litlas
Log inCreate account

Len Neckers

Active 1976–2024

132
Papers
29,035
Citations
95
h-index
132
i10-index

Citations

Citations per year for Len Neckers1976: 1 citations1977: 1 citations1978: 2 citations1979: 1 citations1980: 2 citations1981: 3 citations1982: 4 citations1983: 3 citations1984: 21 citations1985: 25 citations1986: 16 citations1987: 24 citations1988: 14 citations1989: 18 citations1990: 34 citations1991: 47 citations1992: 50 citations1993: 49 citations1994: 47 citations1995: 38 citations1996: 52 citations1997: 88 citations1998: 128 citations1999: 147 citations2000: 160 citations2001: 147 citations2002: 186 citations2003: 274 citations2004: 334 citations2005: 387 citations2006: 337 citations2007: 335 citations2008: 383 citations2009: 397 citations2010: 389 citations2011: 456 citations2012: 409 citations2013: 367 citations2014: 357 citations2015: 288 citations2016: 307 citations2017: 237 citations2018: 273 citations2019: 750 citations2020: 682 citations2021: 648 citations2022: 522 citations2023: 332 citations2024: 548 citations2025: 288 citations2026: 5 citations

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 3,281 citing papers, 35.7% of this breakdownChina: 951 citing papers, 10.3% of this breakdownUnited Kingdom: 543 citing papers, 5.9% of this breakdownGermany: 514 citing papers, 5.6% of this breakdownItaly: 374 citing papers, 4.1% of this breakdownFrance: 299 citing papers, 3.2% of this breakdownCanada: 285 citing papers, 3.1% of this breakdownJapan: 283 citing papers, 3.1% of this breakdownIndia: 248 citing papers, 2.7% of this breakdownSouth Korea: 179 citing papers, 1.9% of this breakdownSpain: 165 citing papers, 1.8% of this breakdownSwitzerland: 157 citing papers, 1.7% of this breakdown
0%35.7%Other 20.9%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology64.9%
  • Medicine23.2%
  • Immunology and Microbiology4.6%
  • Neuroscience2.3%
  • Computer Science1%
  • Chemistry1%
  • Other3%

Topics

  • Heat shock proteins research10.5%
  • Cancer, Hypoxia, and Metabolism3.8%
  • Endoplasmic Reticulum Stress and Disease3.3%
  • Computational Drug Discovery Methods3%
  • Ubiquitin and proteasome pathways2.4%
  • ATP Synthase and ATPases Research2.2%
  • Other74.8%

Coauthors

All papers

Open in search
  1. Targeting the dynamic HSP90 complex in cancer

    Authors: Jane B. Trepel, Mehdi Mollapour, Giuseppe Giaccone, Len Neckers - Nature reviews. Cancer 2010 cited by 1,528

  2. Structural and functional complexity of HSP90 in cellular homeostasis and disease

    Authors: Gabriela Chiosis, Chander Singh Digwal, Jane B. Trepel, Len Neckers - Nature Reviews Molecular Cell Biology 2023 cited by 204

  3. Regulation and function of the human HSP90AA1 gene

    Authors: Abbey D. Zuehlke, Kristin Beebe, Len Neckers, Thomas L. Prince - Gene 2015 cited by 353

  4. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability

    Authors: Jennifer S. Isaacs, Yun Jin Jung, David R. Mole, Sunmin Lee, Carlos A. Torres‐Cabala, Yuen‐Li Chung, Maria J. Merino, Jane B. Trepel, Berton Zbar, Jorge R. Toro, Peter J. Ratcliffe, W. Marston Linehan, Len Neckers - Cancer Cell 2005 cited by 942

  5. Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

    Authors: Len Neckers, Paul Workman - Clinical Cancer Research 2012 cited by 903

  6. An update on the status of HSP90 inhibitors in cancer clinical trials

    Authors: Shraddha Rastogi, Abhinav Joshi, Nahoko Sato, Sunmin Lee, Min-Jung Lee, Jane B. Trepel, Len Neckers - Cell Stress and Chaperones 2024 cited by 103

  7. The Therapeutic Target Hsp90 and Cancer Hallmarks

    Authors: Yoshihiko Miyata, Hitoshi Nakamoto, Len Neckers - Current Pharmaceutical Design 2012 cited by 343

  8. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

    Authors: Luke Whitesell, Edward G. Mimnaugh, B. de Costa, Catherine E. Myers, Len Neckers - National Academy of Sciences, Proceedings of the National Academy of Sciences 1994 cited by 1,446

  9. HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation

    Authors: Toshiki Kijima, Thomas L. Prince, Megan L. Tigue, Kendrick Yim, Harvey Schwartz, Kristin Beebe, Sunmin Lee, Marek A. BudzyƄski, Heinric Williams, Jane B. Trepel, Lea Sistonen, Stuart K. Calderwood, Len Neckers - Scientific Reports 2018 cited by 148

