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Hiroko Tsutsui

Active 1987–2024

58
Papers
19,231
Citations
56
h-index
57
i10-index

Citations

Citations per year for Hiroko Tsutsui1984: 3 citations1987: 1 citations1988: 3 citations1989: 3 citations1990: 1 citations1991: 5 citations1992: 5 citations1993: 4 citations1994: 3 citations1995: 3 citations1996: 5 citations1997: 52 citations1998: 173 citations1999: 261 citations2000: 370 citations2001: 357 citations2002: 364 citations2003: 319 citations2004: 323 citations2005: 245 citations2006: 298 citations2007: 259 citations2008: 229 citations2009: 185 citations2010: 210 citations2011: 179 citations2012: 179 citations2013: 173 citations2014: 182 citations2015: 136 citations2016: 108 citations2017: 143 citations2018: 131 citations2019: 415 citations2020: 400 citations2021: 407 citations2022: 333 citations2023: 234 citations2024: 312 citations2025: 127 citations2026: 1 citations1985–1986: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 2,221 citing papers, 29.3% of this breakdownJapan: 892 citing papers, 11.8% of this breakdownChina: 674 citing papers, 8.9% of this breakdownGermany: 490 citing papers, 6.5% of this breakdownUnited Kingdom: 376 citing papers, 5% of this breakdownFrance: 294 citing papers, 3.9% of this breakdownAustralia: 233 citing papers, 3.1% of this breakdownCanada: 217 citing papers, 2.9% of this breakdownSwitzerland: 192 citing papers, 2.5% of this breakdownItaly: 186 citing papers, 2.5% of this breakdownNetherlands: 155 citing papers, 2% of this breakdownSouth Korea: 124 citing papers, 1.6% of this breakdown
0%29.3%Other 20%

Institutions

Fields

  • Immunology and Microbiology34.8%
  • Medicine29.7%
  • Biochemistry, Genetics and Molecular Biology29.1%
  • Neuroscience2.5%
  • Agricultural and Biological Sciences1.3%
  • Dentistry0.7%
  • Other1.9%

Topics

  • Immune Response and Inflammation7.8%
  • Inflammasome and immune disorders7.7%
  • Immune Cell Function and Interaction6.7%
  • IL-33, ST2, and ILC Pathways3.2%
  • interferon and immune responses2.9%
  • T-cell and B-cell Immunology2.8%
  • Other68.9%

Coauthors

All papers

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  1. Interleukin-18 in Health and Disease

    Authors: Koubun Yasuda, Kenji Nakanishi, Hiroko Tsutsui - International Journal of Molecular Sciences 2019 cited by 560

  2. Cloning of a new cytokine that induces IFN-γ production by T cells

    Authors: Haruki Okamura, Hiroko Tsutsui, Toshinori Komatsu, Masuo Yutsudo, Akira Hakura, Tadao Tanimoto, Kakuji Torigoe, Takanori Okura, Yoshiyuki Nukada, Kazuko Hattori, Kenji Akita, Motoshi Namba, Fujimi Tanabe, Kaori Konishi, Shigeharu Fukuda, Masashi Kurimoto - Nature 1995 cited by 2,621

  3. Interleukin-18 Regulates Both Th1 and Th2 Responses

    Authors: Kenji Nakanishi, Tomohiro Yoshimoto, Hiroko Tsutsui, Haruki Okamura - Annual Review of Immunology 2001 cited by 1,318

  4. Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

    Authors: Osamu Adachi, Taro Kawai, Kiyoshi Takeda, Makoto Matsumoto, Hiroko Tsutsui, Masafumi Sakagami, Kenji Nakanishi, Shizuo Akira - Immunity 1998 cited by 2,024

  5. Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

    Authors: Yong Gu, Keisuke Kuida, Hiroko Tsutsui, George Ku, Kathy Hsiao, Mark Fleming, Nobuki Hayashi, Kazuya Higashino, Haruki Okamura, Kenji Nakanishi, Masashi Kurimoto, Tadao Tanimoto, Richard A. Flavell, Vicki L. Sato, Matthew W. Harding, David J. Livingston, Michael Su - Science 1997 cited by 1,162

