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David Lyden

Active 1987–2025

98
Papers
51,313
Citations
74
h-index
97
i10-index

Citations

Citations per year for David Lyden1926: 2 citations1978: 3 citations1984: 2 citations1989: 1 citations1990: 1 citations1993: 3 citations1994: 3 citations1998: 3 citations1999: 8 citations2000: 20 citations2001: 35 citations2002: 89 citations2003: 300 citations2004: 295 citations2005: 352 citations2006: 419 citations2007: 367 citations2008: 411 citations2009: 368 citations2010: 408 citations2011: 349 citations2012: 365 citations2013: 452 citations2014: 475 citations2015: 504 citations2016: 700 citations2017: 865 citations2018: 910 citations2019: 2,301 citations2020: 2,608 citations2021: 2,969 citations2022: 2,252 citations2023: 1,732 citations2024: 2,293 citations2025: 1,262 citations2026: 63 citations1927–1977: no citations, so these years are not shown1979–1983: no citations, so these years are not shown1985–1988: no citations, so these years are not shown1991–1992: no citations, so these years are not shown1995–1997: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 6,086 citing papers, 25.7% of this breakdownChina: 4,127 citing papers, 17.5% of this breakdownGermany: 1,309 citing papers, 5.5% of this breakdownItaly: 1,136 citing papers, 4.8% of this breakdownUnited Kingdom: 1,068 citing papers, 4.5% of this breakdownJapan: 868 citing papers, 3.7% of this breakdownCanada: 638 citing papers, 2.7% of this breakdownFrance: 636 citing papers, 2.7% of this breakdownAustralia: 591 citing papers, 2.5% of this breakdownSpain: 561 citing papers, 2.4% of this breakdownNetherlands: 508 citing papers, 2.2% of this breakdownIndia: 436 citing papers, 1.8% of this breakdown
0%25.7%Other 24%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology57.5%
  • Medicine32%
  • Immunology and Microbiology6%
  • Engineering1.9%
  • Neuroscience0.8%
  • Materials Science0.7%
  • Other1.1%

Topics

  • Extracellular vesicles in disease12.5%
  • MicroRNA in disease regulation7.5%
  • Cancer Cells and Metastasis4.3%
  • Angiogenesis and VEGF in Cancer3%
  • Immune cells in cancer2.6%
  • RNA Interference and Gene Delivery2.5%
  • Other67.6%

Coauthors

All papers

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  1. Tumour exosome integrins determine organotropic metastasis

    Authors: Ayuko Hoshino, Bruno Costa‐Silva, Tang‐Long Shen, Gonçalo Rodrigues, Ayako Hashimoto, Milica Tešić Mark, Henrik Molina, Shinji Kohsaka, Angela Di Giannatale, Sophia Ceder, Swarnima Singh, Caitlin Williams, Nadine Soplop, Kunihiro Uryu, Lindsay A. Pharmer, Tari A. King, Linda Bojmar, Alexander E. Davies, Yonathan Ararso, Tuo Zhang, Haiying Zhang, Jonathan M. Hernandez, Joshua M. Weiss, Vanessa D Dumont-Cole, Kimberly Kramer, Leonard H. Wexler, Aru Narendran, Gary K. Schwartz, John H. Healey, Per Sandström, Knut Jørgen Labori, Elin H. Kure, Paul M. Grandgenett, Michael A. Hollingsworth, Maria de Sousa, Sukhwinder Kaur, Maneesh Jain, Kavita Mallya, Surinder K. Batra, William R. Jarnagin, Mary S. Brady, Øystein Fodstad, Volkmar Muller, Klaus Pantel, Andy J. Minn, Mina J. Bissell, Benjamin A. García, Yibin Kang, Vinagolu K. Rajasekhar, Cyrus M. Ghajar, Irina Matei, Héctor Peinado, Jacqueline Bromberg, David Lyden - Nature 2015 cited by 5,185

  2. Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

    Authors: Haiying Zhang, Daniela Freitas, Han Sang Kim, Kristina Ivana Fabijanic, Zhong Li, Haiyan Chen, Milica Tešić Mark, Henrik Molina, Alberto Benito‐Martín, Linda Bojmar, Justin Fang, Sham Rampersaud, Ayuko Hoshino, Irina Matei, Candia M. Kenific, Miho Nakajima, Anders P. Mutvei, Pasquale Sansone, Weston Buehring, Huajuan Wang, Juan Pablo Jiménez Navarro, Leona Cohen‐Gould, Navid Paknejad, Matthew Brendel, Katia Manova‐Todorova, Ana Magalhães, José Alexandre Ferreira, Hugo Osório, André M. N. Silva, Ashish C. Massey, Juan R. Cubillos‐Ruiz, Giuseppe Galletti, Paraskevi Giannakakou, Ana María Cuervo, John Blenis, Robert E. Schwartz, Mary Sue Brady, Héctor Peinado, Jacqueline Bromberg, Hiroshi Matsui, Celso A. Reis, David Lyden - Nature Cell Biology 2018 cited by 1,601

