Louis M. Staudt
Active 1984–2025
- 251
- Papers
- 94,937
- Citations
- 145
- h-index
- 247
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Biochemistry, Genetics and Molecular Biology41%
- Medicine40.3%
- Immunology and Microbiology11.6%
- Computer Science3.1%
- Neuroscience0.9%
- Mathematics0.6%
- Other2.5%
Topics
- Lymphoma Diagnosis and Treatment6.8%
- Gene expression and cancer classification3.9%
- Immune Cell Function and Interaction3.7%
- Chronic Lymphocytic Leukemia Research3.2%
- T-cell and B-cell Immunology2.4%
- Bioinformatics and Genomic Networks2.3%
- Other77.7%
Coauthors
- Andreas Rosenwald84
- George W. Wright73
- Elaine S. Jaffe70
- Elı́as Campo63
- Wing C. Chan63
- Randy D. Gascoyne60
- German Ott56
- Dennis D. Weisenburger51
- Jan Delabie51
- Lisa M. Rimsza47
- Arthur L. Shaffer43
- Timothy C. Greiner43
- Wyndham H. Wilson37
- Rita M. Braziel34
- Joseph M. Connors30
- Hong Zhao28
- Yandan Yang27
- Julie M. Vose26
- Kai Fu26
- Erlend B. Smeland24
- Javeed Iqbal24
- Wenming Xiao23
- Xin Yu23
- James D. Phelan22
All papers
- The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee
Authors: Elı́as Campo, Elaine S. Jaffe, James R. Cook, Leticia Quintanilla‐Martínez, Steven H. Swerdlow, Kenneth C. Anderson, Pierre Brousset, Lorenzo Cerroni, Laurence de Leval, Stefan Dirnhofer, Ahmet Doǧan, Andrew L. Feldman, Falko Fend, Jonathan W. Friedberg, Philippe Gaulard, Paolo Ghia, Steven M. Horwitz, Rebecca L. King, Gilles Salles, Jesús F. San Miguel, John F. Seymour, Steven P. Treon, Julie M. Vose, Emanuele Zucca, Ranjana H. Advani, Stephen M. Ansell, Wing-Yan Au, Carlos Barrionuevo, Leif Bergsagel, Wing C. Chan, Jeffrey I. Cohen, Francesco d’Amore, Andrew Davies, Brunangelo Falini, Irene M. Ghobrial, John R. Goodlad, John G. Gribben, Eric D. Hsi, Brad S. Kahl, Won-Seog Kim, Shaji Kumar, Ann S. LaCasce, Camille Laurent, Georg Lenz, John P. Leonard, Michael P. Link, Armando López‐Guillermo, María‐Victoria Mateos, Elizabeth Macintyre, Ari Melnick, Franck Morschhauser, Shigeo Nakamura, Marina Narbaitz, Astrid Pavlovsky, Stefano Pileri, Miguel Á. Piris, Barbara Pro, S. Vincent Rajkumar, Steven T. Rosen, Birgitta Sander, Laurie H. Sehn, Margaret A. Shipp, Sonali M. Smith, Louis M. Staudt, Catherine Thieblemont, Thomas Tousseyn, Wyndham H. Wilson, Tadashi Yoshino, Pier Luigi Zinzani, Martin Dreyling, David W. Scott, Jane N. Winter, Andrew D. Zelenetz - Blood 2022 cited by 1,506
- Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma
Authors: Roland Schmitz, George W. Wright, Da Wei Huang, Calvin A. Johnson, James D. Phelan, James Q. Wang, Sandrine Roulland, Monica Kasbekar, Ryan M. Young, Arthur L. Shaffer, Daniel J. Hodson, Wenming Xiao, Xin Yu, Yandan Yang, Hong Zhao, Weihong Xu, Xuelu Liu, Bin Zhou, Wei Du, Wing C. Chan, Elaine S. Jaffe, Randy D. Gascoyne, Joseph M. Connors, Elı́as Campo, Armando López‐Guillermo, Andreas Rosenwald, German Ott, Jan Delabie, Lisa M. Rimsza, Kevin Tay Kuang Wei, Andrew D. Zelenetz, John P. Leonard, Nancy L. Bartlett, Bao Tran, Jyoti Shetty, Yongmei Zhao, Dan Soppet, Stefania Pittaluga, Wyndham H. Wilson, Louis M. Staudt - New England Journal of Medicine 2018 cited by 2,261
