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James C. Sacchettini

Active 1986–2026

195
Papers
33,719
Citations
104
h-index
176
i10-index

Citations

Citations per year for James C. Sacchettini1963: 1 citations1981: 1 citations1983: 1 citations1987: 11 citations1988: 15 citations1989: 25 citations1990: 26 citations1991: 23 citations1992: 50 citations1993: 60 citations1994: 84 citations1995: 93 citations1996: 123 citations1997: 107 citations1998: 149 citations1999: 153 citations2000: 195 citations2001: 202 citations2002: 268 citations2003: 243 citations2004: 255 citations2005: 264 citations2006: 268 citations2007: 282 citations2008: 289 citations2009: 392 citations2010: 450 citations2011: 365 citations2012: 389 citations2013: 404 citations2014: 417 citations2015: 338 citations2016: 326 citations2017: 310 citations2018: 287 citations2019: 866 citations2020: 832 citations2021: 734 citations2022: 596 citations2023: 457 citations2024: 631 citations2025: 301 citations2026: 14 citations1964–1980: no citations, so these years are not shown1982: no citations, so this year is not shown1984–1986: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 4,280 citing papers, 32.8% of this breakdownChina: 1,108 citing papers, 8.5% of this breakdownUnited Kingdom: 1,067 citing papers, 8.2% of this breakdownGermany: 708 citing papers, 5.4% of this breakdownIndia: 524 citing papers, 4% of this breakdownFrance: 516 citing papers, 4% of this breakdownSwitzerland: 343 citing papers, 2.6% of this breakdownJapan: 316 citing papers, 2.4% of this breakdownCanada: 313 citing papers, 2.4% of this breakdownAustralia: 290 citing papers, 2.2% of this breakdownNetherlands: 282 citing papers, 2.2% of this breakdownItaly: 268 citing papers, 2.1% of this breakdown
0%32.8%Other 23.2%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology38.8%
  • Medicine36.3%
  • Immunology and Microbiology6.7%
  • Chemistry3.5%
  • Nursing2.6%
  • Materials Science2.5%
  • Other9.6%

Topics

  • Tuberculosis Research and Epidemiology7.7%
  • Mycobacterium research and diagnosis4.6%
  • RNA and protein synthesis mechanisms2.6%
  • Antibiotic Resistance in Bacteria2.3%
  • Computational Drug Discovery Methods2.2%
  • Biochemical and Molecular Research2%
  • Other78.6%

Coauthors

All papers

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  1. PHENIX: building new software for automated crystallographic structure determination

    Authors: Paul D. Adams, Ralf W. Grosse‐Kunstleve, Li‐Wei Hung, Thomas R. Ioerger, Airlie J. McCoy, Nigel W. Moriarty, Randy J. Read, James C. Sacchettini, Nicholas K. Sauter, Thomas C. Terwilliger - Acta Crystallographica Section D Biological Crystallography 2002 cited by 4,410

  2. Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice

    Authors: Liam M. Guthrie, Shivatheja Soma, Sai Yuan, Andres Silva, Mohammad Zulkifli, Thomas Snavely, Hannah Faith Greene, Elyssa Nunez, Brogan Lynch, Courtney De Ville, Vinit Shanbhag, Franklin R. Lopez, Arjun Acharya, Michael J. Petris, Byung‐Eun Kim, Vishal M. Gohil, James C. Sacchettini - Science 2020 cited by 188

  3. Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing

    Authors: Philana Ling Lin, Christopher B. Ford, M. Teresa Coleman, Amy Myers, Richa Gawande, Thomas R. Ioerger, James C. Sacchettini, Sarah M. Fortune, JoAnne L. Flynn - Nature Medicine 2013 cited by 547

  4. Crystal structure of a plant catechol oxidase containing a dicopper center

    Authors: Thomas Klabunde, Christoph Eicken, James C. Sacchettini, Bernt Krebs - Nature Structural Biology 1998 cited by 857

  5. Recent developments in thePHENIXsoftware for automated crystallographic structure determination

    Authors: Paul D. Adams, Kreshna Gopal, Ralf W. Grosse‐Kunstleve, Li‐Wei Hung, Thomas R. Ioerger, Airlie J. McCoy, Nigel W. Moriarty, Reetal Pai, Randy J. Read, Tod D. Romo, James C. Sacchettini, Nicholas K. Sauter, Laurent C. Storoni, Thomas C. Terwilliger - Journal of Synchrotron Radiation 2003 cited by 394

