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Nicholas K. Tonks

Active 1984–2025

96
Papers
29,178
Citations
85
h-index
96
i10-index

Citations

Citations per year for Nicholas K. Tonks1969: 2 citations1981: 1 citations1983: 1 citations1985: 5 citations1986: 5 citations1987: 4 citations1988: 17 citations1989: 47 citations1990: 107 citations1991: 208 citations1992: 222 citations1993: 196 citations1994: 211 citations1995: 220 citations1996: 200 citations1997: 233 citations1998: 358 citations1999: 365 citations2000: 350 citations2001: 350 citations2002: 353 citations2003: 368 citations2004: 385 citations2005: 344 citations2006: 296 citations2007: 288 citations2008: 332 citations2009: 264 citations2010: 293 citations2011: 245 citations2012: 284 citations2013: 276 citations2014: 269 citations2015: 173 citations2016: 162 citations2017: 194 citations2018: 133 citations2019: 477 citations2020: 430 citations2021: 421 citations2022: 397 citations2023: 306 citations2024: 569 citations2025: 277 citations2026: 5 citations1970–1980: no citations, so these years are not shown1982: no citations, so this year is not shown1984: no citations, so this year is not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 3,669 citing papers, 38% of this breakdownChina: 1,023 citing papers, 10.6% of this breakdownUnited Kingdom: 660 citing papers, 6.8% of this breakdownGermany: 490 citing papers, 5.1% of this breakdownCanada: 474 citing papers, 4.9% of this breakdownJapan: 348 citing papers, 3.6% of this breakdownItaly: 279 citing papers, 2.9% of this breakdownFrance: 269 citing papers, 2.8% of this breakdownAustralia: 217 citing papers, 2.2% of this breakdownSpain: 187 citing papers, 1.9% of this breakdownSouth Korea: 174 citing papers, 1.8% of this breakdownIndia: 143 citing papers, 1.5% of this breakdown
0%38%Other 17.9%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology63%
  • Medicine20.7%
  • Immunology and Microbiology4.8%
  • Nursing3.5%
  • Neuroscience2.7%
  • Chemistry1.6%
  • Other3.7%

Topics

  • Protein Tyrosine Phosphatases7.5%
  • Protein Kinase Regulation and GTPase Signaling3.8%
  • PI3K/AKT/mTOR signaling in cancer3.7%
  • Galectins and Cancer Biology3%
  • Redox biology and oxidative stress2.4%
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms1.8%
  • Other77.8%

Coauthors

All papers

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  1. Connecting copper and cancer: from transition metal signalling to metalloplasia

    Authors: Eva J. Ge, Ashley I. Bush, Angela Casini, Paul A. Cobine, Justin R. Cross, Gina M. DeNicola, Q. Ping Dou, Katherine J. Franz, Vishal M. Gohil, Sanjeev Gupta, Stephen G. Kaler, Svetlana Lutsenko, Vivek Mittal, Michael J. Petris, Roman Polishchuk, Martina Ralle, Michael L. Schilsky, Nicholas K. Tonks, Linda T. Vahdat, Linda Van Aelst, Dan Xi, Peng Yuan, Donita C. Brady, Christopher J. Chang - Nature reviews. Cancer 2021 cited by 1,273

  2. Protein tyrosine phosphatases: from genes, to function, to disease

    Authors: Nicholas K. Tonks - Nature Reviews Molecular Cell Biology 2006 cited by 1,696

  3. PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity

    Authors: Florian Wiede, Kun‐Hui Lu, Xin Du, Mara N. Zeissig, Rachel Xu, Pei Kee Goh, Chrysovalantou E. Xirouchaki, Samuel J. Hogarth, Spencer Greatorex, Kevin Sek, Roger J. Daly, Paul A. Beavis, Phillip K. Darcy, Nicholas K. Tonks, Tony Tiganis - Cancer Discovery 2021 cited by 137

  4. Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

    Authors: Navasona Krishnan, Dorothy Koveal, Daniel Miller, Bin Xue, S. Dipikaa Akshinthala, Jaka Kragelj, Malene Ringkjøbing Jensen, Carla‐Maria Gauss, Rebecca Page, Martin Blackledge, Senthil K. Muthuswamy, Wolfgang Peti, Nicholas K. Tonks - Nature Chemical Biology 2014 cited by 383

  5. Reactive Oxygen Species Enhance Insulin Sensitivity

    Authors: Kim Loh, Haiyang Deng, Atsushi Fukushima, Xiaochu Cai, Benoît Boivin, Sandra Galić, Clinton R. Bruce, Benjamin J. Shields, Beata Skiba, Lisa M. Ooms, Nigel K. Stepto, Ben J. Wu, Christina A. Mitchell, Nicholas K. Tonks, Matthew J. Watt, Mark A. Febbraio, Peter J. Crack, Sofianos Andrikopoulos, Tony Tiganis - Cell Metabolism 2009 cited by 572

  6. H 2 S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response

    Authors: Navasona Krishnan, Cexiong Fu, Darryl Pappin, Nicholas K. Tonks - Science Signaling 2011 cited by 445

