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David R. Mole

Active 2000–2025

63
Papers
18,162
Citations
46
h-index
59
i10-index

Citations

Citations per year for David R. Mole1990: 1 citations1999: 1 citations2000: 7 citations2001: 87 citations2002: 231 citations2003: 302 citations2004: 287 citations2005: 265 citations2006: 256 citations2007: 208 citations2008: 207 citations2009: 241 citations2010: 220 citations2011: 237 citations2012: 216 citations2013: 251 citations2014: 225 citations2015: 236 citations2016: 266 citations2017: 242 citations2018: 196 citations2019: 556 citations2020: 653 citations2021: 610 citations2022: 505 citations2023: 313 citations2024: 448 citations2025: 203 citations2026: 4 citations1991–1998: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 2,205 citing papers, 27.7% of this breakdownChina: 1,051 citing papers, 13.2% of this breakdownUnited Kingdom: 768 citing papers, 9.7% of this breakdownGermany: 452 citing papers, 5.7% of this breakdownJapan: 284 citing papers, 3.6% of this breakdownCanada: 281 citing papers, 3.5% of this breakdownAustralia: 232 citing papers, 2.9% of this breakdownItaly: 229 citing papers, 2.9% of this breakdownFrance: 226 citing papers, 2.8% of this breakdownSwitzerland: 155 citing papers, 1.9% of this breakdownSpain: 150 citing papers, 1.9% of this breakdownSouth Korea: 129 citing papers, 1.6% of this breakdown
0%27.7%Other 22.6%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology69.2%
  • Medicine20.4%
  • Earth and Planetary Sciences2.6%
  • Immunology and Microbiology2.6%
  • Neuroscience1.2%
  • Environmental Science0.7%
  • Other3.3%

Topics

  • Cancer, Hypoxia, and Metabolism17.9%
  • RNA modifications and cancer4.2%
  • Mitochondrial Function and Pathology3.6%
  • Epigenetics and DNA Methylation3.4%
  • High Altitude and Hypoxia3.3%
  • Cancer-related molecular mechanisms research2.5%
  • Other65.1%

Coauthors

All papers

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  1. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

    Authors: Panu Jaakkola, David R. Mole, Ya‐Min Tian, Michael Wilson, Adriana Gielbert, Simon J. Gaskell, Alex von Kriegsheim, Holger Hebestreit, Mridul Mukherji, Christopher J. Schofield, Patrick H. Maxwell, Christopher W. Pugh, Peter J. Ratcliffe - Science 2001 cited by 5,538

  2. C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

    Authors: Andrew Epstein, Jonathan Gleadle, Luke A. McNeill, Kirsty S. Hewitson, John P. O’Rourke, David R. Mole, Mridul Mukherji, Eric Metzen, Michael Wilson, Anu Dhanda, Ya‐Min Tian, Norma Masson, Donald L. Hamilton, Panu Jaakkola, Robert Barstead, Jonathan Hodgkin, Patrick H. Maxwell, Christopher W. Pugh, Christopher J. Schofield, Peter J. Ratcliffe - Cell 2001 cited by 3,353

  3. Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer

    Authors: Johannes Schödel, Steffen Grampp, Eamonn R. Maher, Holger Moch, Peter J. Ratcliffe, Paul Russo, David R. Mole - European Urology 2015 cited by 423

  4. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability

    Authors: Jennifer S. Isaacs, Yun Jin Jung, David R. Mole, Sunmin Lee, Carlos A. Torres‐Cabala, Yuen‐Li Chung, Maria J. Merino, Jane B. Trepel, Berton Zbar, Jorge R. Toro, Peter J. Ratcliffe, W. Marston Linehan, Len Neckers - Cancer Cell 2005 cited by 942

  5. High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

    Authors: Johannes Schödel, Spyros Oikonomopoulos, Jiannis Ragoussis, Christopher W. Pugh, Peter J. Ratcliffe, David R. Mole - Blood 2011 cited by 734

  6. Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

    Authors: David R. Mole, Christine Blancher, Richard R. Copley, Patrick J. Pollard, Jonathan Gleadle, Jiannis Ragoussis, Peter J. Ratcliffe - Journal of Biological Chemistry 2009 cited by 550

  7. The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes

    Authors: Brian M. Ortmann, Natalie Burrows, Ian Lobb, Esther Arnaiz, Niek Wit, Peter S. J. Bailey, Louise Jordon, Olivia Lombardi, Ana Peñalver, James McCaffrey, Rachel Seear, David R. Mole, Peter J. Ratcliffe, Patrick H. Maxwell, James A. Nathan - Nature Genetics 2021 cited by 84

  8. Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin

    Authors: James Smythies, Min Sun, Norma Masson, Rafik Salama, Peter Simpson, Elizabeth Murray, Viviana K. Neumann, Matthew E. Cockman, Hani Choudhry, Peter J. Ratcliffe, David R. Mole - EMBO Reports 2018 cited by 203

  9. Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

    Authors: Matthew E. Cockman, Norma Masson, David R. Mole, Panu Jaakkola, Gin-Wen Chang, Steven C. Clifford, Eamonn R. Maher, Christopher W. Pugh, Peter J. Ratcliffe, Patrick H. Maxwell - Journal of Biological Chemistry 2000 cited by 1,047

  10. Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)