- Toward a Shared Vision for Cancer Genomic Data
Authors: Robert L. Grossman, Allison P. Heath, Vincent Ferretti, Harold Varmus, Douglas R. Lowy, Warren A. Kibbe, Louis M. Staudt - New England Journal of Medicine 2016 cited by 1,808
- A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications
Authors: George W. Wright, Da Wei Huang, James D. Phelan, Zana Coulibaly, Sandrine Roulland, Ryan M. Young, James Q. Wang, Roland Schmitz, Ryan D. Morin, Jeffrey Tang, Aixiang Jiang, Aleksander Bagaev, Olga Plotnikova, Nikita Kotlov, Calvin A. Johnson, Wyndham H. Wilson, David W. Scott, Louis M. Staudt - Cancer Cell 2020 cited by 1,145
- Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Authors: Ash A. Alizadeh, Michael B. Eisen, R. Eric Davis, Chi Ma, Izidore S. Lossos, Andreas Rosenwald, Jennifer C. Boldrick, Hajeer Sabet, Truc Tran, Xin Yu, John Powell, Liming Yang, Gerald E. Marti, Troy Moore, James E. Hudson, Lisheng Lü, David B. Lewis, Robert Tibshirani, Gavin Sherlock, Wing C. Chan, Timothy C. Greiner, Dennis D. Weisenburger, Jamés O. Armitage, Roger A. Warnke, Ronald Levy, Wyndham H. Wilson, Michael R. Grever, John C. Byrd, David Botstein, Patrick O. Brown, Louis M. Staudt - Nature 2000 cited by 9,984
- The chromatin accessibility landscape of primary human cancers
Authors: M. Ryan Corces, Jeffrey M. Granja, Shadi Shams, Bryan H. Louie, José A. Seoane, Wanding Zhou, Tiago C. Silva, Clarice S. Groeneveld, Christopher K. Wong, Seung Woo Cho, Ansuman T. Satpathy, Maxwell R. Mumbach, Katherine A. Hoadley, A. Gordon Robertson, Nathan C. Sheffield, Ina Felau, Mauro A. A. Castro, Benjamin P. Berman, Louis M. Staudt, Jean C. Zenklusen, Peter W. Laird, Christina Curtis, The Cancer Genome Atlas Analysis Network, William J. Greenleaf, Howard Y. Chang, Rehan Akbani, Christopher C. Benz, Evan A. Boyle, Bradley M. Broom, Andrew D. Cherniack, Brian Craft, John A. Demchok, Ashley S. Doane, Olivier Elemento, Martin L. Ferguson, Mary J. Goldman, D. Neil Hayes, Jing He, Toshinori Hinoue, Marcin Imieliński, Steven J.M. Jones, Anab Kemal, Theo Knijnenburg, Anil Korkut, De‐Chen Lin, Yuexin Liu, Michael K. A. Mensah, Gordon B. Mills, Vincent Reuter, André Schultz, Hui Shen, Jason P. Smith, Roy Tarnuzzer, Sheyla Trefflich, Zhining Wang, John N. Weinstein, Lindsay Westlake, Jin Xu, Liming Yang, Christina Yau, Yang Zhao, Jingchun Zhu - Science 2018 cited by 1,356
- Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Non–Germinal Center B-Cell Diffuse Large B-Cell Lymphoma