  6. SOCS-1 Participates in Negative Regulation of LPS Responses

    Authors: Reiko Nakagawa, Tetsuji Naka, Hiroko Tsutsui, Minoru Fujimoto, Akihiro Kimura, Tatsuo Abe, Ekihiro Seki, Shintaro Sato, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira, Koichi Yamanishi, Ichirou Kawase, Kenji Nakanishi, Tadamitsu Kishimoto - Immunity 2002 cited by 643

  7. Regulation of interferon-γ production by IL-12 and IL-18

    Authors: Haruki Okamura, Shin‐ichiro Kashiwamura, Hiroko Tsutsui, Tomohiro Yoshimoto, Kenji Nakanishi - Current Opinion in Immunology 1998 cited by 527

  8. Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice

    Authors: Kiyoshi Takeda, Hiroko Tsutsui, Tomohiro Yoshimoto, Osamu Adachi, Nobuaki Yoshida, T. Kishimoto, Haruki Okamura, Kenji Nakanishi, Shizuo Akira - Immunity 1998 cited by 914

  9. IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6

    Authors: Tomohiro Yoshimoto, Hitoshi Mizutani, Hiroko Tsutsui, Nancy Noben-Trauth, Keiichi Yamanaka, Minoru Tanaka, Shinzo Izumi, Haruki Okamura, William E. Paul, Kenji Nakanishi - Nature Immunology 2000 cited by 349

  10. Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin

    Authors: Yohei Natsuaki, Gyohei Egawa, Satoshi Nakamizo, Sachiko Ono, Sho Hanakawa, Takaharu Okada, Nobuhiro Kusuba, Atsushi Otsuka, Akihiko Kitoh, Tetsuya Honda, Saeko Nakajima, Soken Tsuchiya, Yukihiko Sugimoto, Ken J. Ishii, Hiroko Tsutsui, Hideo Yagita∥, Yoichiro Iwakura, Masato Kubo, Lai Guan Ng, Takashi Hashimoto, J. P. Castaño Fuentes, Emma Guttman‐Yassky, Yoshiki Miyachi, Kenji Kabashima - Nature Immunology 2014 cited by 230

  11. Cutting Edge: Generation of IL-18 Receptor-Deficient Mice: Evidence for IL-1 Receptor-Related Protein as an Essential IL-18 Binding Receptor

    Authors: Katsuaki Hoshino, Hiroko Tsutsui, Taro Kawai, Kiyoshi Takeda, Kenji Nakanishi, Yoshifumi Takeda, Shizuo Akira - The Journal of Immunology 1999 cited by 271

  12. Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1β

    Authors: Ekihiro Seki, Hiroko Tsutsui, Hiroki Nakano, Noriko M. Tsuji, Katsuaki Hoshino, Osamu Adachi, Keishi Adachi, Shizue Futatsugi, Keisuke Kuida, Osamu Takeuchi, Haruki Okamura, Jiro Fujimoto, Shizuo Akira, Kenji Nakanishi - The Journal of Immunology 2001 cited by 232

  13. Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors

    Authors: Yosuke Kurashima, Takeaki Amiya, Tomonori Nochi, Kumiko Fujisawa, Takeshi Haraguchi, Hideo Iba, Hiroko Tsutsui, Shintaro Sato, Sachiko Nakajima, Hideki Iijima, Masato Kubo, Jun Kunisawa, Hiroshi Kiyono - Nature Communications 2012 cited by 284

  14. Inflammasome Activation by Mitochondrial Oxidative Stress in Macrophages Leads to the Development of Angiotensin II–Induced Aortic Aneurysm

    Authors: Fumitake Usui, Koumei Shirasuna, Hiroaki Kimura, Kazuki Tatsumi, Akira Kawashima, Tadayoshi Karasawa, Koichi Yoshimura, Hiroki Aoki, Hiroko Tsutsui, Tetsuo Noda, Junji Sagara, Shun’ichiro Taniguchi, Masafumi Takahashi - Arteriosclerosis Thrombosis and Vascular Biology 2014 cited by 191

  15. Importance of Kupffer Cells in the Development of Acute Liver Injuries in Mice

    Authors: Hiroko Tsutsui, Shuhei Nishiguchi - International Journal of Molecular Sciences 2014 cited by 147

  16. IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils

    Authors: Tomohiro Yoshimoto, Hiroko Tsutsui, Kouji Tominaga, Katsuaki Hoshino, Haruki Okamura, Shizuo Akira, William E. Paul, Kenji Nakanishi - National Academy of Sciences, Proceedings of the National Academy of Sciences 1999 cited by 436

