Massimo Gadina
Active 1991–2025
- 92
- Papers
- 26,164
- Citations
- 69
- h-index
- 89
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Medicine47%
- Immunology and Microbiology25.7%
- Biochemistry, Genetics and Molecular Biology22.3%
- Neuroscience2%
- Pharmacology, Toxicology and Pharmaceutics0.6%
- Agricultural and Biological Sciences0.6%
- Other1.8%
Topics
- Cytokine Signaling Pathways and Interactions5.3%
- interferon and immune responses4.5%
- Inflammasome and immune disorders4.4%
- Immune Cell Function and Interaction4.1%
- T-cell and B-cell Immunology2.7%
- Immune Response and Inflammation2.3%
- Other76.7%
Coauthors
- John J. O’Shea38
- Wanxia Li Tsai19
- Daniella M. Schwartz11
- Deborah L. Stone9
- Hanna Kim8
- Patrycja Hoffmann8
- Sarfaraz Hasni8
- Adriana A. de Jesus7
- Amanda K. Ombrello7
- Ivona Aksentijevich7
- Yasuko Furumoto7
- Chyi‐Chia Richard Lee6
- Laura Vian6
- Stephen R. Brooks6
- Yuka Kanno6
- Arian Laurence5
- Dan Yang5
- David M. Frucht5
- Edward W. Cowen5
- Elaine F. Remmers5
- Francesca Romana Spinelli5
- Hye Sun Kuehn5
- Jae Jin Chae5
- Raphaela Goldbach‐Mansky5
All papers
- The JAK-STAT pathway at 30: Much learned, much more to do
Authors: Rachael L. Philips, Yuxin Wang, HyeonJoo Cheon, Yuka Kanno, Massimo Gadina, Vittorio Sartorelli, Curt M. Horvath, James Darnell, George R. Stark, John J. O’Shea - Cell 2022 cited by 723
- JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects
Authors: Shubhasree Banerjee, Ann Biehl, Massimo Gadina, Sarfaraz Hasni, Daniella M. Schwartz - Drugs 2017 cited by 1,192
- The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention
Authors: John J. O’Shea, Daniella M. Schwartz, Alejandro V. Villarino, Massimo Gadina, Iain B. McInnes, Arian Laurence - Annual Review of Medicine 2015 cited by 1,577
- Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease
Authors: David B. Beck, Marcela A. Ferrada, Keith A. Sikora, Amanda K. Ombrello, Jason C. Collins, Wuhong Pei, Nicholas Balanda, Daron L. Ross, Daniela Ospina Cardona, Zhijie Wu, Bhavisha A. Patel, Kalpana Manthiram, Emma M. Groarke, Fernanda Gutierrez‐Rodrigues, Patrycja Hoffmann, Sofia Rosenzweig, Shuichiro Nakabo, Laura W. Dillon, Christopher S. Hourigan, Wanxia Li Tsai, Sarthak Gupta, Carmelo Carmona‐Rivera, Anthony J. Asmar, Lisha Xu, Hirotsugu Oda, Wendy Goodspeed, Karyl S. Barron, Michele Nehrebecky, Anne Jones, Ryan S. Laird, Natalie Deuitch, Dorota Rowczenio, Emily Rominger, Kristina V Wells, Chyi‐Chia Richard Lee, Weixin Wang, Megan Trick, James C. Mullikin, Gustaf Wigerblad, Stephen R. Brooks, Stefania Dell’Orso, Zuoming Deng, Jae Jin Chae, Alina Dulau‐Florea, May Christine V. Malicdan, Danica Novacic, Robert A. Colbert, Mariana J. Kaplan, Massimo Gadina, Sinisa Savic, Helen J. Lachmann, Mones Abu‐Asab, Benjamin D. Solomon, Kyle Retterer, William A. Gahl, Shawn M. Burgess, Ivona Aksentijevich, Neal S. Young, Katherine R. Calvo, Achim Werner, Daniel L. Kastner, Peter C. Grayson - New England Journal of Medicine 2020 cited by 1,154
- JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
Authors: Daniella M. Schwartz, Yuka Kanno, Alejandro V. Villarino, Michael M. Ward, Massimo Gadina, John J. O’Shea - Nature Reviews Drug Discovery 2017 cited by 1,209
- Activated STING in a Vascular and Pulmonary Syndrome