Authors: Anas Younes, Laurie H. Sehn, Peter Johnson, Pier Luigi Zinzani, Xiaonan Hong, Jun Zhu, Caterina Patti, David Belada, Olga Samoilova, Cheolwon Suh, Sirpa Leppä, Shinya Rai, Mehmet Turgut, Wojciech Jurczak, Matthew C. Cheung, Ronit Gurion, Su‐Peng Yeh, Andrés López‐Hernandez, Ulrich Dührsen, Catherine Thiéblemont, Carlos Chiattone, Sriram Balasubramanian, Jodi Carey, Grace Liu, S. Martin Shreeve, Steven Sun, Sen Hong Zhuang, Jessica Vermeulen, Louis M. Staudt, Wyndham H. Wilson, on behalf of the PHOENIX investigators - Journal of Clinical Oncology 2019 cited by 616
- Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
Authors: R. Eric Davis, Vu N. Ngo, Georg Lenz, Pavel Tolar, Ryan M. Young, Paul B. Romesser, Holger Kohlhammer, Laurence Lamy, Hong Zhao, Yandan Yang, Weihong Xu, Arthur L. Shaffer, George W. Wright, Wenming Xiao, John Powell, Jian-kang Jiang, Craig J. Thomas, Andreas Rosenwald, German Ott, Hans Konrad Müller‐Hermelink, Randy D. Gascoyne, Joseph M. Connors, Nathalie A. Johnson, Lisa M. Rimsza, Elı́as Campo, Elaine S. Jaffe, Wyndham H. Wilson, Jan Delabie, Erlend B. Smeland, Richard I. Fisher, Rita M. Braziel, Raymond R. Tubbs, James R. Cook, Dennis D. Weisenburger, Wing C. Chan, Susan K. Pierce, Louis M. Staudt - Nature 2010 cited by 1,663
- JAKs and STATs in Immunity, Immunodeficiency, and Cancer
Authors: John J. O’Shea, Steven M. Holland, Louis M. Staudt - New England Journal of Medicine 2013 cited by 920
- Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma
Authors: Wyndham H. Wilson, Ryan M. Young, Roland Schmitz, Yandan Yang, Stefania Pittaluga, George W. Wright, Chih-Jian Lih, P. Mickey Williams, Arthur L. Shaffer, John F. Gerecitano, Sven de Vos, André Goy, Vaishalee P. Kenkre, Paul M. Barr, Kristie A. Blum, Andrei R. Shustov, Ranjana H. Advani, Nathan Fowler, Julie M. Vose, Rebecca Elstrom, Thomas M. Habermann, Jacqueline C. Barrientos, Jesse McGreivy, Maria Fardis, Betty Chang, Fong Clow, Brian Munneke, Davina Moussa, Darrin M. Beaupre, Louis M. Staudt - Nature Medicine 2015 cited by 1,110
- Stromal Gene Signatures in Large-B-Cell Lymphomas
Authors: Georg Lenz, George W. Wright, Sandeep S. Davé, Wenming Xiao, John Powell, Hong Zhao, Weihong Xu, Bruce K. Tan, Neta Goldschmidt, Javeed Iqbal, Julie Vose, M. Bast, Kai Fu, DD Weisenburger, Timothy C. Greiner, Jamés O. Armitage, Alastair H. Kyle, Lorraine F. May, Randy D. Gascoyne, Joseph M. Connors, Gunhild Trøen, Harald Holte, Stein Kvaløy, Daan Dierickx, G. Verhoef, Jan Delabie, Erlend B. Smeland, Pedro Jares, Antonio Martı́nez, Armando López‐Guillermo, Emili Montserrat, Elı́as Campo, Rita M. Braziel, Thomas P. Miller, Lisa M. Rimsza, James R. Cook, Brad Pohlman, John Sweetenham, Raymond R. Tubbs, Richard I. Fisher, Elena Hartmann, Andreas Rosenwald, German Ott, Müller-Hermelink Hk, David Wrench, T. Lister, Elaine S. Jaffe, Wyndham H. Wilson, Wing C. Chan, Louis M. Staudt - New England Journal of Medicine 2008 cited by 1,818
- Toll-Like Receptor Signaling
Authors: Kian‐Huat Lim, Louis M. Staudt - Cold Spring Harbor Perspectives in Biology 2013 cited by 464
- The Use of Molecular Profiling to Predict Survival after Chemotherapy for Diffuse Large-B-Cell Lymphoma