  17. Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages

    Authors: Shiho Suzuki, Hitomi Mimuro, Minsoo Kim, Michinaga Ogawa, Hiroshi Ashida, Takahito Toyotome, Luigi Franchi, Masato Suzuki, Takahito Sanada, Toshihiko Suzuki, Hiroko Tsutsui, Gabriel Núñez, Chihiro Sasakawa - National Academy of Sciences, Proceedings of the National Academy of Sciences 2014 cited by 113

  18. IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions

    Authors: Hiroshi Konishi, Hiroko Tsutsui, Takaaki Murakami, Shizue Yumikura-Futatsugi, Kei-ichi Yamanaka, Minoru Tanaka, Yohichiro Iwakura, Noboru Suzuki, Kiyoshi Takeda, Shizuo Akira, Kenji Nakanishi, Hitoshi Mizutani - National Academy of Sciences, Proceedings of the National Academy of Sciences 2002 cited by 270

  19. Nonredundant Roles of Sema4A in the Immune System: Defective T Cell Priming and Th1/Th2 Regulation in Sema4A-Deficient Mice

    Authors: Atsushi Kumanogoh, Takashi Shikina, Kazuhiro Suzuki, Satoshi Uematsu, Kazunori Yukawa, Shin‐ichiro Kashiwamura, Hiroko Tsutsui, Midori Yamamoto, Hyota Takamatsu, Elizabeth P. Ko-Mitamura, Noriko Takegahara, Satoko Marukawa, Isao Ishida, Hiroshi Morishita, Durbaka V. R. Prasad, Manabu Tamura, Masayuki Mizui, Toshihiko Toyofuku, Shizuo Akira, Kiyoshi Takeda, Masaru Okabe, Hitoshi Kikutani - Immunity 2005 cited by 178

  20. Granzyme B is a novel interleukin-18 converting enzyme

    Authors: Youichi Omoto, Keiichi Yamanaka, Kazuya Tokime, Shigehisa Kitano, Masato Kakeda, Tomoko Akeda, Ichiro Kurokawa, Esteban C. Gabazza, Hiroko Tsutsui, Naoyuki Katayama, K Yamanishi, Kenji Nakanishi, Hitoshi Mizutani - Journal of Dermatological Science 2010 cited by 127

  21. Targeting solid tumors with non‐pathogenic obligate anaerobic bacteria

    Authors: Shun’ichiro Taniguchi, Minoru Fujimori, Takayuki Sasaki, Hiroko Tsutsui, Yuko Shimatani, Keiichi Seki, Jun Amano - Cancer Science 2010 cited by 89

  22. Human Mast Cell Chymase Cleaves Pro-IL-18 and Generates a Novel and Biologically Active IL-18 Fragment

    Authors: Youichi Omoto, Kazuya Tokime, Keiichi Yamanaka, Koji Habe, Tatsuhiko Morioka, Ichiro Kurokawa, Hiroko Tsutsui, K Yamanishi, Kenji Nakanishi, Hitoshi Mizutani - The Journal of Immunology 2006 cited by 136

  23. NLRP3 Regulates Neutrophil Functions and Contributes to Hepatic Ischemia–Reperfusion Injury Independently of Inflammasomes

    Authors: Yoshiyuki Inoue, Koumei Shirasuna, Hiroaki Kimura, Fumitake Usui, Akira Kawashima, Tadayoshi Karasawa, Kenji Tago, Katsuya Dezaki, Satoshi Nishimura, Junji Sagara, Tetsuo Noda, Yoichiro Iwakura, Hiroko Tsutsui, Shun’ichiro Taniguchi, Ken Yanagisawa, Toshihiko Yada, Yoshikazu Yasuda, Masafumi Takahashi - The Journal of Immunology 2014 cited by 127

  24. Lactobacillus plantarum strain YU from fermented foods activates Th1 and protective immune responses

    Authors: Tadaomi Kawashima, Kyoko Hayashi, Akemi Kosaka, Megumi Kawashima, Toshinori Igarashi, Hiroko Tsutsui, Noriko M. Tsuji, Ikuko Nishimura, Toshimitsu Hayashi, Akio Obata - International Immunopharmacology 2011 cited by 119