Authors: Yu Liu, Adriana A. de Jesus, Bernadette Marrero, Dan Yang, Suzanne Ramsey, Gina A. Montealegre Sanchez, Klaus Tenbrock, Helmut Wittkowski, Olcay Y. Jones, Hyesun Kuehn, Chyi‐Chia Richard Lee, Michael A. DiMattia, Edward W. Cowen, B González, Ira Palmer, John J. DiGiovanna, Angélique Biancotto, Hanna Kim, Wen Lin Tsai, Anna M. Trier, Yan Huang, Deborah L. Stone, Suvimol Hill, HyeSoon Kim, Cynthia St. Hilaire, Shakuntala Gurprasad, N Plass, Dawn Chapelle, Iren Horkayne‐Szakaly, Dirk Foell, Andrei Barysenka, Fabio Candotti, Steven M. Holland, Jason D. Hughes, Huseyin Mehmet, Andrew C. Issekutz, M Raffeld, Joshua McElwee, JÉRǑMe Fontana, Caterina P. Minniti, Susan Moir, Daniel L. Kastner, Massimo Gadina, A.C. Steven, Paul T. Wingfield, Stephen R. Brooks, Sergio D. Rosenzweig, Thomas A. Fleisher, Zuoming Deng, Manfred Boehm, Amy S. Paller, Raphaela Goldbach‐Mansky - New England Journal of Medicine 2014 cited by 1,387
- Type 2 immunity in the skin and lungs
Authors: Cezmi A. Akdiş, Peter D. Arkwright, Marie‐Charlotte Brüggen, William W. Busse, Massimo Gadina, Emma Guttman‐Yassky, Kenji Kabashima, Yasutaka Mitamura, Laura Vian, Jianni Wu, Óscar Palomares - Allergy 2020 cited by 552
- Erratum to: JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects
Authors: Shubhasree Banerjee, Ann Biehl, Massimo Gadina, Sarfaraz Hasni, Daniella M. Schwartz - Drugs 2017 cited by 594
- Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
Authors: Najoua Lalaoui, Steven E. Boyden, Hirotsugu Oda, Geryl Wood, Deborah L. Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E. Lawlor, Kristien J.M. Zaal, Patrycja Hoffmann, Nima Etemadi, Kristy Shield‐Artin, Christine Biben, Wanxia Li Tsai, Mary Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, Natasha Silke, Laurens Wachsmuth, Lixin Zheng, Natalia Sampaio Moura, David B. Beck, Gustavo Gutierrez-Cruz, Amanda K. Ombrello, Gineth Paola Pinto-Patarroyo, Andrew J. Kueh, Marco J. Herold, Cathrine Hall, Hongying Wang, Jae Jin Chae, Natalia I. Dmitrieva, Mark McKenzie, Amanda Light, Beverly Barham, Anne Jones, Tina Romeo, Qing Zhou, Ivona Aksentijevich, James C. Mullikin, Andrew J. Gross, Anthony K. Shum, Edwin D. Hawkins, Seth L. Masters, Michael J. Lenardo, Manfred Boehm, Sergio D. Rosenzweig, Manolis Pasparakis, Anne K. Voss, Massimo Gadina, Daniel L. Kastner, John Silke - Nature 2019 cited by 333
- Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases
Authors: Daniella M. Schwartz, Michael Bonelli, Massimo Gadina, John J. O’Shea - Nature Reviews Rheumatology 2015 cited by 643
- JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies
Authors: Gina A. Montealegre Sanchez, Adam Reinhardt, Suzanne Ramsey, Helmut Wittkowski, Philip J. Hashkes, Yackov Berkun, Susanne Schalm, Sara Murías, Jason Dare, Diane E. Brown, Deborah L. Stone, Ling Gao, Thomas Klausmeier, Dirk Foell, Adriana A. de Jesus, Dawn Chapelle, Hanna Kim, Samantha Dill, Robert A. Colbert, Laura Failla, Bahar Kost, Michelle O’Brien, James C. Reynolds, Les Folio, Katherine R. Calvo, Scott M. Paul, Nargues Weir, Alessandra Brofferio, Ariane Soldatos, Angélique Biancotto, Edward W. Cowen, John J. DiGiovanna, Massimo Gadina, Andrew Lipton, Colleen Hadigan, Steven M. Holland, Joseph R. Fontana, Ahmad S. Alawad, Rebecca J. Brown, Kristina I. Rother, Theo Heller, Kristina M. Brooks, Parag Kumar, Stephen R. Brooks, Meryl Waldman, Harsharan K. Singh, Volker Nickeleit, Maria Silk, Apurva Prakash, Jonathan Janes, Seza Özen, Paul Wakim, Paul Brogan, William L. Macias, Raphaela Goldbach‐Mansky - Journal of Clinical Investigation 2018 cited by 521
- Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus
Authors: Sarfaraz Hasni, Sarthak Gupta, Michael A. Davis, Elaine Poncio, Yenealem Temesgen‐Oyelakin, Philip M. Carlucci, Xinghao Wang, Mohammad Naqi, Martin P. Playford, Rishi R. Goel, Xiaobai Li, Ann Biehl, Isabel Ochoa-Navas, Zerai Manna, Yinghui Shi, Donald E. Thomas, Jinguo Chen, Angélique Biancotto, Richard Apps, Foo Cheung, Yuri Kotliarov, Ashley L. Babyak, Huizhi Zhou, Rongye Shi, Katie Stagliano, Wanxia Li Tsai, Laura Vian, Nathalia Gazaniga, Valentina Giudice, Shajia Lu, Stephen R. Brooks, Meggan Mackay, Peter K. Gregersen, Nehal N. Mehta, Alan T. Remaley, Betty Diamond, John J. O’Shea, Massimo Gadina, Mariana J. Kaplan - Nature Communications 2021 cited by 197
- Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story
Authors: Michael Bonelli, Andreas Kerschbaumer, Kastriot Kastrati, Kamran Ghoreschi, Massimo Gadina, Leonhard X. Heinz, Josef S Smolen, Daniel Aletaha, John J. O’Shea, Arian Laurence - Annals of the Rheumatic Diseases 2023 cited by 143
- Erratum: JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
Authors: Daniella M. Schwartz, Yuka Kanno, Alejandro V. Villarino, Michael M. Ward, Massimo Gadina, John J. O’Shea - Nature Reviews Drug Discovery 2017 cited by 382
- Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
Authors: Qing Zhou, Hongying Wang, Daniella M. Schwartz, Monique Stoffels, Yong Hwan Park, Yuan Zhang, Dan Yang, Erkan Demirkaya, Masaki Takeuchi, Wanxia Li Tsai, Jonathan J. Lyons, Xiaomin Yu, Claudia Ouyang, Celeste Chen, David T. Chin, Kristien J.M. Zaal, Settara C. Chandrasekharappa, Eric P. Hanson, Zhen Yu, James C. Mullikin, Sarfaraz Hasni, Ingrid E. Wertz, Amanda K. Ombrello, Deborah L. Stone, Patrycja Hoffmann, Anne Jones, Beverly Barham, Helen L. Leavis, Annet van Royen-Kerkof, Cailin H. Sibley, Ezgi Deniz Batu, Ahmet Gül, Richard M. Siegel, Manfred Boehm, Joshua D. Milner, Seza Özen, Massimo Gadina, JaeJin Chae, Ronald M. Laxer, Daniel L. Kastner, Ivona Aksentijevich - Nature Genetics 2015 cited by 633
- Protein kinases: drug targets for immunological disorders
Authors: Leslie Castelo‐Soccio, Hanna Kim, Massimo Gadina, Pamela L. Schwartzberg, Arian Laurence, John J. O’Shea - Nature reviews. Immunology 2023 cited by 107
- Somatic Mutations in UBA1 Define a Distinct Subset of Relapsing Polychondritis Patients With VEXAS
Authors: Marcela A. Ferrada, Keith A. Sikora, Yiming Luo, Kristina V Wells, Bhavisha A. Patel, Emma M. Groarke, Daniela Ospina Cardona, Emily Rominger, Patrycja Hoffmann, Mimi T. Le, Zuoming Deng, Kaitlin A. Quinn, Emily Rose, Wanxia Li Tsai, Gustaf Wigerblad, Wendy Goodspeed, Anne Jones, Lorena Wilson, Oskar Schnappauf, Ryan S. Laird, Jeff Kim, Clint Allen, Arlene Sirajuddin, Marcus Y. Chen, Massimo Gadina, Katherine R. Calvo, Mariana J. Kaplan, Robert A. Colbert, Ivona Aksentijevich, Neal S. Young, Sinisa Savic, Daniel L. Kastner, Amanda K. Ombrello, David B. Beck, Peter C. Grayson - Arthritis & Rheumatology 2021 cited by 238
- Development of a Validated Interferon Score Using NanoString Technology
Authors: Hanna Kim, Adriana A. de Jesus, Stephen R. Brooks, Yin Liu, Yan Huang, Rachel VanTries, Gina A. Montealegre Sanchez, Yaron Rotman, Massimo Gadina, Raphaela Goldbach‐Mansky - Journal of Interferon & Cytokine Research 2018 cited by 184
- Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)