Authors: Andreas Rosenwald, George W. Wright, Wing C. Chan, Joseph M. Connors, Elı́as Campo, Richard I. Fisher, Randy D. Gascoyne, H. K. Müller-Hermelink, Erlend B. Smeland, Jena M. Giltnane, Elaine M. Hurt, Hong Zhao, Lauren Averett, Liming Yang, Wyndham H. Wilson, Elaine S. Jaffe, Richard H. Simon, Richard D. Klausner, John Powell, P L Duffey, Dan L. Longo, Timothy C. Greiner, Dennis D. Weisenburger, Warren G. Sanger, Bhavana J. Davé, James C. Lynch, Julie M. Vose, Jamés O. Armitage, Emilio Montserrat, Armando López‐Guillermo, Thomas M. Grogan, Thomas P. Miller, M. Leblanc, German Ott, Stein Kvaløy, Jan Delabie, Harald Holte, Peter Krajči, Trond Stokke, Louis M. Staudt - New England Journal of Medicine 2002 cited by 3,859
- Effect of ibrutinib with R-CHOP chemotherapy in genetic subtypes of DLBCL
Authors: Wyndham H. Wilson, George W. Wright, Da Wei Huang, Brendan P. Hodkinson, Sriram Balasubramanian, Yue Fan, Jessica Vermeulen, Martin Shreeve, Louis M. Staudt - Cancer Cell 2021 cited by 311
- Oncogenically active MYD88 mutations in human lymphoma
Authors: Vu N. Ngo, Ryan M. Young, Roland Schmitz, Sameer Jhavar, Wenming Xiao, Kian‐Huat Lim, Holger Kohlhammer, Weihong Xu, Yandan Yang, Hong Zhao, Arthur L. Shaffer, Paul B. Romesser, George W. Wright, John Powell, Andreas Rosenwald, Hans Konrad Müller‐Hermelink, German Ott, Randy D. Gascoyne, Joseph M. Connors, Lisa M. Rimsza, Elı́as Campo, Elaine S. Jaffe, Jan Delabie, Erlend B. Smeland, Richard I. Fisher, Rita M. Braziel, Raymond R. Tubbs, James R. Cook, D D Weisenburger, Wing C. Chan, Louis M. Staudt - Nature 2010 cited by 1,518
- Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture
Authors: Nevin Yusufova, Andreas Kloetgen, Matt Teater, Adewola Osunsade, Jeannie M. Camarillo, Christopher R. Chin, Ashley S. Doane, Bryan J. Venters, Stephanie Portillo‐Ledesma, Joseph Conway, Jude M. Phillip, Olivier Elemento, David W. Scott, Wendy Béguelin, Jonathan D. Licht, Neil L. Kelleher, Louis M. Staudt, Arthur I. Skoultchi, Michael‐Christopher Keogh, Effie Apostolou, Christopher E. Mason, Marcin Imieliński, Tamar Schlick, Yael David, Aristotelis Tsirigos, C. David Allis, Alexey A. Soshnev, Ethel Cesarman, Ari Melnick - Nature 2020 cited by 265
- Dose-Adjusted EPOCH-R Compared With R-CHOP as Frontline Therapy for Diffuse Large B-Cell Lymphoma: Clinical Outcomes of the Phase III Intergroup Trial Alliance/CALGB 50303
Authors: Nancy L. Bartlett, Wyndham H. Wilson, Sin‐Ho Jung, Eric D. Hsi, Matthew J. Maurer, Levi Pederson, Mei‐Yin C. Polley, Brandelyn N. Pitcher, Bruce D. Cheson, Brad S. Kahl, Jonathan W. Friedberg, Louis M. Staudt, Nina D. Wagner‐Johnston, Kristie A. Blum, Jeremy S. Abramson, Nishitha Reddy, Jane N. Winter, Julie Chang, Ajay K. Gopal, Amy Chadburn, Susan Mathew, Richard I. Fisher, Kristy L. Richards, Heiko Schöder, Andrew D. Zelenetz, John P. Leonard - Journal of Clinical Oncology 2019 cited by 423
