Jonathan D. Licht
Active 1990–2025
- 135
- Papers
- 27,080
- Citations
- 87
- h-index
- 131
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Biochemistry, Genetics and Molecular Biology60.7%
- Medicine28.9%
- Immunology and Microbiology6.3%
- Neuroscience1%
- Agricultural and Biological Sciences1%
- Engineering0.4%
- Other1.7%
Topics
- Epigenetics and DNA Methylation7%
- Acute Myeloid Leukemia Research4.3%
- Histone Deacetylase Inhibitors Research3.7%
- Protein Degradation and Inhibitors3%
- RNA modifications and cancer2.9%
- MicroRNA in disease regulation2.8%
- Other76.3%
Coauthors
- Ari Melnick16
- Richard L. Bennett14
- Daphné Dupéré-Richer11
- Neil L. Kelleher11
- Relja Popovic11
- Teresa Ezponda11
- Arthur Zelent10
- Eva Martínez-García9
- Alberto Riva8
- Amin Sobh8
- Jianping Li8
- Christine Will7
- D. Morrison6
- Milton A. English6
- Rita Shaknovich6
- Samuel Waxman6
- Yupeng Zheng6
- Eliza C. Small5
- Helen J. Ball5
- Isabelle Groß5
- Keiran S.M. Smalley5
- M. Albert Basson5
- Melanie J. McConnell5
- Daohong Zhou4
All papers
- Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling
Authors: Laura A. Sena, Sha Li, Amit Jairaman, Murali Prakriya, Teresa Ezponda, David A. Hildeman, Chyung‐Ru Wang, Paul T. Schumacker, Jonathan D. Licht, Harris Perlman, Paul Bryce, Navdeep S. Chandel - Immunity 2013 cited by 1,300
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
Authors: María E. Figueroa, Omar Abdel‐Wahab, Chao Lü, Patrick S. Ward, Jay Patel, Alan H. Shih, Yushan Li, Neha Bhagwat, Aparna Vasanthakumar, Hugo F. Fernández, Martin S. Tallman, Zhuoxin Sun, Kristy Wolniak, Justine Peeters, Wei Liu, Sung Choe, Valeria R. Fantin, Elisabeth Paietta, Bob Löwenberg, Jonathan D. Licht, Lucy A. Godley, Ruud Delwel, Peter J.M. Valk, Craig B. Thompson, Ross L. Levine, Ari Melnick - Cancer Cell 2010 cited by 2,737
- MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Authors: Thomas Thum, Carina Gross, Jan Fiedler, Thomas Fischer, Stephan Kissler, Markus Bussen, Paolo Galuppo, Steffen Just, Wolfgang Rottbauer, Stefan Frantz, M. Castoldi, Jürgen Soutschek, Victor Koteliansky, Andreas Rosenwald, M. Albert Basson, Jonathan D. Licht, John T. R. Pena, Sara H. Rouhanifard, Martina U. Muckenthaler, Thomas Tuschl, Gail R. Martin, Johann Bauersachs, Stefan Engelhardt - Nature 2008 cited by 2,357
- Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture
Authors: Nevin Yusufova, Andreas Kloetgen, Matt Teater, Adewola Osunsade, Jeannie M. Camarillo, Christopher R. Chin, Ashley S. Doane, Bryan J. Venters, Stephanie Portillo‐Ledesma, Joseph Conway, Jude M. Phillip, Olivier Elemento, David W. Scott, Wendy Béguelin, Jonathan D. Licht, Neil L. Kelleher, Louis M. Staudt, Arthur I. Skoultchi, Michael‐Christopher Keogh, Effie Apostolou, Christopher E. Mason, Marcin Imieliński, Tamar Schlick, Yael David, Aristotelis Tsirigos, C. David Allis, Alexey A. Soshnev, Ethel Cesarman, Ari Melnick - Nature 2020 cited by 265
- EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation
Authors: Wendy Béguelin, Relja Popovic, Matt Teater, Yanwen Jiang, Karen Bunting, Monica W. Rosen, Hao Shen, Shao Ning Yang, Ling Wang, Teresa Ezponda, Eva Martínez-García, Haikuo Zhang, Yupeng Zheng, Sharad K. Verma, Michael T. McCabe, Heidi M. Ott, Glenn S. Van Aller, Ryan G. Kruger, Yan Liu, Charles F. McHugh, David W. Scott, Young Rock Chung, Neil L. Kelleher, Rita Shaknovich, Caretha L. Creasy, Randy D. Gascoyne, Kwok‐Kin Wong, Leandro Cerchietti, Ross L. Levine, Omar Abdel‐Wahab, Jonathan D. Licht, Olivier Elemento, Ari Melnick - Cancer Cell 2013 cited by 841
- Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator
Authors: Jung Kim, Yongik Lee, Xiaodong Lü, Bing Song, Ka-wing Fong, Qi Cao, Jonathan D. Licht, Jonathan C. Zhao, Jindan Yu - Cell Reports 2018 cited by 310
- Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition
Authors: Simon J. Hogg, Olga Motorna, Leonie A. Cluse, Timothy M. Johanson, Hannah D. Coughlan, Ramya Raviram, Robert M. Myers, Matteo Costacurta, Izabela Todorovski, Lizzy Pijpers, Stefan Bjelosevic, Tobias Williams, Shannon N. Huskins, Conor J. Kearney, Jennifer R. Devlin, Zheng Fan, Jafar S. Jabbari, Ben P. Martin, Mohamed Fareh, Madison J. Kelly, Daphné Dupéré-Richer, Jarrod J. Sandow, Breon Feran, Deborah A. Knight, Tiffany Khong, Andrew Spencer, Simon J. Harrison, Gareth P. Gregory, Vihandha O. Wickramasinghe, Andrew I. Webb, Phillippa C. Taberlay, Kenneth D. Bromberg, Albert Lai, Anthony T. Papenfuss, Gordon K. Smyth, Rhys S. Allan, Jonathan D. Licht, Dan A. Landau, Omar Abdel‐Wahab, Jake Shortt, Stephin J. Vervoort, Ricky W. Johnstone - Molecular Cell 2021 cited by 170
- Piperlongumine conjugates induce targeted protein degradation
Authors: Jing Pei, Yufeng Xiao, Xingui Liu, Wanyi Hu, Amin Sobh, Yaxia Yuan, Shuo Zhou, Nan Hua, Samuel G. Mackintosh, Xuan Zhang, Kari B. Basso, Manasi Kamat, Qingping Yang, Jonathan D. Licht, Guangrong Zheng, Daohong Zhou, Dongwen Lv - Cell chemical biology 2023 cited by 71
- Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins
Authors: Ryosuke Shirasaki, Geoffrey M. Matthews, Sara Gandolfi, Ricardo De Matos Simoes, Dennis L. Buckley, Joseline Raja, Quinlan Sievers, Johanna B. Brüggenthies, Olga Dashevsky, Haley Poarch, Huihui Tang, Megan Bariteau, Michal Sheffer, Yiguo Hu, Sondra L. Downey-Kopyscinski, Paul J. Hengeveld, Brian Glassner, Eugen Dhimolea, Christopher J. Ott, Tinghu Zhang, Nicholas Kwiatkowski, Jacob P. Laubach, Robert Schlossman, Paul G. Richardson, Aedín C. Culhane, Richard W.J. Groen, Eric S. Fischer, Francisca Vázquez, Aviad Tsherniak, William C. Hahn, Joan Levy, Daniel Auclair, Jonathan D. Licht, Jonathan J. Keats, Lawrence Boise, Benjamin L. Ebert, James E. Bradner, Nathanael S. Gray, Constantine S. Mitsiades - Cell Reports 2021 cited by 115
- The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
Authors: Lucas B. Sullivan, Eva Martínez-García, Hien P. Nguyen, Andrew R. Mullen, Éric Dufour, Sunil Sudarshan, Jonathan D. Licht, Ralph J. DeBerardinis, Navdeep S. Chandel - Molecular Cell 2013 cited by 305
- Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2
Authors: Ronan P. Hanley, David Y. Nie, John R. Tabor, Fengling Li, Amin Sobh, Chenxi Xu, Natalie K. Barker, David Dilworth, Taraneh Hajian, Elisa Gibson, Magdalena M. Szewczyk, Peter J. Brown, Dalia Baršytė-Lovejoy, Laura E. Herring, Gang Greg Wang, Jonathan D. Licht, Masoud Vedadi, C.H. Arrowsmith, Lindsey I. James - Journal of the American Chemical Society 2023 cited by 62
- Targeting Epigenetics in Cancer
Authors: Richard L. Bennett, Jonathan D. Licht - The Annual Review of Pharmacology and Toxicology 2017 cited by 255
- Recruitment of FBXO22 for targeted degradation of NSD2
Authors: Yan Nie, John R. Tabor, Jianping Li, Maria Kutera, Jonathan St‐Germain, Ronan P. Hanley, Esther Wolf, Ethan Paulаkonis, Tristan M. G. Kenney, Shili Duan, Suman Shrestha, Dominic D. G. Owens, Matthew E. R. Maitland, Ailing Pon, Magdalena M. Szewczyk, Anthony Joseph Lamberto, Michael Menes, Fengling Li, Linda Z. Penn, Dalia Baršytė-Lovejoy, Nicholas G. Brown, Anthony M. Barsotti, Andrew W. Stamford, Jon L. Collins, Derek J. Wilson, Brian Raught, Jonathan D. Licht, Lindsey I. James, C.H. Arrowsmith - Nature Chemical Biology 2024 cited by 56
- The Role of Nuclear Receptor–Binding SET Domain Family Histone Lysine Methyltransferases in Cancer
Authors: Richard L. Bennett, Alok Swaroop, Catalina Troche, Jonathan D. Licht - Cold Spring Harbor Perspectives in Medicine 2017 cited by 218
- A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer
Authors: Damiano Fantini, Alexander P. Glaser, Kalen Rimar, Yiduo Wang, Matthew J. Schipma, Nobish Varghese, Alfred Rademaker, Amir Behdad, Aparna Yellapa, Yanni Yu, Christie C. Sze, Lu Wang, Zibo Zhao, Susan E. Crawford, Deqing Hu, Jonathan D. Licht, Clayton K. Collings, Elizabeth T. Bartom, Dan Theodorescu, Ali Shilatifard, Joshua J. Meeks - Oncogene 2018 cited by 197
- Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia
Authors: Marco Tartaglia, Charlotte M. Niemeyer, Alessandra Fragale, Xiaoling Song, Jochen Buechner, Andreas Jung, Karel Hählen, Henrik Hasle, Jonathan D. Licht, Bruce D. Gelb - Nature Genetics 2003 cited by 1,039
- Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation
Authors: Relja Popovic, Eva Martínez-García, Ευγενία Γιαννοπούλου, Quanwei Zhang, Qingyang Zhang, Teresa Ezponda, Mrinal Y. Shah, Yupeng Zheng, Christine Will, Eliza C. Small, Youjia Hua, Marinka Bulic, Yanwen Jiang, Matteo Carrara, Raffaele Calogero, William L. Kath, Neil L. Kelleher, Ji-Ping Wang, Olivier Elemento, Jonathan D. Licht - PLoS Genetics 2014 cited by 239
- Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias
Authors: Ricardo De Matos Simoes, Ryosuke Shirasaki, Sondra L. Downey-Kopyscinski, Geoffrey M. Matthews, Benjamin G. Barwick, Vikas A. Gupta, Daphné Dupéré-Richer, Shizuka Yamano, Yiguo Hu, Michal Sheffer, Eugen Dhimolea, Olga Dashevsky, Sara Gandolfi, Kazuya Ishiguro, Robin M. Meyers, Jordan Bryan, Neekesh V. Dharia, Paul J. Hengeveld, Johanna B. Brüggenthies, Huihui Tang, Andrew J. Aguirre, Quinlan Sievers, Benjamin L. Ebert, Brian Glassner, Christopher J. Ott, James E. Bradner, Nicholas Kwiatkowski, Daniel Auclair, Joan Levy, Jonathan J. Keats, Richard W.J. Groen, Nathanael S. Gray, Aedín C. Culhane, James M. McFarland, Joshua M. Dempster, Jonathan D. Licht, Lawrence Boise, William C. Hahn, Francisca Vázquez, Aviad Tsherniak, Constantine S. Mitsiades - Nature Cancer 2023 cited by 40
- The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells
Authors: Eva Martínez-García, Relja Popovic, Dong Joon Min, Steve M. M. Sweet, Paul M. Thomas, Leonid Zamdborg, Aaron Heffner, Christine Will, Laurence Lamy, Louis M. Staudt, David Levens, Neil L. Kelleher, Jonathan D. Licht - Blood 2010 cited by 357
- The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial–mesenchymal transition and invasive properties of prostate cancer
Authors: Teresa Ezponda, Relja Popovic, Maitri Shah, Eva Martínez-García, Yupeng Zheng, D-J Min, Christine Will, Antonino Neri, Neil L. Kelleher, Jian Yu, Jonathan D. Licht - Oncogene 2012 cited by 159
- Histone mutations in cancer
Authors: Kimberly N. Espinoza Pereira, Jixiu Shan, Jonathan D. Licht, Richard L. Bennett - Biochemical Society Transactions 2023 cited by 34
- A Mutation in Histone H2B Represents a New Class of Oncogenic Driver
Authors: Richard L. Bennett, Aditya Bele, Eliza C. Small, Christine Will, Behnam Nabet, Jon A. Oyer, Xiaoxiao Huang, Rajarshi P. Ghosh, Adrian T. Grzybowski, Tao Yu, Qiao Zhang, Alberto Riva, Tanmay P. Lele, George C. Schatz, Neil L. Kelleher, Alexander J. Ruthenburg, Jan Liphardt, Jonathan D. Licht - Cancer Discovery 2019 cited by 105
- Widespread microRNA degradation elements in target mRNAs can assist the encoded proteins
Authors: Lu Li, Peike Sheng, Tianqi Li, Christopher J. Fields, Nicholas M. Hiers, Yuzhi Wang, Jianping Li, Casey M. Guardia, Jonathan D. Licht, Mingyi Xie - Genes & Development 2021 cited by 60
- UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition
Authors: Teresa Ezponda, Daphné Dupéré-Richer, Christine Will, Eliza C. Small, Nobish Varghese, Tej Patel, Behnam Nabet, Relja Popovic, Jon A. Oyer, Marinka Bulic, Yupeng Zheng, Xiaoxiao Huang, Mrinal Y. Shah, Sayantan Maji, Alberto Riva, Manuela Occhionorelli, Giovanni Tonon, Neil L. Kelleher, Jonathan J. Keats, Jonathan D. Licht - Cell Reports 2017 cited by 135