Authors: Kamran Ghoreschi, Michael I. Jesson, Li Xiong, Jamie L. Lee, Sarbani Ghosh, Jason W. Alsup, James D. Warner, Masao Tanaka, Scott Steward-Tharp, Massimo Gadina, Craig J. Thomas, John C. Minnerly, Chad Storer, Timothy P. LaBranche, Zaher A. Radi, Martin E. Dowty, Richard D. Head, Debra M. Meyer, Nandini Kishore, John J. O’Shea - The Journal of Immunology 2011 cited by 644
- JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition
Authors: Yiming Luo, Madison Alexander, Massimo Gadina, John J. O’Shea, Françoise Meylan, Daniella M. Schwartz - Journal of Allergy and Clinical Immunology 2021 cited by 115
- Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2
Authors: Qing Zhou, Dan Yang, Amanda K. Ombrello, Andrey V. Zavialov, Camilo Toro, Anton V. Zavialov, Deborah L. Stone, Jae Jin Chae, Sergio D. Rosenzweig, Kevin Bishop, Karyl S. Barron, Hye Sun Kuehn, Patrycja Hoffmann, Alejandra Negro, Wanxia Li Tsai, Edward W. Cowen, Wuhong Pei, Joshua D. Milner, Christopher Silvin, Theo Heller, David T. Chin, Nicholas J. Patronas, John S. Barber, Chyi‐Chia Richard Lee, Geryl Wood, Alexander Ling, Susan J. Kelly, David E. Kleiner, James C. Mullikin, Nancy J. Ganson, Heidi H. Kong, Sophie Hambleton, Fabio Candotti, Martha Quezado, Katherine R. Calvo, Hawwa Alao, Beverly Barham, Anne Jones, James F. Meschia, Bradford B. Worrall, Scott E. Kasner, Stephen S. Rich, Raphaela Goldbach‐Mansky, Mario Abinun, Elizabeth Chalom, Alisa Gotte, Marilynn Punaro, Virginia Pascual, James Verbsky, Troy R. Torgerson, Nora G. Singer, Timothy R. Gershon, Seza Özen, Ömer Karadağ, Thomas A. Fleisher, Elaine F. Remmers, Shawn M. Burgess, Susan Moir, Massimo Gadina, Raman Sood, Michael S. Hershfield, Manfred Boehm, Daniel L. Kastner, Ivona Aksentijevich - New England Journal of Medicine 2014 cited by 893
- Cytokine Signaling in 2002
Authors: John J. O’Shea, Massimo Gadina, Robert D. Schreiber - Cell 2002 cited by 1,126
- Germline Mutations in the Extracellular Domains of the 55 kDa TNF Receptor, TNFR1, Define a Family of Dominantly Inherited Autoinflammatory Syndromes
Authors: Michael McDermott, Ivona Aksentijevich, Jérôme Galon, Elizabeth McDermott, B Ogunkolade, Michael Centola, Elizabeth Mansfield, Massimo Gadina, Leena Karenko, Tom Pettersson, John McCarthy, David M. Frucht, Martin Aringer, Yelizaveta Torosyan, Anna‐Maija Teppo, Meredith Wilson, H.Mehmet Karaarslan, Ying Wan, Ian Todd, Geryl Wood, Ryan Schlimgen, Thisum R. Kumarajeewa, Sheldon M. Cooper, John P. Vella, Christopher I. Amos, John C. Mulley, Kathleen A. Quane, Michael G. Molloy, Annamari Ranki, Richard J. Powell, G. A. Hitman, John J. O’Shea, Daniel L. Kastner - Cell 1999 cited by 1,421
- An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist
Authors: Ivona Aksentijevich, Seth L. Masters, Polly J. Ferguson, Paul Dancey, Joost Frenkel, Annet van Royen-Kerkhoff, R M Laxer, Ulf Tedgård, Edward W. Cowen, Tuyet‐Hang Pham, Matthew G. Booty, Jacob D. Estes, Netanya G. Sandler, Nicole Plass, Deborah L. Stone, Maria L. Turner, Suvimol Hill, John A. Butman, Rayfel Schneider, Paul Babyn, Hatem El‐Shanti, Elena Pope, Karyl S. Barron, Xinyu Bing, Arian Laurence, Chyi‐Chia Richard Lee, Dawn Chapelle, Gillian I. Clarke, Kamal Ohson, Marc Nicholson, Massimo Gadina, Barbara Yang, Benjamin D. Korman, Peter K. Gregersen, P. Martin van Hagen, A. Elisabeth Hak, Marjan Huizing, Proton Rahman, Daniel C. Douek, Elaine F. Remmers, Daniel L. Kastner, Raphaela Goldbach‐Mansky - New England Journal of Medicine 2009 cited by 992
