Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI

Authors: Victoria Lauer, Steffen Grampp, James L. Platt, Véronique N. Lafleur, Olivia Lombardi, Hani Choudhry, Franziska Kranz, Arndt Hartmann, Bernd Wullich, Atsushi Yamamoto, Mathew L. Coleman, Peter J. Ratcliffe, David R. Mole, Johannes Schödel - Journal of Biological Chemistry 2019 cited by 52

promoter. Consistent with this we observe NICI-dependent regulation of glucose consumption and cell proliferation. Furthermore, NICI expression is regulated by the von Hippel-Lindau (VHL) tumor suppressor and is highly expressed in clear cell renal cell carcinoma (ccRCC), where SLC2A3 expression is associated with patient prognosis, implying an important role for the HIF/NICI/SLC2A3 axis in this malignancy.