos, Timothy D. W. Claridge, Christopher J. Schofield, Christopher W. Pugh, Patrick H. Maxwell, Peter J. Ratcliffe, David I. Stuart, E. Yvonne Jones - Nature 2002 cited by 753

  6. Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

    Authors: Julie Adam, Emine Hatipoglu, Linda O′Flaherty, Nicola Ternette, Natasha Sahgal, Helen Lockstone, Dilair Baban, Emma Nye, Gordon Stamp, Kathryn Wolhuter, Marcus Stevens, Román Fischer, Peter Carmeliet, Patrick H. Maxwell, Christopher W. Pugh, Norma Frizzell, Tomoyoshi Soga, Benedikt M. Kessler, Mona El‐Bahrawy, Peter J. Ratcliffe, Patrick J. Pollard - Cancer Cell 2011 cited by 578

  7. Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor

    Authors: Rebecca J. Appelhoff, Ya‐Min Tian, Raju R. Raval, Helen Turley, Adrian L. Harris, Christopher W. Pugh, Peter J. Ratcliffe, Jonathan Gleadle - Journal of Biological Chemistry 2004 cited by 1,106

  8. High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

    Authors: Johannes Schödel, Spyros Oikonomopoulos, Jiannis Ragoussis, Christopher W. Pugh, Peter J. Ratcliffe, David R. Mole - Blood 2011 cited by 734

  9. Non-contact video-based vital sign monitoring using ambient light and auto-regressive models

    Authors: Lionel Tarassenko, Mauricio Villarroel, Alessandro Guazzi, João Jorge, David A. Clifton, Christopher W. Pugh - Physiological Measurement 2014 cited by 415

  10. Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

    Authors: Ananda S. Mirchandani, Stephen J. Jenkins, Calum C. Bain, Manuel A. Sánchez-García, Hannah Lawson, Patrícia Coelho, Fiona Murphy, David Griffith, Ailiang Zhang, Tyler Morrison, Tony Ly, Simone Arienti, Pranvera Sadiku, Emily Watts, Rebecca Dickinson, Leila Reyes, George Cooper, Sarah A. Clark, David Lewis, Van Kelly, Christos Spanos, Kathryn Musgrave, Liam Delaney, I. Harper, Jonathan Scott, Nick Parkinson, Anthony Rostron, J. Kenneth Baillie, Sara Clohisey, Clare Pridans, Lara Campana, Philip Starkey Lewis, A. John Simpson, David H. Dockrell, Jürgen Schwarze, Nikhil Hirani, Peter J. Ratcliffe, Christopher W. Pugh, Kamil R. Kranc, Stuart J. Forbes, Moira K. B. Whyte, Sarah R. Walmsley - Nature Immunology 2022 cited by 80

  11. The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

    Authors: Katherine Louise Talks, Helen Turley, Kevin C. Gatter, Patrick H. Maxwell, Christopher W. Pugh, Peter J. Ratcliffe, Adrian L. Harris - American Journal Of Pathology 2000 cited by 1,303

  12. Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs

    Authors: Michael S. Wiesener, Jan Steffen Jürgensen, Christian Rosenberger, Charlotte Scholze, Jan Hörstrup, Christina Warnecke, Stefano J. Mandriota, Ingo Bechmann, Ulrich Frei, Christopher W. Pugh, Peter J. Ratcliffe, Sebastian Bachmann, Patrick H. Maxwell, Kai‐Uwe Eckardt - The FASEB Journal 2002 cited by 734

  13. Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

    Authors: Charles C. Wykoff, Nigel Beasley, Peter H. Watson, Kevin Turner, Jaromı́r Pastorek, Amen Sibtain, George D. Wilson, Helen Turley, Kate Talks, Patrick H. Maxwell, Christopher W. Pugh, Peter J. Ratcliffe, Adrian L. Harris - 2000 cited by 1,284

  14. Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma

    Authors: Raju R. Raval, Kah Weng Lau, Maxine Tran, Heidi Sowter, Stefano J. Mandriota, Jiliang Li, Christopher W. Pugh, Patrick H. Maxwell, Adrian L. Harris, Peter J. Ratcliffe - Molecular and Cellular Biology 2005 cited by 933