    Authors: Armin Thalhammer, Zuzana Bencokova, Rachel L. Poole, Christoph Loenarz, Julie Adam, Linda O′Flaherty, Johannes Schödel, David R. Mole, Konstantinos Giaslakiotis, Christopher J. Schofield, Ester M. Hammond, Peter J. Ratcliffe, Patrick J. Pollard - PLoS ONE 2011 cited by 153

  11. The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia

    Authors: María Tiana, Bárbara Acosta‐Iborra, Laura Puente-Santamaría, Pablo Hernansanz‐Agustín, Rebecca Worsley-Hunt, Norma Masson, Francisco García‐Río, David R. Mole, Peter J. Ratcliffe, Wyeth W. Wasserman, Benilde Jiménez, Luis del Peso - Nucleic Acids Research 2017 cited by 131

  12. Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel–Lindau Gene Mutation Status

    Authors: Yosra Messai, Sophie Gad, Muhammad Zaeem Noman, Gwénaël Le Teuff, Sophie Couvé, Bassam Janji, Solenne Florence Kammerer, Nathalie Rioux-Leclerc, Meriem Hasmim, Sophie Ferlicot, Véronique Baud, Arnaud Méjean, David R. Mole, Stéphane Richard, Alexander Eggermont, Laurence Albigès, Fathia Mami‐Chouaib, Bernard Escudier, Salem Chouaı̈b - European Urology 2015 cited by 176

  13. Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature

    Authors: Olivia Lombardi, Ran Li, Silvia Halim, Hani Choudhry, Peter J. Ratcliffe, David R. Mole - Cell Reports 2022 cited by 48

  14. Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival

    Authors: Hani Choudhry, Ashwag Albukhari, Matteo Morotti, Syed Haider, Daniela Moralli, James Smythies, Johannes Schödel, Catherine Green, Carme Camps, Francesca M. Buffa, Peter J. Ratcliffe, Jiannis Ragoussis, Adrian L. Harris, David R. Mole - Oncogene 2014 cited by 313

  15. The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia

    Authors: Ruth Schietke, Christina Warnecke, Ingrid Wacker, Johannes Schödel, David R. Mole, Valentina Câmpean, Kerstin Amann, Margarete Goppelt‐Struebe, Jürgen Behrens, Kai‐Uwe Eckardt, Michael S. Wiesener - Journal of Biological Chemistry 2009 cited by 251

  16. miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis

    Authors: Robert McCormick, Christopher Blick, Jiannis Ragoussis, J Schoedel, David R. Mole, Anna-Mary Young, Peter J. Selby, Rosamonde E. Banks, Adrian L. Harris - British Journal of Cancer 2013 cited by 189

  17. The formation of Neoarchean continental crust in the south-east Superior Craton by two distinct geodynamic processes

    Authors: David R. Mole, P. C. Thurston, J. H. Marsh, Richard A. Stern, J. A. Ayer, Laure Martin, Yongjun Lu - Precambrian Research 2021 cited by 102

  18. MITF controls the TCA cycle to modulate the melanoma hypoxia response

    Authors: Pakavarin Louphrasitthiphol, Ioanna Ledaki, Jagat Chauhan, Paola Falletta, Robert Siddaway, Francesca M. Buffa, David R. Mole, Tomoyoshi Soga, Colin R. Goding - Pigment Cell & Melanoma Research 2019 cited by 74

  19. Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

    Authors: Sonny Ang, Hua Chen, Kiichi Hirota, Victor R. Gordeuk, Jaroslav Jelı́nek, Yongli Guan, Enli Liu, Adelina Sergueeva, Galina Miasnikova, David R. Mole, Patrick H. Maxwell, David W. Stockton, Gregg L. Semenza, Josef T. Prchal - Nature Genetics 2002 cited by 506

  20. Capture‐C reveals preformed chromatin interactions between HIF‐binding sites and distant promoters

    Authors: James L. Platt, Rafik Salama, James Smythies, Hani Choudhry, James Davies, Jim R. Hughes, Peter J. Ratcliffe, David R. Mole - EMBO Reports 2016 cited by 77

  21. Hypoxic Regulation of Gene Transcription and Chromatin: Cause and Effect

    Authors: Jessica D. Kindrick, David R. Mole - International Journal of Molecular Sciences 2020 cited by 58

  22. Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI

    Authors: Victoria Lauer, Steffen Grampp, James L. Platt, Véronique N. Lafleur, Olivia Lombardi, Hani Choudhry, Franziska Kranz, Arndt Hartmann, Bernd Wullich, Atsushi Yamamoto, Mathew L. Coleman, Peter J. Ratcliffe, David R. Mole, Johannes Schödel - Journal of Biological Chemistry 2019 cited by 52

  23. Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

    Authors: Patrick J. Pollard, Christoph Loenarz, David R. Mole, M.A. McDonough, Jonathan Gleadle, Christopher J. Schofield, Peter J. Ratcliffe - Biochemical Journal 2008 cited by 293

  24. Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

    Authors: Mun Chiang Chan, Nicholas E. Ilott, Johannes Schödel, David Sims, Anthony Tumber, Kerstin Lippl, David R. Mole, Christopher W. Pugh, Peter J. Ratcliffe, Chris P. Ponting, Christopher J. Schofield - Journal of Biological Chemistry 2016 cited by 109