  6. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

    Authors: John D. McKinney, Kerstin Höner zu Bentrup, Ernesto J. Muñoz‐Elías, András Miczák, Bing Chen, Wai-Tsing Chan, Dana L. Swenson, James C. Sacchettini, William R. Jacobs, David G. Russell - Nature 2000 cited by 1,368

  7. Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

    Authors: Yanjia J. Zhang, Manchi C. M. Reddy, Thomas R. Ioerger, Alissa C. Rothchild, Véronique Dartois, Brian M. Schuster, Andrej Trauner, Deeann Wallis, Stacy Galaviz, Curtis Huttenhower, James C. Sacchettini, Samuel M. Behar, Eric J. Rubin - Cell 2013 cited by 371

  8. Modification of the NADH of the Isoniazid Target (InhA) from Mycobacterium tuberculosis

    Authors: Denise A. Rozwarski, Gregory A. Grant, D. H. R. BARTON, William R. Jacobs, James C. Sacchettini - Science 1998 cited by 680

  9. Automated Structure Solution with the PHENIX Suite

    Authors: Peter H. Zwart, Pavel V. Afonine, Ralf W. Grosse‐Kunstleve, Li‐Wei Hung, Thomas R. Ioerger, Airlie J. McCoy, Erik McKee, Nigel W. Moriarty, Randy J. Read, James C. Sacchettini, Nicholas K. Sauter, Laurent C. Storoni, Thomas C. Terwilliger, Paul D. Adams - Methods in molecular biology 2008 cited by 562

  10. Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13

    Authors: Anup Aggarwal, Maloy Kumar Parai, N.D. Shetty, Deeann Wallis, Lisa K. Woolhiser, Courtney Hastings, Noton K. Dutta, Stacy Galaviz, Ramesh Dhakal, Rupesh Shrestha, Shoko Wakabayashi, Chris Walpole, David J. Matthews, David Floyd, Paul Scullion, Jennifer Riley, Ola Epemolu, Suzanne Norval, Thomas Snavely, Gregory T. Robertson, Eric J. Rubin, Thomas R. Ioerger, F A Sirgel, Ruben van der Merwe, Paul D. van Helden, Peter M. Keller, Erik C. Böttger, Petros C. Karakousis, Anne J. Lenaerts, James C. Sacchettini - Cell 2017 cited by 185

  11. Mechanism of thioamide drug action against tuberculosis and leprosy

    Authors: Feng Wang, Robert Langley, Gülçin Gülten, Lynn G. Dover, Gurdyal S. Besra, William R. Jacobs, James C. Sacchettini - The Journal of Experimental Medicine 2007 cited by 295

  12. Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

    Authors: Andrés Palencia, Xianfeng Li, Wei Bu, Wai Choi, Charles Z. Ding, Eric E. Easom, Lisa Feng, Vincent Hernandez, Paul L. Houston, Liang Liu, Maliwan Meewan, Manisha Mohan, Fernando Rock, Holly Sexton, Suoming Zhang, Yasheen Zhou, Baojie Wan, Yuehong Wang, Scott G. Franzblau, Lisa K. Woolhiser, Veronica Gruppo, Anne J. Lenaerts, Theresa O’Malley, Tanya Parish, Christopher B. Cooper, M. Gerard Waters, Zhenkun Ma, Thomas R. Ioerger, James C. Sacchettini, Joaquín Rullás, Íñigo Angulo‐Barturen, Esther Pérez‐Herrán, Alfonso Mendoza, David Barros, S. Cusack, Jacob J. Plattner, M.R. Alley - Antimicrobial Agents and Chemotherapy 2016 cited by 121

  13. Mutations in fbiD ( Rv2983 ) as a Novel Determinant of Resistance to Pretomanid and Delamanid in Mycobacterium tuberculosis

    Authors: Dalin Rifat, Si-Yang Li, Thomas R. Ioerger, Keshav V. Shah, Jean‐Philippe Lanoix, Jin Lee, Ghader Bashiri, James C. Sacchettini, Eric L. Nuermberger - Antimicrobial Agents and Chemotherapy 2020 cited by 88

  14. Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

    Authors: Jared S. Mackenzie, Dirk A. Lamprecht, Rukaya Asmal, John Adamson, Khushboo Borah, Dany J. V. Beste, Bei Shi Lee, Kévin Pethe, Simon Rousseau, Inna V. Krieger, James C. Sacchettini, Joel N. Glasgow, Adrie J. C. Steyn - Nature Communications 2020 cited by 91