  15. Photoplethysmographic derivation of respiratory rate: a review of relevant physiology

    Authors: David Meredith, David A. Clifton, Peter Charlton, John K Brooks, Christopher W. Pugh, Lionel Tarassenko - Journal of Medical Engineering & Technology 2011 cited by 228

  16. Multiparameter persistent homology landscapes identify immune cell spatial patterns in tumors

    Authors: Oliver Vipond, Joshua A. Bull, Philip S. Macklin, Ulrike Tillmann, Christopher W. Pugh, Helen M. Byrne, Heather A. Harrington - National Academy of Sciences, Proceedings of the National Academy of Sciences 2021 cited by 88

  17. New horizons in hypoxia signaling pathways

    Authors: Christopher W. Pugh, Peter J. Ratcliffe - Experimental Cell Research 2017 cited by 183

  18. Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

    Authors: Jenny C. Taylor, Hilary C. Martin, Stefano Lise, John Broxholme, Jean‐Baptiste Cazier, Andy Rimmer, Alexander Kanapin, Gerton Lunter, Simon Fiddy, Chris Allan, A.R. Aricescu, Moustafa Attar, Christian Babbs, Jennifer Becq, David Beeson, Celeste Bento, P Bignell, Edward Blair, Veronica J. Buckle, Katherine R. Bull, Ondřej Cais, Holger Cario, Helen Chapel, Richard R. Copley, Richard J. Cornall, Jude Craft, Karin Dahan, Emma E. Davenport, Calliope A. Dendrou, Olivier Devuyst, Aimée L Fenwick, Jonathan Flint, Lars Fugger, Rodney D. Gilbert, Anne Goriely, Angie Green, Ingo H. Greger, Russell Grocock, Anja V. Gruszczyk, Robert Hastings, Edouard Hatton, Douglas R. Higgs, Adrian V. S. Hill, Chris Holmes, Malcolm F. Howard, Linda Hughes, Peter Humburg, David H. Johnson, Fredrik Karpe, Zoya Kingsbury, Usha Kini, Julian C. Knight, Jonathan Krohn, Sarah Lamble, Craig B. Langman, Lorne Lonie, Joshua Luck, Davis J. McCarthy, Simon J. McGowan, Mary Frances McMullin, Kerry A. Miller, Lisa Murray, Andrea H. Németh, M. Andrew Nesbit, David Nutt, Elizabeth Ormondroyd, Annette Oturai, Alistair T. Pagnamenta, Smita Y. Patel, Melanie J. Percy, Nayia Petousi, Paolo Piazza, Siân E. Piret, Guadalupe Polanco‐Echeverry, Niko Popitsch, Fiona Powrie, Christopher W. Pugh, Lynn Quek, Peter A. Robbins, Kathryn Robson, Alexandra Russo, Natasha Sahgal, Pauline A. van Schouwenburg, Anna Schuh, Earl D. Silverman, Alison Simmons, Per Soelberg Sørensen, Elizabeth Sweeney, John Taylor, Rajesh V. Thakker, Ian Tomlinson, Amy Trebes, Stephen R.F. Twigg, Holm H. Uhlig, Paresh Vyas, Tim J. Vyse, Steven A. Wall, Hugh Watkins, Michael P. Whyte, Lorna Witty and 10 more - Nature Genetics 2015 cited by 388