  7. Reversible Oxidation and Inactivation of Protein Tyrosine Phosphatases In Vivo

    Authors: Tzu‐Ching Meng, Toshiyuki Fukada, Nicholas K. Tonks - Molecular Cell 2002 cited by 1,035

  8. A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models

    Authors: Navasona Krishnan, Konstantis F. Konidaris, Gilles Gasser, Nicholas K. Tonks - Journal of Biological Chemistry 2017 cited by 134

  9. Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

    Authors: Annette Salmeen, Jannik N. Andersen, Michael P. Myers, Tzu‐Ching Meng, John A. Hinks, Nicholas K. Tonks, David Barford - Nature 2003 cited by 954

  10. Redox Redux: Revisiting PTPs and the Control of Cell Signaling

    Authors: Nicholas K. Tonks - Cell 2005 cited by 711

  11. CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B

    Authors: David Barford, Andrew Flint, Nicholas K. Tonks - Science 1994 cited by 762

  12. Structural and Evolutionary Relationships among Protein Tyrosine Phosphatase Domains

    Authors: Jannik N. Andersen, Ole Hartvig Mortensen, Günther H. Peters, Paul G. Drake, Lars Iversen, Ole H. Olsen, Peter Gildsig Jansen, Henrik Sune Andersen, Nicholas K. Tonks, Niels Peter Hundahl Møller - Molecular and Cellular Biology 2001 cited by 711

  13. Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases

    Authors: Andrew Flint, Tony Tiganis, David Barford, Nicholas K. Tonks - National Academy of Sciences, Proceedings of the National Academy of Sciences 1997 cited by 779

  14. PTP1B: From the sidelines to the front lines!

    Authors: Nicholas K. Tonks - FEBS Letters 2003 cited by 373

  15. Molecular Basis for the Dephosphorylation of the Activation Segment of the Insulin Receptor by Protein Tyrosine Phosphatase 1B

    Authors: Annette Salmeen, Jannik N. Andersen, Michael P. Myers, Nicholas K. Tonks, David Barford - Molecular Cell 2000 cited by 464

  16. Protein tyrosine phosphatases – from housekeeping enzymes to master regulators of signal transduction

    Authors: Nicholas K. Tonks - FEBS Journal 2012 cited by 437

  17. TYK2 and JAK2 Are Substrates of Protein-tyrosine Phosphatase 1B

    Authors: Michael P. Myers, Jannik N. Andersen, Alan Cheng, Michel L. Tremblay, Curt M. Horvath, Jean-Patrick Parisien, Annette Salmeen, David Barford, Nicholas K. Tonks - Journal of Biological Chemistry 2001 cited by 467

  18. PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophils

    Authors: Dongyan Song, José M. Adrover, Christy Felice, Lisa N. Christensen, Xue‐Yan He, Joseph R. Merrill, John E. Wilkinson, Tobias Janowitz, Scott K. Lyons, Mikala Egeblad, Nicholas K. Tonks - JCI Insight 2022 cited by 41

  19. Characterization of the major protein-tyrosine-phosphatases of human placenta.

    Authors: Nicholas K. Tonks, C D Diltz, Edmond H. Fischer - Journal of Biological Chemistry 1988 cited by 555

  20. Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling

    Authors: Markus Dagnell, Jeroen Frijhoff, Irina Pader, Martin Augsten, Benoît Boivin, Jianqiang Xu, Pankaj Kumar Mandal, Nicholas K. Tonks, Carina Hellberg, Marcus Conrad, Elias S.J. Arnér, Arne Östman - National Academy of Sciences, Proceedings of the National Academy of Sciences 2013 cited by 100

  21. Purification of the major protein-tyrosine-phosphatases of human placenta.

    Authors: Nicholas K. Tonks, C D Diltz, Edmond H. Fischer - Journal of Biological Chemistry 1988 cited by 569

  22. Superoxide dismutase 1 (SOD1) is essential for H 2 O 2 -mediated oxidation and inactivation of phosphatases in growth factor signaling

    Authors: Jose C. Juarez, Mari Manuia, Mark E. Burnett, Oscar Betancourt, Benoît Boivin, David E. Shaw, Nicholas K. Tonks, Andrew P. Mazar, Fernando Doñate - National Academy of Sciences, Proceedings of the National Academy of Sciences 2008 cited by 258

  23. Coordinated Regulation of Insulin Signaling by the Protein Tyrosine Phosphatases PTP1B and TCPTP

    Authors: Sandra Galić, Christine Hauser, Barbara B. Kahn, Fawaz G. Haj, Benjamin G. Neel, Nicholas K. Tonks, Tony Tiganis - Molecular and Cellular Biology 2005 cited by 210

  24. Structural Basis for Phosphotyrosine Peptide Recognition by Protein Tyrosine Phosphatase 1B

    Authors: Zongchao Jia, David Barford, Andrew Flint, Nicholas K. Tonks - Science 1995 cited by 587