- A multiprotein supercomplex controlling oncogenic signalling in lymphoma
Authors: James D. Phelan, Ryan M. Young, Daniel E. Webster, Sandrine Roulland, George W. Wright, Monica Kasbekar, Arthur L. Shaffer, Michele Ceribelli, James Q. Wang, Roland Schmitz, Masao Nakagawa, Emmanuel Bachy, Da Wei Huang, Yanlong Ji, Lu Chen, Yandan Yang, Hong Zhao, Xin Yu, Weihong Xu, Maryknoll Palisoc, Racquel Valadez, Theresa Davies‐Hill, Wyndham H. Wilson, Wing C. Chan, Elaine S. Jaffe, Randy D. Gascoyne, Elı́as Campo, Andreas Rosenwald, German Ott, Jan Delabie, Lisa M. Rimsza, Fausto J. Rodríguez, Fayez Estephan, Matthias Holdhoff, Michael J. Kruhlak, Stephen M. Hewitt, Craig J. Thomas, Stefania Pittaluga, Thomas Oellerich, Louis M. Staudt - Nature 2018 cited by 403
- Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing
Authors: Wenming Xiao, Luyao Ren, Zhong Chen, Li Tai Fang, Yongmei Zhao, Justin Lack, Meijian Guan, Bin Zhu, Erich Jaeger, Liz Kerrigan, Thomas Blomquist, Tiffany Hung, Marc Sultan, Kenneth B. Idler, Charles Lu, Andreas Scherer, Rebecca Kusko, Malcolm Moos, Chunlin Xiao, Stephen T. Sherry, Ogan D. Abaan, Wanqiu Chen, Xin Chen, Jessica Nordlund, Ulrika Liljedahl, Roberta Maestro, Maurizio Polano, Jir̆ı́ Drábek, Petr Vojta, Sulev Kõks, Ene Reimann, Bindu Swapna Madala, Tim R. Mercer, Chris Miller, Howard J. Jacob, Tiffany Truong, Ali Moshrefi, Aparna Natarajan, Ana Granat, Gary P. Schroth, Rasika Kalamegham, Eric Peters, Virginie Petitjean, Ashley Walton, Tsai-Wei Shen, Keyur Talsania, Cristobal Juan Vera, Kurt J. Langenbach, Maryellen de Mars, Jennifer Hipp, James C. Willey, Jing Wang, Jyoti Shetty, Yuliya Kriga, Arati Raziuddin, Bao Tran, Yuanting Zheng, Ying Yu, Margaret C. Cam, Parthav Jailwala, Cu Nguyen, Daoud Meerzaman, Qingrong Chen, Chunhua Yan, Ben Ernest, Urvashi Mehra, Roderick V. Jensen, Wendell Jones, Jian‐Liang Li, Brian N. Papas, Mehdi Pirooznia, Yunching Chen, Fayaz Seifuddin, Zhipan Li, Xue‐Lu Liu, Wolfgang Resch, Jingya Wang, Leihong Wu, Gökhan Yavaş, Corey J. Miles, Baitang Ning, Weida Tong, Christopher E. Mason, Eric Donaldson, Samir Lababidi, Louis M. Staudt, Živana Težak, Huixiao Hong, Charles Wang, Leming Shi - Nature Biotechnology 2021 cited by 213
- The NCI Genomic Data Commons
Authors: Allison P. Heath, Vincent Ferretti, Stuti Agrawal, Maksim An, James C. Angelakos, Renuka Arya, Rosita Bajari, Bilal Baqar, Justin H. B. Barnowski, Jeffrey Burt, Ann Catton, Brandon F. Chan, Fay Chu, Kim Cullion, Tanja M. Davidsen, Phuong-My Do, Christian Dompierre, Martin L. Ferguson, Michael Fitzsimons, Michael E. Ford, Miyuki Fukuma, Sharon Gaheen, Gajanan Ganji, Tzintzuni I. Garcia, Sameera S. George, Daniela S. Gerhard, Francois Gerthoffert, Fauzi Gomez, Kang Han, Kyle M. Hernandez, Biju Issac, Richard F. W. Jackson, Mark A. Jensen, Sid Joshi, Ajinkya Kadam, Aishmit Khurana, Kyle M. J. Kim, Victoria E. Kraft, Shenglai Li, Tara M. Lichtenberg, Janice Lodato, Laxmi