  10. Drugging the Cancer Chaperone HSP90

    Authors: Paul Workman, Francis Burrows, Len Neckers, Neal Rosen - Annals of the New York Academy of Sciences 2007 cited by 522

  11. Update on Hsp90 Inhibitors in Clinical Trial

    Authors: Yoonhee Kim, S. Alarcon, S. Lee, M.-J. Lee, Giuseppe Giaccone, Len Neckers, Jane B. Trepel - Current Topics in Medicinal Chemistry 2009 cited by 307

  12. Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

    Authors: Byoung Heon Kang, Janet Plescia, Ho Young Song, Massimiliano Meli, Giorgio Colombo, Kristin Beebe, Bradley T. Scroggins, Len Neckers, Dario C. Altieri - Journal of Clinical Investigation 2009 cited by 242

  13. An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function

    Authors: Bradley T. Scroggins, Kenneth Robzyk, Dongxia Wang, Monica G. Marcu, Shinji Tsutsumi, Kristin Beebe, Robert J. Cotter, Sara J. Felts, David O. Toft, Larry M. Karnitz, Neal Rosen, Len Neckers - Molecular Cell 2007 cited by 411

  14. IL‐1ÎČ mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis

    Authors: Yunjin Jung, Jennifer S. Isaacs, Sunmin Lee, Jane B. Trepel, Len Neckers - The FASEB Journal 2003 cited by 675

  15. Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness

    Authors: Brenda K. Eustace, Takashi Sakurai, Jean K. Stewart, Dean Yimlamai, Christine Unger, Carol Zehetmeier, Blanca Lain, Claudia Torella, Stefan Henning, Gerald Beste, Bradley T. Scroggins, Len Neckers, Leodevico L. Ilag, Daniel G. Jay - Nature Cell Biology 2004 cited by 595

  16. Curcumin is an Inhibitor of p300 Histone Acetylatransferase

    Authors: Len Neckers, Jane B. Trepel, Sunmin Lee, Eun-Joo Chung, Min-Jung Lee, Yunjin Jung, Monica G. Marcu - Medicinal Chemistry 2006 cited by 307

  17. Post-translational modifications of Hsp90 and their contributions to chaperone regulation

    Authors: Mehdi Mollapour, Len Neckers - Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2011 cited by 290

  18. Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors

    Authors: Mehdi Mollapour, Dimitra Bourboulia, Kristin Beebe, Mark R. Woodford, Sigrun Polier, Anthony Hoang, Raju Chelluri, Yu Li, Ailan Guo, Min-Jung Lee, Elham Fotooh‐Abadi, Sahar Khan, Thomas L. Prince, Naoto Miyajima, Soichiro Yoshida, Shinji Tsutsumi, Wanping Xu, Barry Panaretou, William G. Stetler‐Stevenson, Gennady Bratslavsky, Jane B. Trepel, Chrisostomos Prodromou, Len Neckers - Molecular Cell 2014 cited by 130

  19. Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development

    Authors: Len Neckers, Brian S. J. Blagg, Timothy Haystead, Jane B. Trepel, Luke Whitesell, Didier Picard - Cell Stress and Chaperones 2018 cited by 128

  20. Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function

    Authors: Mehdi Mollapour, Shinji Tsutsumi, Alison C. Donnelly, Kristin Beebe, Mari Tokita, Min-Jung Lee, Sunmin Lee, Giulia Morra, Dimitra Bourboulia, Bradley T. Scroggins, Giorgio Colombo, Brian S. J. Blagg, Barry Panaretou, William G. Stetler‐Stevenson, Jane B. Trepel, Peter W. Piper, Chrisostomos Prodromou, Laurence H. Pearl, Len Neckers - Molecular Cell 2010 cited by 195

  21. Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein–Protein Interactions with Heat Shock Protein 70 (Hsp70)

    Authors: Hao Shao, Xiaokai Li, Michael A. Moses, Luke A. Gilbert, Chakrapani Kalyanaraman, Zapporah T. Young, Margarita Chernova, Sara N. Journey, Jonathan S. Weissman, Byron Hann, Matthew P. Jacobson, Len Neckers, Jason E. Gestwicki - Journal of Medicinal Chemistry 2018 cited by 120

  22. Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

    Authors: Wanping Xu, Monica G. Marcu, Xitong Yuan, Edward G. Mimnaugh, Cam Patterson, Len Neckers - National Academy of Sciences, Proceedings of the National Academy of Sciences 2002 cited by 430

  23. Hsp90 inhibitors as novel cancer chemotherapeutic agents

    Authors: Len Neckers - Trends in Molecular Medicine 2002 cited by 674

  24. Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells

    Authors: Andrea Rasola, Len Neckers, Didier Picard - Trends in Cell Biology 2014 cited by 140