  3. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

    Authors: Héctor Peinado, Maša Alečković, Simon Lavotshkin, Irina Matei, Bruno Costa‐Silva, Gema Moreno‐Bueno, Marta Hergueta‐Redondo, Caitlin Williams, Guillermo García‐Santos, Cyrus M. Ghajar, Ayuko Nitadori-Hoshino, Caitlin Hoffman, Karen Badal, Benjamin A. Garcia, Margaret K. Callahan, Jianda Yuan, Vilma R. Martins, Johan Skog, Rosandra N. Kaplan, Mary S. Brady, Jedd D. Wolchok, Paul B. Chapman, Yibin Kang, Jacqueline Bromberg, David Lyden - Nature Medicine 2012 cited by 3,704

  4. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

    Authors: Bruno Costa‐Silva, Nicole M. Aiello, Allyson J. Ocean, Swarnima Singh, Haiying Zhang, Basant Kumar Thakur, Annette Becker, Ayuko Hoshino, Milica Tešić Mark, Henrik Molina, Jenny Xiang, Tuo Zhang, Till-Martin Theilen, Guillermo García‐Santos, Caitlin Williams, Yonathan Ararso, Yujie Huang, Gonçalo Rodrigues, Tang‐Long Shen, Knut Jørgen Labori, Inger Marie Bowitz Lothe, Elin H. Kure, Jonathan M. Hernandez, Alexandre Doussot, Saya H. Ebbesen, Paul M. Grandgenett, Michael A. Hollingsworth, Maneesh Jain, Kavita Mallya, Surinder K. Batra, William R. Jarnagin, Robert E. Schwartz, Irina Matei, Héctor Peinado, Ben Z. Stanger, Jacqueline Bromberg, David Lyden - Nature Cell Biology 2015 cited by 2,703

  5. Pre-metastatic niches: organ-specific homes for metastases

    Authors: Héctor Peinado, Haiying Zhang, Irina Matei, Bruno Costa‐Silva, Ayuko Hoshino, Gonçalo Rodrigues, Bethan Psaila, Rosandra N. Kaplan, Jacqueline Bromberg, Yibin Kang, Mina J. Bissell, Thomas R. Cox, Amato J. Giaccia, Janine T. Erler, Sachie Hiratsuka, Cyrus M. Ghajar, David Lyden - Nature reviews. Cancer 2017 cited by 1,861

  6. Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

    Authors: Annette Becker, Basant Kumar Thakur, Joshua M. Weiss, Han Sang Kim, Héctor Peinado, David Lyden - Cancer Cell 2016 cited by 2,034

  7. Exosome-Mediated Metastasis: Communication from a Distance

    Authors: Inbal Wortzel, Shani Dror, Candia M. Kenific, David Lyden - Developmental Cell 2019 cited by 1,333

  8. Double-stranded DNA in exosomes: a novel biomarker in cancer detection

    Authors: Basant Kumar Thakur, Haiying Zhang, Annette Becker, Irina Matei, Yujie Huang, Bruno Costa‐Silva, Yan Zheng, Ayuko Hoshino, Hélène Brazier, Jenny Xiang, Caitlin Williams, Ruth Rodríguez‐Barrueco, José M. Silva, Weijia Zhang, Stephen Hearn, Olivier Elemento, Navid Paknejad, Katia Manova‐Todorova, Karl Welte, Jacqueline Bromberg, Héctor Peinado, David Lyden - Cell Research 2014 cited by 1,567

  9. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

    Authors: Rosandra N. Kaplan, Rebecca D. Riba, Stergios Zacharoulis, Anna H. Bramley, Loı̈c Vincent, Carla Costa, Daniel D. MacDonald, David Jin, Koji Shido, Scott Kerns, Zhenping Zhu, Daniel J. Hicklin, Yan Wu, Jeffrey L. Port, Nasser K. Altorki, Elisa Port, Davide Ruggero, Sergey V. Shmelkov, Kristian K. Jensen, Shahin Rafii, David Lyden - Nature 2005 cited by 3,260