  15. The Tuberculosis Drug Accelerator at year 10: what have we learned?

    Authors: Bree B. Aldridge, David Barros-Aguirre, Clifton E. Barry, Robert H. Bates, Steven J. Berthel, Helena I. Boshoff, Kelly Chibale, Xin‐Jie Chu, Christopher B. Cooper, Véronique Dartois, Ken Duncan, Nader Fotouhi, Fabian Gusovsky, Philip A. Hipskind, Dale J. Kempf, Joël Lelièvre, Anne J. Lenaerts, Case W. McNamara, Valerie Mizrahi, Carl Nathan, David B. Olsen, Tanya Parish, H. Michael Petrassi, Alexander S. Pym, Kyu Y. Rhee, Gregory T. Robertson, Jeremy M. Rock, Eric J. Rubin, Betsy Russell, David G. Russell, James C. Sacchettini, Dirk Schnappinger, Michael R. Schrimpf, Anna M. Upton, Peter Warner, Paul G. Wyatt, Ying Yuan - Nature Medicine 2021 cited by 62

  16. Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe

    Authors: Hexin Xie, J. Mire, Ying Kong, Mi-Hee Chang, Hany Hassounah, Chris N. Thornton, James C. Sacchettini, Jeffrey D. Cirillo, Jianghong Rao - Nature Chemistry 2012 cited by 181

  17. TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities

    Authors: Allison F. Carey, Jeremy M. Rock, Inna V. Krieger, Michael R. Chase, Marta Fernández-Suárez, Sébastien Gagneux, James C. Sacchettini, Thomas R. Ioerger, Sarah M. Fortune - PLoS Pathogens 2018 cited by 135

  18. Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

    Authors: Robert S. Jansen, Lungelo Mandyoli, Ryan Hughes, Shoko Wakabayashi, Jessica T. Pinkham, Bruna P. Selbach, Kristine M. Guinn, Eric J. Rubin, James C. Sacchettini, Kyu Y. Rhee - Nature Communications 2020 cited by 73

  19. Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists

    Authors: Sachin Katti, Inna V. Krieger, Jihyae Ann, Jeewoo Lee, James C. Sacchettini, Tatyana I. Igumenova - Nature Communications 2022 cited by 53

  20. Catechol oxidase — structure and activity

    Authors: Christoph Eicken, Bernt Krebs, James C. Sacchettini - Current Opinion in Structural Biology 1999 cited by 254

  21. Structure of the Mycobacterium tuberculosis d -Alanine: d -Alanine Ligase, a Target of the Antituberculosis Drug d -Cycloserine

    Authors: John B. Bruning, A.C. Murillo, Ofelia Chacón, Raúl G. Barletta, James C. Sacchettini - Antimicrobial Agents and Chemotherapy 2010 cited by 146

  22. Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target

    Authors: Caroline Wilson, Peter C. Ray, Fabio Zuccotto, Jorge Hernández, Anup Aggarwal, Claire J. Mackenzie, Nicola Caldwell, Malcolm Taylor, Margaret Huggett, Michael Mathieson, Dinakaran Murugesan, Alasdair Smith, Susan H. Davis, Mattia Cocco, Maloy Kumar Parai, Arjun Acharya, Fábio K. Tamaki, Paul Scullion, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Eva María López-Román, Pedro Alfonso Torres-Gómez, Ana Maria Toledo, Laura Guijarro-López, Isabel Camino, Curtis A. Engelhart, Dirk Schnappinger, Lisa M. Massoudi, Anne J. Lenaerts, Gregory T. Robertson, Chris Walpole, David J. Matthews, David Floyd, James C. Sacchettini, Kevin D. Read, Lourdes Encinas, Robert H. Bates, Simon R. Green, Paul G. Wyatt - Journal of Medicinal Chemistry 2021 cited by 35

  23. Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection

    Authors: Christopher B. Ford, Philana Ling Lin, Michael R. Chase, Rupal Shah, Oleg Iartchouk, James E. Galagan, Nilofar Mohaideen, Thomas R. Ioerger, James C. Sacchettini, Marc Lipsitch, JoAnne L. Flynn, Sarah M. Fortune - Nature Genetics 2011 cited by 467

  24. Altered NADH/NAD + Ratio Mediates Coresistance to Isoniazid and Ethionamide in Mycobacteria

    Authors: Catherine Vilchèze, Torin R. Weisbrod, Bing Chen, Laurent Kremer, Manzour Hernando Hazbón, Feng Wang, David Alland, James C. Sacchettini, William R. Jacobs - Antimicrobial Agents and Chemotherapy 2005 cited by 283