Lolla, Plamen Martinov, Jeffrey A. Mazzone, Daniel P. Miller, Ian Miller, Joshua S. Miller, Koji Miyauchi, Mark W. Murphy, Thomas Nullet, Rowland O. Ogwara, Francisco Ortuño, Jesús Pedrosa, Phuong Lan Pham, Maxim Y. Popov, James J. Porter, Ray Powell, Karl Rademacher, Colin P. Reid, Samantha Rich, Bessie Rogel, Himanso Sahni, Jeremiah Savage, Kyle A. Schmitt, Trevar Simmons, Joseph Sislow, Jonathan Spring, Lincoln Stein, S. Mažeika P. Sullivan, Yajing Tang, Mathangi Thiagarajan, Heather D. Troyer, Chang Wang, Zhining Wang, Bedford L. West, Alex Wilmer, Shane Wilson, Kaman Wu, William P. Wysocki, Linda Xiang, Joseph T. Yamada, Liming Yang, Christine Yu, Christina K. Yung, Jean C. Zenklusen, Junjun Zhang, Zhenyu Zhang, Yuanheng Zhao, Ariz Zubair, Louis M. Staudt, Robert L. Grossman - Nature Genetics 2021 cited by 211
- Most non-canonical proteins uniquely populate the proteome or immunopeptidome
Authors: Maria Virginia Ruiz Cuevas, Marie‐Pierre Hardy, Jaroslav Hollý, Éric Bonneil, Chantal Durette, Mathieu Courcelles, Joël Lanoix, Caroline Côté, Louis M. Staudt, Sébastien Lemieux, Pierre Thibault, Claude Perreault, Jonathan W. Yewdell - Cell Reports 2021 cited by 207
- Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics
Authors: Roland Schmitz, Ryan M. Young, Michele Ceribelli, Sameer Jhavar, Wenming Xiao, Meili Zhang, George W. Wright, Arthur L. Shaffer, Daniel J. Hodson, Eric D. Buras, Xuelu Liu, John Powell, Yandan Yang, Weihong Xu, Hong Zhao, Holger Kohlhammer, Andreas Rosenwald, Philip M. Kluin, Hans Konrad Müller‐Hermelink, German Ott, Randy D. Gascoyne, Joseph M. Connors, Lisa M. Rimsza, Elı́as Campo, Elaine S. Jaffe, Jan Delabie, Erlend B. Smeland, Martin D. Ogwang, Steven J. Reynolds, Richard I. Fisher, Rita M. Braziel, Raymond R. Tubbs, James R. Cook, Dennis D. Weisenburger, Wing C. Chan, Stefania Pittaluga, Wyndham H. Wilson, Thomas A. Waldmann, Martin Rowe, Sam M. Mbulaiteye, Alan B. Rickinson, Louis M. Staudt - Nature 2012 cited by 920
- IRF4 addiction in multiple myeloma
Authors: Arthur L. Shaffer, N. C. Tolga Emre, Laurence Lamy, Vu N. Ngo, George W. Wright, Wenming Xiao, John Powell, Sandeep S. Davé, Xin Yu, Hong Zhao, Yuxin Zeng, Bangzheng Chen, Joshua Epstein, Louis M. Staudt - Nature 2008 cited by 736
- Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma
Authors: Javeed Iqbal, George W. Wright, Chao Wang, Andreas Rosenwald, Randy D. Gascoyne, Dennis D. Weisenburger, Timothy C. Greiner, Lynette M. Smith, Shuangping Guo, Ryan A. Wilcox, Bin Tean Teh, Soon Thye Lim, Soon Yong Tan, Lisa M. Rimsza, Elaine S. Jaffe, Elı́as Campo, Antonio Martı́nez, Jan Delabie, Rita M. Braziel, James R. Cook, Raymond R. Tubbs, German Ott, Eva Geissinger, Philippe Gaulard, Pier Paolo Piccaluga, Stefano Pileri, Wing Y. Au, Shigeo Nakamura, Masao Seto, Françoise Berger, Laurence de Leval, Joseph M. Connors, Jamés O. Armitage, Julie M. Vose, Wing C. Chan, Louis M. Staudt - Blood 2014 cited by 540