  10. Tumour extracellular vesicles and particles induce liver metabolic dysfunction

    Authors: Gang Wang, Jianlong Li, Linda Bojmar, Haiyan Chen, Zhong Li, Gabriel Cardial Tobias, Mengying Hu, Edwin A. Homan, Serena Lucotti, Fengbo Zhao, Valentina Posada, Peter R. Oxley, Michele Cioffi, Han Sang Kim, Huajuan Wang, Pernille Lauritzen, Nancy Boudreau, Zhanjun Shi, Christin E. Burd, Jonathan H. Zippin, James C. Lo, Geoffrey S. Pitt, Jonathan M. Hernandez, Constantinos P. Zambirinis, Michael A. Hollingsworth, Paul M. Grandgenett, Maneesh Jain, Surinder K. Batra, Dominick J. DiMaio, Jean L. Grem, Kelsey Klute, Tanya Trippett, Mikala Egeblad, Doru Paul, Jacqueline Bromberg, David P. Kelsen, Vinagolu K. Rajasekhar, John H. Healey, Irina Matei, William R. Jarnagin, Robert E. Schwartz, Haiying Zhang, David Lyden - Nature 2023 cited by 261

  11. Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

    Authors: Pasquale Sansone, Claudia Savini, Ivana Kurelac, Qing Chang, Laura Benedetta Amato, Antonio Strillacci, Анна Степанова, Luisa Iommarini, Chiara Mastroleo, Laura Daly, Alexander Galkin, Basant Kumar Thakur, Nadine Soplop, Kunihiro Uryu, Ayuko Hoshino, Larry Norton, Massimiliano Bonafè, Monica Cricca, Giuseppe Gasparre, David Lyden, Jacqueline Bromberg - National Academy of Sciences, Proceedings of the National Academy of Sciences 2017 cited by 723

  12. Asymmetric-flow field-flow fractionation technology for exomere and small extracellular vesicle separation and characterization

    Authors: Haiying Zhang, David Lyden - Nature Protocols 2019 cited by 468

  13. The perivascular niche regulates breast tumour dormancy

    Authors: Cyrus M. Ghajar, Héctor Peinado, Hidetoshi Mori, Irina Matei, Kimberley Evason, Hélène Brazier, Dena Almeida, Antonius Koller, Katherine A. Hajjar, Didier Y. R. Stainier, Emily I. Chen, David Lyden, Mina J. Bissell - Nature Cell Biology 2013 cited by 1,133

  14. Immune determinants of the pre-metastatic niche

    Authors: Laura Pătraș, Lee Shaashua, Irina Matei, David Lyden - Cancer Cell 2023 cited by 195

  15. Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis

    Authors: Gonçalo Rodrigues, Ayuko Hoshino, Candia M. Kenific, Irina Matei, Loïc Steiner, Daniela Freitas, Han Sang Kim, Peter R. Oxley, Ilana Scandariato, Irene Casanova‐Salas, Jinxiang Dai, Chaitanya R. Badwe, Brunilde Gril, Milica Tešić Mark, Brian D. Dill, Henrik Molina, Haiying Zhang, Alberto Benito‐Martín, Linda Bojmar, Yonathan Ararso, Katharine Offer, Quincey LaPlant, Weston Buehring, Huajuan Wang, Xinran Jiang, Tyler M. Lu, Yuan Liu, Joshua K. Sabari, Sandra J. Shin, Navneet Narula, Paula S. Ginter, Vinagolu K. Rajasekhar, John H. Healey, Etienne Meylan, Bruno Costa‐Silva, Shizhen Emily Wang, Shahin Rafii, Nasser K. Altorki, Charles M. Rudin, David R. Jones, Patricia S. Steeg, Héctor Peinado, Cyrus M. Ghajar, Jacqueline Bromberg, Maria de Sousa, David J. Pisapia, David Lyden - Nature Cell Biology 2019 cited by 432

  16. Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

    Authors: Bi‐Sen Ding, Daniel J. Nolan, Jason M. Butler, Daylon James, Alexander O. Babazadeh, Zev Rosenwaks, Vivek Mittal, Hideki Kobayashi, Koji Shido, David Lyden, Thomas N. Sato, Sina Y. Rabbany, Shahin Rafii - Nature 2010 cited by 851