  19. Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases

    Authors: Alistair T. Pagnamenta, Carlos Camps, Edoardo Giacopuzzi, John Taylor, Mona Hashim, Eduardo Calpena, Pamela J. Kaisaki, Akiko Hashimoto, Jing Yu, Edward Sanders, Ron Schweßinger, Jim R. Hughes, Gerton Lunter, Hélène Dreau, Matteo P. Ferla, Lukas Lange, Yeşim Kesim, Vassilis Ragoussis, Dimitrios V. Vavoulis, Holger Allroggen, Olaf Ansorge, Christian Babbs, Siddharth Banka, Benito Baños-Piñero, David Beeson, Tal Ben‐Ami, David Bennett, Celeste Bento, Edward Blair, Charlotte Brasch‐Andersen, Katherine R. Bull, Holger Cario, Deirdre Cilliers, Valerio Conti, E. Graham Davies, Fatima Dhalla, Beatriz Diez Dacal, Dong Yin, James E. Dunford, Renzo Guerrini, Adrian L. Harris, Jane Hartley, Georg A. Holländer, M K Javaid, Maureen A. Kane, Déirdre Kelly, Dominic F. Kelly, Samantha J.L. Knight, Alexandra Y. Kreins, Erika Kvikstad, Craig B. Langman, Tracy Lester, Kate E Lines, Simon Lord, Xin Lü, Sahar Mansour, Adnan Manzur, Reza Maroofian, Brian D. Marsden, Joanne Mason, Simon J. McGowan, Davide Mei, Hana Mlčochová, Yoshiko Murakami, Andrea H. Németh, Steven Okoli, Elizabeth Ormondroyd, Lilian Bomme Ousager, Jacqueline Palace, Smita Y. Patel, Melissa M. Pentony, Christopher W. Pugh, Abolfazl Rad, Archana Ramesh, Simone G. Riva, Irene Roberts, Noémi Roy, Outi Salminen, Kyleen D. Schilling, Caroline Scott, Arjune Sen, Conrad Smith, Mark Stevenson, Rajesh V. Thakker, Stephen R.F. Twigg, Holm H. Uhlig, Richard van Wijk, Barbara Vona, Steven A. Wall, Jing Wang, Hugh Watkins, Jaroslav Žák, Anna Schuh, Usha Kini, Andrew O.M. Wilkie, Niko Popitsch, Jenny C. Taylor - Genome Medicine 2023 cited by 72

  20. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

    Authors: Patrick H. Maxwell, Gabi U. Dachs, Jonathan Gleadle, Lynn G. Nicholls, Adrian L. Harris, Ian J. Stratford, Oliver Hankinson, Christopher W. Pugh, Peter J. Ratcliffe - National Academy of Sciences, Proceedings of the National Academy of Sciences 1997 cited by 1,084

  21. Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

    Authors: Matthew E. Cockman, Norma Masson, David R. Mole, Panu Jaakkola, Gin-Wen Chang, Steven C. Clifford, Eamonn R. Maher, Christopher W. Pugh, Peter J. Ratcliffe, Patrick H. Maxwell - Journal of Biological Chemistry 2000 cited by 1,047

  22. Aberrant succination of proteins in fumarate hydratase‐deficient mice and HLRCC patients is a robust biomarker of mutation status

    Authors: Chiara Bardella, Mona El‐Bahrawy, Norma Frizzell, Julie Adam, Nicola Ternette, Emine Hatipoglu, Kimberley Howarth, Linda O′Flaherty, Ian Roberts, Gareth D. H. Turner, Jennifer Taylor, Konstantinos Giaslakiotis, Valentine M. Macaulay, Adrian L. Harris, Ashish Chandra, Heli Lehtonen, Virpi Launonen, Lauri A. Aaltonen, Christopher W. Pugh, Radu Mihai, David C. Trudgian, Benedikt M. Kessler, John Baynes, Peter J. Ratcliffe, Ian Tomlinson, Patrick J. Pollard - The Journal of Pathology 2011 cited by 279

  23. Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

    Authors: Tzu‐Lan Yeh, T.M. Leissing, Martine I. Abboud, Cyrille C. Thinnes, Onur Atasoylu, James P. Holt‐Martyn, Dong Zhang, Anthony Tumber, Kerstin Lippl, Christopher T. Lohans, Ivanhoe K. H. Leung, Helen Morcrette, I.J. Clifton, Timothy D. W. Claridge, Akane Kawamura, Emily Flashman, Xin Lü, Peter J. Ratcliffe, Rasheduzzaman Chowdhury, Christopher W. Pugh, Christopher J. Schofield - Chemical Science 2017 cited by 226

  24. Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

    Authors: Xiaotong Cheng, Maria Prange‐Barczynska, James W. Fielding, Minghao Zhang, Alana Burrell, Joanna D.C.C. Lima, Luise Eckardt, Isobel L.A. Argles, Christopher W. Pugh, Keith J. Buckler, Peter A. Robbins, Emma J. Hodson, Richard K. Bruick, Lucy Collinson, Fraydoon Rastinejad, Tammie Bishop, Peter J. Ratcliffe - Journal of Clinical Investigation 2020 cited by 58