  17. Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism

    Authors: Susana Garcı́a-Silva, Alberto Benito‐Martín, Laura Nogués, Alberto Hernández‐Barranco, Marina S. Mazariegos, Vanesa Santos, Marta Hergueta‐Redondo, Pilar Ximénez‐Embún, Raghu P. Kataru, Ana Amor López, Cristina Merino, Sara Sánchez‐Redondo, Osvaldo Graña‐Castro, Irina Matei, José Ángel Nicolás-Ávila, Raúl Torres, Sandra Rodríguez, Lola Martínez, Manuel Pérez‐Martínez, Gadea Mata, Anna Szumera‐Ciećkiewicz, Iwona Kalinowska, Annalisa Saltari, Julia M. Martínez-Gómez, Sabrina A. Hogan, H. Uri Saragovi, Sagrario Ortega, Carmen García‐Martín, Jasminka Boskovic, Mitchell P. Levesque, Piotr Rutkowski, Andrés Hidalgo, Javier Muñoz, Diego Megı́as, Babak J. Mehrara, David Lyden, Héctor Peinado - Nature Cancer 2021 cited by 188

  18. Extracellular vesicles and particles impact the systemic landscape of cancer

    Authors: Serena Lucotti, Candia M. Kenific, Haiying Zhang, David Lyden - The EMBO Journal 2022 cited by 122

  19. Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain

    Authors: Jinxiang Dai, Patrick J. Cimino, Kenneth Gouin, Candice Alexandra Grzelak, Alexander Barrett, Andrea R. Lim, Annalyssa Long, Stephanie Weaver, Lindsey T. Saldin, Aiyedun Uzamere, Vera Schulte, Nigel Clegg, Laura Pisarsky, David Lyden, Mina J. Bissell, Simon Knott, Alana L. Welm, Jason H. Bielas, Kirk C. Hansen, Frank Winkler, Eric C. Holland, Cyrus M. Ghajar - Nature Cancer 2021 cited by 134

  20. The IL-6/JAK/Stat3 Feed-Forward Loop Drives Tumorigenesis and Metastasis

    Authors: Qing Chang, Eirini Bournazou, Pasquale Sansone, Marjan Berishaj, Sizhi Paul Gao, Laura Daly, Jared Wels, Till M. Theilen, Selena Granitto, Xinmin Zhang, Jesse Cotari, Mary L. Alpaugh, Elisa de Stanchina, Katia Manova, Ming Li, Massimiliano Bonafè, Claudio Ceccarelli, Mario Taffurelli, Donatella Santini, Grégoire Altan‐Bonnet, Rosandra N. Kaplan, Larry Norton, Norihiro Nishimoto, Dennis Huszar, David Lyden, Jacqueline Bromberg - Neoplasia 2013 cited by 508

  21. The metastatic niche: adapting the foreign soil

    Authors: Bethan Psaila, David Lyden - Nature reviews. Cancer 2009 cited by 1,301

  22. Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression

    Authors: Zhongchi Li, Vivien Low, Valbona Luga, Janet Sun, Ethan M. Earlie, Bobak Parang, Kripa Shobana Ganesh, Sungyun Cho, Jennifer E. Endress, Tanya Schild, Mengying Hu, David Lyden, Wen‐Bing Jin, Chun‐Jun Guo, Noah Dephoure, Lewis C. Cantley, Ashley M. Laughney, John Blenis - Nature Communications 2022 cited by 66

  23. Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease

    Authors: Varsha Prakash, Brittany B. Carson, Jennifer M. Feenstra, Randall A. Dass, Petra Sekyrová, Ayuko Hoshino, Julian Petersen, Yuan Guo, Matthew Parks, Chad M. Kurylo, Jake E. Batchelder, Kristian Hallermalm, Ayako Hashimoto, Helene Rundqivst, John S. Condeelis, C. David Allis, Denis Drygin, M. Ángela Nieto, Michael Andäng, Piergiorgio Percipalle, Jonas Bergh, Igor Adameyko, Ann-Kristin Östlund Farrants, Johan Hartman, David Lyden, Kristian Pietras, Scott C. Blanchard, C. Theresa Vincent - Nature Communications 2019 cited by 236

  24. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

    Authors: Liuliu Yang, Yuling Han, Benjamin E. Nilsson-Payant, Vikas Gupta, Pengfei Wang, Xiaohua Duan, Xuming Tang, Jiajun Zhu, Zeping Zhao, Fabrice Jaffré, Tuo Zhang, Tae Wan Kim, Oliver Harschnitz, David Redmond, Sean Houghton, Chengyang Liu, Ali Naji, Gabriele Ciceri, Sudha R. Guttikonda, Yaron Bram, Duc-Huy T. Nguyen, Michele Cioffi, Vasuretha Chandar, Daisy A. Hoagland, Yaoxing Huang, Jenny Xiang, Hui Wang, David Lyden, Alain Borczuk, Huanhuan Joyce Chen, Lorenz Studer, Fong Cheng Pan, David D. Ho, Benjamin R. tenOever, Todd Evans, Robert E. Schwartz, Shuibing Chen - Cell stem cell 2020 cited by 675